JackAdamYanovskiMD

Pediatric Endocrinology • Bethesda, MD

Physician

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Office
10 Center Dr
Nih Hatfield Crc, Rm 1e-3330 Msc 1103
Bethesda, MD 20892
Phone+1 301-496-0858

Fax+1 301-402-0574
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Education & Training

National Institutes of Health Clinical Center/Eunice Kennedy Shriver NICHDFellowship, Pediatric Endocrinology, 1989 - 1992
Childrens Hospital of PhiladelphiaInternship, Transitional Year, 1986 - 1987
Perelman School of Medicine at the University of PennsylvaniaClass of 1986

Certifications & Licensure

MD State Medical License 1989 - 2025
PA State Medical License 1987 - 2002
American Board of Pediatrics Pediatric Endocrinology

Clinical Trials

Endocrine Studies of Healthy Children Start of enrollment: 1984 Aug 28
Completed
Metabolic Differences of Overweight Children and Children of Overweight Parents Start of enrollment: 1996 Jun 06
Completed
Safety and Efficacy of Xenical in Children and Adolescents With Obesity-Related Diseases Start of enrollment: 1998 May 01
Completed
Phase 2
Supplemental Calcium in Overweight People Start of enrollment: 2002 Feb 06
Completed
Phase 3
Pilot Program for Targeted Prevention of Child or Adolescent Weight Gain Start of enrollment: 2005 Dec 05
Completed
Phase 1
Body Heat Content and Dissipation in Obese and Normal Weight Adults Start of enrollment: 2005 Dec 12
Completed
Eating Behavior in Children Start of enrollment: 2003 Nov 26
Completed
The Role of Motion in Infants' Ability to Categorize Start of enrollment: 1998 Sep 03
Completed
Effects of Betahistine Hydrochloride in Overweight Women Start of enrollment: 2007 Apr 10
Completed
Phase 1
Effects of Sun Filters on Age-related Macular Degeneration in People With Lens Implants Start of enrollment: 2007 Jun 14
Withdrawn
Eating Behavior in Adolescents Start of enrollment: 2008 Mar 05
Completed
Preventing Excessive Weight Gain in Adolescent Girls at High-Risk for Adult Obesity Start of enrollment: 2008 May 15
Completed
Phase 2
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions Start of enrollment: 2008 Sep 11
Completed
Free Fatty Acids, Body Weight, and Growth Hormones Secretion in Children Start of enrollment: 2011 Jul 01
Terminated
Phase 1, Phase 2
Mood and Insulin Resistance in Adolescents At-Risk for Diabetes Start of enrollment: 2011 Aug 23
Completed
Phase 2
Brain-Derived Neurotrophic Factor in Obesity and Brain Function Start of enrollment: 2012 Jan 09
Completed
Fat Metabolism and Melanocortin 3 Receptors in African Americans Start of enrollment: 2013 Sep 23
Terminated
Effects of Interrupting Sedentary Behavior on Metabolic and Cognitive Outcomes in Children Start of enrollment: 2013 Jun 26
Completed
Phase 1, Phase 2
Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome Start of enrollment: 2014 May 31
Completed
Phase 1, Phase 2
Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi Syndrome Start of enrollment: 2014 Sep 01
Terminated
Phase 3
Children s Growth and Behavior Study Start of enrollment: 2015 Apr 21
Recruiting
Mobile Attention Retraining in Overweight Female Adolescents Start of enrollment: 2017 Feb 10
Active, not recruiting
Phase 2
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity Start of enrollment: 2021 Nov 08
Recruiting
Phase 2
Roles: Principal Investigator, Contact
Liraglutide (Saxenda(R)) in Adolescents With Obesity After Sleeve Gastrectomy Start of enrollment: 2021 Jun 21
Active, not recruiting
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Effects of Therapeutic Alliance in Interpersonal Psychotherapy Among Adolescent Girls With Loss-of-Control Eating.
Elizabeth B Ruzicka, Lauren B Shomaker, Laura Pyle, Jennifer L Bakalar, Lisa M Shank, Ross D Crosby, Denise E Wilfley, Jami F Young, Tracy Sbrocco, Sheila M Brady, Lau...> ;American Journal of Psychotherapy. 2024 Mar 15
Approach to Obesity Treatment in Primary Care: A Review.
Susan Z Yanovski, Jack A Yanovski> ;JAMA Internal Medicine. 2024 Mar 11
Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation.
