FrederickF.LangJr.MD

PubMed

• Facilitating Repeat Intracarotid Injections in Mouse Models by a Novel Injection Site Repair Technique.
  Daniel Ledbetter, Joy Gumin, Lynette Phillips, Yuzaburo Shimizu, Chibawanye Ene, Frederick F Lang> ;Journal of Visualized Experiments. 2024 Mar 15
• Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma.
  Vinodh A Kumar, Alejandro Perez, Angela L Young, Julia Jones, Barbara J O'Brien, Frederick F Lang, Jason T Huse, Gregory N Fuller> ;Neuropathology. 2024 Feb 27
• 1 citations
  Chimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized mice.
  Shin, D., Jiang, H., Kim, D., Fan, X., Nguyen, T., Parthasarathy, A., Gumin, J., Alonso, M., Gomez-Manzano, C., Fueyo, J., Ene, C., Gillard, A., Singh, S., Sohoni, S.,...> ;Molecular Therapy. 2024 Mar 6
• The AANS/CNS Section on Tumors: a summary of 40 years of advocacy to advance the care of patients with brain and spine tumors.
  Warnick, R., Rutka, J., Glick, R., Parney, I., Lang, F., Kalkanis, S., Rosenblum, M., Germano, I.> ;Journal of Neurosurgery. 2024 Jan 26
• The genomic alterations in glioblastoma influence the levels of CSF metabolites.
  Wang, D., Fujita, Y., Rodriguez Armendariz, A., Shah, M., Putluri, N., Pichardo-Rojas, P., Parker Kerrigan, B., Dono, A., Patel, C., Zhu, J., Huse, J., Lang, F., Esque...> ;Acta Neuropathologica Communications. 2024 Jan 19
• 1 citations
  Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma.
  Mekenzie M Peshoff, Pravesh Gupta, Shivangi Oberai, Rakesh Trivedi, Hiroshi Katayama, Prashanth Chakrapani, Minghao Dang, Simona Migliozzi, Joy Gumin, Divya B Kadri, J...> ;Neuro-Oncology. 2024 Jan 18
• 1 citations
  Development of a rabbit human glioblastoma model for testing of endovascular selective intra-arterial infusion (ESIA) of novel stem cell-based therapeutics.
  Kan, P., Srinivasan, V., Gumin, J., Garcia, R., Chen, S., Johnson, J., Collins, D., Chen, M., Ledbetter, D., Huse, J., Evan Luna, Z., Robledo, A., Vasandani, V., Rao, ...> ;Neuro-Oncology. 2024 Jan 5
• Rapid detection of mutations in CSF-cfTNA with the Genexus Integrated Sequencer.
  Srividya Arjuna, Mauli Shah, Antonio Dono, Luis Nunez-Rubiano, Pavel S Pichardo-Rojas, Jay-Jiguang Zhu, Roy F Riascos, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri, Dzi...> ;Journal of Neuro-Oncology. 2024 Jan 1
• MGMT function determines the differential response of ATR inhibitors with DNA-damaging agents in glioma stem cells for GBM therapy.
  Leong, V., Khan, S., Sharma, P., Wu, S., Thomas, R., Li, X., Singh, S., Yung, A., Koul, D., Lang, F.> ;Neuro-Oncology Advances. 2023 Dec 19
• 1 citations
  Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma.
  Arpan De, John M Lattier, John E Morales, Jack R Kelly, Xiaofeng Zheng, Zhihua Chen, Sumod Sebastian, Zahra Nassiri Toosi, Jason T Huse, Frederick F Lang, Joseph H McC...> ;The Journal of Neuroscience. 2023 Nov 22
• Subependymomas of the fourth ventricle: To operate or not to operate?
  Ali S Haider, Ian E McCutcheon, Chibawanye I Ene, Gregory N Fuller, Donald F Schomer, Maria Gule-Monroe, Franco DeMonte, Sherise D Ferguson, Frederick F Lang, Sujit S ...> ;Journal of Clinical Neuroscience. 2023 Dec 1
• 2 citations
  Tumor-specific polycistronic miRNA delivered by engineered exosomes for the treatment of glioblastoma.
  Malcolm F McDonald, Anwar Hossain, Irtiza Hasan, Sanjay Singh, Satoshi Adachi, Joy Gumin, Daniel Ledbetter, Jing Yang, Lihong Long, Marc Daou, Sricharan Gopakumar, Lyn...> ;Neuro-Oncology. 2024 Feb 2
• 2 citations
  Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade.
