JasonSperryMD

General Surgery • Pittsburgh, PA

Trauma Surgery & Surgical Critical Care

Assistant Professor, Surgery, University of Pittsburgh School of Medicine

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Office
200 Lothrop Street
Pittsburgh, PA 15213
Phone+1 412-648-3000
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Education & Training

University of Texas Southwestern Medical CenterFellowship, Surgical Critical Care, 2005 - 2007
Johns Hopkins UniversityResidency, Surgery, 1997 - 2005
Case Western Reserve University School of MedicineClass of 1997

Certifications & Licensure

PA State Medical License 2007 - 2024
TX State Medical License 2005 - 2008
MD State Medical License 1999 - 2005
American Board of Surgery Surgery
American Board of Surgery Surgical Critical Care

Awards, Honors, & Recognition

Fellow (FACS) American College of Surgeons

Clinical Trials

PreHospital Air Medical Plasma Trial Start of enrollment: 2014 May 01
Completed
Phase 3
Study of Tranexamic Acid During Air and Ground Medical Prehospital Transport Trial (STAAMP Trial) Start of enrollment: 2015 Jul 01
Completed
Phase 3
Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2) Start of enrollment: 2018 May 01
Completed
Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial Start of enrollment: 2018 Nov 20
Terminated
Phase 3
LITES Task Order 0005 Prehospital Airway Control Trial (PACT) Start of enrollment: 2021 Apr 01
Recruiting
Not Applicable
Cold Stored Platelet in Hemorrhagic Shock Start of enrollment: 2022 Jun 21
Completed
Phase 2
Roles: Sponsor-Investigator, Principal Investigator, Contact
Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial Start of enrollment: 2022 Apr 19
Recruiting
Phase 3
DSUVIA Early Evaluation of Pain Trial Start of enrollment: 2022 Aug 05
Completed
Phase 3
Roles: Contact, Study Director
Prehospital Analgesia INtervention Trial (PAIN) Start of enrollment: 2023 Nov 27
Recruiting
Phase 3
Roles: Principal Investigator, Sponsor-Investigator, Contact
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial Start of enrollment: 2024 Jul 01
Not yet recruiting
Phase 2
Roles: Principal Investigator, Contact, Sponsor-Investigator
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Publications & Presentations

