GeorgeSomloMD

Oncology • Duarte, CA

Breast Cancer, Hematologic Oncology

Professor, Departments of Medical Oncology&Therapeutics Research and Hematology and Hematopoietic Cell Transplantation

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Office
1500 E Duarte Rd
Duarte, CA 91010
Phone+1 626-359-8111
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Education & Training

City of Hope National Medical CenterFellowship, Hematology and Medical Oncology, 1985 - 1987
University of California (Irvine)Residency, Internal Medicine, 1983 - 1985
Semmelweis UniversityClass of 1978

Certifications & Licensure

CA State Medical License 1983 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2014
Top Doctors:LA Area Castle Connolly, 2013
America's Top Doctors for Cancer Castle Connolly, 2013
Top Doctors:Southern California Castle Connolly, 2012
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Clinical Trials

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma Start of enrollment: 1994 Sep 01
Completed
Phase 2
High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer Start of enrollment: 1994 Dec 01
Completed
Phase 1
Chemotherapy and Stem Cell Transplantation in Treating Patients With Stage IIIB Breast Cancer Start of enrollment: 1997 May 30
Active, not recruiting
Phase 2
Combination Chemotherapy, Amifostine, and Peripheral Stem Cell Transplantation in Treating Patients With Stage II, Stage III, or Stage IV Breast Cancer Start of enrollment: 1999 May 18
Completed
Phase 1
Combination Chemo, Peripheral Stem Cell Transplant, Biological Therapy, Pamidronate and Thalidomide for Multiple Myeloma Start of enrollment: 1999 Apr 13
Completed
Phase 2
Combination Chemotherapy in Treating Patients With High-Risk Breast Cancer Start of enrollment: 1999 May 01
Completed
Phase 2
Gefitinib, Trastuzumab, and Docetaxel in Treating Patients With Metastatic Breast Cancer Start of enrollment: 2004 Jan 01
Completed
Phase 1, Phase 2
Melphalan and Radiation Therapy Followed By Lenalidomide in Treating Patients Who Are Undergoing Autologous Stem Cell Transplant for Stage I, Stage II, or Stage III Multiple Myeloma Start of enrollment: 2004 Nov 01
Completed
Phase 1, Phase 2
Combination Chemotherapy With or Without Trastuzumab Followed By an Autologous Stem Cell Transplant and Radiation Therapy in Treating Patients With Stage III or Stage IV Breast Cancer Start of enrollment: 2005 Jul 01
Completed
Phase 2
Exemestane in Treating Postmenopausal Women With Stage IV Breast Cancer Start of enrollment: 2008 Dec 02
Completed
Phase 2
Characterization of Circulating Tumor Cells (CTC-s) in Patients With Locally Advanced or Metastatic Stage IV Breast Cancer Start of enrollment: 2008 Sep 04
Completed
Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702) Start of enrollment: 2010 May 01
Completed
Phase 3
MIRNA Profiling of Breast Cancer in Patients Undergoing Neoadjuvant or Adjuvant Treatment for Locally Advanced & Inflammatory Breast Cancer Start of enrollment: 2009 Nov 01
Completed
Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer Start of enrollment: 2011 Apr 20
Active, not recruiting
Phase 2
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Locally Advanced or Inflammatory Triple Negative Breast Cancer Start of enrollment: 2012 Feb 15
Active, not recruiting
Phase 2
Pertuzumab, Trastuzumab, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With HER2-Positive Advanced Breast Cancer Start of enrollment: 2013 Jul 17
Active, not recruiting
Phase 2
S1222 Trial (Everolimus, Anastrozole and Fulvestrant) in Post-Menopausal Stage IV Breast Cancer Start of enrollment: 2014 May 01
Terminated
Phase 3
Pembrolizumab and Doxorubicin Hydrochloride or Anti-Estrogen Therapy in Treating Patients With Triple-Negative or Hormone Receptor-Positive Metastatic Breast Cancer Start of enrollment: 2016 Mar 28
Completed
Phase 2
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles Start of enrollment: 2017 Apr 28
Recruiting
Melphalan, Total Marrow Irradiation, and Autologous Stem Cell Transplantation in Treating Patients With High-Risk Multiple Myeloma Start of enrollment: 2018 Jan 01
Withdrawn
Phase 1, Phase 2
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Publications & Presentations

