JeffreyMBurnsMD

Neurodegenerative

Jeffrey Burns is the Edward H. Hashinger Professor of Neurology. Dr. Burns is the co-director of the KU Alzheimer's Disease Center and also directs the Frontiers Clinical and Translational Science Unit and the Alzheimer and Memory Clinic

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Office
4350 Shawnee Mission Pkwy
Fairway, KS 66205
Phone+1 913-945-7508

Fax+1 913-588-6965
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Education & Training

Washington University in St. Louis School of Medicine2011
University of Virginia Medical CenterResidency, Neurology, 2002
University of Virginia Medical CenterInternship, Internal Medicine, 1998 - 1999
University of Kansas School of MedicineClass of 1998

Certifications & Licensure

MO State Medical License 2002 - 2025
KS State Medical License 2004 - 2024
VA State Medical License 1998 - 2002
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Brain Aging Project--Kansas University Start of enrollment: 2004 Nov 01
Completed
Memory and Insulin in Early Alzheimer's Disease Start of enrollment: 2007 Oct 01
Completed
Phase 1, Phase 2
Pilot Study of Aerobic Exercise in Early Alzheimer's Disease(AD) Start of enrollment: 2010 May 01
Completed
Not Applicable
Dose Response Study of Aerobic Exercise in Older Adults Start of enrollment: 2010 May 01
Completed
Early Phase 1
Safety Study of R(+)Pramipexole to Treat Early Alzheimer's Disease Start of enrollment: 2011 Jul 01
Completed
Phase 2
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF) Start of enrollment: 2014 Jan 08
Completed
Phase 2, Phase 3
Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo Start of enrollment: 2013 Jul 01
Terminated
Phase 3
Alzheimer's Prevention Through Exercise Start of enrollment: 2013 Nov 01
Completed
Not Applicable
Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss Start of enrollment: 2014 Feb 28
Completed
Phase 3
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Publications & Presentations

