GeorgeALopezMDPhD

PubMed

• 288 citations
  Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.
  Michael D. Hill, Mayank Goyal, Bijoy K Menon, Raul G. Nogueira, Ryan A McTaggart, Andrew M. Demchuk, Alexandre Y Poppe, Brian H Buck, Thalia S Field, Dar Dowlatshahi, ...> ;Lancet. 2020 Mar 14
• 126 citations
  Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial.
  Magdy Selim, Lydia D. Foster, Claudia S. Moy, Guohua Xi, Michael D. Hill, Lewis B. Morgenstern, Steven M. Greenberg, Michael L. James, Vineeta Singh, Wayne M. Clark, C...> ;The Lancet. Neurology. 2019 May 1
• 247 citations
  Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III t...
  Daniel F. Hanley, Karen Lane, Nichol McBee, Wendy C. Ziai, Stanley Tuhrim, Kennedy R. Lees, Jesse Dawson, Dheeraj Gandhi, Natalie Ullman, W. Andrew Mould, Steven Mayo,...> ;Lancet. 2017 Feb 11
• Prospective, open-label safety study of intravenous recombinant tissue plasminogen activator in wake-up stroke.
  Barreto AD, Fanale CV, Alexandrov AV, Gaffney KC, Vahidy FS, Nguyen CB, Sarraj A, Rahbar M, Grotta JC, Savitz SI> ;Ann Neurol. 2016 Aug
• 6 citations
  Temperature Management in the Neurointensive Care Unit
  George A. Lopez> ;Current Treatment Options in Neurology. 2016 Feb 26
• 8 citations
  Falcine and Tentorial Subdural Hematomas May Not Routinely Require Transfer to a Tertiary Care Center
  Rochelle T. Sweis, Bichun Ouyang, George A. Lopez, Thomas P. Bleck, Katharina M. Busl> ;The Journal of Emergency Medicine. 2015 Nov 1
• 103 citations
  Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III
  Alastair J.S. Webb, Natalie Ullman, Timothy C. Morgan, John Muschelli, Joshua Kornbluth, Issam A. Awad, Stephen Mayo, Michael Rosenblum, Wendy C. Ziai, Mario Zuccarrel...> ;Stroke. 2015 Sep 1
• 4 citations
  CTP infarct core may predict poor outcome in stroke patients treated with IV t-PA.
  Tzu C Wu, Clark Sitton, Andrew W Potter, Ritvij Bowry, Preeti Sahota, Chunyan Cai, Peng Hui, Zhongxue Chen, Nicole R. Gonzales, Andrew D Barreto, George A. Lopez, Jame...> ;Journal of the Neurological Sciences. 2014 May 15
• 76 citations
  Optimizing Prediction Scores for Poor Outcome After Intra-Arterial Therapy in Anterior Circulation Acute Ischemic Stroke
  Amrou Sarraj, Karen C. Albright, Andrew D Barreto, Amelia K Boehme, Clark Sitton, Jeanie Choi, Steven L Lutzker, Chung Huan J Sun, Wafi Bibars, Claude Nguyen, Osman Mi...> ;Stroke. 2013 Dec 1
• 57 citations
  Design of a prospective, dose-escalation study evaluating the Safety of Pioglitazone for Hematoma Resolution in Intracerebral Hemorrhage (SHRINC).
  Nicole R. Gonzales, Jharna Shah, Navdeep Sangha, Lenis Sosa, Rebecca Martinez, Loren Shen, Mallikarjunarao Kasam, Miriam M. Morales, Monir Hossain, Andrew D Barreto, S...> ;International Journal of Stroke. 2013 Jul 1
• 20 citations
  Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization.