Irini Manoli, Justin R Sysol, PamelaSara E Head, Madeline W Epping, Oksana Gavrilova, Melissa K Crocker, Jennifer L Sloan, Stefanos A Koutsoukos, Cindy Wang, Yiouli P ...> ;JCI Insight. 2024 Feb 22
Phenotyping children and adolescents with obesity using behavioral, psychological, and familial data.
Ruth G St Fleur, Marian Tanofsky-Kraff, Jack A Yanovski, Nicholas J Horton, Joel N Hirschhorn, Alison E Field> ;Obesity. 2023 Dec 1
Independent and Interactive Associations of Subjective and Objective Socioeconomic Status With Body Composition and Parent-Reported Hyperphagia Among Children.
Meegan R Smith, Julia M P Bittner, Lucy K Loch, Hannah E Haynes, Bess F Bloomer, Jennifer Te-Vazquez, Andrea I Bowling, Sheila M Brady, Marian Tanofsky-Kraff, Kong Y C...> ;Childhood Obesity. 2023 Nov 9
Diazoxide choline extended-release tablet in people with Prader-Willi syndrome: results from long-term open-label study.
Jennifer L Miller, Evelien Gevers, Nicola Bridges, Jack A Yanovski, Parisa Salehi, Kathryn S Obrynba, Eric I Felner, Lynne M Bird, Ashley H Shoemaker, Moris Angulo, Me...> ;Obesity. 2024 Feb 1
Changes in Food Consumption, BMI, and Body Composition in Youth in the US during the COVID-19 Pandemic.
Nasreen Moursi, Marian Tanofsky-Kraff, Megan Parker, Lucy Loch, Bess Bloomer, Jennifer Te-Vazquez, Ejike Nwosu, Julia Lazareva, Shanna B Yang, Sara Turner, Sheila Brad...> ;International Journal of Environmental Research and Public Health. 2023 Sep 21
Metabolic syndrome prevalence and impact on outcomes in patients with chronic graft-versus-host disease.
Aaron T Zhao, Filip Pirsl, Seth M Steinberg, Noa G Holtzman, Eduard Schulz, Alain Mina, Jacqueline W Mays, Edward W Cowen, Leora E Comis, Galen O Joe, Jack A Yanovski,...> ;Bone Marrow Transplantation. 2023 Dec 1
1 citations
Cell-free DNA reveals distinct pathology of multisystem inflammatory syndrome in children.
Temesgen E Andargie, Katerina Roznik, Neelam Redekar, Tom Hill, Weiqiang Zhou, Zainab Apalara, Hyesik Kong, Oren Gordon, Rohan Meda, Woojin Park, Trevor S Johnston, Yi...> ;The Journal of Clinical Investigation. 2023 Nov 1
Associated features of pediatric loss-of-control eating severity during a laboratory-based feeding paradigm.
Megan N Parker, Sarah LeMay-Russell, Lucy K Loch, Bess F Bloomer, Jennifer Te-Vazquez, Nasreen A Moursi, Ejike E Nwosu, Julia Lazareva, Natasha A Schvey, Sheila M Brad...> ;Eating Behaviors. 2023 Aug 1
1 citations
Associations of food reinforcement and food- related inhibitory control with adiposity and weight gain in children and adolescents.
Lucy K Loch, Marian Tanofsky-Kraff, Megan N Parker, Hannah E Haynes, Jennifer A Te-Vazquez, Bess F Bloomer, Julia Lazareva, Nasreen A Moursi, Ejike E Nwosu, Shanna B Y...> ;Physiology & Behavior. 2023 Jul 1
2 citations
An evaluation of setmelanotide injection for chronic weight management in adult and pediatric patients with obesity due to Bardet-Biedl syndrome.
Julia Lazareva, Sheila M Brady, Jack A Yanovski> ;Expert Opinion on Pharmacotherapy. 2023 Apr 1
12 citations
Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure.
John R Speakman, Jasper M A de Jong, Srishti Sinha, Klaas R Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Liam J Anderson, Lenore Arab, Kweku Bedu-Ad...> ;Nature Metabolism. 2023 Apr 1
Influence of puberty on relationships between body composition and blood pressure: a cross-sectional study.
Esther A Kwarteng, Lisa M Shank, Loie M Faulkner, Lucy K Loch, Syeda Fatima, Suryaa Gupta, Hannah E Haynes, Kaitlin L Ballenger, Megan N Parker, Sheila M Brady, Anna Z...> ;Pediatric Research. 2023 Aug 1
4 citations
Immunomodulatory effects of colchicine on peripheral blood mononuclear cell subpopulations in human obesity: Data from a randomized controlled trial.
Tushar P Patel, Jordan A Levine, Diana M Elizondo, Brooke E Arner, Arad Jain, Ankit Saxena, Maria Lopez-Ocasio, Pradeep K Dagur, Olufisola Famuyiwa, Suryaa Gupta, Zahr...> ;Obesity. 2023 Feb 1
Circadian variation of serum leptin and adipose tissue changes in children.
Anna Zenno, Sheila M Brady, Loie M Faulkner, Kaitlin L Ballenger, Syeda Fatima, Jack A Yanovski> ;Pediatric Obesity. 2023 Feb 1
