JamesFMarkmannMD

General Surgery • Philadelphia, PA

Transplantation

Professor, Surgery-Massachusetts General Hospital, Harvard Medical School

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Office
3400 Civic Center Boulevard
Philadelphia, PA 19104
Phone+1 617-643-4533

Fax+1 617-643-4579
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Education & Training

University of Pennsylvania Health SystemResidency, Surgery, 1990 - 1996
Perelman School of Medicine at the University of PennsylvaniaClass of 1989

Certifications & Licensure

CA State Medical License 1996 - Present
NH State Medical License 2021 - 2025
PA State Medical License 1992 - 2024
RI State Medical License 2020 - 2024
MA State Medical License 2007 - 2024
VT State Medical License 2013 - 2024
ME State Medical License 2020 - 2021
American Board of Surgery Surgery

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2006-2008, 2011-2014
Boston Magazine Castle Connolly, 2011-2013
Philadelphia Magazine Castle Connolly, 2006-2007
Fellow (FACS) American College of Surgeons
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Clinical Trials

Efficacy of Islet After Kidney Transplantation Start of enrollment: 2007 Jan 01
Completed
Phase 3
Study of Islet Transplantation in Type 1 Diabetic Kidney Transplant Recipients Start of enrollment: 2009 May 01
Completed
Phase 1, Phase 2
Research Study of ATG and Rituximab in Renal Transplantation Start of enrollment: 2011 Jul 25
Terminated
Early Phase 1
Reference Group Trial for The ONE Study Start of enrollment: 2012 Dec 01
Completed
Phase 4
Infusion of T-Regulatory Cells in Kidney Transplant Recipients (The ONE Study) Start of enrollment: 2014 May 01
Completed
Phase 1
Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant Start of enrollment: 2017 Jan 01
Completed
Phase 2
Liver Transplantation With Tregs at MGH Start of enrollment: 2019 Mar 29
Active, not recruiting
Phase 1, Phase 2
OCS Liver PROTECT Continued Access Protocol Start of enrollment: 2020 Feb 03
Completed
Not Applicable
OCS Liver DCD Trial Start of enrollment: 2020 Jul 24
Active, not recruiting
Not Applicable
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Publications & Presentations

