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Education & Training

  • University of Washington
    University of WashingtonFELLOWSHIP
  • Duke University Hospital
    Duke University HospitalRESIDENCY
  • Duke University School of Medicine
    Duke University School of MedicineMEDICAL_SCHOOL
  • Duke University Medical Center
    Duke University Medical CenterOTHER_TRAINING
  • Princeton UniversityOTHER_TRAINING

Certifications & Licensure

  • MO State Medical License
    MO State Medical License 1984 - 2019
  • American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

  • Member Institute of Medicine of the National Academies, 2013
  • Fellow American Heart Association, 2001
  • Distinguished Career Award, Tenth Biennial Awards for Contributions to Hemostasis ISTH, 2001
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Clinical Trials

Publications & Presentations


Journal Articles

  • Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings  
    De Ceunynck K, Rocha S, De Meyer SF, Sadler JE, Uji-I H, Deckmyn H, Hofkens J, Vanhoorelbeke K, J Biol Chem, 1/1/2013
  • Rearranging exosites in non-catalytic domains can redirect the substrate specificity of ADAMTS proteases  
    Gao W, Zhu J, Westfield LA, Tuley EA, Anderson PJ, Sadler JE, J Biol Chem, 1/1/2012
  • The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1 dependent manner  
    Huang J, Haberichter SL, Sadler JE, Blood, 1/1/2012
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Books/Book Chapters

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  • Differential Effect of Rituximab on Relapse-Free Survival in De Novo and Relapsed Immune Thrombotic Thrombocytopenic Purpura in African-American and Caucasian Populations
    J. Evan Sadler, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019


  • Von Willebrand factor biosynthesis, structure and function. 
  • von Willebrand factor, ADAMTS13, and thrombotic microangiopathy. 
    University of Michigan, Ann Arbor, MI - 1/21/2012
  • von Willebrand factor assembly and destruction in human disease. 
    London, United Kingdom - 1/8/2010
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  • Fluorogenic substrate for ADAMTS13. 
    Sadler JE, Muia J, Gao W, U.S. Patent Number 8,663,912
  • Knockout mice and their progeny with a disrupted hepsin gene. 
    Wu Q, Sadler JE, U.S. Patent Number 5,981,830
  • DNA clones of human placental plasminogen activator inhibitor. 
    Sadler JE, Wun, T-C., U.S. Patent Number 5,028,534
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Grant Support

  • Proteases In The Pathogenesis And Treatment Of ThrombosisNational Heart, Lung, And Blood Institute2012
  • Pre- And Postgraduate Training In Molecular HematologyNational Heart, Lung, And Blood Institute2011–2012
  • Regulation Of ADAMTS13 ActivityNational Heart, Lung, And Blood Institute2007–2011
  • Von Willebrand Factor Multimer Assembly And StructureNational Heart, Lung, And Blood Institute2003–2011
  • Pre-And Postgraduate Training In Molecular HematologyNational Heart, Lung, And Blood Institute2009–2010
  • Clinical Hematology Research Career Development Program At Washington UniversityNational Heart, Lung, And Blood Institute2006–2010
  • Enterokinase--An Intestinal Digestive ProteaseNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2003
  • Enterokinase, An Intestinal Digestive ProteaseNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1998


  • Member, NIH Hemostasis and Thrombosis Study Section 2013 - Present
  • Chair, NIH Hematology Study Section 1 1995 - 1997

Hospital Affiliations