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Office
55 Fruit St
White 502
Boston, MA 02114Phone+1 617-726-4922- Is this information wrong?
Summary
- I am a faculty member in the Department of Neurological Surgery with an appointment in the Department of Pathology and Immunology at Washington University, where I am a member of the newly established interdisciplinary Center for Human Immunology and Immunotherapy Programs. I oversee a research program focused on the immunobiology of malignant glioma with the goal of translational and clinical trial efforts in the treatment of this disease. Whereas extensive genomic profiling is uncovering tumor cell vulnerabilities across many cancer types, this paradigm has not extended to glioblastoma due, at least in part, to the tremendous heterogeneity within these tumors. In contrast to conventional targeted therapeutic approaches, immune-based strategies may be particularly well-suited to treating these tumors due to the incredible diversity of antigens recognizable by immune cells.
My laboratory is focused on understanding the molecular and cellular basis of the immune response to glioblastoma in preclinical and translational settings as well as clarifying the relationships between glioma genomics and immunogenicity, an area termed “cancer immunogenomics.” These investigations are complemented by ongoing clinical trial efforts in this area.
Education & Training
Massachusetts General HospitalResidency, Neurological Surgery, 2006 - 2013- Massachusetts General HospitalResidency, Surgery, 2006 - 2007
Washington University School of Medicine in St. LouisPhD, Pathology and Immunology, 1998 - 2006
Washington University in St. Louis School of MedicineClass of 2006, MD
Certifications & Licensure
ME State Medical License Current
MA State Medical License 2011 - 2026
NH State Medical License 2023 - 2025
MO State Medical License 2014 - 2025
IL State Medical License 2021 - 2023- American Board of Neurological Surgery Neurological Surgery
Clinical Trials
- Neoantigen-based Personalized Vaccine Combined With Immune Checkpoint Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma Start of enrollment: 2018 Oct 31
- Neoantigen-based Personalized DNA Vaccine in Patients With Newly Diagnosed, Unmethylated Glioblastoma Start of enrollment: 2020 Jul 14
- Mapping Draining Lymph Nodes in CNS Malignancies Start of enrollment: 2019 Dec 03
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Publications & Presentations
PubMed
- Radical surgical resection with molecular margins is associated with improved survival in IDH wildtype GBM.Elie Massaad, William J Smith, Joseph Bradley, Eric Esposito, Mihir Gupta, Evan Burns, Ryan Burns, José K Velarde, Inka K Berglar, Rajiv Gupta, Maria Martinez-Lage, Jo...> ;Neuro-Oncology. 2024 Apr 6
- 1 citationsLetter: Answering Our Nation's Call: A Solution for Military Neurosurgery Wartime Readiness Through Civilian Collaboration.Richard P Menger, Gavin P Dunn> ;Neurosurgery. 2024 Feb 1
- Lessons for the Next Generation of Scientists from the Second Annual Arthur and Sandra Irving Cancer Immunology Symposium.Christopher Alvarez-Breckenridge, Kristin G Anderson, Ana Luisa Correia, Shadmehr Demehri, Huy Q Dinh, Karen Olivia Dixon, Gavin P Dunn, Laura Evgin, Jeremy Goc, Zinai...> ;Cancer Immunology Research. 2023 Dec 1
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Journal Articles
- A Deep Learning Approach to Automate Refinement of Somatic Variant Calling from Cancer Sequencing DataRavindra Uppaluri, Gavin P Dunn, Ramaswamy Govindan, S Joshua Swamidass, Todd A Fehniger, Nature
Press Mentions
ASCO21 Preview - Equity: Every Patient. Every Day. EverywhereMay 27th, 2021- Brain Tumor Awareness Month: 2021 Immunotherapy Research UpdatesMay 5th, 2021
- Current Trends in Cancer ImmunotherapyDecember 17th, 2020
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Professional Memberships
- Member
Hospital Affiliations
Siteman Cancer CenterSaint Louis, Missouri
Massachusetts General HospitalBoston, Massachusetts
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