PubMed

Acellular Perfusate is an Adequate Alternative to Packed Red Blood Cells During Normothermic Human Kidney Perfusion.
Alban Longchamp, Fermin M Fontan, Mohamed M Aburawi, Corey Eymard, Negin Karimian, Danielle Detelich, Casie Pendexter, Stephanie Cronin, Thomas Agius, Sonal Nagpal, Pe...> ;Transplantation Direct. 2024 Apr 1
Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.
Agius, T., Emsley, R., Lyon, A., MacArthur, M., Kiesworo, K., Faivre, A., Stavart, L., Lambelet, M., Legouis, D., de Seigneux, S., Golshayan, D., Lazeyras, F., Yeh, H....> ;Nature Communications. 2024 Feb 5
Role of Machine Perfusion in Liver Transplantation.
Alban Longchamp, Tsukasa Nakamura, Korkut Uygun, James F Markmann> ;The Surgical Clinics of North America. 2024 Feb 1
1 citations
Impact of Portable Normothermic Machine Perfusion for Liver Transplantation From Adult Deceased Donors.
Takayuki Yamamoto, Srilakshmi Atthota, Divyansh Agarwal, Kerry Crisalli, Malcolm MacConmara, Tsukasa Nakamura, Richard Teo, Leigh Anne Dageforde, Shoko Kimura, Nahel E...> ;Annals of Surgery. 2023 Nov 1
Sodium Hydrosulfide Treatment During Porcine Kidney Ex Vivo Perfusion and Transplantation.
Thomas Agius, Julien Songeon, Arnaud Lyon, Justine Longchamp, Raphael Ruttimann, Florent Allagnat, Sébastien Déglise, Jean-Marc Corpataux, Déla Golshayan, Léo Buhler, ...> ;Transplantation Direct. 2023 Nov 1
Anti-apoptotic treatment of warm ischemic male rat livers in machine perfusion improves symptoms of ischemia-reperfusion injury.
Mohammadreza Mojoudi, McLean S Taggart, Anil Kharga, Huyun Chen, Antonia T Dinicu, Benjamin T Wilks, James F Markmann, Mehmet Toner, Shannon N Tessier, Heidi Yeh, Kork...> ;Research Square. 2023 Aug 22
3 citations
American Society of Transplant Surgeons-American Society of Transplantation report of FDA meeting on regulatory expectations for xenotransplantation products.
Andrew Adams, Linda C Cendales, David K C Cooper, Emanuele Cozzi, John Gill, Eric Judd, Eliezer Katz, Allan D Kirk, Jay A Fishman, Peter P Reese, Anji Wall, James F Ma...> ;American Journal of Transplantation. 2023 Sep 1
Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells.
Jifu Ge, Weikang Pan, Noel J Feeney, Leah Ott, Emily Anderson, Alessandro Alessandrini, Ivan Zanoni, James F Markmann, Alex G Cuenca> ;American Journal of Transplantation. 2023 Jul 1
Outcomes in liver transplant recipients with nonalcoholic fatty liver disease-related HCC: results from the US multicenter HCC transplant consortium.
Elizabeth C Verna, Meaghan M Phipps, Karim J Halazun, Daniela Markovic, Sander S Florman, Brandy M Haydel, Richard Ruiz, Goran Klintmalm, David D Lee, Burcin Taner, Ma...> ;Liver Transplantation. 2023 Jan 1
1 citations
Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol.
Casie A Pendexter, Omar Haque, Mohammadreza Mojoudi, Sarah Maggipinto, Marion Goutard, Simona Baicu, Alexandre G Lellouch, James F Markmann, Gerald Brandacher, Heidi Y...> ;Plos One. 2023 Jan 1
1 citations
Leveraging the tolerogenic potential of TNF-α and regulatory B cells in organ transplantation.
Sonya A Poznansky, Matthew Yu, Kevin Deng, Qiang Fu, James F Markmann, Christian LeGuern> ;Frontiers in Immunology. 2023 Jan 1
Revisiting the "Weekend Effect" on Adult and Pediatric Liver and Kidney Offer Acceptance.
Takayuki Yamamoto, Mike Fruscione, Shoko Kimura, Nahel Elias, Heidi Yeh, Tatsuo Kawai, James F Markmann, Shah, A.> ;Annals of Transplantation. 2022 Nov 4
8 citations
A Phase I/IIa study of autologous tolerogenic dendritic cells immunotherapy in kidney transplant recipients.
Aurélie Moreau, Delphine Kervella, Laurence Bouchet-Delbos, Cécile Braudeau, Soraya Saïagh, Pierrick Guérif, Sophie Limou, Anne Moreau, Sylvain Bercegeay, Mathias Stre...> ;Kidney International. 2023 Mar 1
6 citations
Long-term Outcomes With Islet-Alone and Islet-After-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: The CIT-08 Study.
Michael R Rickels, Thomas L Eggerman, Levent Bayman, Julie C Qidwai, Rodolfo Alejandro, Nancy D Bridges, Bernhard J Hering, James F Markmann, Peter A Senior, Lawrence ...> ;Diabetes Care. 2022 Oct 17
4 citations
Subnormothermic Ex Vivo Porcine Kidney Perfusion Improves Energy Metabolism: Analysis UsingP Magnetic Resonance Spectroscopic Imaging.
Thomas Agius, Julien Songeon, Antoine Klauser, Florent Allagnat, Grégoire Longchamp, Raphael Ruttimann, Arnaud Lyon, Julijana Ivaniesevic, Raphael Meier, Sébastien Dég...> ;Transplantation Direct. 2022 Oct 1
1 citations
In vivo induction of regulatory T cells by anti-CD45RB antibody causes transferable tolerance to discordant human xenogenic islets.
Yanling Zhang, Maozhu Yang, Guiqing Jia, Shaoping Deng, Ji Lei, James Markmann, Gaoping Zhao> ;Xenotransplantation. 2022 Nov 1
5 citations
Suppression of allograft rejection by regulatory B cells induced via TLR signaling.
Kang Mi Lee, Qiang Fu, Guoli Huai, Kevin Deng, Ji Lei, Lisa Kojima, Divyansh Agarwal, Peter van Galen, Shoko Kimura, Naoki Tanimine, Laura Washburn, Heidi Yeh, Ali Naj...> ;JCI Insight. 2022 Sep 8
3 citations
Normothermic Machine Perfusion Increases Donor Liver Use.
James F Markmann, Parsia A Vagefi, Malcolm P MacConmara> ;JAMA Surgery. 2022 Aug 1
5 citations
Kidney xenotransplantation in a brain-dead donor: Glass half-full or half-empty?
Leonardo V Riella, James F Markmann, Joren C Madsen, Ivy A Rosales, Robert B Colvin, Tatsuo Kawai, Richard N Pierson 3rd> ;American Journal of Transplantation. 2022 Jul 1
20 citations
Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life-sustaining NHP renal allo- an...
Daniel J Firl, James F Markmann> ;American Journal of Transplantation. 2022 Jun 1
2 citations
Anastomosis Time and Outcomes after Donation after Circulatory Death Kidney Transplantation.
David C Cron, Naoka Murakami, Lingwei Xiang, James F Markmann, Heidi Yeh, Joel T Adler> ;Journal of the American College of Surgeons. 2022 Jun 1
24 citations
FasL microgels induce immune acceptance of islet allografts in nonhuman primates.
Ji Lei, María M Coronel, Esma S Yolcu, Hongping Deng, Orlando Grimany-Nuno, Michael D Hunckler, Vahap Ulker, Zhihong Yang, Kang M Lee, Alexander Zhang, Hao Luo, Cole W...> ;Science Advances. 2022 May 13
Reply to "Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes anal...
Daniel J Firl, James F Markmann> ;American Journal of Transplantation. 2022 Sep 1
123 citations
Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant: The OCS Liver PROTECT Randomized Clinical Trial.
James F Markmann, Marwan S Abouljoud, R Mark Ghobrial, Chandra S Bhati, Shawn J Pelletier, Amy D Lu, Shane Ottmann, Tarunjeet Klair, Corey Eymard, Garrett R Roll, Jose...> ;JAMA Surgery. 2022 Mar 1
11 citations
The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.
Francesca D'Addio, Anna Maestroni, Emma Assi, Moufida Ben Nasr, Giovanni Amabile, Vera Usuelli, Cristian Loretelli, Federico Bertuzzi, Barbara Antonioli, Francesco Car...> ;Nature Communications. 2022 Feb 3
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Journal Articles

