GraceAMccomseyMD

Infectious Disease • Cleveland, OH

HIV/AIDS Medicine, Transplant/Immunocompromised States

Professor, Pediatrics and Medicine, Case Western Reserve University School of Medicine

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Office
UH Rainbow Babies and Children's Hospital
2061 Cornell Rd Department of Pediatrics-Infectious Diseases
Cleveland, OH 44106
Phone+1 216-844-7892

Fax+1 216-844-5356
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Education & Training

Case Western Reserve University/University Hospitals Cleveland Medical CenterFellowship, Infectious Disease, 1994 - 1997
The MetroHealth System/Case Western Reserve UniversityResidency, Internal Medicine, 1991 - 1994
St Joseph's University Medical SchoolClass of 1989

Certifications & Licensure

OH State Medical License 1993 - 2024
American Board of Internal Medicine Infectious Disease
American Board of Pediatrics Pediatric Infectious Diseases

Awards, Honors, & Recognition

America's Top Doctor 2015-2023
America's Top Doctors Castle Connolly, 2012-2014

Clinical Trials

Use of Muscle Spectroscopy to Evaluate Mitochondrial Dysfunction in HIV-Infected Patients
Withdrawn
A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs
Withdrawn
Not Applicable
The Effect of Alendronate, Calcium, and Vitamin D on Bone Mineral Density in HIV Infected Patients
Completed
Phase 2
Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected Adults Start of enrollment: 2005 Apr 01
Completed
Phase 2
Observational Study of Fat Loss in HIV Infected Adults Taking Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Start of enrollment: 2005 Apr 01
Completed
Effects of a Uridine Supplement on HIV Infected Adults With Lipoatrophy Start of enrollment: 2006 Sep 01
Completed
Phase 2, Phase 3
Rosiglitazone Effect on Mitochondria and Lipoatrophy Start of enrollment: 2006 Jul 01
Completed
Phase 2
Metabolic Effects of Non-Thymidine Analogue Anti-HIV Medications Start of enrollment: 2006 Apr 01
Completed
Antiretrovirals and Rate of Progression in Carotid Artery Intima-medial Thickness in HIV Start of enrollment: 2007 Nov 01
Completed
Raltegravir Therapy for Women With HIV and Fat Accumulation Start of enrollment: 2008 Sep 01
Completed
Phase 2
Comparative Study of Three NNRTI-Sparing HAART Regimens Start of enrollment: 2009 May 01
Completed
Phase 3
Pilot Placebo Controlled Study With Lovaza in Cardiovascular Disease Start of enrollment: 2009 Apr 01
Completed
Phase 2
Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults Start of enrollment: 2009 Jan 01
Completed
Phase 2
Use of Rosuvastatin in HIV-Infected Subjects to Modulate Cardiovascular Risks Start of enrollment: 2011 Feb 01
Completed
Phase 2
Vitamin D and HIV-Cardiovascular Disease in Children and Young Adults Start of enrollment: 2011 Sep 01
Completed
Vitamin D Supplementation in HIV Youth Start of enrollment: 2011 Dec 01
Completed
Phase 2, Phase 3
The Cleveland Cardiometabolic Cohort Start of enrollment: 2016 Sep 01
Recruiting
Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV Start of enrollment: 2017 Jul 14
Completed
Effects of Semaglutide in HIV-Associated Lipohypertrophy Start of enrollment: 2019 May 16
Active, not recruiting
Phase 2
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Publications & Presentations

