JamesFChmielMD

Pediatric Pulmonology • Indianapolis, IN

Cystic Fibrosis Pulmonology, Pediatric Asthma Pulmonology, Pediatric Bronchoscopy

Professor of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine

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Office
Riley Hospital for Children
705 Riley Hospital Drive, ROC 4270
Indianapolis, IN 46202
Phone+1 317-948-7768

Fax+1 317-944-7247
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Education & Training

Case Western Reserve Univ/Univ Hosps Cleveland Med Ctr/Rainbow Babies and Childrens HospitalFellowship, Pediatric Pulmonology, 1995 - 1998
McGaw Medical Center of Northwestern UniversityResidency, Pediatrics, 1991 - 1994
University of Michigan Medical SchoolClass of 1991

Certifications & Licensure

IN State Medical License 2019 - 2025
OH State Medical License 1995 - 2019
IL State Medical License 1991 - 1996
American Board of Pediatrics Pediatric Pulmonology

Clinical Trials

Assessment of Inflammatory Mediators (AIM) Start of enrollment: 2004 Aug 01
Completed
Not Applicable
Nasal Epithelial Cells/Blood Lymphocyte Markers for Cystic Fibrosis (CF)/CF Pulmonary Exacerbations Start of enrollment: 2006 Sep 01
Completed
Study of the Effect of Vitamin D as an Add-on Therapy to Corticosteroids in Asthma Start of enrollment: 2011 Apr 01
Completed
Phase 3
Treatment of Preschool Children With Upper Respiratory Tract Illnesses Using Azythromycin and Lower Respiratory Tract Symptoms Using Oral Corticosteroids. Start of enrollment: 2011 Mar 01
Completed
Phase 3
Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation Start of enrollment: 2011 Apr 01
Completed
Not Applicable
Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC Study) Start of enrollment: 2011 Oct 01
Completed
Phase 3
Severe Asthma Research Program Start of enrollment: 2012 Oct 01
Active, not recruiting
Airway Redox and Gender Determinants in Severe Asthma Start of enrollment: 2012 Dec 01
Active, not recruiting
IL-17 Neutrophils in CF Lung Inflammation Start of enrollment: 2014 Feb 01
Completed
OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis Start of enrollment: 2014 Jun 01
Completed
Phase 3
Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation Start of enrollment: 2015 Nov 01
Completed
Phase 2
Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With Cystic Fibrosis (CF) Start of enrollment: 2016 Oct 21
Completed
Phase 4
Pulmonary Vascular Disease in CF Start of enrollment: 2020 Jul 29
Recruiting
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Publications & Presentations