PubMed

Authors' Response to Peer Reviews of "Impact of the COVID-19 Pandemic on Latino Families With Alzheimer Disease and Related Dementias: Qualitative Interviews With Fami...
Jaime Perales-Puchalt, Jill Peltzer, Monica Fracachan-Cabrera, G Adriana Perez, Mariana Ramírez, K Allen Greiner, Jeffrey Murray Burns> ;Jmirx Med. 2024 Mar 8
1 citations
Impact of the COVID-19 Pandemic on Latino Families With Alzheimer Disease and Related Dementias: Qualitative Interviews With Family Caregivers and Primary Care Providers.
Jaime Perales-Puchalt, Jill Peltzer, Monica Fracachan-Cabrera, G Adriana Perez, Mariana Ramírez, K Allen Greiner, Jeffrey Murray Burns> ;Jmirx Med. 2024 Mar 8
Design of a pragmatic randomized implementation effectiveness trial testing a health system wide hypertension program for older adults.
Aditi Gupta, Hira Chouhdry, Shellie D Ellis, Kate Young, Jonathan Mahnken, Branden Comfort, Denton Shanks, Sheila McGreevy, Courtney Rudy, Tahira Zufer, Sharissa Mabry...> ;Contemporary Clinical Trials. 2024 Mar 1
1 citations
Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes.
Robyn A Honea, Suzanne Hunt, Rebecca J Lepping, Eric D Vidoni, Jill K Morris, Amber Watts, Elias Michaelis, Jeffrey M Burns, Russell H Swerdlow> ;Neurobiology of Aging. 2023 Dec 1
Development of a Culturally Adapted Dietary Intervention to Reduce Alzheimer's Disease Risk among Older Black Adults.
Ashley R Shaw, Mickeal N Key, Samantha Fikru, Saria Lofton, Debra K Sullivan, Jannette Berkley-Patton, Crystal M Glover, Jeffrey M Burns, Eric D Vidoni> ;International Journal of Environmental Research and Public Health. 2023 Sep 2
4 citations
A text message intervention to support latino dementia family caregivers (CuidaTEXT): feasibility study.
Jaime Perales-Puchalt, Mariana Ramírez-Mantilla, Mónica Fracachán-Cabrera, Eric D Vidoni, Edward F Ellerbeck, A Susana Ramírez, Amber Watts, Kristine Williams, Jeffrey...> ;Clinical Gerontologist. 2022 Oct 21
3 citations
COMbined Exercise Trial (COMET) to improve cognition in older adults: Rationale and methods.
Amanda Szabo-Reed, Jonathan Clutton, Sydney White, Angela Van Sciver, Dreu White, Jill Morris, Laura Martin, Rebecca Lepping, Ashley Shaw, Jaime Perales Puchalt, Rober...> ;Contemporary Clinical Trials. 2022 Jul 1
6 citations
EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid.
Hannes Devos, Kathleen Gustafson, Ke Liao, Pedram Ahmadnezhad, Bradley Estes, Laura E Martin, Jonathan D Mahnken, William M Brooks, Jeffrey M Burns> ;Translational Neurodegeneration. 2022 Feb 9
4 citations
Evaluation of noise regression techniques in resting-state fMRI studies using data of 434 older adults.
Norman Scheel, Jeffrey N Keller, Ellen F Binder, Eric D Vidoni, Jeffrey M Burns, Binu P Thomas, Ann M Stowe, Linda S Hynan, Diana R Kerwin, Wanpen Vongpatanasin, Heidi...> ;Frontiers in Neuroscience. 2022 Jan 1
8 citations
Potential for Ketotherapies as Amyloid-Regulating Treatment in Individuals at Risk for Alzheimer's Disease.
Matthew K Taylor, Debra K Sullivan, Jessica E Keller, Jeffrey M Burns, Russell H Swerdlow> ;Frontiers in Neuroscience. 2022 Jan 1
4 citations
Correlation of Skin Carotenoid Content with 3-Day Dietary Intake in Community Dwelling Older Adults.
Jessica Keller, Matthew K Taylor, Aaron N. Smith, Juleah Littrell, Kendra Spaeth, Caitlin R. Boeckman, Jeffrey M. Burns, Debra K. Sullivan> ;Journal of Food Composition and Analysis. 2021 Nov 1
2 citations
Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for Whit...
Shawn N. Whitehead, Askiel Bruno, Jeffrey M. Burns, S. Thomas Carmichael, Anna Csiszar, Jodi D. Edwards, Fanny M. Elahi, Giuseppe Faraco, Douglas B. Gould, Deborah Gus...> ;Geroscience. 2021 Oct 4
9 citations
High Glycemic Diet Is Related to Brain Amyloid Accumulation Over One Year in Preclinical Alzheimer's Disease
Matthew K Taylor, Debra K. Sullivan, Jill K. Morris, Eric D. Vidoni, Robyn A. Honea, Jonathan D. Mahnken, Jeffrey M. Burns> ;Frontiers in Nutrition. 2021 Sep 27
6 citations
Physician perceived barriers and facilitators for self-measured blood pressure monitoring- a qualitative study.
Saahith Gondi, Shellie D. Ellis, Mallika Gupta, Edward F. Ellerbeck, Kimber P. Richter, Jeffrey M. Burns, Aditi Gupta> ;Plos One. 2021 Aug 20
8 citations
Mild to moderate decrease in eGFR and cognitive decline in older adults.
Michael Grasing, Kevin Kenned, Mark J. Sarnak, Jeffrey M. Burns, Aditi Gupta> ;Nephrology, Dialysis, Transplantation. 2021 Jul 20
6 citations
A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise.
Dreu White, Casey S. John, Ashley Kucera, Bryce Truver, Rebecca J. Lepping, Paul J. Kueck, Phil Lee, Laura E. Martin, Sandra A. Billinger, Jeffrey M. Burns, Jill K. Mo...> ;Scientific Reports. 2021 Jun 17
1 citations
Rationale and methods to characterize the acute exercise response in aging and Alzheimer's Disease: the AEROBIC pilot study.
Zachary D. Green, Casey S. John, Paul J. Kueck, Jeffrey M. Burns, Mark Perry, Joseph Donald, Jonathan D. Mahnken, Robyn A. Honea, Eric D. Vidoni, Jill K. Morris> ;Contemporary Clinical Trials. 2021 May 26
10 citations
Bioenergetic and inflammatory systemic phenotypes in Alzheimer's disease APOE ε4-carriers.
Heather M. Wilkins, Xiaowan Wang, Blaise W. Menta, Scott J. Koppel, Rebecca Bothwell, Annette M. Becker, Heidi Anderson, Erin Schwartz, Dong Pei, Nanda Kumar Yellapu, ...> ;Aging Cell. 2021 May 3
2 citations
Estimating the financial costs associated with a phase III, multi-site exercise intervention trial: Investigating gains in neurocognition in an intervention trial of e...
Patrick T. Donahue, George A. Grove, Chelsea M. Stillman, Chaeryon Kang, Jeffrey M. Burns, Charles H. Hillman, Arthur F. Kramer, Edward McAuley, Eric D. Vidoni, Kirk I...> ;Contemporary Clinical Trials. 2021 Apr 12
2 citations
Apolipoprotein E4 Moderates the Association Between Vascular Risk Factors and Brain Pathology.
Carolyn S Kaufman, Jill K. Morris, Eric D. Vidoni, Jeffrey M. Burns, Sandra A. Billinger> ;Alzheimer Disease and Associated Disorders. 2021 Mar 16
1 citations
CONSENSUS: a Shiny application of dementia evaluation and reporting for the KU ADC longitudinal Clinical Cohort database.
Palash Sharma, Robert N. Montgomery, Rasinio S Graves, Kayla Meyer, Suzanne L. Hunt, Eric D. Vidoni, Jonathan D. Mahnken, Russell H. Swerdlow, Jeffrey M. Burns, Dinesh...> ;JAMIA Open. 2021 Feb 1
18 citations
Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers.
Carolyn S Kaufman, Robyn A. Honea, Joseph Pleen, Rebecca J. Lepping, Amber Watts, Jill K. Morris, Sandra A. Billinger, Jeffrey M. Burns, Eric D. Vidoni> ;Journal of Cerebral Blood Flow and Metabolism. 2021 Jan 28
34 citations
Effect of aerobic exercise on amyloid accumulation in preclinical Alzheimer's: A 1-year randomized controlled trial.
Eric D. Vidoni, Jill K. Morris, Amber Watts, Mark Perry, Jon Clutton, Angela Van Sciver, Ashwini S. Kamat, Jonathan D. Mahnken, Suzanne L. Hunt, Ryan A. Townley, Robyn...> ;Plos One. 2021 Jan 14
7 citations
Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle.
Jill K. Morris, Colin S. McCoin, Kelly N. Z. Fuller, Casey S. John, Heather M. Wilkins, Zachary D. Green, Xiaowan Wang, Palash Sharma, Jeffrey M. Burns, Eric D. Vidoni...> ;Function. 2021 Jan 1
9 citations
Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients.
Eric D. Vidoni, In-Young Choi, Phil Lee, Gregory A. Reed, Na Zhang, Joseph Pleen, Jonathan D. Mahnken, Jonathan Clutton, Annette M. Becker, Erica Sherry, Rebecca Bothw...> ;Alzheimer's & Dementia. 2021 Jan 1
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Journal Articles