  Sangeeta Goswami, Deblina Raychaudhuri, Pratishtha Singh, Seanu Meena Natarajan, Yulong Chen, Candice Poon, Mercedes Hennessey, Aminah J Tannir, Jan Zhang, Swetha Anan...> ;Nature Cancer. 2023 Oct 1
• 6 citations
  Multiomics analyses reveal/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance.
  Caishang Zheng, Yanjun Wei, Qiang Zhang, Ming Sun, Yunfei Wang, Jiakai Hou, Peng Zhang, Xiangdong Lv, Dan Su, Yujie Jiang, Joy Gumin, Nidhi Sahni, Baoli Hu, Wenyi Wang...> ;Science Advances. 2023 Aug 4
• Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity.
  Hong Jiang, Dong Ho Shin, Yanhua Yi, Xuejun Fan, Joy Gumin, Jiasen He, Andrew G Gillard, Frederick F Lang, Candelaria Gomez-Manzano, Juan Fueyo> ;Cancer Research Communications. 2023 Jun 1
• 37 citations
  Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.
  Farshad Nassiri, Vikas Patil, Leeor S Yefet, Olivia Singh, Jeff Liu, Rachel M A Dang, Takafumi N Yamaguchi, Mariza Daras, Timothy F Cloughesy, Howard Colman, Priya U K...> ;Nature Medicine. 2023 Jun 1
• 83 citations
  Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma.
  Jaime Gállego Pérez-Larraya, Marc Garcia-Moure, Sara Labiano, Ana Patiño-García, Jessica Dobbs, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martin...> ;The New England Journal of Medicine. 2022 Jun 30
• 49 citations
  Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
  Enric Xipell, Marisol Gonzalez-Huarriz, Juan Jose Martinez de Irujo, Antonia García-Garzón, F. Lang, Hong Jiang, Juan Fueyo, Candelaria Gomez-Manzano, Marta M. Alonso> ;Oncotarget. 2016 Apr 21
• 1 citations
  Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles.
  Lea M Stitzlein, Achintyan Gangadharan, Leslie M Walsh, Deokhwa Nam, Alexsandra B Espejo, Melissa M Singh, Kareena H Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan...> ;Frontiers in Neurology. 2023 Jan 1
• 4 citations
  Changes in outcomes and factors associated with survival in melanoma patients with brain metastases.
  Merve Hasanov, Denái R Milton, Alicia Bea Davies, Elizabeth Sirmans, Chantal Saberian, Eliza L Posada, Sylvia Opusunju, Jeffrey E Gershenwald, Carlos A Torres-Cabala, ...> ;Neuro-Oncology. 2023 Jul 6
• 14 citations
  Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry.
  Teresa T Nguyen, Dong Ho Shin, Sagar Sohoni, Sanjay K Singh, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F Lang, Christopher Alvarez-Breckenridge...> ;Journal for Immunotherapy of Cancer. 2022 Jul 1
• 1 citations
  A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology.
  Michael A Vogelbaum, Gongbo Li, Amy B Heimberger, Frederick F Lang, Juan Fueyo, Candelaria Gomez-Manzano, Nader Sanai> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2022 Apr 1
• Preclinical animal brain tumor models for interventional neuro-oncology.
  Stephen R Chen, Frederick F Lang, Peter Kan> ;Journal of Neurointerventional Surgery. 2022 May 1
• 31 citations
  Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies.
  Erik H P van Putten, Anne Kleijn, Victor W van Beusechem, David Noske, Cor H J Lamers, Anna L de Goede, Sander Idema, Daphna Hoefnagel, Jenneke J Kloezeman, Juan Fueyo...> ;Clinical Cancer Research. 2022 Apr 14
• 2 citations
  PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells.
  Aram S Modrek, Eskil Eskilsson, Ravesanker Ezhilarasan, Qianghu Wang, Lindsey D Goodman, Yingwen Ding, Ze-Yan Zhang, Krishna P L Bhat, Thanh-Thuy T Le, Floris P Barthe...> ;Frontiers in Oncology. 2022 Jan 1
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Abstracts/Posters

• Predicting glioblastoma recurrence with hyperpolarized magnetic resonance
  Salzillo T, Gumin J, Lee J, Millward NZ, Gammon ST, Lang FF, Bhattacharya P, World Molecular Imaging Congress 2021 Meeting, Miami, FL, 10/2021
• 4th Ventricle Subependymoma: To operate or not to operate?