1 citations
A Combined Region- and Pixel-Based Deep Learning Approach for Quantifying Abdominal Adipose Tissue in Adolescents Using Dixon Magnetic Resonance Imaging.
Olanrewaju A Ogunleye, Harish Raviprakash, Ashlee M Simmons, Rhasaan T M Bovell, Pedro E Martinez, Jack A Yanovski, Karen F Berman, Peter J Schmidt, Elizabeth C Jones,...> ;Tomography. 2023 Jan 15
8 citations
Diazoxide Choline Extended-Release Tablet in People With Prader-Willi Syndrome: A Double-Blind, Placebo-Controlled Trial.
Jennifer L Miller, Evelien Gevers, Nicola Bridges, Jack A Yanovski, Parisa Salehi, Kathryn S Obrynba, Eric I Felner, Lynne M Bird, Ashley H Shoemaker, Moris Angulo, Me...> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Jun 16
Colchicine effects on the gut microbiome in adults with metabolic syndrome.
Celine M Kisimba, Jack L Donahue, Krishna Karthik Chivukula, Poorani Subramanian, Shreni D Mistry, Anna Wolska, Alan T Remaley, Jack A Yanovski, Andrew P Demidowich> ;Bioscience of Microbiota, Food and Health. 2023 Jan 1
Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight.
Meghan E Byrne, Marian Tanofsky-Kraff, Lucrezia Liuzzi, Tom Holroyd, Megan N Parker, Bess F Bloomer, Allison Nugent, Sheila M Brady, Shanna B Yang, Sara A Turner, Dani...> ;Frontiers in Psychiatry. 2023 Jan 1
2 citations
Eating disorders in weight-related therapy (EDIT): Protocol for a systematic review with individual participant data meta-analysis of eating disorder risk in behaviour...
Hiba Jebeile, Natalie B Lister, Sol Libesman, Kylie E Hunter, Caitlin M McMaster, Brittany J Johnson, Louise A Baur, Susan J Paxton, Sarah P Garnett, Amy L Ahern, Deni...> ;Plos One. 2023 Jan 1
22 citations
Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double...
Andrea M Haqq, Wendy K Chung, Hélène Dollfus, Robert M Haws, Gabriel Á Martos-Moreno, Christine Poitou, Jack A Yanovski, Robert S Mittleman, Guojun Yuan, Elizabeth For...> ;The Lancet. Diabetes & Endocrinology. 2022 Dec 1
Effects of interrupting daily sedentary behavior on children's glucose metabolism: A 6-day randomized controlled trial.
Miranda M Broadney, Britni R Belcher, Nejla Ghane, Risha Sheni, Michael J Jayson, Robert W Trenschel, Shavonne M Collins, Robert J Brychta, Elisabeth K Davis, Sheila M...> ;Pediatric Diabetes. 2022 Dec 1
17 citations
Variation in human water turnover associated with environmental and lifestyle factors.
Yosuke Yamada, Xueying Zhang, Mary E T Henderson, Hiroyuki Sagayama, Herman Pontzer, Daiki Watanabe, Tsukasa Yoshida, Misaka Kimura, Philip N Ainslie, Lene F Andersen,...> ;Science. 2022 Nov 25
7 citations
State negative affect in relation to loss-of-control eating among children and adolescents in the natural environment.
Megan N Parker, Marian Tanofsky-Kraff, Ross D Crosby, Lisa M Shank, Esther A Kwarteng, Lucy K Loch, Loie M Faulkner, Hannah E Haynes, Suryaa Gupta, Syeda Fatima, Jesse...> ;Appetite. 2022 Nov 1
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Journal Articles

Working Toward Precision Medicine Approaches to Treat Severe Obesity in Adolescents: Report of an NIH Workshop
Marsha D Marcus, Jack A Yanovski, Nature
Effects of Interrupting Sedentary Behavior with Short Bouts of Moderate Physical Activity on Glucose Tolerance in Children with Overweight and Obesity: A Randomized, C...
Jack Yanovski, MD, Diabetes Care

Press Mentions

Drug to Delay T1D Gets Tepid Endorsement by FDA AdvisorsMay 28th, 2021
Oral AbstractsNovember 4th, 2020
The Obesity Society 2019 Awards and GrantsDecember 20th, 2019
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Grant Support

Physiology, Psychology, And Genetics Of ObesityEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Physiology, Psychology, And Genetics Of ObesityEunice Kennedy Shriver National Institute Of Child Health &Human Development2004–2008
Physiology And Genetics Of ObesityEunice Kennedy Shriver National Institute Of Child Health &Human Development1996–2003

JackAdamYanovskiMD

Dr. Yanovski is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

Grant Support

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