PubMed

3 citations
A phase I study assessing the safety and tolerability of allogeneic mesenchymal stem cell infusion in adults with cystic fibrosis.
Erica A Roesch, Tracey L Bonfield, Hillard M Lazarus, Jane Reese, Kathleen Hilliard, Jay Hilliard, Umer Khan, Sonya Heltshe, Adam Gluvna, Elliot Dasenbrook, Arnold I C...> ;Journal of Cystic Fibrosis. 2023 May 1
10 citations
Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial.
David P. Nichols, Pradeep K. Singh, Arthur Baines, Lindsay J. Caverly, James F Chmiel, Ronald L. Gibson, Jorge Lascano, Sarah J. Morgan, George Z. Retsch-Bogart, Lisa ...> ;Thorax. 2021 Oct 27
3 citations
Somatic cell hemoglobin modulates nitrogen oxide metabolism in the human airway epithelium.
Nadzeya Marozkina, Laura Smith, Yi Zhao, Joe Zein, James F Chmiel, Jeeho Kim, Janna Kiselar, Michael D Davis, Rebekah S Cunningham, Scott H. Randell, Benjamin Gaston> ;Scientific Reports. 2021 Jul 29
9 citations
Geography, generalisability, and susceptibility in clinical trials.
Jane E. Clougherty, Ellen Kinnee, Juan Carlos Cardet, David T. Mauger, Leonard B. Bacharier, Avraham Beigelman, Kathryn V. Blake, Michael D. Cabana, Mario Castro, Jame...> ;The Lancet. Respiratory Medicine. 2021 Feb 1
12 citations
Early-Life Height Attainment in Cystic Fibrosis Is Associated with Pulmonary Function at Age 6 Years.
Don B. Sanders, James E. Slaven, Karen Maguiness, James F Chmiel, Clement L. Ren> ;Annals of the American Thoracic Society. 2021 Jul 30
5 citations
Drug development for cystic fibrosis.
Don B. Sanders, James F Chmiel> ;Pediatric Pulmonology. 2021 Jan 12
15 citations
Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with cystic fibrosis.
James F Chmiel, Patrick Flume, Damian G Downey, Allen J Dozor, Carla Colombo, Henryk Mazurek, Ewa Sapiejka, Marta Rachel, Scott Constantine, Brian Conley, Nancy Dgetlu...> ;Journal of Cystic Fibrosis. 2021 Jan 1
4 citations
Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort.
Samuel Y. Ash, Gonzalo Vegas Sanchez-Ferrero, Mark L. Schiebler, Farbod N. Rahaghi, Ashish Rai, Carolyn E. Come, James C. Ross, Alysha Colon, Juan Carlos Cardet, Eugen...> ;Chest. 2020 Feb 1
74 citations
Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): a multicentre, randomised, double-blind, placebo-controlled trial
Felix Ratjen, Stephanie D. Davis, Sanja Stanojevic, Richard A. Kronmal, Karen Hinckley Stukovsky, Neal W. Jorgensen, Margaret Rosenfeld, Gwen Kerby, Carol Kopecky, Meg...> ;The Lancet. Respiratory Medicine. 2019 Sep 1
38 citations
A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11 years with cystic fibrosis.
Seth Walker, Patrick A. Flume, John McNamara, Melinda Solomon, Mark A. Chilvers, James Chmiel, R. Scott Harris, Eric L. Haseltine, David Stiles, Chonghua Li, Neil Ahlu...> ;Journal of Cystic Fibrosis. 2019 Sep 1
75 citations
Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level
Stephen C. Lazarus, Jerry A. Krishnan, Tonya S. King, Jason E. Lang, Kathryn V. Blake, Ronina A. Covar, Njira L Lugogo, Sally E. Wenzel, Vernon M. Chinchilli, David T....> ;The New England Journal of Medicine. 2019 May 19
19 citations
Vitamin D for the Immune System in Cystic Fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled clinical trial
Vin Tangpricha, Joshua Lukemire, Yuqing Chen, Jose N. Binongo, Suzanne E. Judd, Ellen S. Michalski, Moon Jeong Lee, Seth Walker, Thomas R. Ziegler, Rabin Tirouvanziam,...> ;The American Journal of Clinical Nutrition. 2019 Mar 1
26 citations
Eradication of persistent methicillin-resistant Staphylococcus aureus infection in cystic fibrosis.
Rebecca Dezube, Mark T. Jennings, Mary F. Rykiel, Marie Diener-West, Michael P. Boyle, James F. Chmiel, Elliott C. Dasenbrook> ;Journal of Cystic Fibrosis. 2019 May 1
149 citations
Inflammation in cystic fibrosis: An update.
