JamesHoffmanMD

Obstetrics & Gynecology • Springfield, MA

Gynecologic Oncology

Associate Professor, Obstetrics & Gynecology, University of Connecticut SOM

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Office
3300 Main St
Springfield, MA 01107
Phone+1 860-826-1101

Fax+1 860-826-1845
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Education & Training

University of Michigan Health SystemResidency, Obstetrics and Gynecology, 1979 - 1982
Beth Israel Deaconess Medical CenterInternship, Transitional Year, 1977 - 1978
Albert Einstein College of MedicineClass of 1976

Certifications & Licensure

MA State Medical License 2015 - 2020
CT State Medical License 1982 - 2016
MI State Medical License 1979 - 1984
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Gynecologic Oncology

Awards, Honors, & Recognition

Fellow (FACOG) American Congress of Obstetricians and Gynecologists

Clinical Trials

Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial Cancer Start of enrollment: 2008 Feb 25
Active, not recruiting
Phase 2
Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian, Epithelial, Primary Peritoneal, or Fallopian Tube Cancer Start of enrollment: 2007 Dec 06
Active, not recruiting
Phase 3
Diet and Physical Activity Change or Usual Care in Improving Progression-Free Survival in Patients With Previously Treated Stage II, III, or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Start of enrollment: 2012 Jun 18
Recruiting
Phase 3
CA-IX, p16, Proliferative Markers, and HPV in Diagnosing Cervical Lesions in Patients With Abnormal Cervical Cells Start of enrollment: 2009 Feb 09
Active, not recruiting
Not Applicable
Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer Start of enrollment: 2012 Jun 01
Unknown status
Not Applicable
Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Start of enrollment: 2010 Feb 08
Active, not recruiting
Phase 2
Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery Start of enrollment: 2010 Apr 12
Active, not recruiting
Phase 3
Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer Start of enrollment: 2012 Jan 09
Completed
Phase 3
Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery Start of enrollment: 2012 Jun 04
Terminated
Phase 3
Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Start of enrollment: 2012 Jun 18
Completed
Phase 3
Radiation Therapy, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Locally Advanced Squamous Cell Cancer of the Vulva Start of enrollment: 2012 Jul 02
Active, not recruiting
Phase 2
Chemoradiation Therapy and Ipilimumab in Treating Patients With Stages IB2-IIB or IIIB-IVA Cervical Cancer Start of enrollment: 2012 Oct 01
Completed
Phase 1
Zoptarelin Doxorubicin (AEZS 108) as Second Line Therapy for Endometrial Cancer Start of enrollment: 2013 Apr 01
Completed
Phase 3
Trametinib With or Without GSK2141795 in Treating Patients With Recurrent or Persistent Endometrial Cancer Start of enrollment: 2013 Sep 30
Completed
Phase 1
Dasatinib in Treating Patients With Recurrent or Persistent Ovarian, Fallopian Tube, Endometrial or Peritoneal Cancer Start of enrollment: 2014 Feb 14
Terminated
Phase 2
Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer Start of enrollment: 2014 Mar 17
Active, not recruiting
Phase 2, Phase 3
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Publications & Presentations