Short-Term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment
Jeffrey M Burns, Keith A Johnson, Reisa A Sperling, Jason Karlawish, JAMA Neurology

Authored Content

Short-Term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive ImpairmentAugust 2020

Press Mentions

KU Alzheimer’s Disease Research Center Receives $15 Million and Second Renewal as One of 31 Nationally Designated Centers by the National Institute on AgingAugust 31st, 2021
F.D.A. Approves Alzheimer’s Drug Despite Fierce Debate over Whether It WorksJune 7th, 2021
Kansas Woman’s YouTube Home Show Reveals ‘Our Secret’: Her Husband, 43, Has DementiaMarch 14th, 2021
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Grant Support

Aerobic Fitness In Slowing The Progression Of Alzheimer'S DiseaseNational Institute On Aging2010–2012
Dose-Response Study Of Exercise In Older AdultsNational Institute On Aging2009–2011
Energy Metabolism And Brain Changes With Age And Alzheimer'S DiseaseNational Center For Research Resources2009–2010
Alterations In Body Composition Are Associated With Brain Atrophy In MCI And ADNational Center For Research Resources2008–2010
Energy Metabolism And Brain Changes With Age And Alzheimer'S DiseaseNational Institute Of Neurological Disorders And Stroke2006–2010
Clinical Trial: Valproate In ADNational Center For Research Resources2009
Clinical Trial: DHA Effect On Alzheimer'SNational Center For Research Resources2009
Alzheimer'S RegistryNational Center For Research Resources2009
Intranasal Insulin In ADNational Center For Research Resources2008–2009
Brain Aging ProjectNational Center For Research Resources2008–2009
ADNINational Center For Research Resources2008–2009
Clinical Trial: Valproate In ADNational Center For Research Resources2008
Clinical Trial: DHA Effect On Alzheimer'SNational Center For Research Resources2008
Longitudial Study Of Cardiorespiratory Fitness In Alzheimer'S DiseaseNational Institute On Aging2007–2008
Modifiers Of Brain Aging And Alzheimer'S DiseaseNational Center For Research Resources2007–2008
Placebo-Controlled Trial Valproate To Attenuate Progression Of Alzheimer'S(Ad)National Center For Research Resources2007
Brain Aging Proj: Energy Metabolism &Brain Changes W/ Age &Alzheimer'S DiseaseNational Center For Research Resources2007
Alzheimer'S Disease Neuroimaging InitiativeNational Center For Research Resources2007
Cardiorespiratory Fitness In Alzheimer'S DiseaseNational Institute On Aging2005–2006