GeorgeKGittesMD

PubMed

• Interventions for Pancreatitis-New Approaches, Knowledge Gaps, and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Disease...
  Anna Evans Phillips, Steven J Hughes, Dana K Andersen, Adam Bell, Randall Brand, Gregory A Coté, Adriana Cowdin, Nancy Diazgranados, Vikas Dudeja, Sinead N Duggan, Eva...> ;Pancreas. 2024 Apr 1
• Intra-Amniotic Sildenafil and Rosiglitazone Late in Gestation Ameliorate the Pulmonary Hypertension Phenotype in Congenital Diaphragmatic Hernia.
  Yoshida, S., Eichelberger, O., Ulis, M., Kreger, A., Gittes, G., Church, J.> ;Journal of Pediatric Surgery. 2024 Jan 23
• 3 citations
  Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.
  Joseph T Glessner, Mylarappa B Ningappa, Kim A Ngo, Maliha Zahid, Juhoon So, Brandon W Higgs, Patrick M A Sleiman, Tejaswini Narayanan, Sarangarajan Ranganathan, Micha...> ;Journal of Hepatology. 2023 Dec 1
• 1 citations
  Time-dependent effects of endogenous hyperglucagonemia on glucose homeostasis and hepatic glucagon action.
  Camila Lubaczeuski, Nadejda Bozadjieva-Kramer, Ruy A Louzada, George K Gittes, Gil Leibowitz, Ernesto Bernal-Mizrachi> ;JCI Insight. 2023 Jun 8
• 2 citations
  Intra-amniotic sildenafil administration in rabbits: Safety, pharmacokinetics, organ distribution and histologic evaluation.
  Shiho Yoshida, Alexander M Kreger, Imam H Shaik, Raymond E West 3rd, Raman Venkataramanan, George K Gittes> ;Toxicology and Applied Pharmacology. 2023 Jun 15
• 1 citations
  Chemical pancreatectomy in non-human primates ablates the acini and ducts and enhances beta-cell function.
  Kalsi, R., Kreger, A., Saleh, M., Yoshida, S., Sharma, K., Fusco, J., Saloman, J., Zhang, T., Thomas, M., Sehrawat, A., Wang, Y., Reif, J., Mills, J., Raad, S., Zengin...> ;Research Square. 2023 Mar 8
• 5 citations
  A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis.
  Han Zou, Bradley Poore, Emily E Brown, Jieqi Qian, Bin Xie, Evridiki Asimakidou, Vladislav Razskazovskiy, Deanna Ayrapetian, Vaibhav Sharma, Shunjin Xia, Fei Liu, Apen...> ;Nature Cell Biology. 2023 Mar 1
• 30 citations
  Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer.
  Jilian R Melamed, Saigopalakrishna S Yerneni, Mariah L Arral, Samuel T LoPresti, Namit Chaudhary, Anuradha Sehrawat, Hiromi Muramatsu, Mohamad-Gabriel Alameh, Norbert ...> ;Science Advances. 2023 Jan 27
• 1 citations
  Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats.
  Shiho Yoshida, Alexander M Kreger, George K Gittes> ;Frontiers in Bioengineering and Biotechnology. 2023 Jan 1
• Bone-marrow derived cells do not contribute to new beta-cells in the inflamed pancreas.
  Yinan Jiang, John Wiersch, Wei Wu, Jieqi Qian, Maharana Prathap R Adama, Nannan Wu, Weixia Yang, Congde Chen, Lingyan Zhu, Krishna Prasadan, George K Gittes, Xiangwei ...> ;Frontiers in Immunology. 2023 Jan 1
• Roles of Pancreatic Islet Catecholamine Neurotransmitters in Glycemic Control and in Antipsychotic Drug-Induced Dysglycemia.
  Zachary Freyberg, George K Gittes> ;Diabetes. 2023 Jan 1
• 3 citations
  Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation.
  Uylissa A Rodriguez, Shakti Dahiya, Michelle L Raymond, Chenxi Gao, Christina P Martins-Cargill, Jon D Piganelli, George K Gittes, Jing Hu, Farzad Esni> ;Development. 2022 Sep 1
• 2 citations
  Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.
  Yinan Jiang, Apeng Chen, Diana Kline, Qun Liu, Jie Ma, Yan Wang, Ting Zhang, Jieqi Qian, Laura Nelson, Krishna Prasadan, Baoli Hu, George K Gittes, Xiangwei Xiao> ;Diabetes, Obesity & Metabolism. 2022 Sep 1
• 3 citations
  Alpha-to-beta cell trans-differentiation for treatment of diabetes.
  Mohamed Saleh, George K Gittes, Krishna Prasadan> ;Biochemical Society Transactions. 2021 Dec 17
