HowardMarkLedermanMD

Clinical & Laboratory Immunology

Professor of Pediatrics, Johns Hopkins University School of Medicine; Director, Immunodeficiency Clinic, Director, Ataxia-Telangiectasia Clinical Center, Director, Pediatric Immunology Laboratory

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Office
600 N. Wolfe Street
Sheikh Zayed Tower Suite 1102
Baltimore, MD 21287
Phone+1 410-955-5883

Fax+1 410-955-0229
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Education & Training

Johns Hopkins UniversityResidency, Pediatrics, 1978 - 1981
University of Michigan Medical SchoolClass of 1977

Certifications & Licensure

MD State Medical License 1983 - 2024
NC State Medical License 2021 - 2022
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2014

Clinical Trials

Cell-Based Approaches For Modeling and Treating Ataxia-Telangiectasia Start of enrollment: 2015 Feb 03
Terminated
Not Applicable

Publications & Presentations

PubMed

Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in Ataxia Telangiectasia.
Nigel S Michki, Benjamin D Singer, Javier V Perez, Aaron J Thomas, Valerie Natale, Kathryn A Helmin, Jennifer Wright, Leon Cheng, Lisa R Young, Howard M Lederman, Shar...> ;Orphanet Journal of Rare Diseases. 2024 Feb 14
1 citations
Ataxia-telangiectasia clinical trial landscape and the obstacles to overcome.
Katrina Kuhn, Howard M Lederman, Sharon A McGrath-Morrow> ;Expert Opinion on Investigational Drugs. 2023 Aug 28
Novel Functional Assay to Characterize Mutations in Alternative Pathway of Complement.
Gloria F Gerber, Xiang-Zuo Pan, Howard M Lederman, Tammy M Brady, Robert A Brodsky> ;Journal of Clinical Immunology. 2023 Aug 1
Natural history of infants with non-SCID T cell lymphopenia identified on newborn screen.
Stephanie A Kubala, Amandeep Sandhu, Thamiris Palacios-Kibler, Brant Ward, Gretchen Harmon, Magee L DeFelice, Vanessa Bundy, M Elizabeth M Younger, Howard Lederman, Hu...> ;Clinical Immunology. 2022 Dec 1
10 citations
Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children.
Oren Gordon, Mary Katherine Brosnan, Steve Yoon, Dawoon Jung, Kirsten Littlefield, Abhinaya Ganesan, Christopher Caputo, Maggie Li, William R. Morgenlander, Stephanie ...> ;JCI Insight. 2021 Dec 2
9 citations
Multidisciplinary Management of Ataxia Telangiectasia: Current Perspectives.
Sharon A McGrath-Morrow, Cynthia C Rothblum-Oviatt, Jennifer Wright, Haley Schlechter, Maureen A. Lefton-Greif, Valerie A. I. Natale, Thomas O. Crawford, Howard M. Led...> ;Journal of Multidisciplinary Healthcare. 2021 Jun 28
Correction to: Growth in ataxia telangiectasia.
Valerie A. I. Natale, Tim J Cole, Cynthia Rothblum-Oviatt, Jennifer Wright, Thomas O. Crawford, Maureen A. Lefton-Greif, Sharon A. McGrath-Morrow, Haley Schlechter, Ho...> ;Orphanet Journal of Rare Diseases. 2021 Jun 1
9 citations
Growth in ataxia telangiectasia
Valerie A. I. Natale, Tim J Cole, Cynthia Rothblum-Oviatt, Jennifer Wright, Thomas O. Crawford, Maureen A. Lefton-Greif, Sharon A. McGrath-Morrow, Haley Schlechter, Ho...> ;Orphanet Journal of Rare Diseases. 2021 Mar 10
12 citations
Reduced Intensity Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Pediatric Inherited Immune Deficiencies and Bone Marrow Failure Syndromes.
Orly R. Klein, Samantha Bapty, Howard M. Lederman, M. Elizabeth M. Younger, Elias T. Zambidis, Richard J. Jones, Kenneth R. Cooke, Heather J. Symons> ;Journal of Clinical Immunology. 2021 Feb 1
Fever and an Abdominal Mass in an 18-month-old Boy.
Rachel L. Troch, Suzanne Kochis, Aaron M. Milstone, Sanjay K. Jain, Howard M. Lederman, Anna C. Sick-Samuels> ;Pediatrics in Review. 2020 Oct 1
11 citations
Desperate Times: Protecting the Public From Research Without Consent or Oversight During Public Health Emergencies.
Mary Catherine Beach, Howard M. Lederman, Megan Kasimatis Singleton, Roy G. Brower, Joseph A. Carrese, Daniel E. Ford, Bhakti Hansoti, Craig W. Hendrix, Ellen Verena J...> ;Annals of Internal Medicine. 2020 Dec 1
