IanR.RifkinMD

Nephrology • West Roxbury, MA

Associate Professor, Medicine, Boston University School of Medicine

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Office
1400 Vfw Pkwy
West Roxbury, MA 02132
Phone+1 617-323-7700
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Summary

Dr. Ian Rifkin, MD is a nephrologist in West Roxbury, Massachusetts. He is currently licensed to practice medicine in Massachusetts. He is affiliated with Boston Medical Center and is an Associate Professor at Boston University School of Medicine.

Education & Training

Boston University Medical CenterFellowship, Nephrology, 1995 - 1998
University of the WitwatersrandClass of 1983

Certifications & Licensure

MA State Medical License 1999 - 2026
American Board of Internal Medicine Nephrology

Publications & Presentations

PubMed

7 citations
Monoallelic IRF5 deficiency in B cells prevents murine lupus
Alex Pellerin, Kei Yasuda, Abraham Cohen-Bucay, Vanessa Sandra, Prachi Shukla, Barry K Horne, Kerstin Nündel, Gregory A. Viglianti, Yao Xie, Ulf Klein, Ying Tan, Ramon...> ;JCI Insight. 2021 Aug 9
10 citations
Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute...
Rachel Yuen, Dylan Steiner, Riley M.F. Pihl, Elizabeth Chavez, Alex Olson, Erika L Smith, L. Baird, Filiz Korkmaz, Patricia Urick, Manish Sagar, Jacob Berrigan, Suryar...> ;Frontiers in Immunology. 2021 Apr 9
21 citations
Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses
Corr, M. P., Jihyung Lee, Junyan Zhang, Young Jun Chung, Jun Hwan Kim, Chae Min Kook, José M. González-Navajas, David S. Herdman, Bernd Nürnberg, Paul A. Insel, Maripa...> ;Elife. 2020 Feb 4
41 citations
c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth
Chimera Lyle, Sean Richards, Kei Yasuda, Marc A Napoleon, Joshua Walker, Nkiruka Arinze, Mostafa Belghasem, Irva Vellard, Wenqing Yin, Jonathan D. Ravid, Elias Zavaro,...> ;Scientific Reports. 2019 Dec 27
3 citations
Editorial: Podocytes as Active Participants in Lupus Nephritis.
Ian R. Rifkin, Ramon G. Bonegio> ;Arthritis & Rheumatology. 2017 Aug 1
15 citations
TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects
Min-Kyung Choo, Yasuyo Sano, Changhoon Kim, Kei Yasuda, Xiao Dong Li, Xin Lin, Mary P. Stenzel-Poore, Lena Alexopoulou, Sankar Ghosh, Eicke Latz, Ian R. Rifkin, Zhijia...> ;The Journal of Experimental Medicine. 2017 May 1
69 citations
Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses
Abhishek Das, Balthasar A. Heesters, Allison R. Bialas, Joseph O'Flynn, Ian R. Rifkin, Jordi Ochando, Nanette Mittereder, Gianluca Carlesso, Ronald Herbst, Michael C. ...> ;Immunity. 2017 Jan 17
34 citations
Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model
Pierre Duffau, Hanni Menn-Josephy, Carla M. Cuda, Salina Dominguez, Tamar Aprahamian, Amanda A. Watkins, Kei Yasuda, Paul A. Monach, Robert Lafyatis, Lisa M. Rice, G. ...> ;Arthritis & Rheumatology. 2015 Dec 1
45 citations
IRF5 Deficiency Ameliorates Lupus but Promotes Atherosclerosis and Metabolic Dysfunction in a Mouse Model of Lupus-Associated Atherosclerosis
Amanda A. Watkins, Kei Yasuda, Gabriella E. Wilson, Tamar Aprahamian, Yao Xie, Elena Maganto-Garcia, Prachi Shukla, Lillian Oberlander, Bari Laskow, Hanni Menn-Josephy...> ;Journal of Immunology. 2015 Feb 15
37 citations
The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model
Tamar Aprahamian, Xuemei Zhong, Shahzada Amir, Christoph J. Binder, Lo-Ku Chiang, Lamyaa Al-Riyami, Raffi Gharakhanian, Margaret M. Harnett, William Harnett, Ian R. Ri...> ;International Journal for Parasitology. 2015 Mar 1
10 citations
CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin
Allison L. Mathes, Lisa M. Rice, Alsya J. Affandi, Michael DiMarzio, Ian R. Rifkin, Giuseppina Stifano, Romy B. Christmann, Robert Lafyatis> ;Experimental Dermatology. 2015 Feb 1
12 citations
Inhibition of Type 4 Cyclic Nucleotide Phosphodiesterase Blocks Intracellular TLR Signaling in Chronic Lymphocytic Leukemia and Normal Hematopoietic Cells
Ying Tan, Amanda A. Watkins, Benjamin B. Freeman, John A. Meyers, Ian R. Rifkin, Adam Lerner> ;Journal of Immunology. 2015 Jan 1
67 citations
Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways.
Jeffrey Ericson, Pierre Duffau, Kei Yasuda, Adriana Ortiz-Lopez, Katherine Rothamel, Ian R. Rifkin, Paul A. Monach> ;Plos One. 2014 Oct 3
22 citations
Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.
Kei Yasuda, Amanda A. Watkins, Guneet S. Kochar, Gabriella E. Wilson, Bari Laskow, Christophe Richez, Ramon G. Bonegio, Ian R. Rifkin> ;Plos One. 2014 Jul 30
23 citations
Peroxisome proliferator‐activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus
Tamar Aprahamian, Ramon G. Bonegio, Zachary Weitzner, Raffi Gharakhanian, Ian R. Rifkin> ;Immunology. 2014 Jul 1
2 citations
Evaluating the Role of Nucleic Acid Antigens in Murine Models of Systemic Lupus Erythematosus
Amanda A. Watkins, Ramon G. Bonegio, Ian R. Rifkin> ;Methods in Molecular Biology. 2014 Jan 1
42 citations
Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.
Kei Yasuda, Kerstin Nündel, Amanda A. Watkins, Tania Dhawan, Ramon G. Bonegio, Jessalyn M. Ubellacker, Ann Marshak-Rothstein, Ian R. Rifkin> ;International Immunology. 2013 May 1
16 citations
The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus.
Christophe Richez, Rocco J. Richards, Pierre Duffau, Zachary Weitzner, Chris Andry, Ian R. Rifkin, Tamar Aprahamian> ;Plos One. 2013 Apr 8
80 citations
Role for toll-like receptors in autoimmune disease: the example of systemic lupus erythematosus.
Christophe Richez, Patrick Blanco, Ian R. Rifkin, Jean-François Moreau, Thierry Schaeverbeke> ;Joint Bone Spine. 2011 Mar 1
17 citations
Role for interferon regulatory factors in autoimmunity.
Christophe Richez, Thomas Barnetche, Corinne Miceli-Richard, Patrick Blanco, Jean-François Moreau, Ian R. Rifkin, Thierry Schaeverbeke> ;Joint Bone Spine. 2010 Dec 1
105 citations
Poly(I:C) drives type I IFN- and TGFβ-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis.
Giuseppina Farina, Michael York, Mike Di Marzio, Cindy Collins, Stephan Meller, Bernhard Homey, Ian R. Rifkin, Ann Marshak-Rothstein, Timothy R D J Radstake, Robert La...> ;The Journal of Investigative Dermatology. 2010 Nov 1
73 citations
IFN Regulatory Factor 5 Is Required for Disease Development in the FcγRIIB−/−Yaa and FcγRIIB−/− Mouse Models of Systemic Lupus Erythematosus
Christophe Richez, Kei Yasuda, Ramon G. Bonegio, Amanda A. Watkins, Tamar Aprahamian, Patricia Busto, Rocco J. Richards, Chih Long Liu, Regina Cheung, Paul J. Utz, Ann...> ;Journal of Immunology. 2010 Jan 15
92 citations
Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes
Kei Yasuda, Christophe Richez, Melissa B. Uccellini, Rocco J. Richards, Ramon G. Bonegio, Shizuo Akira, Marc Monestier, Ronald B. Corley, Gregory A. Viglianti, Ann Mar...> ;Journal of Immunology. 2009 Sep 1
95 citations
Murine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop
Nathaniel M. Green, Amy Laws, Kerstin Kiefer, Liliana Busconi, You-Me Kim, Melanie M. Brinkmann, Erin Hodges Trail, Kei Yasuda, Sean R. Christensen, Mark J Shlomchik, ...> ;Journal of Immunology. 2009 Aug 1
45 citations
DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody product...
Petar Lenert, Kei Yasuda, Liliana Busconi, Patrice Nelson, Courtney J. Fleenor, Radhika S. Ratnabalasuriar, Peter L Nagy, Robert F. Ashman, Ian R. Rifkin, Ann Marshak-...> ;Arthritis Research & Therapy. 2009 May 28
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Grant Support

The Role Of Interferon Regulatory Factor 5 In The Pathogenesis Of SLENational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009–2011
The Role Of Interferon Regulatory Factor 5 In The Pathogenesis Of SLENational Institute Of Arthritis And Musculoskeletal And Skin Diseases2009
Animal CoreNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2008
Tlr-Dependent Dendritic Cell Activation In SLENational Institute Of Arthritis And Musculoskeletal And Skin Diseases2004–2008
Core C (BU)National Institute Of Arthritis And Musculoskeletal And Skin Diseases2007
Pathogenic Autoreactive T Cells In Murine AutoimmunityNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2002

Hospital Affiliations

Boston Medical CenterBoston, Massachusetts