  Haider AS, Ene C, Fuller GN, Schomer DF, Gule-Monroe MK, DeMonte F, Ferguson SD, Lang FF, McCutcheon I, Prabhu S, Raza SM, Suki D, Weinberg JS, Sawaya R, Congress of Neurological Surgeons Annual Meeting, Austin, TX, 10/2021
• Predictors of overall survival (OS) in patients (Pts) with melanoma brain metastasis (MBM) in the modern era
  Hasanov M, Milton DR, Davies A, Sirmans E, Saberian C, Posada E, Gershenwald JE, Torres-Cabala CA, Huse JT, Tawbi HA, Glitza IC, Li J, Chung C, Yeboa DN, Opusunju S, K..., American Society of Clinical Oncology, Virtual, 6/2021
• Viroimmunotherapy for diffuse intrinsic pontine gliomas
  Gupta S, Laspidea V, Fueyo J, Becher O, Nguyen T, Shin DH, Jiang H, Sohoni S, Fan X, Yi Y, Gumin J, Lang FF, Gomez-Manzano C, Alonso MM, American Society of Pediatric Hematology/Oncology Conference, Virtual, 4/2021
• Implementation of human induced pluripotent stem cell derived cerebral organoids to model normal tissue radio response
  Bronk L, Singh S, Thomas R, Parkitny L, Maletic-Savatic M, Mohan R, Lang FF, Grosshans D, Society for Neuro-Oncology Virtual Annual Meeting, Virtual, 11/2020
• Behavior of glioblastoma stem-like cells with known IDH1 Status in cerebral organoids
  Singh S, Munyeshyaka M, Gumin J, Yang J, Ledbetter D, Hossain A, Kerrigan BP, Lang FF, Society for Neuro-Oncology, Virtual, 11/2020
• Enhanced exosomes and microRNA cocktails in the treatment of glioblastoma
  Lang FF, McDonald MF, Hossain A, American Academy of Neurological Surgery, Virtual, 9/2020
• Intercellular communication between normal and tumor cells in glioma microenvironment
  Hossain A, Hasan I, Adachi S, Ledbetter D, McDonald M, Gumin J, Daou M, Phillips L, Parker Kerrigan B, Lang F, Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, 11/2019
• Engineered exosomes for therapeutic gene delivery in brain tumors
  McDonald M, Hasan I, Adachi S, Gumin J, Ledbetter D, Daou M, Gopakumar S, Momin E, Long L, Phillips L, Parker Kerrigan B, Hossain A, Lang F, Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, 11/2019
• Comprehensive spatial characterization of immune cells in the CNS brain tumor microenvironment
  Kassab C, Zamler D, Gupta P, Srinivasan V, Rao G, Prabhu S, Huse J, Fuller G, Bruner J, Langford L, McCutcheon I, Ferguson S, Weinberg J, Wistuba I, Lang F, Bhat K, He..., Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, 11/2019
• Combined IDO inhibitor and OX40L-armed-oncolytic-adenovirus therapy improves survival in murine glioblastoma
  Nguyen T, Shin DH, Jiang H, Lang F, Gomez-Manzano C, Fueyo J, American Association for Cancer Research Tumor Immunology & Immunotherapy Annual Meeting, Boston, MA, 11/2019
• Activating the immunity within the tumor using viroimmunotherapy: Delta-24-RGD oncolytic adenovirus armed with the immunopositive regulator GITRL
  Rivera-Molina Y, Fueyo J, Jiang H, Nguyen T, Shin DO, Youssef G, Fan X, Gumin J, Alonso MM, Phadnis S, Lang F, Gomez-Manzano C, Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, 11/2019
• Treatment with Delta-24-RGDOX of subcutaneous tumors results in abscopal effect eradicating intracranial melanomas
  Jiang H, Shin DH, Nguyen T, Alonso MM, Lang F, Gomez-Manzano C, Fueyo J., Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, 11/2019
• Stem cell delivery of oncolytic adenovirus DNX-2401 following surgical resection for the treatment of glioblastoma
  Gopakumar S, Gumin J, Daou M, Ledbetter D, McDonald M, Hossain A, Hingtgen S, Ewend M, Lang FF, Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, 11/2019
• Interim results of a phase II multi-center study of oncolytic adenovirus DNX-2401 with Pembrolizumab for recurrent glioblastoma; CAPTIVE study (KEYNOTE-192)
  Aiken R, Chen C, Cloughesy T, Colman H, Daras M, Groves M, Khagi S, Kumthekar P, Lang F, Nassiri F, Ong S, Ramakrishna R, Sonabend A, Vogelbaum M, Zadeh G, Agensky L, ..., Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ, 11/2019
• Imaging the metabolic evolution of patient-derived glioblastoma xenografts in vivo with hyperpolarized magnetic resonance during tumor development and following radiat...