PubMed

Antiretrovirals and Weight Change: Weighing the Evidence.
David Alain Wohl, John R Koethe, Paul E Sax, Graeme Moyle, Lee Kaplan, Jean van Wyk, Rafael E Campo, Calvin Cohen, Grace A McComsey, Daniel R Kuritzkes> ;Clinical Infectious Diseases. 2024 Apr 12
Gut permeability is associated with lower insulin sensitivity in youth living with perinatally-acquired HIV.
Wendy Yu, Denise L Jacobson, Ayesha Mirza, Jennifer Jao, , Sahera Dirajlal-Fargo, Mitchell E Geffner, Grace A Mccomsey> ;AIDS. 2024 Mar 28
1 citations
Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection.
Maison, D., Durieux, J., Andrukhiv, A., Funderburg, N., Ailstock, K., Gerschenson, M., Dirajlal-Fargo, S., Mccomsey, G.> ;Mitochondrion. 2024 Mar 1
Higher Vitamin D Levels before Methotrexate Therapy Initiation Are Associated with Lower Subsequent Mortality in Patients with Rheumatoid Arthritis.
Siddiqui, H., Wilson, B., Bej, T., O'Mara, M., Desotelle, A., Lange, A., Shive, C., Singer, N., Zidar, D., Anthony, D., Malakooti, S., McComsey, G., Kostadinova, L., M...> ;Nutrients. 2024 Jan 30
New-onset autoimmune disease after COVID-19.
Corrilynn O Hileman, Shahdi K Malakooti, Nirav Patil, Nora G Singer, Grace A McComsey> ;Frontiers in Immunology. 2024 Jan 1
Associations between post-acute sequelae of SARS-CoV-2, COVID-19 vaccination and HIV infection: a United States cohort study.
George A Yendewa, Jaime Abraham Perez, Nirav Patil, Grace A McComsey> ;Frontiers in Immunology. 2024 Jan 1
1 citations
Comparison of the incidence of smell and taste disorders between influenza and COVID-19.
Cabrera, C., Gerka Stuyt, J., D'Anza, B., Hicks, K., Rodriguez, K., McComsey, G.> ;American Journal of Otolaryngology. 2023 Dec 11
Zinc Deficiency And sTNF-RII Are Associated With Worse COVID-19 Outcomes.
Mouchati, C., Durieux, J., Tribout, H., Scott, S., Smith, B., Labbato, D., Zisis, S., McComsey, G.> ;The Journal of Nutrition. 2023 Dec 2
Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208].
Al Ozonoff, Joanna Schaenman, Naresh Doni Jayavelu, Carly E Milliren, Carolyn S Calfee, Charles B Cairns, Monica Kraft, Lindsey R Baden, Albert C Shaw, Florian Krammer...> ;Ebiomedicine. 2023 Dec 1
Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV.
Sahera Dirajlal-Fargo, Denise L Jacobson, Wendy Yu, Ayesha Mirza, Mitchell E Geffner, Grace A Mccomsey, Jennifer Jao> ;HIV Medicine. 2024 Feb 1
Low-dose naltrexone use for the management of post-acute sequelae of COVID-19.
Hector Bonilla, Lu Tian, Vincent C Marconi, Robert Shafer, Grace A McComsey, Mitchel Miglis, Philip Yang, Andres Bonilla, Lauren Eggert, Linda N Geng> ;International Immunopharmacology. 2023 Nov 1
1 citations
Factors associated with insulin resistance in a longitudinal study of Ugandan youth with and without HIV.
Sahera Dirajlal-Fargo, Monika Strah, Kate Ailstock, Abdus Sattar, Christine Karungi, Rashidah Nazzinda, Nicholas Funderburg, Cissy Kityo, Victor Musiime, Grace A McComsey> ;AIDS. 2024 Feb 1
Rheumatoid arthritis and older age are associated with lower humoral and cellular immune response to primary series COVID-19 mRNA vaccine.
Holly M Dudley, Megan O'Mara, Ann Auma, Jenny Gong, Yael Ross, Natalie Gurevich, Sarah Carbone, Alex Reihs, Ynez Nguyen, Grace A McComsey, Yi Cao, Alejandro B Balazs, ...> ;Vaccine. 2023 Sep 22
2 citations
Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection.
Nicholas T Funderburg, Carey L Shive, Zhengyi Chen, Curtis Tatsuoka, Emily R Bowman, Chris T Longenecker, Grace A McComsey, Brian M Clagett, Dominic Dorazio, Michael L...> ;Clinical Infectious Diseases. 2023 Jul 26
2 citations
HIV and race are independently associated with endothelial dysfunction.
Christian Mouchati, Jared C Durieux, Sokratis N Zisis, Grace A McComsey> ;AIDS. 2023 Feb 1
6 citations
Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design.
Chu, H. Y., Leora I Horwitz, Tanayott Thaweethai, Shari B Brosnahan, Mine S Cicek, Megan L Fitzgerald, Jason D Goldman, Rachel Hess, S L Hodder, Vanessa L Jacoby, Mich...> ;Plos One. 2023 Jan 1
Arterial Stiffness and Oxidized LDL Independently Associated With Post-Acute Sequalae of SARS-CoV-2.
Zisis, S., Durieux, J., Mouchati, C., Funderburg, N., Ailstock, K., Chong, M., Labbato, D., McComsey, G.> ;Pathogens & Immunity. 2023 Jan 1
2 citations
Increase in gut permeability and oxidized ldl is associated with post-acute sequelae of SARS-CoV-2.
Christian Mouchati, Jared C Durieux, Sokratis N Zisis, Danielle Labbato, Michael A Rodgers, Kate Ailstock, Brian L Reinert, Nicholas T Funderburg, Grace A McComsey> ;Frontiers in Immunology. 2023 Jan 1
2 citations
Persistent immune activation and altered gut integrity over time in a longitudinal study of Ugandan youth with perinatally acquired HIV.
Sahera Dirajlal-Fargo, Monika Strah, Kate Ailstock, Abdus Sattar, Christine Karungi, Rashidah Nazzinda, Cissy Kityo, Victor Musiime, Nicholas Funderburg, Grace A McComsey> ;Frontiers in Immunology. 2023 Jan 1
13 citations
Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative.
Hector Bonilla, Michael J Peluso, Kathleen Rodgers, Judith A Aberg, Thomas F Patterson, Robert Tamburro, Lawrence Baizer, Jason D Goldman, Nadine Rouphael, Amelia Deit...> ;Frontiers in Immunology. 2023 Jan 1
2 citations
A randomized, placebo-controlled pilot study of upamostat, a host-directed serine protease inhibitor, for outpatient treatment of COVID-19.
Terry F Plasse, Belkis Delgado, Jeffrey Potts, Danielle Abramson, Clara Fehrmann, Reza Fathi, Grace A McComsey> ;International Journal of Infectious Diseases. 2023 Mar 1
4 citations
COVID-19 plasma exosomes promote proinflammatory immune responses in peripheral blood mononuclear cells.
Lechuang Chen, Rui Chen, Min Yao, Zhimin Feng, Guoxiang Yuan, Fengchun Ye, Kien Nguyen, Jonathan Karn, Grace A McComsey, Thomas M McIntyre, Ge Jin> ;Scientific Reports. 2022 Dec 16
Comprehensive assessment of neurocognitive function, inflammation markers, and adiposity in treated HIV and control.
Christian Mouchati, Vanessa El Kamari, Abdus Sattar, Jiao Yu, Grace A McComsey> ;Medicine. 2022 Oct 21
1 citations
Heroin Use Is Associated With Vascular Inflammation in Human Immunodeficiency Virus.
Corrilynn O Hileman, Jared C Durieux, Scott E Janus, Emily Bowman, Aaren Kettelhut, Ann K Avery, Nicholas Funderburg, Claire Sullivan, Grace A McComsey, Trong-Tuong Ng...> ;Clinical Infectious Diseases. 2023 Feb 8
1 citations
Longitudinal Changes in Subclinical Vascular Disease in Ugandan Youth With Human Immunodeficiency Virus.
Sahera Dirajlal-Fargo, Chenya Zhao, Danielle Labbato, Abdus Sattar, Christine Karungi, Chris T Longenecker, Rashidah Nazzinda, Nicholas Funderburg, Cissy Kityo, Victor...> ;Clinical Infectious Diseases. 2023 Feb 8
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Press Mentions

