JohnCEdwardsMDPh.D.

PubMed

• Regulatory T cells in kidney transplant recipients with LIMS1 rs893403 risk genotype.
  Safak Mirioglu, Bayram Kiran, Yasar Caliskan, Krista L Lentine, John C Edwards> ;Clinical Transplantation. 2024 Apr 1
• 2 citations
  Genetic Testing in Patients With Recent African Ancestry and Hypertension: A Pilot Study of Attitudes and Perceptions.
  Krista L Lentine, Anthony N Muiru, Kathryn K Lindsay, Yasar Caliskan, John C Edwards, Aliza Anwar Memon, Amy K Mosman, Kana N Miyata, Than-Mai Vo, Barry I Freedman, Am...> ;Kidney Medicine. 2022 Dec 1
• Arrhythmia in chronic hemodialysis as a function of predialysis electrolytes and interdialytic interval.
  John C Edwards, Amy Mosman, Paul J Hauptman, Taewoo Lee, Marie Philipneri, Firoozeh Farahmand, Louis Yn, Margaret Brandon, Paula M Buchanan> ;Hemodialysis International. International Symposium on Home Hemodialysis. 2023 Jan 1
• 9 citations
  CLIC4 localizes to mitochondrial-associated membranes and mediates cardioprotection.
  Devasena Ponnalagu, Shanna Hamilton, Shridhar Sanghvi, Diego Antelo, Neill Schwieterman, Inderjot Hansra, Xianyao Xu, Erhe Gao, John C Edwards, Shyam S Bansal, Loren E...> ;Science Advances. 2022 Oct 21
• Cation Channel Activity of Apolipoprotein L1 is Modulated by Haplotype Background.
  Rebecca L Winkler, Jonathan Bruno, Paula Buchanan, John C Edwards> ;Journal of the American Society of Nephrology. 2022 Sep 1
• 1 citations
  COVID-19 among Hospitalized Patients with Kidney Disease: Experience at a U.S. Midwestern Academic Medical Center.
  Yasar Caliskan, Seyedmahdi Pahlavani, Ariel Schnell, Aliza Anwar Memon, Fadee Abu Al Rub, Usama Elewa, Marie Philipneri, Kana Miyata, Thanh-Mai Vo, Amy Mosman, Thomas ...> ;Turkish Journal of Nephrology. 2022 Jul 1
• 9 citations
  LIMS1 risk genotype and T cell-mediated rejection in kidney transplant recipients.
  Yasar Caliskan, Gonca E. Karahan, Sebahat Akgul, Safak Mirioglu, Yasemin Ozluk, Halil Yazici, Erol Demir, Ahmet Burak Dirim, Aydin Turkmen, John C. Edwards, Fatma Oguz...> ;Nephrology, Dialysis, Transplantation. 2021 Apr 28
• 5 citations
  Kidney-disease-associated variants of Apolipoprotein L1 show gain of function in cation channel activity.
  Jonathan Bruno, John C Edwards> ;The Journal of Biological Chemistry. 2021 Jan 9
• 6 citations
  Treatment of Gabapentin Toxicity With Peritoneal Dialysis: Assessment of Gabapentin Clearance
  Hisham Ibrahim, Zachary Oman, Matthew Schuelke, John C. Edwards> ;American Journal of Kidney Diseases. 2017 Dec 1
• 31 citations
  Apolipoprotein L1 confers pH-switchable ion permeability to phospholipid vesicles
  Jonathan Bruno, Nicola Pozzi, Jonathan Oliva, John C. Edwards> ;The Journal of Biological Chemistry. 2017 Nov 3
• 13 citations
  CLIC1 null mice demonstrate a role for CLIC1 in macrophage superoxide production and tissue injury.
  Barbara Ulmasov, Jonathan Bruno, Kiyoko Oshima, Yao Wen Cheng, Stephen P. Holly, Leslie V. Parise, Terrance M. Egan, John C. Edwards> ;Physiological Reports. 2017 Mar 1
• 13 citations
  Both CLIC4 and CLIC5A activate ERM proteins in glomerular endothelium
  Mahtab Tavasoli, Abass Al-Momany, Xin Wang, Laiji Li, John C. Edwards, Barbara J. Ballermann> ;American Journal of Physiology. Renal Physiology. 2016 Aug 31
• 17 citations
  Data supporting characterization of CLIC1, CLIC4, CLIC5 and DmCLIC antibodies and localization of CLICs in endoplasmic reticulum of cardiomyocytes
  Devasena Ponnalagu, Shubha Gururaja Rao, Jason Farber, Wenyu Xin, Ahmed Tafsirul Hussain, Kajol Shah, Soichi Tanda, Mark Berryman, John C. Edwards, Harpreet Singh> ;Data in Brief. 2016 Mar 26
• 59 citations
  Molecular identity of cardiac mitochondrial chloride intracellular channel proteins.
  Devasena Ponnalagu, Shubha Gururaja Rao, Jason Farber, Wenyu Xin, Ahmed Tafsirul Hussain, Kajol Shah, Soichi Tanda, Mark Berryman, John C. Edwards, Harpreet Singh> ;Mitochondrion. 2016 Mar 1
• 48 citations
  Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension
  Beata Wojciak-Stothard, Vahitha B. Abdul-Salam, Ka Hou Lao, Hilda Tsang, David Irwin, Christina Lisk, Zoe Loomis, Kurt R. Stenmark, John C. Edwards, Stuart H. Yuspa, L...> ;Circulation. 2014 Apr 29
• 60 citations
  Absence of chloride intracellular channel 4 (CLIC4) predisposes to acute kidney injury but has minimal impact on recovery
  John C. Edwards, Jonathan Bruno, Phillip Key, Yao-Wen Cheng> ;BMC Nephrology. 2014 Apr 3
• 4 citations
  Chloride transport.
  John C Edwards> ;Comprehensive Physiology. 2012 Apr 1
• 4 citations
  What's a CLIC doing in the podocyte?
  John C. Edwards> ;Kidney International. 2010 Nov 1
• 54 citations
  Chloride Channels of Intracellular Membranes
  John C. Edwards> ;FEBS Letters. 2010 May 17
• 66 citations
  Chloride intracellular channel-4 is a determinant of native collateral formation in skeletal muscle and brain.
  Dan Chalothorn, Hua Zhang, Jennifer E. Smith, John C. Edwards, James E. Faber> ;Circulation Research. 2009 Jul 2
• 82 citations
  Chloride Intracellular Channel Protein-4 Functions in Angiogenesis by Supporting Acidification of Vacuoles Along the Intracellular Tubulogenic Pathway
  Barbara Ulmasov, Jonathan Bruno, Nicarter Gordon, M. Elizabeth Hartnett, John C. Edwards> ;The American Journal of Pathology. 2009 Mar 1
• 56 citations
  Tissue and subcellular distribution of CLIC1
  Barbara Ulmasov, Jonathan Bruno, Philip G. Woost, John C. Edwards> ;BMC Cell Biology. 2007 Feb 27
• 44 citations
  c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.
  John C. Edwards, Christopher Cohen, Weibing Xu, Paul H. Schlesinger> ;The Journal of Biological Chemistry. 2006 Sep 22
• 11 citations
  The CLIC1 chloride channel is regulated by the cystic fibrosis transmembrane conductance regulator when expressed in Xenopus oocytes.
  John C. Edwards> ;The Journal of Membrane Biology. 2006 Jan 1
• 70 citations
  CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.
  Mark Berryman, Jonathan Bruno, Jessica Price, John C. Edwards> ;The Journal of Biological Chemistry. 2004 Aug 13
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Journal Articles

