GregoryMSullivanMD

Psychiatry • New York, NY

Chief Medical Officer, Tonix Pharmaceuticals, Inc.

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Office
33 W 85th St
Apt 1A
New York, NY 10024
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Education & Training

New York Presbyterian Hospital (Columbia Campus)/New York State Psychiatric InstituteResidency, Psychiatry, 1994 - 1997
New York Presbyterian Hospital (Columbia Campus)Internship, Internal Medicine, 1992 - 1993
Columbia University Vagelos College of Physicians and SurgeonsClass of 1992

Certifications & Licensure

NY State Medical License 1995 - 2026

Clinical Trials

BEdtime Sublingual TNX-102 SL as Fibromyalgia Intervention Therapy (BESTFIT) Start of enrollment: 2013 Sep 01
Completed
Phase 2, Phase 3
12-Month Open-Label Long-term Safety Study of TNX-102 SL Tablets in Fibromyalgia Patients Start of enrollment: 2013 Dec 01
Completed
Phase 3
Safety and Efficacy Study of TNX-102 SL in Subjects With Military-Related PTSD and Related Conditions Start of enrollment: 2014 Oct 01
Completed
Phase 2
Phase 1 Single Ascending Dose Safety Study of TNX-201 Capsules in Healthy Volunteers Start of enrollment: 2014 Nov 01
Completed
Phase 1
Open Label Extension Safety and Efficacy Study of TNX-102 SL Tablets in Military Related PTSD and Related Conditions Start of enrollment: 2015 Apr 01
Completed
Phase 2
Safety and Efficacy Study of TNX-201 Capsules for Treatment of Single Tension-Type Headache Start of enrollment: 2015 Jun 01
Completed
Phase 2
A Study to Evaluate eFFIcacy and Safety of Sublingual TNX-102 SL Tablet Taken at Bedtime in Patients With fibRoMyalgia Start of enrollment: 2015 Apr 01
Completed
Phase 3
A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Participants With PTSD Start of enrollment: 2019 Mar 07
Terminated
Phase 3
A Phase 2 Study to Evaluate the Efficacy and Safety of TNX-102 SL in Patients With Multi-Site Pain Associated With Post-Acute Sequelae of SARS-CoV-2 Infection Start of enrollment: 2022 Aug 18
Completed
Phase 2
A Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With Fibromyalgia Start of enrollment: 2019 Dec 09
Completed
Phase 3
A Phase 3 Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily in Patients With Fibromyalgia Start of enrollment: 2022 Apr 06
Completed
Phase 3
A Phase 3 Study To Evaluate The Efficacy And Safety Of TNX-102 SL In Patients With Fibromyalgia Start of enrollment: 2020 Jul 22
Completed
Phase 3
Study to Evaluate TNX-601 ER Monotherapy Versus Placebo in Patients With Major Depressive Disorder (MDD) Start of enrollment: 2023 Mar 02
Completed
Phase 2
A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine Start of enrollment: 2022 Dec 06
Completed
Phase 2
Safety and Efficacy Study of TNX-102 SL in Participants With PTSD Start of enrollment: 2022 Oct 14
Withdrawn
Phase 2
Assessment of Delayed-type Hypersensitivity Reactions to SARS-CoV-2 Peptide Antigens Start of enrollment: 2022 Jan 07
Active, not recruiting
Phase 1
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Publications & Presentations