PubMed

Prehospital tranexamic acid is associated with a survival benefit without an increase in complications: results of two harmonized randomized clinical trials.
Michael Mazzei, Jack K Donohue, Terence O'Keeffe, Martin Schreiber, Susan Rowell, Francis X Guyette, Bryan Cotton, Brian J Eastridge, Raminder Nirula, Gary A Vercruyss...> ;The Journal of Trauma and Acute Care Surgery. 2024 Mar 25
Mechanism matters: mortality and endothelial cell damage marker differences between blunt and penetrating traumatic injuries across three prehospital clinical trials.
Donohue, J., Gruen, D., Iyanna, N., Lorence, J., Brown, J., Guyette, F., Daley, B., Eastridge, B., Miller, R., Nirula, R., Harbrecht, B., Claridge, J., Phelan, H., Ver...> ;Scientific Reports. 2024 Feb 2
Time to First Whole Blood Associated With Survival-First (Whole) Blood?
Jason L Sperry, Matthew D Neal> ;JAMA Surgery. 2024 Apr 1
Missingness matters: a secondary analysis of thromboelastography measurements from a recent prehospital randomized tranexamic acid clinical trial.
Jack K Donohue, Nidhi Iyanna, John M Lorence, Joshua B Brown, Frances X Guyette, Brian J Eastridge, Raminder Nirula, Gary A Vercruysse, Terence O'Keeffe, Bellal Joseph...> ;Trauma Surgery & Acute Care Open. 2024 Jan 1
Incompatible plasma transfusion is not associated with increased mortality in civilian trauma patients.
Jack K Donohue, Jason L Sperry, Philip C Spinella, Darrell J Triulzi, Christine L Leeper, Mark H Yazer> ;Hematology. 2023 Dec 1
Association Between Emergency Medical Service Agency Volume and Mortality in Trauma Patients.
David S Silver, Jason L Sperry, Jamison Beiriger, Liling Lu, Francis X Guyette, Stephen Wisniewski, Ernest E Moore, Martin Schreiber, Bellal Joseph, Chad T Wilson, Bry...> ;Annals of Surgery. 2024 Jan 1
2 citations
The Geography of Injuries in Trauma Systems: Using Home as a Proxy for Incident Location.
Jamison Beiriger, David Silver, Liling Lu, Francis X Guyette, Stephen Wisniewski, Ernest E Moore, Martin Schreiber, Bellal Joseph, Chad T Wilson, Bryan Cotton, Daniel ...> ;The Journal of Surgical Research. 2023 Oct 1
1 citations
Timing of RhD-positive red blood cell administration is associated with D-alloimmunization in injured patients.
Mark H Yazer, Philip C Spinella, Jason Sperry, Darrell J Triulzi, Christine Leeper> ;Transfusion. 2023 May 1
8 citations
Whole Blood Resuscitation and Association with Survival in Injured Patients with an Elevated Probability of Mortality.
Jason L Sperry, Bryan A Cotton, James F Luther, Jeremy W Cannon, Martin A Schreiber, Ernest E Moore, Nicholas Namias, Joseph P Minei, Stephen R Wisniewski, Frank X Guy...> ;Journal of the American College of Surgeons. 2023 Aug 1
Funding the war in America: A look in the mirror.
Allyson M Hynes, Jessica L Weaver, Justin S Hatchimonji, Jason L Sperry, Sabrina E Sanchez, Mark J Seamon, Tareq Kheirbek, Dane R Scantling> ;The Journal of Trauma and Acute Care Surgery. 2023 Nov 1
1 citations
Optimal Prehospital Crystalloid Resuscitation Volume in Trauma Patients at Risk for Hemorrhagic Shock.
Andrew-Paul Deeb, Liling Lu, Frank X Guyette, Andrew B Peitzman, Brian J Daley, Richard S Miller, Brian G Harbrecht, Herb A Phelan, Jason L Sperry, Joshua B Brown> ;Journal of the American College of Surgeons. 2023 Aug 1
1 citations
Transfusion of ABO-group identical red blood cells following uncrossmatched transfusion does not lead to higher mortality in civilian trauma patients.
Mark H Yazer, Nancy M Dunbar, John R Hess, Erin E Tuott, Mohammad Bahmanyar, Jessica Campbell, Magali Fontaine, Ara Ko, Jian Mi, Michael F Murphy, Jessica Poisson, Jay...> ;Transfusion. 2023 May 1
1 citations
Establishing a core outcomes set for massive transfusion: An Eastern Association for the Surgery of Trauma modified Delphi method consensus study.
Rondi B Gelbard, Jeffry Nahmias, Saskya Byerly, Markus Ziesmann, Deborah Stein, Elliott R Haut, Jason W Smith, Melissa Boltz, Ben Zarzaur, Jeannie Callum, Bryan A Cott...> ;The Journal of Trauma and Acute Care Surgery. 2023 Jun 1
Evaluation of critical care burden following traumatic injury from two randomized controlled trials.