  Navdeep Sangha, Ramy El Khoury, Vivek Misra, George A. Lopez> ;Journal of Stroke and Cerebrovascular Diseases. 2012 Nov 1
• 3 citations
  Care of the Stroke Patient: Routine Management to Lifesaving Treatment Options
  George A. Lopez, Arash Afshinnik, Owen Samuels> ;Neurotherapeutics. 2011 Jul 12
• 27 citations
  Pharmacological Deep Vein Thrombosis Prophylaxis Does Not Lead to Hematoma Expansion in Intracerebral Hemorrhage With Intraventricular Extension
  Tzu-Ching Wu, Mallik Kasam, Nusrat Harun, Hen Hallevi, Hesna Bektas, Indrani Acosta, Vivek Misra, Andrew D Barreto, Nicole R. Gonzales, George A. Lopez, James C. Grott...> ;Stroke. 2011 Mar 1
• 18 citations
  A report of fetal demise during therapeutic hypothermia after cardiac arrest.
  Elissa Fory Wible, Joseph S. Kass, George A. Lopez> ;Neurocritical Care. 2010 Jun 18
• 26 citations
  Intracranial Hemorrhage Following Thrombolytic Use for Stroke Caused by Infective Endocarditis
  Parita Bhuva, Sheng-Han Kuo, J. Claude Hemphill, George A. Lopez> ;Neurocritical Care. 2010 Feb 1
• 11 citations
  Emerging Subspecialties in Neurology: Neurocritical care
  Asma Zakaria, J. Javier Provencio, George A. Lopez> ;Neurology. 2008 Apr 29
• Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.
  Goldstein DS, Imrich R, Peckham E, Holmes C, Lopez G, Crews C, Hardy J, Singleton A, Hallett M> ;Neurology. 2007-10-16
• 5 citations
  Retinopathy and choroidopathy as the initial signs of hypertensive brainstem encephalopathy.
  Thomas A. Albini, Rohit R. Lakhanpal, Rod Foroozan, George A. Lopez, Alice R. McPherson> ;Archives of Ophthalmology. 2006 Dec 1
• 2 citations
  Update on therapies for acute ischemic stroke.
  Dean D. Kindler, George A. Lopez, Bradford B. Worrall, Karen C. Johnston> ;Neurosurgical Focus. 2000 May 15
• A case of a nasogastric tube knotting around a tracheal tube: detection and management.
  Au-Truong X, Lopez G, Joseph NJ, Salem MR> ;Anesth. Analg.. 1999-12-01
• 106 citations
  Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.
  George A. Lopez, Yuh Nung Ian, Lily Yeh Ian> ;Neuron. 1991 Aug 1
• Dietary sodium deficiency potentiates the effect of prostaglandin E2 on in vitro renin release in the rat.
  Lopez GA, Khalighi K, Ebneshahidi A, Gonzales E, Jaramillo S, Rivas S> ;Prostaglandins Leukot Med. 1985-08-01
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Journal Articles

• Comparison of ABC/2 with the Simplified ABC/2 Formula in Calculating Intracerebral Hemorrhage Volume  
  Lee, V, Conners, J, John, S, Busl, K, Song, S, Cutting, S, Cherian, L, Pollandt, S, Boland, T, Goodman, D, Lopez, George, Bleck, T, Garg, R, J Neurol Disord Stroke, 1/1/2016
• Temperature Management in the Neurointensive Care Unit  
  Lopez, George, Current Treatment Options in Neurology, 1/1/2016
• Falcine and Tentorial Subdural Hematomas May Not Routinely Require Transfer to a Tertiary Care Center  
  Sweis, R, Ouyang, B, Lopez, George, Bleck, T, Busl, K, J Emerg Medicine, 1/1/2015
• Accuracy of the ABC/2 score for intracerebral hemorrhage: Systematic review and analysis of MISTIE, CLEAR-IVH, CLEAR III  
  Webb, A, Ullman, N, Morgan, T, Muschelli, J, Kornbluth, J, Awad, I, Mayo, S, Rosenblum, M, Ziai, W, Zuccarrello, M, Aldrich, F, John, S, Harnof, S, Lopez, George, Broa..., Stroke, 1/1/2015
• A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR ...  