12 citations
DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype.
Sharon A. McGrath-Morrow, Roland Ndeh, Kathryn A. Helmin, Basil Khuder, Cynthia Rothblum-Oviatt, Joseph M. Collaco, Jennifer Wright, Paul A. Reyfman, Howard M. Lederma...> ;Scientific Reports. 2020 May 4
29 citations
Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study
Carole Ober, Chris McKennan, Kevin M. Magnaye, Matthew C. Altman, Charles Washington, Catherine Stanhope, Katherine A. Naughton, Mario G. Rosasco, Leonard B. Bacharier...> ;The Lancet. Respiratory Medicine. 2020 May 1
1 citations
Retrospective Diagnosis of Ataxia-Telangiectasia in an Adolescent Patient With a Remote History of T-Cell Leukemia.
Sei Gyung K. Sze, Howard M. Lederman, Thomas O. Crawford, Michael F. Wangler, Andrea M. Lewis, Michael B. Kastan, Harpreet Dibra, Alex M. Taylor, Daniel S. Wechsler> ;Journal of Pediatric Hematology/oncology. 2021 Jan 1
17 citations
Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia.
Sharon A. McGrath-Morrow, Roland Ndeh, Joseph M. Collaco, Cynthia Rothblum-Oviatt, Jennifer Wright, Michael A. O'Reilly, Benjamin D. Singer, Howard M. Lederman> ;Plos One. 2018 Dec 26
30 citations
Health supervision for people with Bloom syndrome.
Christopher Cunniff, Amir Reza Djavid, Steven Carrubba, Bernard A. Cohen, Nathan A. Ellis, Carolyn Fein Levy, Stacy Jeong, Howard M. Lederman, Maria G. Vogiatzi, Micha...> ;American Journal of Medical Genetics. Part A. 2018 Sep 1
21 citations
Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy
James E. Gern, Agustin Calatroni, Katy F. Jaffee, Henry Lynn, Amy Dresen, William W. Cruikshank, Howard M. Lederman, Hugh A. Sampson, Wayne G. Shreffler, Leonard B. Ba...> ;The Journal of Allergy and Clinical Immunology. 2017 Sep 1
69 citations
Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing.
Yosef Shiloh, Howard M. Lederman> ;Ageing Research Reviews. 2017 Jan 1
333 citations
Ataxia telangiectasia: a review
Cynthia Rothblum-Oviatt, Jennifer Wright, Maureen A. Lefton-Greif, Sharon A. McGrath-Morrow, Thomas O. Crawford, Howard M. Lederman> ;Orphanet Journal of Rare Diseases. 2016 Nov 25
2 citations
Bronchus-associated Lymphoid Tissue in Kabuki Syndrome with Associated Hyper-IgM Syndrome/Common Variable Immunodeficiency.
Jason R. Mock, Todd M. Kolb, Peter B. Illei, Stephen C. Yang, Howard M. Lederman, Christian A. Merlo> ;American Journal of Respiratory and Critical Care Medicine. 2016 Aug 15
9 citations
Assessment of impaired coordination between respiration and deglutition in children and young adults with ataxia telangiectasia.
Maureen A. Lefton-Greif, Adrienne L. Perlman, Xuming He, Howard M. Lederman, Thomas O. Crawford> ;Developmental Medicine and Child Neurology. 2016 Oct 1
25 citations
Serum Interleukin-6 Levels and Pulmonary Function in Ataxia-Telangiectasia
Sharon A. McGrath-Morrow, Joseph M. Collaco, Barbara Detrick, Howard M. Lederman> ;The Journal of Pediatrics. 2016 Apr 1
77 citations
Overview of Infections in the Immunocompromised Host.
Lesia K. Dropulic, Howard M. Lederman> ;Microbiology Spectrum. 2016 Aug 12
9 citations
Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line.
Lucy Lin, Mavis R. Swerdel, Michael P. Lazaropoulos, Gary S. Hoffman, Alana J. Toro-Ramos, Jennifer M. Wright, Howard M. Lederman, Jianmin Chen, Jennifer C. Moore, Ron...> ;Stem Cell Reports. 2015 Dec 8
36 citations
Immunologic Effects of Hydroxyurea in Sickle Cell Anemia
Howard M. Lederman, Margaret A. Connolly, Ram Kalpatthi, Russell E. Ware, Winfred C. Wang, Lori Luchtman-Jones, Myron A. Waclawiw, Jonathan C. Goldsmith, Andrea J. Swi...> ;Pediatrics. 2014 Oct 1
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Journal Articles

Health Supervision for People with Bloom Syndrome
Christopher Cunniff, Steven Carrubba, Bernard Cohen, Howard M Lederman, Maria Vogiatzi, American Journal of Medical Genetics Part A