FredECohenMDD.Phil.

Endocrinology • San Francisco, CA

Diabetes, Lipid Metabolism

Professor, UCSF School of Medicine

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Office
345 California St
Suite 3300
San Francisco, CA 94104
Phone+1 415-743-1559
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Education & Training

University of California (San Francisco)Fellowship, Endocrinology, Diabetes, and Metabolism, 1987 - 1988
University of California (San Francisco)Residency, Internal Medicine, 1984 - 1987
Stanford University School of MedicineClass of 1984

Certifications & Licensure

CA State Medical License 1985 - 2024
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Elected Member Institute of Medicine, 2004
Whos Who in Medicine and Healthcare Marquis Whos Who

Publications & Presentations

PubMed

128 citations
Protease-Sensitive Synthetic Prions
David W. Colby, Rachel Wain, Ilia V. Baskakov, Giuseppe Legname, Christina G. Palmer, Hoang-Oanh B. Nguyen, Azucena Lemus, Fred E. Cohen, Stephen J. DeArmond, Stanley ...> ;Plos Pathogens. 2010 Jan 22
25 citations
Molecular Modeling of the Misfolded Insulin Subunit and Amyloid Fibril
Jay H. Choi, Barnaby C. H. May, Holger Wille, Fred E. Cohen> ;Biophysical Journal. 2009 Dec 16
41 citations
Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model.
Nancy E Lane, Donald B. Kimmel, Magnus H.L. Nilsson, Fred E. Cohen, Suellen Newton, Robert A. Nissenson, Gordon J Strewler> ;Journal of Bone and Mineral Research. 2009 Dec 3
Natural and synthetic prion structure from X-ray fiber diffraction.
Wille, H., Bian, W., McDonald, M., Kendall, A., Colby, D.W., Bloch, L., Ollesch, J., Borovinskiy, A.L., Cohen, F.E., Prusiner, S.B., Stubbs, G.> ;Proc Natl Acad Sci U S A. 2009-10-06
7 citations
Site-directed mutagenesis demonstrates the plasticity of the beta helix: implications for the structure of the misfolded prion protein.
Jay H. Choi, Barnaby C. H. May, Cédric Govaerts, Fred E. Cohen> ;Structure. 2009 Jul 15
176 citations
Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry.
Randy M. Whittal, Haydn L. Ball, Fred E. Cohen, Alma L. Burlingame, Stanley B. Prusiner, Michael A. Baldwin> ;Protein Science. 2008 Dec 31
Analysis of the sequence and structural features of the left-handed beta-helical fold.
Choi, J.H., Govaerts, C., May, B.H., Cohen, F.E.> ;Proteins. 2008 Oct
96 citations
Genes contributing to prion pathogenesis.
Gültekin Tamgüney, Kurt Giles, David V. Glidden, Pierre Lessard, Holger Wille, Patrick Tremblay, Darlene Groth, Fruma Yehiely, Carsten Korth, Richard C. Moore, Jörg Ta...> ;The Journal of General Virology. 2008 Jul 1
25 citations
Electron crystallography of the scrapie prion protein complexed with heavy metals.
Holger Wille, Cédric Govaerts, Alexander L. Borovinskiy, Diane Latawiec, Kenneth H. Downing, Fred E. Cohen, Stanley B. Prusiner> ;Archives of Biochemistry and Biophysics. 2007 Nov 15
Cell division modulates prion accumulation in cultured cells.
Ghaemmaghami, S., Phuan, P., Perkins, B., Ullman, J., May, B.H., Cohen, F.E., Prusiner, S.B.> ;Proc Natl Acad Sci U S A. 2007 Nov 13
6 citations
Prion Protein Amyloid: Separation of Scrapie Infectivity from PrP Polymers
Holger Wille, Michael A. Baldwin, Fred E. Cohen, Stephen J. DeArmond, Stanley B. Prusiner> ;Ciba Foundation Symposium. 1996 Jan 1
20 citations
Bis-Acridines as Lead Antiparasitic Agents: Structure-Activity Analysis of a Discrete Compound Library In Vitro
Conor R. Caffrey, Dietmar Steverding, Ryan K. Swenerton, Ben L. Kelly, Deirdre Walshe, Anjan Debnath, Yuan-Min Zhou, Patricia S. Doyle, Aaron T. Fafarman, Julie A. Zor...> ;Antimicrobial Agents and Chemotherapy. 2007 Jun 1
14 citations
Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.
Puay Wah Phuan, Julie A. Zorn, Jiri G. Safar, Kurt Giles, Stanley B. Prusiner, Fred E. Cohen, Barnaby C. H. May> ;The Journal of General Virology. 2007 Apr 1
30 citations
Automatic Extraction of Protein Point Mutations Using a Graph Bigram Association
Lawrence C Lee, Florence Horn, Fred E. Cohen> ;Plos Computational Biology. 2007 Feb 2
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmaco...
May, B.H., Zorn, J.A., Witkop, J., Sherrill, J., Wallace, A.C., Legname, G., Prusiner, S.B., Cohen, F.E.> ;J Med Chem. 2007 Jan 11
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
Legname, G., Nguyen, H.B., Peretz, D., Cohen, F.E., DeArmond, S.J., Prusiner, S.B.> ;Proc Natl Acad Sci U S A. 2006 Dec 12
67 citations
Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
Béatrice Luginbühl, Z.F. Kanyo, R. Mark Jones, Robert J. Fletterick, Stanley B. Prusiner, Fred E. Cohen, R. Anthony Williamson, Dennis R. Burton, Andreas Plückthun> ;Journal of Molecular Biology. 2006 Oct 13
19 citations
Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
Barnaby C. H. May, Juanita Witkop, John Sherrill, Marc O. Anderson, Peter B. Madrid, Julie A. Zorn, Stanley B. Prusiner, Fred E. Cohen, R. Kiplin Guy> ;Bioorganic & Medicinal Chemistry Letters. 2006 Sep 15
92 citations
Searching for new antimalarial therapeutics amongst known drugs
Jennifer L. Weisman, Ally P. Liou, Anang A. Shelat, Fred E. Cohen, R. Kiplin Guy, Joseph L. DeRisi> ;Chemical Biology & Drug Design. 2006 Jun 1
Developing therapeutics for the diseases of protein misfolding.
May, B.H., Govaerts, C., Cohen, F.E.> ;Neurology. 2006 Jan 24
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Ye, S., Huang, Y., Müllendorff, K., Dong, L., Giedt, G., Meng, E. C., Cohen, F. E., Kuntz, I. D., Weisgraber, K. H., Mahley, R. W.> ;Proc Natl Acad Sci U S A. 2005 Dec 20
Strain-specified characteristics of mouse synthetic prions.
Legname, G.,Nguyen, H. O.,Baskakov, I. V.,Cohen, F. E.,Dearmond, S. J.,Prusiner, S. B.> ;Proc Natl Acad Sci U S A. 2005 Feb 8
783 citations
Synthetic Mammalian Prions
Giuseppe Legname, Ilia V. Baskakov, Hoang-Oanh B. Nguyen, Detlev Riesner, Fred E. Cohen, Stephen J. DeArmond, Stanley B. Prusiner> ;Science. 2004 Jul 30
403 citations
Evidence for assembly of prions with left-handed β-helices into trimers
Cédric Govaerts, Holger Wille, Stanley B. Prusiner, Fred E. Cohen> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 Jun 1
133 citations
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues
Gerold Schmitt-Ulms, Kirk C. Hansen, Jialing Liu, Cynthia Cowdrey, Jian Yang, Stephen J. DeArmond, Fred E. Cohen, Stanley B. Prusiner, Michael A. Baldwin> ;Nature Biotechnology. 2004 May 16
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Press Mentions