  Ziai WC, Tuhrim S, Lane K, McBee N, Lees K, Dawson J, Butcher K, Vespa P, Wright DW, Keyl PM, Mendelow AD, Kase C, Wijman C, Lapointe M, John S, Thompson R, Thompson C..., Int J Stroke, 1/1/2014
• CTP infarct core may predict poor outcome in stroke patients treated with IV t-PA  
  Wu TC, Sitton C, Potter A, Bowry R, Sahota P, Cai C, Hui P, Chen Z, Gonzales N, Barreto A, Lopez, George, Grotta JC, Savitz SI, J Neurol Sci, 1/1/2014
• Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema  
  Mould WA, Carhuapoma JR, Muschelli J, Lane K, Morgan TC, McBee NA, Bistran-Hall AJ, Ullman NL, Vespa P, Martin NA, Awad I, Zuccarello M, Hanley DF; MISTIE Investigators, Stroke, 1/1/2013
• Design of a Prospective, Dose-Escalation Study Evaluating the Safety of Pioglitazone for Hematoma Resolution in Intercerebral Hemorrhage (SHRINC)  
  Gonzales NR, Shah J, Sangha N, Sosa L, Martinez R, Shen L, Kasam M, Morales MM, Hossain MM, Barreto AD, Savitz SI, Lopez, George, Misra V, Wu RC, El Khoury R, Sarraj A..., Int J Stroke, 1/20/2012
• Intracranial Hemorrhage Following Thrombolytic Use for Stroke Caused by Infective Endocarditis  
  Bhuva, P., Kuo, S-H., Hemphill, J. C. and Lopez, George, A, Neurocritical Care, 1/1/2010
• Report of Fetal Demise During Therapeutic Hypothermia After Cardiac Arrest  
  Wible, E., F. Kass, J. and Lopez, George, A, Neurocritical Care, 1/1/2010
• Update on therapies for acute ischemic stroke  
  Kindler, D.D., Lopez, George A., Worrall, B.B., Johnston, K, Neurosurgical Focus, 1/1/2000
• Evidence that the S6 Segment of the Shaker Voltage-Gated Potassium Channel Comprises Part of the Pore  
  Lopez, George A., Jan, Y.N. and Jan, L.Y., Nature, 1/1/1994
• Elucidation of Biophysical and Biological Properties of Voltage-Gated Potassium Channels  
  Baldwin, T.J., Isacoff, E.Y., Li, M., Lopez, George A., Sheng, M., Tsaur, M., Jan, Y.N. and Jan, L.Y., Cold Spring Harbor Symposium on Quantitative Biology, 1/1/1992
• Beta-NGF-Endopeptidase: Structure and Activity of a Kallikrein Encoded by the Gene MGK-22  
  Fahnestock, M., Woo, J., Lopez, George A., Snow, J., Walz, D. Arici, M. and Mobley, W.C., Biochemistry, 1/1/1991
• Characterization of a Mammalian cDNA for an Inactivating Voltage-Sensitive Potassium Channel  
  Baldwin, T. J., Tsaur, M., Lopez, George A., Jan, Y.N. and Jan, L.Y., Neuron, 1/1/1991
• Hydrophobic Substitutions in the S4 Sequence Alter Voltage-Dependent Gating in Shaker Potassium Channels  
  Lopez, George A., Jan, Y.N. and Jan, L.Y., Neuron, 1/1/1991
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Books/Book Chapters

• Self-Assessment in Multidisciplinary Critical Care: A Comprehensive Review. 
  Provencio, Javier, J. and LOPEZ GEORGE AEditors: R. Phillip Dellinger.Society of Critical Care MedicineEdition 5th,2003
• Critical Care Medicine: Principles of Diagnosis and Management in the Adult. 
  Chapter: Acute and Subacute Psychiatric Disorders 
  Cassem, N.H., Lopez, George A., and Bleck, T.P.Editors: Joseph E. Parrillo, R. Phillip Dellinger.2002

Abstracts/Posters

• Safety of Intravenous Thrombolysis in Wake-Up Stroke: a multicenter, prospective, open-label study.