Insiyah Campwala, Francis X Guyette, Joshua B Brown, Mark H Yazer, Brian J Daley, Richard S Miller, Brian G Harbrecht, Jeffrey A Claridge, Herbert A Phelan, Brian East...> ;Scientific Reports. 2023 Jan 20
1 citations
Pregnancy in trauma-A Western Trauma Association algorithm.
Anne Rizzo, Matthew Martin, Kenji Inaba, Martin Schreiber, Karen Brasel, Jack Sava, David Ciesla, Jason Sperry, Rosemary Kozar, Carlos Brown, Ernest Moore> ;The Journal of Trauma and Acute Care Surgery. 2022 Oct 1
3 citations
Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients.
Sultan S Abdelhamid, Jacob Scioscia, Yoram Vodovotz, Junru Wu, Anna Rosengart, Eunseo Sung, Syed Rahman, Robert Voinchet, Jillian Bonaroti, Shimena Li, Jennifer L Darb...> ;Metabolites. 2022 Aug 23
4 citations
An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: Planning and execution.
Deborah J Del Junco, Matthew D Neal, Stacy A Shackelford, Philip C Spinella, Francis X Guyette, Jason L Sperry, Roger J Lewis, Kabir Yadav> ;Transfusion. 2022 Aug 1
8 citations
Toward a more complete understanding of who will benefit from prehospital transfusion.
Mark H Yazer, Andrew P Cap, Elon Glassberg, Laura Green, John B Holcomb, Mansoor A Khan, Ernest E Moore, Matthew D Neal, Gavin D Perkins, Jason L Sperry, Patrick Thomp...> ;Transfusion. 2022 Aug 1
5 citations
Receipt of at least 4 units of low titer group O whole blood with titer <100 does not lead to hemolysis in adult trauma patients.
Mark H Yazer, Alain Corcos, Jason L Sperry, Darrell J Triulzi, Christine Leeper> ;Transfusion. 2022 Aug 1
How do we forecast tomorrow's transfusion? Prehospital transfusion.
Mark H Yazer, Donald H Jenkins, Jason L Sperry, Philip C Spinella> ;Transfusion Clinique Et Biologique. 2023 Feb 1
9 citations
High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI.
Junru Wu, Hamed Moheimani, Shimena Li, Upendra K Kar, Jillian Bonaroti, Richard S Miller, Brian J Daley, Brian G Harbrecht, Jeffrey A Claridge, Herbert A Phelan, Franc...> ;Annals of Surgery. 2022 Oct 1
3 citations
Prehospital plasma is associated with survival principally in patients transferred from the scene of injury: A secondary analysis of the PAMPer trial.
Rachel E Lewis, Sruthi L Muluk, Katherine M Reitz, Francis X Guyette, Joshua B Brown, Richard S Miller, Brian G Harbrecht, Jeffrey A Claridge, Herb A Phelan, Mark H Ya...> ;Surgery. 2022 Oct 1
16 citations
Association Between Time to Source Control in Sepsis and 90-Day Mortality.
Katherine M Reitz, Jason Kennedy, Shimena R Li, Robert Handzel, Daniel A Tonetti, Matthew D Neal, Brian S Zuckerbraun, Daniel E Hall, Jason L Sperry, Derek C Angus, Ed...> ;JAMA Surgery. 2022 Sep 1
3 citations
Prehospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage.
Andrew-Paul Deeb, Lara Hoteit, Shimena Li, Francis X Guyette, Brian J Eastridge, Raminder Nirula, Gary A Vercruysse, Terence O'Keeffe, Bellal Joseph, Matthew D Neal, J...> ;The Journal of Trauma and Acute Care Surgery. 2022 Jul 1
1 citations
Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion.
Hunter B Moore, Matthew D Neal, Marnie Bertolet, Brian A Joughin, Michael B Yaffe, Christopher D Barrett, Molly A Bird, Russell P Tracy, Ernest E Moore, Jason L Sperry...> ;Annals of Surgery Open. 2022 Jun 1
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Journal Articles

In Silico Model of the Dilutional Effects of Conventional Component Therapy Versus Whole Blood in the Management of Massively Bleeding Adult Trauma Patients
Darrell J Triulzi, Mark H Yazer, Philip C Spinella, Jason Sperry, Jansen N Seheult, Transfusion

Press Mentions

UPMC Trial for Safer Pain Management for Trauma PatientsJuly 19th, 2022
Is Whole Blood Best for Severely Bleeding Trauma Victims? Study Aims to Find OutApril 11th, 2022
Harborview, Airlift Northwest Study in-Flight TransfusionMarch 9th, 2022
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Grant Support

Characterization Of The Mechanisms Responsible For Sex Based Outcome Difference FNational Institute Of General Medical Sciences2010–2011
NFKB And Vascular Transplant GraftsNational Heart, Lung, And Blood Institute1999–2000