JoanneKurtzbergMD

Pediatric Hematology & Oncology • Durham, NC

Professor of Pediatrics, Duke University

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Office
2301 Erwin Rd
Durham, NC 27705
Phone+1 919-668-1100
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Education & Training

Duke University HospitalFellowship, Pediatric Hematology/Oncology, 1980 - 1983
SUNY Upstate Medical UniversityFellowship, Hematology and Medical Oncology, 1979 - 1980
SUNY Upstate Medical UniversityResidency, Pediatrics, 1977 - 1979
Dartmouth-Hitchcock/Mary Hitchcock Memorial HospitalInternship, Pediatrics, 1976 - 1977
New York Medical CollegeClass of 1976

Certifications & Licensure

FL State Medical License 2021 - 2026
NJ State Medical License 2021 - 2025
NC State Medical License 1983 - 2024
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Fellow (FAAP) American Academy of Pediatrics
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Clinical Trials

Blood and Marrow Transplant Clinical Research Network Start of enrollment: 2001 Sep 01
Completed
Not Applicable
Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia Start of enrollment: 1999 Jan 01
Completed
Phase 2
Comparison of Fluconazole vs Voriconazole to Treat Fungal Infections for Blood and Marrow Transplants (BMT CTN 0101) Start of enrollment: 2003 Nov 01
Completed
Phase 3
Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma (BMT CTN 0202) Start of enrollment: 2004 Aug 01
Terminated
Phase 2, Phase 3
Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302) Start of enrollment: 2005 Sep 01
Completed
Phase 2
Safety and Efficacy of Prochymal® for the Salvage of Treatment-Refractory Acute GVHD Patients Start of enrollment: 2005 Nov 18
Completed
Phase 2
Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501) Start of enrollment: 2006 Dec 01
Completed
Phase 3
Allogeneic Stem Cell Transplantation for the Treatment of Multiple Sclerosis Start of enrollment: 2007 Jul 01
Withdrawn
Phase 1, Phase 2
Adult Double Cord Blood Transplant Study Start of enrollment: 2007 Aug 01
Completed
Phase 2
Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy Start of enrollment: 2008 Jan 01
Completed
Phase 1
ALD-101 Adjuvant Therapy of Unrelated Umbilical Cord Blood Transfusion (UCBT) in Patients With Inherited Metabolic Diseases Start of enrollment: 2008 Mar 01
Terminated
Phase 3
Unrelated Cord Blood Transplant Plus a Haplo-Identical (Half-Matched), T-Cell Depleted Stem Transplant From a Related Donor for Subjects With High Risk Malignancies Start of enrollment: 2007 Aug 01
Completed
Phase 1, Phase 2
Unrelated Umbilical Cord Blood Transplantation Augmented With ALDHbr Umbilical Cord Blood Cells Start of enrollment: 2005 Oct 01
Completed
Phase 1
Fetal Umbilical Cord Blood (UCB) Transplant for Lysosomal Storage Diseases Start of enrollment: 2009 Oct 01
Withdrawn
Phase 1
A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy Start of enrollment: 2010 Jun 01
Completed