Intellia Therapeutics Names Fred Cohen, M.D., to Board of DirectorsJanuary 24th, 2019
Hot Topics in Clinical Diagnostics—“Bucking the Odds: Veracyte’s Route to Building a Sustainable Genomics Dx Business”September 1st, 2017
Bortezomib-Induced Muscle Toxicity in Multiple MyelomaJune 19th, 2017
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Grant Support

Structural Analysis Of Synthetic PrionsNational Institute On Aging2005–2009
Toward A Structure Of PrpscNational Institute On Aging2004–2008
Understanding And Improving Small Molecule Inhibitors Of Prion ReplicationNational Institute On Aging2007
Structure Based Design Of Anti Prion TherapeuticsNational Center For Research Resources2004–2005
Computer Analysis And Prediction Of Protein StructureNational Institute Of General Medical Sciences1992–2003
Peptides And Small Molecules That Influence Prion DiseaseNational Institute On Aging2000–2002
Interdisciplinary Drug Design Targeting Trypanozoma CruziNational Institute Of Allergy And Infectious Diseases1999–2002
Computational Studies Of Prion Protein StructureNational Institute On Aging1994–2002
Computer Analysis &Prediction Of Protein StructureNational Institute Of General Medical Sciences1997–1999
Computational Studies On The Structures Of Chimeric Prion ProteinsNational Institute Of Neurological Disorders And Stroke1995–1999
Computer-Aided Drug Design/Discovery For Chagas DiseaseNational Institute Of Allergy And Infectious Diseases1995–1998
Structural Studies Of Prion ProteinsNational Center For Research Resources1996–1997
Model Building By Homology &Drug DiscoveryNational Center For Research Resources1996–1997
DE Novo Protein Structure PredictionNational Center For Research Resources1996–1997
Conformational Properties Of Polypeptide ChainsNational Center For Research Resources1996–1997
Computer Analysis And Prediction Of Protein StruNational Institute Of General Medical Sciences1996
Structure Evaluation W/ Multiple Sequence AlignmentsNational Center For Research Resources1996
Sequence &Modelling Function &Conformation Of Prion ProteinsNational Center For Research Resources1996
Peptoid Modeling &CharacterizationNational Center For Research Resources1996
Molecular Modeling Of Parasite Cysteine Proteases &Prediction Of New InhibitorsNational Center For Research Resources1996
Mol Model Of Phosphofructokinase For Prediction Of New Antiparasitic AgentsNational Center For Research Resources1996
Modelling Of G Protein Coupled ReceptorsNational Center For Research Resources1996
Family Specific Analysis Of Beta Bulges &Beta Twist In Beta Sandwich ProteinsNational Center For Research Resources1996
Computer Analysis Prediction Of Protein StructureNational Institute Of General Medical Sciences1989–1991

FredECohenMDD.Phil.

Dr. Cohen is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Publications & Presentations

Press Mentions

Grant Support

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