  Barreto, A., Fanale, C., Alexandrov, A., Sands, K., Gaffney, K., Vahidy, F., Navalkele, D., Tremont, C., Roldan, A., Hamilton, K., Nguyen, C., Sarraj, A., Lopez, Georg..., International Stroke Conference, Nashville, TN, 1/1/2015
• Intraventricular Hemorrhage Recovery: Change in disability and function at Year 1.
  Yenokyan, G., Ziai, W., Thompson, R., Mayo, S., Dlugash, R., Lane, K., McBee, N., John, S., Harnof, S., Lopez, George, Aldrich, E.F., Harrigan, M., Awad, I., Hanley, D..., International Stroke Conference, Nashville, TN, 1/1/2015
• A Questionnaire Study Examining the Rate of Change of Clinical Practice: Targeted Temperature Management in Post-Cardiac Arrest Patients. What Target Temperature is in...
  George A. Lopez, Sayona John, Rajeev Garg, Katharina Busl, Sebastian Pollandt, Torrey Boland, Diana Goodman and Tom Bleck, 13th Annual Meeting of The Neurocritical Care Society, Scottsdale, AZ, 1/1/2015
• Impact of Epileptiform EEG Findings on Outcome in Patients with Acute Subdural Hematoma
  Busl, K., Ouyang, B, Boland, T., Lopez, George, Goodman, D., Bleck, T, Garg, R., John, S., Pollandt S., 13th Annual Neurocritical Care Society Meeting, Scottsdale, AZ, 1/1/2015
• Impact of Interhospital Transfers on Outcomes for Acute Subdural Hematoma.
  Busl, K., Ouyang, B., Pollandt, S., Boland, T., Goodman, D., Garg, R., Lopez, George, Bleck, T., John, S., 13th Annual Neurocritical Care Society Meeting, Scottsdale, AZ, 1/1/2015
• A National Survey Examining Targeted Temperature Management in Post-Cardiac Arrest Patients.
  Lopez, George, John, S., Garg, R., Busl, K., Pollandt, S., Boland, T., Goodman, D., Bleck, T., 13th Annual Neurocritical Care Society Meeting, Scottsdale, AZ, 1/1/2015
• Status Epilepticus in Patients with Acute Subdural Hematoma. Prevalence and Impact on Outcomes.
  Pollandt, S., Ouyang, B., Boland, T., Lopez, George, Goodman, D., Bleck, T., Garg, R., John, S., Busl, K., 13th Annual Neurocritical Care Society Meeting, Scottsdale, AZ, 1/1/2015
• Should Patients with Falcine or Tentorial Subdural Hematomas be Transferred to a Neurocritical Care Unit.
  Sweis, R., Ouyang, B., Lopez, George, Temes, R., Pollandt, S., Busl, K., 12th Annual Neurocritical Care Society Meeting, Seattle, WA, 1/1/2015
• EVD-output predicts requirement of VP shunt placement in patients with aneurysmal SAH.
  Mercado, M., Ouyang, b., Pollandt, S., Boland, T., Goodman, D., Lopez, George, Bleck, T., John, S., Busl, K., Garg, R., European Stroke Conference, Vienna, Austria, 1/1/2015
• Cutoff Values for Cerebrospinal Fluid Lactate to Treat Presumed Infection in Patients with Ventriculostomies.
  Dunn, E., Ouyang, B., John, S., Temes, R., Garg, R., Busl, K., Boland, T., Pollandt, S., Lopez, George, Singh, K., Bleck, T., 12th Annual Neurocritical Care Society Meeting, Seattle, WA, 1/1/2014
• Phase 2/3 Study of Thrombolysis with Hypothermia for Acute Treatment of Ischemic Stroke.
  Hemmen, T. Lopez, George, Raman, R., Tafreshi, G., Concha, M., et al, International Stroke Conference, Honolulu, HI, 1/1/2013
• Transferring Patients with Intracerebral Hemorrhage to Tertiary Stroke Centers.