Phase 2
Pilot Study Evaluating Safety & Efficacy of DCBT: NiCord® & UNM CBU to Patients With Hematological Malignancies Start of enrollment: 2010 Nov 01
Completed
Phase 1, Phase 2
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) Start of enrollment: 2011 Oct 01
Recruiting
Roles: Contact, Principal Investigator
Phase I/II Pilot Study of Mixed Chimerism to Treat Inherited Metabolic Disorders Start of enrollment: 2011 Apr 01
Terminated
Phase 1, Phase 2
Safety and Feasibility Study of Umbilical Cord Blood Cells for Infants With Hypoplastic Left Heart Syndrome Start of enrollment: 2011 Sep 01
Terminated
Phase 1
Evaluation of the Safety and Efficacy of TXA127 (Angiotensin 1-7) to Enhance Engraftment in Pediatric Patients Undergoing Single or Double Umbilical Cord Blood Transplantation Start of enrollment: 2012 Mar 01
Withdrawn
Phase 2
Allogeneic SCT of NiCord®, UCB-Derived Ex Vivo Expanded Stem and Progenitor Cells, in Patients With Hemoglobinopathies Start of enrollment: 2012 Sep 01
Completed
Phase 1, Phase 2
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants
Available
Single Patient Expanded Access Protocol: Metabolic Boost
No longer available
Allogeneic Stem Cell Transplantation for the Treatment of Multiple Sclerosis (Compassionate Use)
No longer available
Autologous Umbilical Cord Blood Infusion for Children With Autism Spectrum Disorder (ASD) Start of enrollment: 2014 Jun 01
Completed
Phase 1
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells Start of enrollment: 2014 Sep 01
Recruiting
Phase 1
Cord Blood Infusion for Children With Autism Spectrum Disorder Start of enrollment: 2016 Sep 01
Completed
Phase 2
Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke Start of enrollment: 2017 Mar 14
Completed
Phase 2
hCT-MSCs for Children With Autism Spectrum Disorder (ASD) Start of enrollment: 2017 Jun 06
Completed
Phase 1
Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries
Available
A Study of UCB and MSCs in Children With CP: ACCeNT-CP Start of enrollment: 2018 Apr 10
Completed
Phase 1, Phase 2
Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE Start of enrollment: 2018 Dec 27
Completed
Phase 1
hCT-MSC in Children With Autism Spectrum Disorder Start of enrollment: 2020 Oct 12
Completed
Phase 2
Open Label Phase I hCT-MSC in Toddlers With Autism Spectrum Disorder Start of enrollment: 2021 Feb 24
Completed
Phase 1
hCT-MSCs for COVID19 ARDS Start of enrollment: 2020 Jun 18
Terminated
Phase 1, Phase 2
hCT-MSC Infusion in Adults With Autism Spectrum Disorder Start of enrollment: 2022 Jan 24
Active, not recruiting
Phase 1
Infusions of Mesenchymal Stromal Cells in Children With Multisystem Inflammatory Syndrome Start of enrollment: 2021 Mar 12
Withdrawn
Phase 1
Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) Start of enrollment: 2022 Apr 19
Recruiting
Phase 2
Roles: Principal Investigator
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Publications & Presentations