PubMed

Phase 1 Study of Bortezomib, Fludarabine, and Melphalan, With or Without Total Marrow Irradiation, as Allogeneic Hematopoietic Stem Cell Transplant Conditioning for Hi...
Colton Ladbury, James Sanchez, Arnab Chowdhury, Joycelynne Palmer, An Liu, Anthony Stein, Myo Htut, Leonardo Farol, Ji-Lian Cai, George Somlo, Michael Rosenzweig, Jeff...> ;American Journal of Clinical Oncology. 2024 Mar 14
5 citations
Immunogenicity and efficacy of pembrolizumab and doxorubicin in a phase I trial for patients with metastatic triple-negative breast cancer.
Colt A Egelston, Weihua Guo, Susan E Yost, Xuan Ge, Jin Sun Lee, Paul H Frankel, Yujie Cui, Christopher Ruel, Daniel Schmolze, Mireya Murga, Aileen Tang, Norma Martine...> ;Cancer Immunology, Immunotherapy. 2023 Sep 1
2 citations
Phase 2 prospective open label study of neoadjuvant nab-paclitaxel, trastuzumab, and pertuzumab in patients with HER2-positive primary breast cancer.
Sayeh M Lavasani, George Somlo, Susan E Yost, Paul H Frankel, Christopher Ruel, Yujie Cui, Mireya Murga, Aileen Tang, Norma Martinez, Laura Kruper, Lusine Tumyan, Dani...> ;Cancer. 2023 Mar 1
Oligometastatic Breast Cancer Patients Treated with High-Dose Chemotherapy and Targeted Radiation: Long-Term Follow-Up of a Phase II Trial.
Colton Ladbury, Claire Hao, Christopher Ruel, Jason Liu, Scott Glaser, Arya Amini, Jeffrey Wong, Isaac Paz, Lucille Leong, Robert Morgan, Kim Margolin, Stephen Shibata...> ;Cancers. 2022 Oct 13
2 citations
Phase II Study Combining Pembrolizumab with Aromatase Inhibitor in Patients with Metastatic Hormone Receptor Positive Breast Cancer.
Xuan Ge, Susan E Yost, Jin Sun Lee, Paul H Frankel, Christopher Ruel, Yujie Cui, Mireya Murga, Aileen Tang, Norma Martinez, Samuel Chung, Christina Yeon, Daphne Stewar...> ;Cancers. 2022 Sep 1
16 citations
Genomic and epigenomicalterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas.
Francesca Menghi, Kalyan Banda, Pooja Kumar, Robert Straub, Lacey Dobrolecki, Isabel V Rodriguez, Susan E Yost, Harshpreet Chandok, Marc R Radke, George Somlo, Yuan Yu...> ;Science Translational Medicine. 2022 Jul 6
4 citations
Long-Term Follow-Up of Multiple Myeloma Patients Treated with Tandem Autologous Transplantation Following Melphalan and Upon Recovery, Total Marrow Irradiation.
Colton Ladbury, George Somlo, Andy Dagis, Dongyun Yang, Saro Armenian, Joo Y Song, Firoozeh Sahebi, Ricardo Spielberger, Leslie Popplewell, Pablo Parker, Stephen Forma...> ;Transplantation and Cellular Therapy. 2022 Jul 1
40 citations
CALGB 40603 (Alliance): Long-Term Outcomes and Genomic Correlates of Response and Survival After Neoadjuvant Chemotherapy With or Without Carboplatin and Bevacizumab i...
Jonathan H Shepherd, Karla Ballman, Mei-Yin C Polley, Jordan D Campbell, Cheng Fan, Sara Selitsky, Aranzazu Fernandez-Martinez, Joel S Parker, Katherine A Hoadley, Zhi...> ;Journal of Clinical Oncology. 2022 Apr 20
8 citations
Total marrow irradiation (TMI): Addressing an unmet need in hematopoietic cell transplantation - a single institution experience review.
