JohnEBurkeMD

PubMed

• The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3.
  McPhail JA, Ottosen EH, Jenkins ML, Burke JE> ;Structure. 2016-12-07
• Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.
  Ziemba BP, Swisher GH, Masson G, Burke JE, Williams RL, Falke JJ> ;Biochemistry. 2016-11-22
• Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin.
  Haji-Ghassemi O, Gilbert M, Spence J, Schur MJ, Parker MJ, Jenkins ML, Burke JE, van Faassen H, Young NM, Evans SV> ;J. Biol. Chem.. 2016-11-11
• Comparative study of naturally occurring huntingtin fragments in Drosophila points to Exon 1 as the most pathogenic species in Huntington's Disease.
  Barbaro, B. A.,Lukacsovich, T.,Agrawal, N.,Burke, J.,Bornemann, D. J.,Purcell, J. M.,Worthge, S. A.,Caricasole, A.,Weiss, A.,Song, W.,Morozova, O. A.,Colby, D. W.,Mars...> ;Hum. Mol. Genet.. 2014 Oct 12
• Phospholipase A2 biochemistry.
  Burke, J.E., Dennis, E.A.> ;Cardiovasc Drugs Ther. 2009-02-01
• Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).
  Burke JE, Williams RL> ;Adv Biol Regul. 2013-01-01
• Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and memb...
  Cao, J.,Burke, J. E.,Dennis, E. A.> ;J Biol Chem. 2013 Jan 18
• Dynamics of the Phosphoinositide 3-Kinase p110? Interaction with p85? and Membranes Reveals Aspects of Regulation Distinct from p110?.
  Burke, J.E., Vadas, O., Berndt, A., Finegan, T., Perisic, O., Williams, R.L.> ;Structure. 2011 Aug 10
• Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.
  Vadas, O., Burke, J.E., Zhang, X., Berndt, A., Williams, R.L.> ;Sci Signal. 2011 Oct 18
• Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
  Kokotos, G., Hsu, Y., Burke, J.E., Baskakis, C., Kokotos, C.G., Magrioti, V., Dennis, E.A.> ;J Med Chem. 2010 May 13
• Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry.
  Hsu, Y., Burke, J.E., Li, S., Woods, V.L., Dennis, E.A.> ;J Biol Chem. 2009-08-28
• 53 citations
  Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.
  John E. Burke, Arneh Babakhani, Alemayehu A. Gorfe, George Kokotos, Sheng Li, Virgil L. Woods, J. Andrew McCammon, Edward A. Dennis> ;Journal of the American Chemical Society. 2009 Jun 17
• Phospholipase A2 structure/function, mechanism, and signaling.
  Burke, J.E., Dennis, E.A.> ;J Lipid Res. 2009-04-01
• Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets.
  Prévost, N., Mitsios, J. V., Kato, H., Burke, J. E., Dennis, E. A., Shimizu, T., Shattil, S. J.> ;Blood. 2009-01-08
• A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2.
  Burke, J.E., Hsu, Y., Deems, R.A., Li, S., Woods, V.L., Dennis, E.A.> ;J Biol Chem. 2008 Nov 7
• Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry.
  Burke, J.E., Karbarz, M.J., Deems, R.A., Li, S., Woods, V.L., Dennis, E.A.> ;Biochemistry. 2008 Jun 17
• Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry.
  Hsu, Y., Burke, J.E., Stephens, D.L., Deems, R.A., Li, S., Asmus, K.M., Woods, V.L., Dennis, E.A.> ;J Biol Chem. 2008 Apr 11
• Homoclinic snaking: structure and stability.
  Burke, J.,Knobloch, E.> ;Chaos. 2007 Oct 02
• Glycerol dehydrogenase. structure, specificity, and mechanism of a family III polyol dehydrogenase.
  Ruzheinikov SN, Burke J, Sedelnikova S, Baker PJ, Taylor R, Bullough PA, Muir NM, Gore MG, Rice DW> ;Structure. 2001-09-01
• Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a point mutation in N-acetylglucosaminyltransferase I gene.
  Puthalakath H, Burke J, Gleeson PA> ;J. Biol. Chem.. 1996-11-01
• The transmembrane and flanking sequences of beta 1,2-N-acetylglucosaminyltransferase I specify medial-Golgi localization.
  Burke J, Pettitt JM, Schachter H, Sarkar M, Gleeson PA> ;J. Biol. Chem.. 1992-12-05
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