HelenaRChangMD

General Surgery • Los Angeles, CA

Breast, Surgical Oncology (Other than Breast)

Professor of Surgery, UCLA

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Office
757 Westwood Plz
Los Angeles, CA 90095
Phone+1 310-825-9111
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Education & Training

New York Presbyterian Hospital (Cornell Campus)Residency, Surgery, 1986 - 1988
Episcopal HospitalResidency, Surgery, 1981 - 1986
Lewis Katz School of Medicine at Temple UniversityClass of 1981

Certifications & Licensure

NY State Medical License 1986 - Present
CA State Medical License 1988 - 2023
RI State Medical License 1991 - 1998
PA State Medical License 1983 - 1988
American Board of Surgery Surgery

Awards, Honors, & Recognition

Fellow (FACS) American College of Surgeons
Super Doctor SuperDoctors.com

Clinical Trials

Timing of Menstrual Cycle and Surgery in Treating Premenopausal Women With Stage I, Stage II, or Stage III Breast Cancer Start of enrollment: 1999 Jan 01
Completed
Phase 3
Cryosurgery in Treating Women With Breast Lesions Start of enrollment: 2001 May 01
Completed
Phase 1
Docetaxel and Carboplatin With or Without Trastuzumab Before Surgery in Treating Women With Locally Advanced Breast Cancer Start of enrollment: 2003 Jul 01
Completed
Phase 2
Delayed Adjuvant Herceptin® Treatment in Patients With HER-2 Positive Breast Cancer Start of enrollment: 2007 Jan 01
Terminated
Phase 2
Safety and Efficacy Study of the Xoft® Axxent® eBx® IORT System® Start of enrollment: 2012 May 08
Active, not recruiting
Not Applicable
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Publications & Presentations