PubMed

1 citations
Antisuicidal effect of lithum in bipolar disorder: is there an age-specific effect?
Kanita Dervic, Leo Sher, Hanga C Galfalvy, Michael Grunebaum, Ainsley K Burke, Gregory Sullivan, M Elizabeth Sublette, J John Mann, Maria A Oquendo> ;Journal of Affective Disorders. 2023 Nov 15
3 citations
Predictors of Response to Prolonged Exposure, Sertraline, and Their Combination for the Treatment of Military PTSD.
Sheila A.M. Rauch, H. Myra Kim, Seth Lederman, Gregory M. Sullivan, Ron Acierno, Peter W. Tuerk, Naomi M. Simon, Margaret R. Venners, Sonya B. Norman, Carolyn B. Allar...> ;The Journal of Clinical Psychiatry. 2021 Jun 15
5 citations
Randomized clinical trial of bedtime sublingual cyclobenzaprine (TNX-102 SL) in military-related PTSD and the role of sleep quality in treatment response.
Gregory M. Sullivan, R. Michael Gendreau, Judith Gendreau, Perry Scott Peters, Ashild Peters, Jean Engels, Bruce L. Daugherty, Benjamin Vaughn, Frank W. Weathers, Seth...> ;Psychiatry Research. 2021 Apr 30
1 citations
Examining the relationship between gray matter volume and a continuous measure of bipolarity in unmedicated unipolar and bipolar depression.
Reuben Heyman-Kantor, Mina M. Rizk, M. Elizabeth Sublette, Harry Rubin-Falcone, Yashar Yousefzadeh Fard, Ainsley K. Burke, Maria A. Oquendo, Gregory M. Sullivan, Matth...> ;Journal of Affective Disorders. 2021 Feb 1
22 citations
Brain serotonin transporter binding, plasma arachidonic acid and depression severity: A positron emission tomography study of major depression.
Manesh Gopaldas, Francesca Zanderigo, Serena Zhan, R. Todd Ogden, Jeffrey M. Miller, Harry Rubin-Falcone, Thomas B. Cooper, Maria A. Oquendo, Gregory M. Sullivan, J. J...> ;Journal of Affective Disorders. 2019 Jul 5
30 citations
Development and evaluation of a multimodal marker of major depressive disorder
Jie Yang, Mengru Zhang, Hongshik Ahn, Qing Zhang, Tony B. Jin, Ien Li, Matthew Nemesure, Nandita Joshi, Haoran Jiang, Jeffrey M. Miller, R.T. Ogden, Eva Petkova, Matth...> ;Human Brain Mapping. 2018 Nov 1
12 citations
In vivo relationship between serotonin 1A receptor binding and gray matter volume in the healthy brain and in major depressive disorder
Francesca Zanderigo, Spiro P. Pantazatos, Harry Rubin-Falcone, R. Todd Ogden, Binod Thapa Chhetry, Gregory M. Sullivan, Maria A. Oquendo, Jeffrey M. Miller, J. John Mann> ;Brain Structure & Function. 2018 Mar 17
19 citations
Are comorbid anxiety disorders a risk factor for suicide attempts in patients with mood disorders? A two-year prospective study.
Lena Nabuco de Abreu, Maria A. Oquendo, Hanga Galfavy, Ainsley K. Burke, Michael F. Grunebaum, Leo Sher, Gregory M. Sullivan, M. E. Sublette, J. John Mann, Beny Lafer> ;European Psychiatry. 2018 Jan 1
8 citations
A positron emission tomography study of the serotonergic system in relation to anxiety in depression.
Zafer Iscan, Gopalkumar Rakesh, Samantha Rossano, Jie Yang, Mengru Zhang, Jeffrey M. Miller, Gregory M. Sullivan, Priya Sharma, Matthew McClure, Maria A. Oquendo, J. J...> ;European Neuropsychopharmacology. 2017 Oct 1
44 citations
Positron Emission Tomographic Imaging of the Serotonergic System and Prediction of Risk and Lethality of Future Suicidal Behavior.
Maria A. Oquendo, Hanga Galfalvy, Gregory M. Sullivan, Jeffrey M. Miller, Matthew Milak, M. Elizabeth Sublette, Sebastian Cisneros-Trujillo, Ainsley K. Burke, Ramin V....> ;JAMA Psychiatry. 2016 Oct 1
5 citations
Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults.
Michael Strupp-Levitsky, Jeffrey M. Miller, Harry Rubin-Falcone, Francesca Zanderigo, Matthew S. Milak, Gregory M. Sullivan, R. Todd Ogden, Maria A. Oquendo, Christine...> ;Psychiatry Research. Neuroimaging. 2016 Sep 30
24 citations
PTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT IS ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION.
Liat Helpman, Santiago Papini, Binod T. Chhetry, Erel Shvil, Mikael Rubin, Gregory M. Sullivan, John C. Markowitz, J. John Mann, Yuval Neria> ;Depression and Anxiety. 2016 Feb 10
75 citations
Neural changes in extinction recall following prolonged exposure treatment for PTSD: A longitudinal fMRI study.