• Pancreatic Duct Infusion: An Effective and Selective Method of Drug and Viral Delivery.
  Joseph C Fusco, Chen Congde, Xiangwei Xiao, Krishna Prasadan, David Ricks, George K. Gittes> ;Journal of Visualized Experiments. 2021 Sep 30
• 4 citations
  β-cell Smad2 null mice have improved β-cell function and are protected from diet-induced hyperglycemia
  Mohamed Saleh, Nada Mohamed, Anuradha Sehrawat, Ting Zhang, Madison Thomas, Yan Wang, Ranjeet Kalsi, Justin Molitoris, Krishna Prasadan, George K. Gittes, Kalsi, R. S.> ;The Journal of Biological Chemistry. 2021 Sep 25
• 2 citations
  Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants.
  Mylarappa Ningappa, Morayooluwa Adenuga, Kim A. Ngo, Nada Mohamed, Tejaswini Narayanan, Krishna Prasadan, Chethan Ashokkumar, Jishnu Das, Lori Schmitt, Hannah Hartman,...> ;Frontiers in Physiology. 2021 Jul 14
• 45 citations
  Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma
  Apeng Chen, Yinan Jiang, Zhengwei Li, Lingxiang Wu, Ulises Santiago, Han Zou, Chunhui Cai, Vaibhav Sharma, Yongchang Guan, Lauren McCarl, Jie Ma, Yijen L. Wu, Joshua M...> ;The Journal of Clinical Investigation. 2021 Aug 16
• 2 citations
  Conversion of α-Cells to β-Cells in the Postpartum Mouse Pancreas Involves Lgr5 Progeny.
  Uylissa A. Rodriguez, Mairobys Socorro, Angela Criscimanna, Christina P. Martins, Nada Mohamed, Jing Hu, Krishna Prasadan, George K. Gittes, Farzad Esni> ;Diabetes. 2021 Apr 27
• 2 citations
  Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy.
  Qun Liu, Yinan Jiang, Lingyan Zhu, Jieqi Qian, Chaoban Wang, Tianlun Yang, Krishna Prasadan, George K. Gittes, Xiangwei Xiao> ;Experimental & Molecular Medicine. 2021 Apr 5
• 8 citations
  Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models
  Mohamed A. Saleh, Kartikeya Sharma, Ranjeet Kalsi, Joseph C Fusco, Anuradha Sehrawat, Jami L. Saloman, Ping Guo, Ting Zhang, Nada Mohamed, Yan Wang, Krishna Prasadan, ...> ;The Journal of Clinical Investigation. 2021 Feb 1
• 13 citations
  Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia
  Nadejda Bozadjieva Kramer, Camila Lubaczeuski, Manuel Blandino-Rosano, Grant P. Barker, George K. Gittes, Alejandro Caicedo, Ernesto Bernal-Mizrachi> ;Diabetes. 2020 Nov 25
• 13 citations
  Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality.
  Juhoon So, Mylarappa Ningappa, Joseph T. Glessner, Jun Min, Chethan Ashokkumar, Sarangarajan Ranganathan, Brandon W. Higgs, Dong Li, Qing Sun, Lori Schmitt, A. Biery, ...> ;Frontiers in Physiology. 2020 Oct 30
• 4 citations
  Intra-Amniotic Sildenafil Treatment Promotes Lung Growth and Attenuates Vascular Remodeling in an Experimental Model of Congenital Diaphragmatic Hernia
  Frances C. Okolo, Guangfeng Zhang, Julie Rhodes, George K. Gittes, Douglas A. Potoka> ;Fetal Diagnosis and Therapy. 2020 Jul 14
• 10 citations
  SMAD7 enhances adult β-cell proliferation without significantly affecting β-cell function in mice.
  Anuradha Sehrawat, Chiyo Shiota, Nada Mohamed, Julia DiNicola, Mohamed Saleh, Ranjeet Kalsi, Ting Zhang, Yan Wang, Krishna Prasadan, George K. Gittes> ;The Journal of Biological Chemistry. 2020 Apr 10
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Lectures

• Long-term Immunologically Unrecognized Reprogrammed Beta Cells as a Promising Cure for Autoimmune Diabetes 
  Pittsburgh, PA - 6/15/2014
• Exposure to Exendin-4 In Utero Results in Diabetes 
  Pittsburgh, PA - 6/15/2014
• Exendin-4 Enhances Endocrine Differentiation and Redirects Acinar Progenitors to an Endocrine Fate 
  Pittsburgh, PA - 6/15/2014
• Transforming Growth Factor ß Signaling Molecules and Phosphorylated Mitogen-activated Protein Kinase Are Upregulated in Workload-Induced Islet Cell Proliferation 
  Pittsburgh, PA - 6/15/2014
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