“Work with Talented People Who Challenge You to Think in Different Ways”December 13th, 2018
Fat, Lean Mass Grows with Raltegravir and Protease InhibitorsFebruary 28th, 2015
Interview with Dr Grace McComsey on HIV LipodystrophyMay 6th, 2017
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Grant Support

Vitamin D, Drug Metabolism, And Cardiovascular Complications In Pediatric HIVEunice Kennedy Shriver National Institute Of Child Health &Human Development2011
Inflammation, Heart And BoneNational Institute Of Nursing Research2010–2011
Research Training In Pediatric Infectious DiseasesNational Institute Of Allergy And Infectious Diseases2008–2011
Metabolic Consequences Of Thymidine Sparing RegimensNational Institute Of Allergy And Infectious Diseases2006–2010
Role Of Mitochondria In HIV LipoatrophyNational Institute Of Allergy And Infectious Diseases2005–2009
Uridine Supplementation For HIV LipoatrophyNational Center For Complementary &Alternative Medicine2005–2007
Training Program In Pediatric Infectious DiseasesNational Institute Of Allergy And Infectious Diseases2004–2006
Role Of Mitochondria In HIV LipoatrophyNational Institute Of Allergy And Infectious Diseases2004
Longitudinal Assessment Of Mtdna Kinetics In PTS On Nrti-Containing HaartNational Center For Research Resources2004

Hospital Affiliations

University Hospitals Cleveland Medical CenterCleveland, Ohio
UH Rainbow Babies and Childrens HospitalCleveland, Ohio