  Nguyen, C., Mir, O., Vahidy, F., Lopez, George, Gonzales, N., Savitz, S., International Stroke Conference, Honolulu, HI, 1/1/2013
• MISTIE Phase II Results: Safety, Efficacy and Surgical Performance.
  Hanley, D., Lane, K., Broaddus, W., Awad, I., Aldrich, E., Wijman, C., Vespa, Caron, J., Huang, J., Bailey, B., LaPointe, M., Bederson, J., Gizzi, M., Mendelow, A., T..., International Stroke Conference, 1/1/2013
• Intra-Arterial Thrombolysis Demonstrates Better Clinical Outcome than Intra-Arterial Thrombectomy.
  Gonzales, N., Barreto, A., Harun, N., Wu, T-C., Sahota, P., Sarraj, A., El Khoury, R., Hicks, W., Sangha, N., Misra, V., Lopez, George, Savitz, S., Grotta, J., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Phase 2/3 Study of Intravenous Thrombolysis and Hypothermia for Acute Treatment of Ischemic Stroke.
  Hemmen, T., Raman, R., Brown, D., Chang, F-L., Broessner, G., Cruz-Florez, S., Kollmar, R., Tafreshi, G., Concha, M., Altafullah, I., Michel, P., Poli, S., Alexandrov,..., International Stroke Conference, Los Angeles, CA, 1/1/2011
• High Incidence of Vascular Risk Factors and Small Vessel Disease in Young Patients with Stroke.
  Hicks, W., Harun, N., Pandurengan, R., Wu, T-C., Misra, V., Lopez, George, Gonzales, N., Barreto, A., Grotta, J., Savitz, S., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Intravenous Thrombolysis for Ischemic Stroke in Patients with ongoing Acute Myocardial Ischemia.
  Misra, V., Harun, N., Sline, R., Barreto, A., Lopez, George, Gonzales, N., Grotta, J., Savitz, S., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Response to Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with Reduced Cardiac Ejection Fraction.
  Misra, V., Harun, N., Sline, R., Barreto, A., Lopez, George, Gonzales, N., Grotta, J., Savitz, S., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Longitudinal Assessment of Functional Outcome in Intracerebral Hemorrhage.
  Sangha, N., Irani, M., Peng, H., Rahbar, M., Martinez, R., Barreto, A., Savitz, S., Wu,T-C., Lopez, George, Misra, V., Ifejika-Jones, N., Grotta, J., Gonzales, N., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Delay in Evaluation and Treatment of Posterior Circulation Stroke Compared with Anterior Circulation Stroke.
  Sarraj, A., Medrek, S., Garza, A., Pruit, S., Rhodes, J., Harun, N., Alderman, S., Sline, R., Pandurengan, R., El Khoury, R., Wu, T-C., Lopez, George, Barreto, A., Gon..., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Tissue Plasminogen Activator for Acute Cerebellar Strokes.
  Sarraj, A., Medrek, S., Harun, N., Sline, R., Pandurengan, R., Lopez, George, Barreto, A., Gonzales, N., Grotta, J., Savitz, S., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Risk of Hemorrhage in patients on Coumadin who are treated with Tissue Plasminogen Activator for Acute Ischemic Stroke.
  Sarraj, A., Medrek, S., Rhodes, J., Garza, A., Pruit, J., Martinez, R., Harun, N., Sline, M., Pandurengan, R., LOPEZ GEORGE, Barreto, A., Gonzales, N., Grotta, J. Savi..., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Maximizing Subject Follow-Up by Minimizing the Number of Cooks in the Kitchen.
  Sosa, L., Martinez, R., Shen, L., Harun, N., Sline, R., Sangha, N., Wu, T-C., Indupuru, H., Misra, V., Sarraj, A., Alderman, S., Hess, M., Fontenot, T., El Khoury, R.,..., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Pharmacological deep vein thrombosis prophylaxis does not lead to hematoma expansion in intracerebral hemorrhage with intraventricular extension.
