IriniSeretiMD

Infectious Disease • Bethesda, MD

Physician

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Office
9000 Rockville Pike
Bethesda, MD 20892
Phone+1 301-496-5533
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Education & Training

National Institutes of Health Clinical CenterFellowship, Infectious Disease, 1997 - 1999
University of AthensClass of 1991

Certifications & Licensure

IL State Medical License 1993 - 2026

Clinical Trials

Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Antiretroviral Treatment in HIV-Infected Patients With CD4 T-Lymphocyte Count Greater Than 500 Cells/mm3 Who Received Antiretroviral Tx Start of enrollment: 2003 Oct 01
Completed
Phase 2
Safety of Interleukin-7 in HIV Infected People Currently Taking Anti-HIV Drugs Start of enrollment: 2005 Apr 01
Completed
Phase 1
Immune Reconstitution Syndrome in HIV-Infected Patients Taking Antiretroviral Therapy Start of enrollment: 2006 Feb 01
Completed
Safety Study of IL-7 in HIV-infected Patients (Inspire) Start of enrollment: 2007 May 01
Completed
Phase 1
Maraviroc (CCR5) Antagonism to Decrease the Incidence of the Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients Start of enrollment: 2009 Dec 01
Unknown status
Not Applicable
Gene Expression in HIV and Tuberculosis Co-infection Start of enrollment: 2012 May 29
Completed
Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study Start of enrollment: 2014 Apr 18
Completed
Phase 2
PET Imaging and Lymph Node Assessment of IRIS in People With AIDS Start of enrollment: 2014 May 30
Recruiting
CC-11050 in Human Immunodeficiency Virus-1-Infected Adults With Suppressed Plasma Viremia on Antiretroviral Therapy (APHRODITE) Start of enrollment: 2016 Jan 09
Completed
Phase 1
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Publications & Presentations