Jeffrey Y C Wong, An Liu, Chunhui Han, Savita Dandapani, Timothy Schultheiss, Joycelynne Palmer, Dongyun Yang, George Somlo, Amandeep Salhotra, Susanta Hui, Monzr M Al...> ;Frontiers in Oncology. 2022 Jan 1
5 citations
Influence of Estrogen Treatment onandCells in ERBreast Cancer: Insights from Single-Cell Analysis of Patient-Derived Xenograft Models.
Hitomi Mori, Kohei Saeki, Gregory Chang, Jinhui Wang, Xiwei Wu, Pei-Yin Hsu, Noriko Kanaya, Xiaoqiang Wang, George Somlo, Masafumi Nakamura, Andrea Bild, Shiuan Chen> ;Cancers. 2021 Dec 19
4 citations
A randomized trial of fulvestrant, everolimus and anastrozole for the front-line treatment of patients with advanced hormone receptor-positive breast cancer, SWOG S1222.
Halle C. F. Moore, William E. Barlow, George Somlo, Julie R. Gralow, Anne F. Schott, Daniel F. Hayes, Peter Kuhn, James W. Hicks, Lisa Welter, Philip A. Dy, Christina ...> ;Clinical Cancer Research. 2021 Nov 29
14 citations
Indatuximab ravtansine plus dexamethasone with lenalidomide or pomalidomide in relapsed or refractory multiple myeloma: a multicentre, phase 1/2a study
Kevin R. Kelly, Sikander Ailawadhi, David S. Siegel, Leonard T. Heffner, George Somlo, Sundar Jagannath, Todd M. Zimmerman, Nikhil C. Munshi, Sumit Madan, Asher Chanan...> ;The Lancet. Haematology. 2021 Nov 1
3 citations
Functional characterization of androgen receptor in two patient-derived xenograft models of triple negative breast cancer
Xiaoqiang Wang, Karineh Petrossian, Miao-Juei Huang, Kohei Saeki, Noriko Kanaya, Gregory Chang, George Somlo, Shiuan Chen> ;The Journal of Steroid Biochemistry and Molecular Biology. 2021 Feb 1
22 citations
Phase II Trial of Neoadjuvant Carboplatin and Nab-Paclitaxel in Patients with Triple-Negative Breast Cancer.
Yuan Yuan, Jin Sun Lee, Susan E. Yost, Sierra Min Li, Paul Frankel, Christopher Ruel, Daniel Schmolze, Kim Robinson, Aileen Tang, Norma Martinez, Daphne Stewart, James...> ;The Oncologist. 2021 Mar 1
11 citations
LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis
Maider Zabala, Neethan A. Lobo, Jane Antony, Luuk S. Heitink, Gunsagar S. Gulati, Jessica Lam, Natesh Parashurama, Kassandra Sanchez, Maddalena Adorno, Shaheen S. Sika...> ;Cell Stem Cell. 2020 Aug 6
26 citations
Tandem Autologous-Autologous versus Autologous-Allogeneic Hematopoietic Stem Cell Transplant for Patients with Multiple Myeloma: Long-Term Follow-Up Results from the B...
Sergio Giralt, Luciano J. Costa, David G. Maloney, Amrita Krishnan, Mingwei Fei, Joseph H. Antin, Claudio G. Brunstein, Nancy L. Geller, Stacey Goodman, Parameswaran H...> ;Biology of Blood and Marrow Transplantation. 2020 Apr 1
186 citations
STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth.
Chunyan Zhang, Chanyu Yue, Andreas Herrmann, Jieun Song, Colt Egelston, Tianyi Wang, Zhifang Zhang, Wenzhao Li, Heehyoung Lee, Maryam Aftabizadeh, Yi Jia Li, Peter P. ...> ;Cell Metabolism. 2020 Jan 7
38 citations
Radiation-Related Toxicities Using Organ Sparing Total Marrow Irradiation Transplant Conditioning Regimens