PubMed

Impact of FDA's HCT/P ZIKV Recommendations on Cord Blood Unit Eligibility and Utilization in a Large Public Cord Blood Bank.
Dana S Guggenheim, Joanne Kurtzberg, Beth H Shaz> ;Stem Cells Translational Medicine. 2024 Mar 23
1 citations
Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance.
Min, H., O'Neil, S., Xu, L., Moseman, E., Filiano, A., Kurtzberg, J.> ;The Journal of Experimental Medicine. 2024 Feb 5
1 citations
Newborn Screening for Krabbe Disease: Status Quo and Recommendations for Improvements.
Dietrich Matern, Khaja Basheeruddin, Tracy L Klug, Gwendolyn McKee, Patricia U Edge, Patricia L Hall, Joanne Kurtzberg, Joseph J Orsini> ;International Journal of Neonatal Screening. 2024 Jan 28
1 citations
Author Correction: Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial.
Ken Mautner, Michael Gottschalk, Scott D Boden, Alison Akard, Won C Bae, Lora Black, Blake Boggess, Paramita Chatterjee, Christine B Chung, Kirk A Easley, Greg Gibson,...> ;Nature Medicine. 2024 Mar 1
A Randomized, Placebo-Controlled, Phase II Trial of Intravenous Allogeneic Non-HLA Matched, Unrelated Donor, Cord Blood Infusion for Ischemic Stroke.
Troy, J., Poehlein, E., Bennett, E., Shpall, E., Wingard, J., Freed, B., Jones, W., Laskowitz, D., Belagaje, S., Khanna, A., Volpi, J., Marrotte, E., Kurtzberg, J.> ;Stem Cells Translational Medicine. 2024 Feb 14
Mesenchymal stromal cells suppress microglial activation and tumor necrosis factor production.
Xu, L., Min, H., Saha, A., Schwartzman, J., Parrott, R., Filiano, A., Gunaratne, A., Kurtzberg, J.> ;Cytotherapy. 2024 Feb 1
Newborn Screening for Krabbe Disease and Identification of Minority Patients.
Wilkes, J., Baker, M., Grantham, A., Orsini, J., Bonkowsky, J., Kurtzberg, J.> ;Pediatric Neurology. 2024 Feb 1
4 citations
Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial.
Ken Mautner, Michael Gottschalk, Scott D Boden, Alison Akard, Won C Bae, Lora Black, Blake Boggess, Paramita Chatterjee, Christine B Chung, Kirk A Easley, Greg Gibson,...> ;Nature Medicine. 2023 Dec 1
5 citations
A Pilot Phase I Trial of Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells in Neonates With Hypoxic-Ischemic Encephalopathy.
Charles Michael Cotten, Kimberley Fisher, William Malcolm, Kathryn E Gustafson, Lynn Cheatham, Amanda Marion, Rachel Greenberg, Joanne Kurtzberg> ;Stem Cells Translational Medicine. 2023 Jun 15
3 citations
Feasibility Study of Cord Tissue Derived Mesenchymal Stromal Cells in COVID-19-Related Acute Respiratory Distress Syndrome.
Beth H Shaz, Bryan D Kraft, Jesse D Troy, Emily Poehlein, Lingye Chen, Lynn Cheatham, Raha Manyara, Khalid Hanafy, Linda Brown, Margaret Scott, Ralph Palumbo, Frank Vr...> ;Stem Cells Translational Medicine. 2023 Apr 17
4 citations
Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades.
Joanne Kurtzberg, Jesse D Troy, Kristin M Page, Hanadi Rafii El Ayoubi, Fernanda Volt, Graziana Maria Scigliuolo, Barbara Cappelli, Vanderson Rocha, Annalisa Ruggeri, ...> ;Stem Cells Translational Medicine. 2023 Jan 30
The potential cost-effectiveness of novel cord blood therapies in children with autism spectrum disorder.
Ethan D Borre, Evan Myers, Marianne Hamilton Lopez, Joanne Kurtzberg, Beth Shaz, Jesse Troy, Gillian D Sanders Schmidler> ;Plos One. 2023 Jan 1
Improving thymus implantation for congenital athymia with interleukin-7.
Hyunjung Min, Laura A Valente, Li Xu, Shane M O'Neil, Lauren R Begg, Anthony J Filiano, Kurtzberg, J.> ;Clinical & Translational Immunology. 2023 Jan 1
4 citations
Genetic and phenotypic spectrum in the NONO-associated syndromic disorder.
Franziska Roessler, Anita E Beck, Ball Susie, Bartolomaeus Tobias, Amber Begtrup, Saskia Biskup, Oana Caluseriu, Norman Delanty, Christine Fröhlich, Marie T Greally, M...> ;American Journal of Medical Genetics. Part A. 2023 Feb 1