PubMed

Helper T cell immunity in humans with inherited CD4 deficiency.
Antoine Guérin, Marcela Moncada-Vélez, Katherine Jackson, Masato Ogishi, Jérémie Rosain, Mathieu Mancini, David Langlais, Andrea Nunez, Samantha Webster, Jesse Goyette...> ;The Journal of Experimental Medicine. 2024 May 6
Clonal hematopoiesis in people with advanced HIV and associated inflammatory syndromes.
Joseph M Rocco, Yifan Zhou, Nicholas S Liu, Elizabeth Laidlaw, Frances Galindo, Megan V Anderson, Adam Rupert, Silvia Lucena Lage, Ana M Ortega-Villa, Shiqin Yu, Andre...> ;JCI Insight. 2024 Apr 2
Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency.
Aristine Cheng, Anuj Kashyap, Helene Salvator, Lindsey B Rosen, Devon Colby, Fatemeh Ardeshir-Larijani, Patrick J Loehrer, Li Ding, Saul O Lugo Reyes, Sean Riminton, M...> ;The New England Journal of Medicine. 2024 Mar 21
SARS-CoV-2 seroprevalence in vaccine-naïve participants from the Democratic Republic of Congo, Guinea, Liberia, and Mali.
, Sylvain Laverdure, Donatien Kazadi, Kadidia Kone, Viviane Callier, Djeneba Dabitao, Dehkontee Dennis, Mory Cherif Haidara, Sally Hunsberger, Olivier Tshiani Mbaya, K...> ;International Journal of Infectious Diseases. 2024 May 1
Culturing the Future of Medicine: The Imperative of Strengthening the ID Physician-Scientist Pipeline.
Titanji, B., Sereti, I., Singer, B.> ;The Journal of Infectious Diseases. 2024 Feb 14
Immune responses to SARS-CoV-2 mRNA vaccination in people with idiopathic CD4 lymphopenia.
Rocco, J., Boswell, K., Laidlaw, E., Epling, B., Anderson, M., Serebryannyy, L., Narpala, S., O'Connell, S., Kalish, H., Kelly, S., Porche, S., Oguz, C., McDermott, A....> ;The Journal of Allergy and Clinical Immunology. 2024 Feb 1
1 citations
Transcriptionally-active "defective" HIV-1 proviruses and their association with immunological non-response to antiretroviral therapy.
Scrimieri, F., Bastian, E., Smith, M., Rehm, C., Morse, C., McLaughlin, M., Chang, W., Kovacs, J., Lane, H., Imamichi, H., Kuruppu, J., Sereti, I.> ;The Journal of Infectious Diseases. 2024 Jan 16
Prolonged Mpox Disease in People With Advanced HIV: Characterization of Mpox Skin Lesions.
Jesse O'Shea, Jason Zucker, Samuel Stampfer, Shama Cash-Goldwasser, Faisal S Minhaj, Alexandra Dretler, Justin Cheeley, Shaoli Chaudhuri, Stephanie M Gallitano, Shauna...> ;The Journal of Infectious Diseases. 2024 Mar 26
Long-term Outcomes of Patients With HIV andPneumonia in the Antiretroviral Therapy Era.
Brian P Epling, Maura Manion, Arlene Sirajuddin, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Gregg Roby, Joseph M Rocco, Andrea Lisco, Virginia Sheikh, Joseph ...> ;Open Forum Infectious Diseases. 2023 Aug 1
1 citations
An open label randomized controlled trial of atorvastatin versus aspirin in elite controllers and antiretroviral-treated people with HIV.
Harry A Mystakelis, Eleanor Wilson, Elizabeth Laidlaw, April Poole, Sonya Krishnan, Adam Rupert, Jorden L Welker, Robert J Gorelick, Andrea Lisco, Maura Manion, Jason ...> ;AIDS. 2023 Oct 1
Immunophenotypic analysis in participants with Kaposi sarcoma following pomalidomide administration.
Kathryn Lurain, Mark N Polizzotto, Laurie T Krug, Griffin Shoemaker, Amrit Singh, Stig M R Jensen, Kathleen M Wyvill, Ramya Ramaswami, Thomas S Uldrick, Robert Yarchoa...> ;AIDS. 2023 Sep 1
1 citations
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV.
Andrea Lisco, Camille Lange, Maura Manion, Safia Kuriakose, Robin Dewar, Robert J Gorelick, Kristi Huik, Quan Yu, Dima A Hammoud, Bryan R Smith, Pawel Muranski, Cather...> ;Nature Medicine. 2023 Jun 1
A Gut Feeling: Inflammatory Disease Revealed During Immune Reconstitution.
Joseph M Rocco, Aaron Richterman, Irini Sereti> ;Gastroenterology. 2023 Sep 1
3 citations
Reappraisal of Idiopathic CD4 Lymphocytopenia at 30 Years.
Andrea Lisco, Ana M Ortega-Villa, Harry Mystakelis, Megan V Anderson, Allyson Mateja, Elizabeth Laidlaw, Maura Manion, Gregg Roby, Jeanette Higgins, Safia Kuriakose, M...> ;The New England Journal of Medicine. 2023 May 4
1 citations