PubMed

2 citations
A Pilot Study of Neoadjuvant Nivolumab, Ipilimumab, and Intralesional Oncolytic Virotherapy for HER2-negative Breast Cancer.
Vina P Nguyen, Katie M Campbell, Theodore S Nowicki, Nila Elumalai, Egmidio Medina, Ignacio Baselga-Carretero, Maggie L DiNome, Helena R Chang, Denise K Oseguera, Anto...> ;Cancer Research Communications. 2023 Aug 1
13 citations
HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma.
Na Sun, Ceng Zhang, Yi-Te Lee, Benjamin V Tran, Jing Wang, Hyoyong Kim, Junseok Lee, Ryan Y Zhang, Jasmine J Wang, Junhui Hu, Zhicheng Zhang, Manaf S Alsudaney, Kuan-C...> ;Hepatology. 2023 Mar 1
6 citations
Integrated multiomic predictors for ovarian cancer survival
Alan Fu, Helena R. Chang, Zuo-Feng Zhang> ;Carcinogenesis. 2018 Jul 3
30 citations
CD24 Expression and differential resistance to chemotherapy in triple-negative breast cancer.
Xinyu Deng, Sophia K. Apple, Hong Zhao, Jeongyoon Song, Minna Lee, William Y. Luo, Xiancheng Wu, Debra U. Chung, Richard J. Pietras, Helena R. Chang> ;Oncotarget. 2017 Mar 15
7 citations
Hydrophobic Fractionation Enhances Novel Protein Detection by Mass Spectrometry in Triple Negative Breast Cancer.
Ming Lu, Julian P. Whitelegge, Stephen A. Whelan, Jianbo He, Romaine E. Saxton, Kym F. Faull, Helena R. Chang> ;Journal of Proteomics & Bioinformatics. 2017 Jan 1
28 citations
ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast.
Zheng Ping, Gene P. Siegal, Shuko Harada, Isam-Eldin Eltoum, Mariam Youssef, Tiansheng Shen, Jianbo He, Yingjie Huang, Dongquan Chen, Yi-Ping Li, Kirby I. Bland, Helen...> ;Oncotarget. 2016 Nov 2
53 citations
miR-145 suppresses breast cancer cell migration by targeting FSCN-1 and inhibiting epithelial-mesenchymal transition.
Hong Zhao, Xing Kang, Xuefeng Xia, Wo Like, Xidong Gu, Yuanyuan Hu, Xiaohong Xie, Helena Chang, Lihua Lou, Xuning Shen> ;American Journal of Translational Research. 2016 Jul 15
Significant differences in struvite and cystine stone frequency seen among Chinese nephrolithiasis patients living in North America compared to those living in China.
Thomas Chi, Manint Usawachintachit, Pauline Filippou, David Bayne, Weiguo Hu, Helena Chang, Lei Xia, Qi Chen, Wei Xue, Hui He, Qingzhi Long, Olga Arsovska, Eric Taylor...> ;Translational Andrology and Urology. 2016 Jun 1
17 citations
The Effect of Young Age in Hormone Receptor Positive Breast Cancer.
Minna K. Lee, Leo A. Varzi, Debra U. Chung, Minh-an Cao, Jeffrey Gornbein, Sophia K. Apple, Helena R. Chang> ;Biomed Research International. 2015 Aug 16
20 citations
Predictors for contralateral prophylactic mastectomy in breast cancer patients.
Yun Fu, Zhi-gang Zhuang, Michelle Dewing, Sophia K. Apple, Helena R. Chang> ;International Journal of Clinical and Experimental Pathology. 2015 Apr 1
28 citations
Luminal B subtype: A key factor for the worse prognosis of young breast cancer patients in China
Li Chen Tang, Xi Jin, Hai Yuan Yang, Min He, Helena Chang, Zhi Ming Shao, Gen Hong Di> ;BMC Cancer. 2015 Mar 29
3 citations
Combined Phosphoproteomics and Bioinformatics Strategy in Deciphering Drug Resistant Related Pathways in Triple Negative Breast Cancer
Xinyu Deng, Morris Kohanfars, Huan Ming Hsu, Puneet Souda, Joe Capri, Julian P. Whitelegge, Helena R. Chang> ;International Journal of Proteomics. 2014 Nov 13
30 citations
Is Axillary Lymph Node Dissection Necessary After Sentinel Lymph Node Biopsy in Patients with Mastectomy and Pathological N1 Breast Cancer
Yun Fu, Debra U. Chung, Minh-an Cao, Sophia K. Apple, Helena R. Chang> ;Annals of Surgical Oncology. 2014 Aug 1
380 citations
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Randall Chin, Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang, Gang Deng, Simon Diep, Brett Lomenick, Vijaykumar S. Meli, Gabriela C. Monsalve, Eileen Hu, Step...> ;Nature. 2014 Jun 19
34 citations
Mass spectrometry (LC-MS/MS) identified proteomic biosignatures of breast cancer in proximal fluid.
Stephen A. Whelan, Jianbo He, Ming Lu, Puneet Souda, Romaine E. Saxton, Kym F. Faull, Julian P. Whitelegge, Helena R. Chang> ;Journal of Proteome Research. 2012 Oct 5
28 citations
Proteomic-Based Biosignatures in Breast Cancer Classification and Prediction of Therapeutic Response
Jianbo He, Stephen A. Whelan, Ming Lu, Dejun Shen, Debra U. Chung, Romaine E. Saxton, Kym F. Faull, Julian P. Whitelegge, Helena R. Chang> ;International Journal of Proteomics. 2011 Oct 24
32 citations
Management Options in Triple-Negative Breast Cancer
Christina A. Minami, Debra U. Chung, Helena R. Chang> ;Breast Cancer. 2011 Jul 27
126 citations
Higher levels of GATA3 predict better survival in women with breast cancer
Nam K. Yoon, Erin L. Maresh, Dejun Shen, Yahya Elshimali, Sophia K. Apple, Steve Horvath, Vei Mah, Shikha Bose, David Chia, Helena R. Chang, Lee Goodglick> ;Human Pathology. 2010 Dec 1
80 citations
Differential response of triple-negative breast cancer to a docetaxel and carboplatin-based neoadjuvant treatment.
Helena R. Chang, John A. Glaspy, Mary Ann Allison, Frederic C. Kass, Robert Elashoff, Debra U. Chung, Jeffrey Gornbein> ;Cancer. 2010 Sep 15
11 citations
Hydrophobic Proteome Analysis of Triple Negative and Hormone-Receptor-Positive-Her2-Negative Breast Cancer by Mass Spectrometer.
Ming Lu, Stephen A. Whelan, Jianbo He, Romaine E. Saxton, Kym F. Faull, Julian P. Whitelegge, Helena R. Chang> ;Clinical Proteomics. 2010 Sep 7
2 citations
Heterotopic breast tissue versus occult metastatic carcinoma in lymph node, a diagnostic dilemma.
Steven J. Ohsie, Neda A. Moatamed, Helena R. Chang, Sophia K. Apple> ;Annals of Diagnostic Pathology. 2010 Aug 1
78 citations
Trastuzumab‐based neoadjuvant therapy in patients with HER2‐positive breast cancer
Helena R. Chang> ;Cancer. 2010 Jun 15
18 citations
Tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy.
Jianbo He, Dejun Shen, Debra U. Chung, Romaine E. Saxton, Julian P. Whitelegge, Kym F. Faull, Helena R. Chang> ;International Journal of Oncology. 2009 Oct 1
68 citations
Mass spectrometry (LC-MS/MS) site-mapping of N-glycosylated membrane proteins for breast cancer biomarkers
Stephen A. Whelan, Ming Lu, Jianbo He, Weihong Yan, Romaine E. Saxton, Kym F. Faull, Julian P. Whitelegge, Helena R. Chang> ;Journal of Proteome Research. 2009 Jul 17
45 citations
Accuracy of clinical evaluation of locally advanced breast cancer in patients receiving neoadjuvant chemotherapy.
Raquel Prati, Christina A. Minami, Jeff Gornbein, Nanette DeBruhl, Debbie Chung, Helena R. Chang> ;Cancer. 2009 Mar 15
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Press Mentions

12 Exciting Cancer Breakthroughs You Should Know AboutOctober 3rd, 2014

Grant Support

Ethnicity-Based Proteomic Biomarkers In Breast CancerNational Cancer Institute2002–2004
Generation Of Mabs Against Pancreatic CancerNational Cancer Institute1994–1996
Generation Of Human Mabs Against Pancreatic CancerNational Cancer Institute1992–1993