18 citations
Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection.
Eleanor C Semmes, Itzayana G Miller, Courtney E Wimberly, Caroline T Phan, Jennifer A Jenks, Melissa J Harnois, Stella J Berendam, Helen Webster, Jillian H Hurst, Joan...> ;The Journal of Clinical Investigation. 2022 Aug 15
2 citations
Making Decisions About Krabbe Disease Newborn Screening.
Joanne Kurtzberg, Dietrich Matern, Joseph J Orsini, Michael Gelb, Stacy Pike-Langenfeld, Lesa Brackbill, Anna Grantham, Anthony C Steyermark> ;Pediatrics. 2022 Aug 1
13 citations
Motor function and safety after allogeneic cord blood and cord tissue-derived mesenchymal stromal cells in cerebral palsy: An open-label, randomized trial.
Jessica M Sun, Laura E Case, Colleen McLaughlin, Alicia Burgess, Natalie Skergan, Sydney Crane, Joan M Jasien, Mohamad A Mikati, Jesse Troy, Joanne Kurtzberg> ;Developmental Medicine and Child Neurology. 2022 Dec 1
6 citations
Characterizing human mesenchymal stromal cells' immune-modulatory potency using targeted lipidomic profiling of sphingolipids.
S'Dravious A DeVeaux, Molly E Ogle, Sofiya Vyshnya, Nathan F Chiappa, Bobby Leitmann, Ryan Rudy, Abigail Day, Luke J Mortensen, Joanne Kurtzberg, Krishnendu Roy, Edwar...> ;Cytotherapy. 2022 Jun 1
8 citations
Benefits of newborn screening and hematopoietic cell transplant in infantile Krabbe disease.
Kristin M Page, Margie A Ream, Hemalatha G Rangarajan, Rafael Galindo, Ali Y Mian, Mai-Lan Ho, James Provenzale, Kathryn E Gustafson, Jennifer Rubin, Shalini Shenoy, J...> ;Blood Advances. 2022 May 10
6 citations
Gene therapy offers new hope for children with metachromatic leukodystrophy.
Joanne Kurtzberg> ;Lancet. 2022 Jan 22
2 citations
Changes in the geometry and robustness of diffusion tensor imaging networks: Secondary analysis from a randomized controlled trial of young autistic children receiving...
Anish K Simhal, Kimberly L H Carpenter, Joanne Kurtzberg, Allen Song, Allen Tannenbaum, Lijia Zhang, Guillermo Sapiro, Geraldine Dawson> ;Frontiers in Psychiatry. 2022 Jan 1
14 citations
Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations
Camila Medrano-Trochez, Paramita Chatterjee, Pallab Pradhan, Hazel Y. Stevens, Molly E Ogle, Edward A. Botchwey, Joanne Kurtzberg, Carolyn Yeago, Greg Gibson, Krishnen...> ;Stem Cell Research & Therapy. 2021 Nov 4
4 citations
Guidelines for Pediatric Unrelated Cord Blood Transplantation—Unique Considerations
Ann Dahlberg, Joanne Kurtzberg, Jaap Jan Boelens, Caridad Martinez, Paul A. Carpenter, Priti Tewari> ;Transplantation and Cellular Therapy. 2021 Sep 24
A Novel Mechanism for Mesenchymal Stromal Cells to Induce Long-Term Suppression of Pulmonary Inflammation
Hyunjung Min, Li Xu, Roberta E. Parrott, Sebastian A. Wellford, Ashley Moseman, Joanne Kurzberg, Anthony J. Filiano> ;Stem Cells Translational Medicine. 2021 Sep 18
Expanded Access Protocol of Umbilical Cord Blood Infusion for Children with Neurological Conditions: An Update.
Colleen McLaughlin, Tara West, Rachel Hollowell, Natalie Skergan, Paige Giguere, Richard Vinesett, Erin Arbuckle, Jayne Cash, Kerry Hoyle, Sydney Crane, Lettie Moore, ...> ;Stem Cells Translational Medicine. 2021 Sep 1
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Abstracts/Posters

Automated Thawing Increases Recovery of Colony‐Forming Units from Banked Cord Blood Unit Grafts
Joanne Kurtzberg, MD, Transfusion, Orlando, FL, 12/7/2019

Press Mentions

More Options for People with Blood CancersMay 10th, 2023
Duke Has Quietly Discontinued a Costly, Unproven Autism TreatmentApril 17th, 2023
Developing New Tools to Fight CancerOctober 17th, 2022
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