Ashwin Shinde, Dongyun Yang, Paul Frankel, An Liu, Chunhui Han, Bianca del Vecchio, Timothy E. Schultheiss, Jonathan Cheng, Richard Li, Daniel H. Kim, Eric Radany, Sus...> ;International Journal of Radiation Oncology, Biology, Physics. 2019 Dec 1
167 citations
Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)-Positive Breast Cancer.
Nathaniel Braman, Prateek Prasanna, Jon Whitney, Salendra Singh, Niha Beig, Maryam Etesami, David D. B. Bates, Katherine M. Gallagher, B. Nicolas Bloch, Manasa Vulchi,...> ;JAMA Network Open. 2019 Apr 5
14 citations
A Phase II Trial of Older Adults With Metastatic Breast Cancer Receiving nab-Paclitaxel: Melding the Fields of Geriatrics and Oncology.
Arti Hurria, Enrique Soto-Perez-de-Celis, Suzette Blanchard, Peggy Burhenn, Christina Yeon, Yuan Yuan, Daneng Li, Vani Katheria, J Waisman, Thehang H. Luu, G. Somlo, A...> ;Clinical Breast Cancer. 2019 Apr 1
159 citations
Autologous Transplantation, Consolidation, and Maintenance Therapy in Multiple Myeloma: Results of the BMT CTN 0702 Trial
Edward A. Stadtmauer, Marcelo C. Pasquini, Beth Blackwell, Parameswaran Hari, Asad Bashey, Steven M. Devine, Yvonne A. Efebera, S. Ganguly, Cristina Gasparetto, Nancy ...> ;Journal of Clinical Oncology. 2019 Jan 17
42 citations
Synergistic anti-cancer activity of CDK4/6 inhibitor palbociclib and dual mTOR kinase inhibitor MLN0128 in pRb-expressing ER-negative breast cancer
Takuro Yamamoto, Noriko Kanaya, George Somlo, Shiuan Chen> ;Breast Cancer Research and Treatment. 2019 Jan 3
13 citations
Randomized trial of oral cyclophosphamide versus oral cyclophosphamide with celecoxib for recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer.
Rohan Gupta, Mihaela C. Cristea, Paul Frankel, Christopher Ruel, Chen Chen, Yingyu Wang, Robert J. Morgan, Lucille Leong, Warren Chow, Marianna Koczywas, Steve Koehler...> ;Cancer Treatment and Research Communications. 2019 Jan 1
10 citations
Subcortical brain iron deposition and cognitive performance in older women with breast cancer receiving adjuvant chemotherapy: A pilot MRI study.
Bihong T. Chen, Kiarash Ghassaban, Taihao Jin, Sunita K. Patel, Ningrong Ye, Can Lan Sun, Heeyoung Kim, Russell C. Rockne, E. Mark Haacke, James C. Root, Andrew J. Say...> ;Magnetic Resonance Imaging. 2018 Dec 1
26 citations
Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer.
Bihong T. Chen, Taihao Jin, Sunita K. Patel, Ningrong Ye, Can Lan Sun, Huiyan Ma, Russell C. Rockne, James C. Root, Andrew J. Saykin, Tim A. Ahles, Andrei I. Holodny, ...> ;Breast Cancer Research and Treatment. 2018 Aug 7
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Journal Articles

ERα-Mediated Cell Cycle Progression Is an Important Requisite for CDK4/6 Inhibitor Response in HR+ Breast Cancer
Joanne Mortimer, Laura Kruper, Raju Pillai, George Somlo, Yuan Yuan, Oncotarget

Press Mentions

Late-Breaking Abstracts SessionDecember 6th, 2016
Advances in Multiple MyelomaOctober 3rd, 2016
Cancer MoonShot 2020 Announces Breast Cancer Working Group with Multiple Leading Cancer Centers and the Launch of GPS Cancer at ASCO 2016June 7th, 2016
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