  Wu TC, Kasam M, Harun N, Hallevi H, Bektas H, Acosta I, Misra V, Barreto AD, Gonzales NR, Lopez, George, A., Grotta JC, Savitz SI., International Stroke Conference, Los Angeles, CA, 1/1/2011
• Surgical Variability and Radiological Predictors of Outcome or Reoperation in Patients that Undergo Hemicraniectomy for Malignant Middle Cerebral Artery Infarction.
  Wu, T-C., Choi, J., Friedman, E., Ashley, W., Sahota, P., Harun, N., Pandurengan, R., Sangha, N., Gonzales, N., Lopez, George, Grotta, J., Savitz, S., Barreto, A., International Stroke Conference, Los Angeles, CA, 1/1/2011
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Lectures

• The Worst type of Hemorrhagic Stroke: Results of the CLEAR III Trial of Thrombolysis for Intraventricular Hemorrhage and Clinical Implications 
  University of Chicago, Chicago, IL - 1/25/2016
• Updates on Cerebral Vasospasm in Subarachnoid Hemorrhage 
  Rush University Medical College - 1/6/2016
• Fundamentals of Critical Care Support 
  Rush University - 1/1/2016
• Emergency Neurological Life Support 
  Rush University - 1/1/2016
• Brain Death Simulation Workshop 
  University of Chicago Medicine - 1/1/2016
• Temperature Management in the Neuro-ICU: The Hot and Cold of it 
  Chicago, IL - 1/23/2015
• Targeted Temperature Management in Acute Brain Injuries. 
  Panama City, Panama - 1/16/2015
• Updates in SAH: Cerebral Vasospasm. 
  Panama City, Panama - 1/16/2015
• Mars: The Neurology of Prolonged Space Travel 
  Rush University Medical College - 1/11/2015
• Fever Management in the Neuro-ICU: The Hot of it 
  Vancouver, WA - 1/9/2015
• Cryptogenic Stroke or Undetected Atrial Fibrillation 
  Munster, IN - 1/2/2015
• Physical Diagnosis Course 
  Rush University - 1/1/2015
• Hypothermia: To cool or not to cool 
  Rush University Medical Center, Chicago, IL - 1/6/2014
• Aneurysmal Subarachnoid Hemorrhage: New guidelines, new updates and new research 
  Oakbrook, IL - 1/5/2014
• Temperature Management in Acute Brain Injury. 
  Cedars Sinai Medical Center, Los Angeles, CA - 1/11/2013
• Decompressive Craniectomy: Ischemic Stroke and Posterior-Fossa Intracerebral Hemorrhage 
  University Texas & Mischer Neuroscience Institute, Houston, TX - 1/7/2013
• Herniation Syndromes and ICP Crisis 
  University Texas & Mischer Neuroscience Institute, Houston, TX - 1/7/2013
• How to Overcome the Challenges of Implementing Stroke Prevention 
  University of Texas, Houston, TX - 1/4/2012
• Stroke Lecture 
  University of Texas - 1/1/2012
• Critical Care Stroke Lecture 
  University of Texas - 1/1/2012
• Hypothermia after Cardiac Arrest. 
  Houston Northwest Medical Center, Houston, TX - 1/13/2011
• Intracerebral Hemorrhage: 
  University of Texas, Houston, TX - 1/30/2010
• Clinical Application of Hypothermia. 
  Texas Heart Institute, St. Lukes Episcopal Hospital, Houston, TX - 1/12/2010
• Hypothermia for Cardiac Arrest Stroke, American Guidelines and New Evidence. 
  Mexico City, Mexico - 1/26/2009
• Hypothermia for Stroke 
  Mexico City, Mexico - 1/26/2009
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Other

• The structure and function of the Shaker voltage-gated potassium . A mutational analysis examining voltage sensitivity, the potassium ion permeation pathway, and the T... 
  Lopez, George A., Thesis
  1/1/1993