Persistence of Human Immunodeficiency Virus-Associated Cerebral Toxoplasmosis Lesions in Successfully Treated Patients Receiving Combination Antiretroviral Therapy.
Benjamin Coleman, Bryan R Smith, Rama Kapoor, Michael A Proschan, Irini Sereti, Dima A Hammoud, Joseph A Kovacs> ;Open Forum Infectious Diseases. 2023 May 1
3 citations
Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related Genes.
Joseph M Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Ornella Sortino, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti> ;The Journal of Infectious Diseases. 2023 Jul 14
Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV.
Márton Kolossváry, Chris deFilippi, Sara McCallum, Kathleen V Fitch, Marissa R Diggs, Evelynne S Fulda, Heather J Ribaudo, Carl J Fichtenbaum, Judith A Aberg, Carlos D...> ;Ebiomedicine. 2023 Apr 1
3 citations
Association between severe anaemia and inflammation, risk of IRIS and death in persons with HIV: A multinational cohort study.
Mariana Ara Jo-Pereira, Virginia Sheikh, Irini Sereti, Beatriz Barreto-Duarte, Mar Ía B Arriaga, Rafael Tib Rcio, Caian L Vinhaes, Manuella Pinto-de-Almeida, Jing Wang...> ;Ebiomedicine. 2022 Nov 1
25 citations
Clinical, Virologic, and Immunologic Evaluation of Symptomatic Coronavirus Disease 2019 Rebound Following Nirmatrelvir/Ritonavir Treatment.
Brian P Epling, Joseph M Rocco, Kristin L Boswell, Elizabeth Laidlaw, Frances Galindo, Anela Kellogg, Sanchita Das, Allison Roder, Elodie Ghedin, Allie Kreitman, Robin...> ;Clinical Infectious Diseases. 2023 Feb 18
10 citations
Clinical exome sequencing of 1000 families with complex immune phenotypes: Toward comprehensive genomic evaluations.
Myles, I. A., Morgan N Similuk, Jia Yan, Rajarshi Ghosh, Andrew J Oler, Luis M Franco, Michael R Setzer, Michael Kamen, Colleen Jodarski, Thomas DiMaggio, Joie Davis, ...> ;The Journal of Allergy and Clinical Immunology. 2022 Oct 1
6 citations
Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.
Sadia Samer, Yanique Thomas, Mariluz Araínga, Crystal Carter, Lisa M Shirreff, Muhammad S Arif, Juan M Avita, Ines Frank, Michael D McRaven, Christopher T Thuruthiyil,...> ;JCI Insight. 2022 Nov 8
6 citations
Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytos...
Joseph M Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Adam Rupert, Jeanette Higgins, Ornella Sortino, Ana M Ortega-Villa, Virginia Sheikh, Gregg Roby, Sa...> ;Clinical Infectious Diseases. 2023 Feb 8
2 citations
Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.
Joseph M Rocco, Paola Laghetti, Mariantonietta Di Stefano, Irini Sereti, Ana Ortega-Villa, Jing Wang, Adam Rupert, Maria Chironna, Lara Ye, Xiangdong Liu, Megan V Ande...> ;Open Forum Infectious Diseases. 2022 Sep 1
9 citations
Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregul...
Joseph M Rocco, Christina Mallarino-Haeger, Attiya H Randolph, Susan M Ray, Marcos C Schechter, Christa S Zerbe, Steven M Holland, Irini Sereti> ;Clinical Infectious Diseases. 2022 Aug 24
1 citations
Improvement of liver metabolic activity in people with advanced HIV after antiretroviral therapy initiation.
Reema Patel, Maura M Manion, Elizabeth Laidlaw, Paul Wakim, Zeping Wang, Megan Anderson, Frances Galindo, Adam Rupert, Andrea Lisco, Theo Heller, Irini Sereti, Dima A ...> ;AIDS. 2022 Oct 1
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Press Mentions

Types of HIV Papers — A Quick GuideMay 15th, 2023
Government Scientists: COVID-19 Rebound Not Caused by Impaired Immune ResponseOctober 12th, 2022
NIAID Scientists Illuminate Mechanism of Increased Cardiovascular Risks with HIVSeptember 5th, 2017
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Grant Support

Immunopathogenic Mechanisms Of Human Immunodeficiency Virus (HIV) DiseaseNational Institute Of Allergy And Infectious Diseases2011
Human Immunodeficiency Virus (HIV) And CD4 Lymphopenia ImmunopathogenesisNational Institute Of Allergy And Infectious Diseases2010

IriniSeretiMD

Dr. Sereti is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

Grant Support

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