Liat Helpman, Marie-France Marin, MA Santiago Papini, Xi Zhu, Gregory M. Sullivan, Franklin R. Schneier, MA Mariana Neria, Erel Shvil, Maria Josefa Malaga Aragon, John...> ;Neuroimage. Clinical. 2016 Feb 1
63 citations
Positron Emission Tomography Quantification of Serotonin1A Receptor Binding in Suicide Attempters With Major Depressive Disorder
Gregory M. Sullivan, Maria A. Oquendo, Matthew S. Milak, Jeffrey M. Miller, Ainsley K. Burke, R. Todd Ogden, Ramin V. Parsey, J. John Mann> ;JAMA Psychiatry. 2015 Feb 1
46 citations
Quantification of the Serotonin 1A Receptor Using PET: Identification of a Potential Biomarker of Major Depression in Males.
Joshua Kaufman, Gregory M. Sullivan, Jie Yang, R. Todd Ogden, Jeffrey M. Miller, Maria A. Oquendo, J. John Mann, Ramin V. Parsey, Christine DeLorenzo> ;Neuropsychopharmacology. 2015 Jan 8
28 citations
Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: a critical review of preclinical research.
Santiago Papini, Gregory M. Sullivan, Denise A. Hien, Erel Shvil, Yuval Neria> ;Biological Psychology. 2015 Jan 1
18 citations
Cerebrospinal Fluid Neuropeptide Y Levels in Major Depression and Reported Childhood Trauma
Laili Soleimani, Maria A. Oquendo, Gregory M. Sullivan, Aleksander A. Mathé, J. John Mann> ;The International Journal of Neuropsychopharmacology. 2015 Jan 1
170 citations
Toward a Biosignature for Suicide
Maria A. Oquendo, Gregory M. Sullivan, Katherin Sudol, Enrique Baca-García, Barbara Stanley, M. Elizabeth Sublette, J. John Mann> ;The American Journal of Psychiatry. 2014 Dec 1
37 citations
ANXIETY IN MAJOR DEPRESSION AND CEREBROSPINAL FLUID FREE GAMMA-AMINOBUTYRIC ACID
J. John Mann, Maria A. Oquendo, Kalycia Trishana Watson, Maura Boldrini, Kevin M. Malone, Steven P. Ellis, Gregory M. Sullivan, Thomas B. Cooper, Shan Xie, Dianne Currier> ;Depression and Anxiety. 2014 Oct 1
37 citations
Association of testosterone levels and future suicide attempts in females with bipolar disorder
Leo Sher, Michael F. Grunebaum, Gregory M. Sullivan, Ainsley K. Burke, Thomas B. Cooper, J. John Mann, Maria A. Oquendo> ;Journal of Affective Disorders. 2014 Sep 1
79 citations
Sex differences in extinction recall in posttraumatic stress disorder: a pilot fMRI study.
Erel Shvil, Gregory M. Sullivan, Scott Schafer, John C. Markowitz, Miriam Campeas, Tor D. Wager, Mohammed R. Milad, Yuval Neria> ;Neurobiology of Learning and Memory. 2014 Sep 1
36 citations
Life events: a complex role in the timing of suicidal behavior among depressed patients.
Maria A. Oquendo, M. Mercedes Perez-Rodriguez, E Poh, Gregory M. Sullivan, Ainsley K. Burke, M. E. Sublette, J. John Mann, Hanga Galfalvy> ;Molecular Psychiatry. 2014 Aug 1
9 citations
Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain
Martin J. Lan, R. Todd Ogden, Yung-yu Huang, Maria A. Oquendo, Gregory M. Sullivan, Jeffrey M. Miller, Matthew S. Milak, J. John Mann, Ramin V. Parsey> ;Neuroimage. 2014 Jul 1
51 citations
Cortical thickness differences between bipolar depression and major depressive disorder
Martin J. Lan, Binod Thapa Chhetry, Maria A. Oquendo, M. Elizabeth Sublette, Gregory M. Sullivan, J. John Mann, Ramin V. Parsey> ;Bipolar Disorders. 2014 Jun 1
50 citations
A diffusion tensor imaging study of suicide attempters.
Doreen M. Olvet, Denis Peruzzo, Binod Thapa-Chhetry, M. Elizabeth Sublette, Gregory M. Sullivan, Maria A. Oquendo, J. John Mann, Ramin V. Parsey> ;Journal of Psychiatric Research. 2014 Apr 1
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Press Mentions

Tonix Pharmaceuticals Presented Results from Pharmacokinetic Analyses of TNX-102 SL in a Poster Presentation at the American Society of Clinical PsychopharmacologyMay 30th, 2019
Tonix Pharmaceuticals Will Present Phase 3 HONOR and Phase 2 AtEase Study Results in a Poster Presentation at the 2018 Military Health System Research SymposiumAugust 15th, 2018
Tonix Pharmaceuticals to Present Additional Clinical Results of Military-Related PTSD Study at the 2017 American Society of Clinical Psychopharmacology Annual MeetingMay 24th, 2017