JamesRobertReedMD

PubMed

• Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithel...
  Harmon, A. C.,Hebert, V. Y.,Cormier, S. A.,Subramanian, B.,Reed, J. R.,Backes, W. L.,Dugas, T. R.> ;PLoS ONE. 2018 Oct 12
• Characterization of interactions among CYP1A2, CYP2B4, and NADPH-cytochrome P450 reductase: Identification of specific protein complexes.
  Connick, J. P.,Reed, J. R.,Backes, W. L.> ;Drug Metab. Dispos.. 2017 Dec 14
• The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function.
  Scott, E. E.,Wolf, C. R.,Otyepka, M.,Humphreys, S. C.,Reed, J. R.,Henderson, C. J.,McLaughlin, L. A.,Paloncyova, M.,Navratilova, V.,Berka, K.,Anzenbacher, P.,Dahal, U....> ;Drug Metab. Dispos.. 2016 Feb 07
• Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.
  Reed, J. R.,Dela Cruz, A. L.,Lomnicki, S. M.,Backes, W. L.> ;Toxicol. Appl. Pharmacol.. 2015 Oct 02
• The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions.
  Park, J. W.,Reed, J. R.,Backes, W. L.> ;J. Biol. Chem.. 2015 Oct 16
• Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter.
  Reed, J. R.,Cruz, A. L.,Lomnicki, S. M.,Backes, W. L.> ;Biochem. Pharmacol.. 2015 Mar 31
• Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum.
  Park, J. W.,Reed, J. R.,Brignac-Huber, L. M.,Backes, W. L.> ;Biochem. J.. 2014 Sep 23
• Environmentally persistent free radicals inhibit cytochrome P450 activity in rat liver microsomes.
  Reed, J. R.,Cawley, G. F.,Ardoin, T. G.,Dellinger, B.,Lomnicki, S. M.,Hasan, F.,Kiruri, L. W.,Backes, W. L.> ;Toxicol. Appl. Pharmacol.. 2014 Apr 10
• Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.
  Johnson, E. F.,Connick, J. P.,Reed, J. R.,Backes, W. L.,Desai, M. C.,Xu, L.,Estrada, D. F.,Laurence, J. S.,Scott, E. E.> ;Drug Metab. Dispos.. 2013 Oct 17
• Relationship between CYP1A2 localization and lipid microdomain formation as a function of lipid composition.
  Brignac-Huber, L. M.,Reed, J. R.,Eyer, M. K.,Backes, W. L.> ;Drug Metab. Dispos.. 2013 Aug 22
• Interactions between Cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) Lead to Alterations in Toluene Disposition and P450 Uncoupling.
  Reed, J. R.,Cawley, G. F.,Backes, W. L.> ;Biochemistry. 2013 Jun 11
• Effect of homomeric P450-P450 complexes on P450 function.
  Reed, J. R.,Connick, J. P.,Cheng, D.,Cawley, G. F.,Backes, W. L.> ;Biochem. J.. 2012 Jun 29
• Formation of P450 · P450 complexes and their effect on P450 function.
  Reed, J.R., Backes, W.L.> ;Pharmacol Ther. 2012 Mar
• Mutations of human cytochrome P450 reductase differentially modulate heme oxygenase-I activity and oligomerization.
  Marohnic, C. C., Huber Iii, W. J., Patrick Connick, J., Reed, J. R., McCammon, K., Panda, S. P., Martásek, P., Backes, W. L., Masters, B. S.> ;Arch Biochem Biophys. 2011 Sep 1
• Organization of NADPH-cytochrome P450 reductase and CYP1A2 in the endoplasmic reticulum--microdomain localization affects monooxygenase function.
  Brignac-Huber, L., Reed, J.R., Backes, W.L.> ;Mol Pharmacol. 2011 Mar
• Human heme oxygenase-1 efficiently catabolizes heme in the absence of biliverdin reductase.
  Reed, J.R., Huber, W.J., Backes, W.L.> ;Drug Metab Dispos. 2010 Nov
• Functional interactions between cytochromes P450 1A2 and 2B4 require both enzymes to reside in the same phospholipid vesicle: evidence for physical complex formation.
  Reed, J.R., Eyer, M., Backes, W.L.> ;J Biol Chem. 2010 Mar 19
• The use of liposomes in the study of drug metabolism: a method to incorporate the enzymes of the cytochrome p450 monooxygenase system into phospholipid, bilayer vesicles.
  Reed, J.R.> ;Methods Mol Biol. 2010
• Measurement of membrane-bound human heme oxygenase-1 activity using a chemically defined assay system.
  Huber, W.J., Marohnic, C.C., Peters, M., Alam, J., Reed, J.R., Masters, B.S., Backes, W.L.> ;Drug Metab Dispos. 2009-04-01
• Physical incorporation of NADPH-cytochrome P450 reductase and cytochrome P450 into phospholipid vesicles using glycocholate and Bio-Beads.
  Reed, J.R., Brignac-Huber, L.M., Backes, W.L.> ;Drug Metab Dispos. 2008 Mar
• Inhibition of CYP2B4 by 2-ethynylnaphthalene: evidence for the co-binding of substrate and inhibitor within the active site.
  Cheng, D., Harris, D., Reed, J.R., Backes, W.L.> ;Arch Biochem Biophys. 2007 Dec 15
• Inhibition of CYP2B4 by the mechanism-based inhibitor 2-ethynylnaphthalene: inhibitory potential of 2EN is dependent on the size of the substrate.
  Cheng, D., Reed, J.R., Harris, D., Backes, W.L.> ;Arch Biochem Biophys. 2007 Jun 1
• Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans.
  Vincent, S.H., Reed, J.R., Bergman, A.J., Elmore, C.S., Zhu, B., Xu, S., Ebel, D., Larson, P., Zeng, W., Chen, L., Dilzer, S., Lasseter, K., Gottesdiener, K., Wagner, ...> ;Drug Metab Dispos. 2007 Apr
• Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs.
  Beconi, M.G., Reed, J.R., Teffera, Y., Xia, Y., Kochansky, C.J., Liu, D.Q., Xu, S., Elmore, C.S., Ciccotto, S., Hora, D.F., Stearns, R.A., Vincent, S.H.> ;Drug Metab Dispos. 2007 Apr
• An evaluation of methods for the reconstitution of cytochromes P450 and NADPH P450 reductase into lipid vesicles.
  Reed, J.R., Kelley, R.W., Backes, W.L.> ;Drug Metab Dispos. 2006 Apr
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