James Kai-Chen Liu MD
Brain & Spinal Tumor, Neurosurgical Spine Surgery
Neurosurgical Oncology Associate Member, Department of Neuro-Oncology Associate Professor Morsani College of Medicine University of South Florida
12902 USF Magnolia DrTampa, FL 33612
Overview of Dr. Liu
James Liu, MD is a neurosurgeon located in Tampa, FL, with subspecialties in brain and spinal tumors and neurosurgical spine surgery. He completed a fellowship in neurosurgical oncology at Memorial Sloan Kettering Cancer Center and a residency in neurological surgery at the Cleveland Clinic Foundation. Liu is currently an associate member in the Department of Neuro-Oncology at H. Lee Moffitt Cancer Center and Research Institute, where he also serves as an attending surgeon. He has held previous roles at Cleveland Clinic and MetroHealth Medical Center and was an assistant professor at Case Western Reserve University School of Medicine. His areas of expertise include glioblastoma, primary brain tumors, and skull base surgery, with several publications and ongoing clinical trials in his field.
Education & Training
Memorial Sloan Kettering Cancer CenterFellowship, Neurosurgical Oncology, 2013 - 2014
Cleveland ClinicPost-Doctoral Fellowship, 2011 - 2013- Cleveland Clinic FoundationResidency, Neurological Surgery, 2006 - 2013
Case Western Reserve University School of MedicineClass of 2006
University of MichiganBS, Cell and Molecular Biology, 1996 - 2000
Certifications & Licensure
CA State Medical License 2014 - Present
FL State Medical License 2018 - 2026
NY State Medical License 2013 - 2018
OH State Medical License 2006 - 2018
American Board of Neurological Surgery Neurological Surgery
Clinical Trials
- Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease Start of enrollment: 2020 Dec 10
- Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases Start of enrollment: 2021 Nov 30
Publications & Presentations
PubMed
- Results of a Pilot Trial of Infusion Rate Escalation During Convection Enhanced Delivery of Topotecan with a Multiport Catheter.James K C Liu, Nam Tran, Cecily Piteo, Alisa Peinhardt, Michael A Vogelbaum
World Neurosurgery. 2025-12-02 - 2 citationsA genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis.Shawn C Chafe, Kui Zhai, Nikoo Aghaei, Petar Miletic, Zhi Huang
Science Translational Medicine. 2025-07-02 - 28 citationsFunctional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation.Alessio Ugolini, Alessandra De Leo, Xiaoqing Yu, Fabio Scirocchi, Xiaoxian Liu
Cancer Discovery. 2025-06-03
Press Mentions
Surgical Skills Lab and Dissection Curricula Train Neurosurgical ResidentsMay 26th, 2015
Committees
- Board of Directors, MetroHealth Cancer Center 2015 - Present
Professional Memberships
- Member
- Member
- Member
- Society for Neuro-OncologyMember
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