  Salzillo T, Gumin J, Lee J, Hassan I, Millward NZ, Colen R, Lang F, Bhattacharya P, 12th Annual World Molecular Imaging Congress (WMIC), Montreal, Quebec, 9/2019
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Lectures

• Biological Therapies for Brain Tumors: Oncolytic Viruses & Bone Marrow Stem Cells' 
  NYU Langone Health Neurosurgery Grand Rounds, New York, NY - 10/2021
• Neurosurgical Management of Low Grade Gliomas: Insular Tumors 
  26th Annual Meeting of the Japanese Congress for Brain Tumor Surgery, Virtual - 9/2021
• Biological Therapies for Gliomas: Viruses and Stem Cells 
  The University of Texas at Austin Dell Medical School Dept. of Neurosurgery Grand Rounds - 8/2021
• Developing a Brain Metastasis Clinic 
  Clinica Alemana VI Neuro Oncology Online Course: A Multidisciplinary Approach, Virtual - 6/2021
• Establishing Neurooncological Centres and Foster New Therapeutic Strategies 
  72nd Annual Meeting German Society of Neurosurgery (DGNC), Virtual - 6/2021
• Sulcus-guided Resection: Insular Tumors 
  Clinica Alemana VI Neuro Oncology Online Course: A Multidisciplinary Approach, Virtual - 5/2021
• En Bloc Sulcus-Guided Resection of Gliomas 
  Gleneagles Global Hospital Neuro-Oncology Monthly Webinar Virtual Talk, Mumbai, India - 5/2021
• Delta-24 Adenoviral Therapy for Glioblastoma: From Bench to Bedside 
  12th Annual Conference of Indian Society of Neuro-Oncology, Virtual - 4/2021
• Biological Therapies in the Treatment of Gliomas 
  University of Virginia (Visiting Professor), Neurosurgery, Virtual - 4/2021
• A Novel Adenoviral-Permissive, Immunocompetent Hamster Model to Evaluate Oncolytic Adenoviral Therapy for Glioblastoma 
  Oncology Models Forum Annual Meeting, Virtual - 3/2021
• Biological Therapies for Brain Tumors: Oncolytic Viruses & Bone Marrow Stem Cells 
  Cedars-Sinai Distinguished Neurosurgery Visiting Professor Lecture Series Grand Rounds - 3/2021
• Overview of the Brain SPORE 
  Brain Cancer SPORE Mid-Winter Workshop, Virtual - 2/2021
• Biological Therapies for Brain Tumors 
  Ascension Providence Hospital Southfield Campus Oncology Grand Rounds, Virtual - 1/2021
• Biological Therapies for Brain Tumors: Viruses and Stem Cells 
  The Andrew Connor Curtis Endowed Featured Speaker Series, University of Miami - 9/2020
• Oncolytic Adenoviruses for Glioma Therapy 
  Brain Tumor SPORE Mid-Winter Workshop, Chicago, IL - 2/2020
• Immunotherapy in Gliomas: Oncolytic Viruses 
  Annual Conference on Evidence Based Management of Cancers in India, Mumbai, India - 2/2020
• Does Extent of Resection Impact Survival in GBMs 
  Annual Conference on Evidence Based Management of Cancers in India, Mumbai, India - 2/2020
• Biological Therapies for Gliomas: Viruses & Stem Cells 
  Medstar Georgetown University Hospital Interdepartmental Neuroscience Grand Rounds - 1/2020
• Trials of Oncolytic Viruses: The Impact of the Neurosurgeon," 
  The Society for Neuro-Oncology Scientific Meeting and Education Day, Sunrise Session, Phoenix, AZ - 11/2019
• Principles of Viral Therapies Against Gliomas: Oncolytic & Immunological Aspects 
  The Society for Neuro-Oncology Scientific Meeting and Education Day, Phoenix, AZ - 11/2019
• Oncolytic Viral Therapy 
  The Society for Neuro-Oncology & Society for CNS - 11/2019
• Introduction of Honored Guest Speaker: Dr. Raymond Sawaya 
  Congress of Neurological Surgeons Annual Meeting, General Scientific Session II, San Francisco, CA - 10/2019
• Dr. Raymond Sawaya's Professional Career 
  Congress of Neurological Surgeons Annual Meeting, Honored Guest Speaker Dinner, San Francisco, CA - 10/2019
• MSC Delivery of Oncolytic Adenovirus Delta-24-RGD Following Surgical Resection of Glioblastoma 
  81st Annual Meeting of the American Academy of Neurological Surgery, Rome, Italy - 9/2019
• Intraoperative Techniques to Enhance Safety of Resection of Intrinsic Tumors: Insular Tumors and Low Grade Gliomas 
  World Federation of Neurosurgical Societies Special World Congress, Beijing, China - 9/2019
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