PubMed

17 citations
A phase 2 study of alisertib (MLN8237) in recurrent or persistent uterine leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group study 0231D
David M. Hyman, Michael W. Sill, Heather A. Lankes, Richard Piekarz, Mark S. Shahin, Mildred Ridgway, Floor J. Backes, Meaghen E Tenney, Cara Mathews, James S. Hoffman...> ;Gynecologic Oncology. 2017 Jan 1
36 citations
Second Curettage for Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia.
Raymond Osborne, Virginia L. Filiaci, Julian C. Schink, Robert S. Mannel, Kian Behbakht, James S. Hoffman, Nick M. Spirtos, John K. Chan, John Tidy, David Miller> ;Obstetrics and Gynecology. 2016 Sep 1
Developing Knowledge Resources to Support Precision Medicine: Principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC)
James M Hoffman, Henry M Dunnenberger> ;Journal of the American Medical Informatics Association. 2016 Mar 31
4 citations
A phase I study of IV doxorubicin plus intraperitoneal (IP) paclitaxel and IV or IP cisplatin in endometrial cancer patients at high risk for peritoneal failure (GOG 9...
D. Scott McMeekin, Michael W. Sill, Joan L. Walker, Kathleen N. Moore, Steven E. Waggoner, Premal H. Thaker, Tina Rizack, James S. Hoffman, Paula M. Fracasso> ;Gynecologic Oncology. 2015 Jul 1
63 citations
A phase II trial of brivanib in recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group Study
Matthew A. Powell, Michael W. Sill, Paul J. Goodfellow, Doris M. Benbrook, Heather A. Lankes, Kimberly K. Leslie, Yvette W. Jeske, Robert S. Mannel, Monique A. Spillma...> ;Gynecologic Oncology. 2014 Oct 1
31 citations
A phase II evaluation of AMG 102 (rilotumumab) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma: a Gyneco...
Lainie P. Martin, Michael W. Sill, Mark S. Shahin, Matthew A. Powell, Paul DiSilvestro, Lisa M. Landrum, Stephanie Gaillard, Michael J. Goodheart, James S. Hoffman, Ru...> ;Gynecologic Oncology. 2014 Mar 1
3 citations
Attempted conservative management of a placental site trophoblastic tumor: A case report
Erin Ashton, Magdalena Szutowska, Aaron B. A. Shafer, James Hoffman> ;Connecticut Medicine. 2014 Sep 1
55 citations
A phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: A Gynecologic Oncology Group study
Robert L. Coleman, Michael W. Sill, Heather A. Lankes, Amanda N. Fader, Neil J. Finkler, James S. Hoffman, Peter G. Rose, Gregory P. Sutton, Charles W. Drescher, D. Sc...> ;Gynecologic Oncology. 2012 Dec 1
4 citations
Gastrointestinal stromal tumor of the pelvic soft tissue presenting with symptomatic hypoglycemia: A case report and brief review of current literature of non-islet ce...
Kathleen Dean, Jessica Hsieh, Christopher M. Morosky, James Hoffman> ;Gynecologic Oncology Case Reports. 2012 Aug 1
78 citations
A phase II evaluation of nanoparticle, albumin-bound (nab) paclitaxel in the treatment of recurrent or persistent platinum-resistant ovarian, fallopian tube, or primar...
Robert L. Coleman, William E. Brady, D. Scott McMeekin, Peter G. Rose, John T. Soper, Samuel S. Lentz, James S. Hoffman, Mark S. Shahin> ;Gynecologic Oncology. 2011 Jul 1
30 citations
A phase II study of gemcitabine (gemzar, LY188011) in the treatment of recurrent or persistent endometrial carcinoma: A gynecologic oncology group study☆
David L. Tait, John A. Blessing, James S. Hoffman, Kathleen N. Moore, Nick M. Spirtos, Jason A. Lachance, Jacob Rotmensch, David Miller> ;Gynecologic Oncology. 2011 Apr 1
27 citations
A phase II evaluation of mifepristone in the treatment of recurrent or persistent epithelial ovarian, fallopian or primary peritoneal cancer: a gynecologic oncology gr...
Thomas F. Rocereto, William E. Brady, Mark S. Shahin, James S. Hoffman, Laurie Small, Jacob Rotmensch, Robert S. Mannel> ;Gynecologic Oncology. 2010 Mar 1
20 citations
A Phase II evaluation of weekly topotecan as a single agent second line therapy in persistent or recurrent carcinoma of the cervix: a Gynecologic Oncology Group study.
James Fiorica, John A. Blessing, Louis V. Puneky, Angeles Alvarez Secord, James S. Hoffman, S. Diane Yamada, Thomas E. Buekers, Jeffrey G. Bell, Jeanne M. Schilder> ;Gynecologic Oncology. 2009 Nov 1
172 citations
A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study.
Susan C. Modesitt, Michael W. Sill, James S. Hoffman, David Bender> ;Gynecologic Oncology. 2008 May 1
34 citations
A phase II evaluation of flavopiridol as second-line chemotherapy of endometrial carcinoma: a Gynecologic Oncology Group study.
Edward C. Grendys, John A. Blessing, Robert A. Burger, James S. Hoffman> ;Gynecologic Oncology. 2005 Aug 1
120 citations
A phase II study of docetaxel in paclitaxel-resistant ovarian and peritoneal carcinoma: a Gynecologic Oncology Group study
Peter G. Rose, John A. Blessing, Harrison G. Ball, James S. Hoffman, David Warshal, Koen DeGeest, David H. Moore> ;Gynecologic Oncology. 2003 Feb 1
11 citations
Term delivery following conservative treatment for villoglandular papillary adenocarcinoma of the uterine cervix: Report of a case and analysis of the literature
James S. Hoffman, Luca Bazzurini, Lisa Laird, June Murphy, Urania Magriples, John L. Lewis> ;Gynecologic Oncology. 2001 May 1
22 citations
In vitro fertilization following conservative management of stage 3 serous borderline tumor of the ovary.
James S. Hoffman, Lisa Laird, Claudio Benadiva, Richard Dreiss> ;Gynecologic Oncology. 1999 Sep 1
16 citations
Placental Site Trophoblastic Tumor: A Report of Radiologic, Surgical, and Pathologic Methods of Evaluating the Extent of Disease
James S. Hoffman, Anita D. Silverman, Joel Gelber, Richard W. Cartun> ;Gynecologic Oncology. 1993 Jul 1
14 citations
Immature teratoma of the ovary.
John P. Koulos, James S. Hoffman, Margaret M. Steinhoff> ;Gynecologic Oncology. 1989 Jul 1
13 citations
Molar pregnancy coexisting with a normal fetus: A case report
Jeffrey L. Deaton, James S. Hoffman, Howard Saal, Craig Allred, John P. Koulos> ;Gynecologic Oncology. 1989 Mar 1
1 citations
Late brain recurrence of choriocarcinoma.
John P. Koulos, James S. Hoffman> ;Gynecologic Oncology. 1988 Nov 1
10 citations
Central nervous system lesions and advanced ovarian cancer
James S. Hoffman, Yolanda M. Pena> ;Gynecologic Oncology. 1988 May 1
11 citations
Imaging pattern of previously in vitro sensitized and interleukin-2 expanded autologous lymphocytes in human cancer.
Bijay Mukherji, Oskar Arnbjarnarson, Larry A. Spitznagle, Robert I. Kalish, James S. Hoffman, M. T. Ergin, Richard P. Spencer> ;International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology. 1988 Jan 1
9 citations
The role of second-look laparotomy in treatment of epithelial ovarian cancer.
Michelle C. McCusker, James S. Hoffman, Stephen L. Curry, John P. Koulos, Bernard Gondos> ;Gynecologic Oncology. 1987 Sep 1
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Hospital Affiliations

Hartford HospitalHartford, Connecticut
The Hospital of Central Connecticut at Bradley MemorialSouthington, Connecticut
Baystate Medical CenterSpringfield, Massachusetts
Baystate Wing HospitalPalmer, Massachusetts