Erica A. Roesch, David P. Nichols, James F. Chmiel> ;Pediatric Pulmonology. 2018 Nov 1
56 citations
Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma
Mark D. DeBoer, Brenda R. Phillips, David T. Mauger, Joe Zein, Serpil C. Erzurum, Anne M. Fitzpatrick, Benjamin Gaston, Ross Myers, Kristie R. Ross, James F. Chmiel, M...> ;BMC Pulmonary Medicine. 2018 Apr 10
84 citations
Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations
Daniel J. Jackson, Leonard B. Bacharier, David T. Mauger, Susan J. Boehmer, Avraham Beigelman, James F. Chmiel, Anne M. Fitzpatrick, Jonathan M. Gaffin, Wayne J. Morga...> ;The New England Journal of Medicine. 2018 Mar 3
34 citations
Airway Mucosal Host Defense Is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity.
Deepika Polineni, Hong Dang, Paul J. Gallins, Lisa C. Jones, Rhonda G. Pace, Jaclyn R. Stonebraker, Leah A. Commander, Jeanne E. Krenicky, Yi-Hui Zhou, Harriet Corvol,...> ;American Journal of Respiratory and Critical Care Medicine. 2018 Jan 1
61 citations
KB001-A, a novel anti-inflammatory, found to be safe and well-tolerated in cystic fibrosis patients infected with Pseudomonas aeruginosa
Raksha Jain, V. V. Beckett, Michael W. Konstan, Frank J. Accurso, Jane L. Burns, Nicole Mayer-Hamblett, Carlos Milla, Donald R. VanDevanter, James F. Chmiel> ;Journal of Cystic Fibrosis. 2017 Dec 29
10 citations
Impaired innate immune cells in cystic fibrosis: Is it really a surprise?
Tracey L. Bonfield, James F. Chmiel> ;Journal of Cystic Fibrosis. 2017 Jul 1
202 citations
Efficacy and safety of lumacaftor and ivacaftor in patients aged 6-11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled, phase 3...
Felix Ratjen, Christopher Hug, Gautham Marigowda, S. Tian, Xiaohong Huang, Sanja Stanojevic, Carlos E Milla, Paul Robinson, David Waltz, Jane C. Davies, Margaret Rosen...> ;The Lancet. Respiratory Medicine. 2017 Jul 1
11 citations
The Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC) trial: Rationale and design of a multi-center, double-blind, placebo-controlled trial of high d...
Vin Tangpricha, Ellen M. Smith, Jose N. Binongo, Suzanne E. Judd, Thomas R. Ziegler, Seth Walker, Rabindra Tirouvanziam, Susu M. Zughaier, Moon Jeong Lee, Supavit Ches...> ;Contemporary Clinical Trials Communications. 2017 Jun 1
40 citations
Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis
Dave P. Nichols, Carrie Happoldt, Preston E. Bratcher, Silvia M. Caceres, James F. Chmiel, Kenneth C. Malcolm, Milene T. Saavedra, Lisa Saiman, Jennifer L. Taylor-Cous...> ;Journal of Cystic Fibrosis. 2017 May 1
36 citations
Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR
Scott H. Donaldson, George M. Solomon, Pamela L. Zeitlin, Patrick A. Flume, Alicia Casey, Karen McCoy, Edith T. Zemanick, Arun Mandagere, Janice M. Troha, Steven A. Sh...> ;Journal of Cystic Fibrosis. 2017 May 1
36 citations
Bacterial infections in patients with primary ciliary dyskinesia: Comparison with cystic fibrosis.
Christiaan Wijers, James F. Chmiel, Benjamin Gaston> ;Chronic Respiratory Disease. 2017 Mar 6
15 citations
Preliminary comparison of normalized T1 and non-contrast perfusion MRI assessments of regional lung disease in cystic fibrosis patients.
Shannon B. Donnola, Elliott C. Dasenbrook, David Weaver, Lan Lu, Karishma Gupta, Anjali Prabhakaran, Xin Yu, James F. Chmiel, Kimberly McBennett, Michael W. Konstan, M...> ;Journal of Cystic Fibrosis. 2017 Mar 1
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Press Mentions

Researchers Awarded $12 Million to Pursue Personalized Therapies for Severe AsthmaOctober 18th, 2021
University Hospitals Rainbow Babies & Children’s Hospital to Study African Americans Response to Asthma MedicationsFebruary 12th, 2016

Hospital Affiliations

Riley Hospital for Children at IU HealthIndianapolis, Indiana
Indiana University Health University HospitalIndianapolis, Indiana