Hepatocellular Carcinoma in Transplantable Child-Pugh A Cirrhotics: Should Cost Affect Resection vs Transplantation?
Theodoros Michelakos, Dimitrios Xourafas, David Berger, James F Markmann, Cristina R Ferrone, Motaz Qadan, Kenneth K Tanabe, Joel T Adler, Nahel Elias, Heidi Yeh, Madh..., Journal of gastrointestinal surgery
Signatures of Tolerance or Immunosuppression?
James Markmann, MD, American journal of transplantation

Press Mentions

Vertex Releases New Data on Potential Cure for Type 1 DiabetesJune 21st, 2022
First Patient Gains Insulin Independence with Novel Stem Cell-Derived Islet Cell TherapyJune 7th, 2022
Stem Cell Transplants Promising so Far in Type 1 DiabetesJune 7th, 2022
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Grant Support

Mechanisms Of B Cell-Dependent Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2012
Mechanisms Of B Cell-Dependent Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2011
Regulation And Counter-Regulation In TransplantationNational Institute Of Allergy And Infectious Diseases2010
Mechanism Of Anti-Cd45 Induced Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2007–2010
Regulatory T Cells In Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2007–2008
Mechanism Of Anti-Cd45 Induced Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2006–2007
Regulatory T Cells In Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2004–2007
Mechanisms Of Acquired Central Transplantation ToleranceNational Institute Of Allergy And Infectious Diseases2001–2003
Gene Transfer For Autoimmune Beta Cell Damage PreventionNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2002