• Data supporting characterization of CLIC1, CLIC4, CLIC5 and DmCLIC antibodies and localization of CLICs in endoplasmic reticulum of cardiomyocytes  
  Ponnalagu D, Rao SG, Farber J, Xin W, Hussain AT, Shah K, Tanda S, Berryman MA, Edwards JC, Singh H, Data Brief., 1/26/2016
• Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice  
  Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL, Hwang S, Edwards JC, Coppola V, Tessarollo L, Stepp MA, Yuspa SH, Am J Pathol, 1/1/2012
• Chloride Transport  
  Edwards JC, Comprehensive Physiology, 1/1/2012
• What’s a CLIC doing in the podocyte?  
  Edwards, JC, Kidney Int, 1/1/2010
• Chloride intracellular channel-4 is a determinant of native collateral formation in skeletal muscle and brain  
  Chalothorn D, Zhang H, Smith JE, Edwards JC, and Faber JE, Circ. Res., 1/1/2009
• CLIC4 Functions in Angiogenesis by Supporting Acidification of Vacuoles Along the Intracellular Tubulogenic Pathway  
  Ulmasov B, Bruno J, Gordon N, Hartnett ME, and Edwards JC, Am. J. Path, 1/1/2009
• Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models  
  Dogrukol-Ak D, Kumar VB, Ryerse JS, Farr SA, Verma S, Nonaka N, Nakamachi T, Ohtaki H, Niehoff ML, Edwards JC, Shioda S, Morley JE, and Banks WA, J. Cereb. Blood Flow Metab, 1/1/2009
• The CLIC1 chloride channel is regulated by the cystic fibrosis transmembrane conductance regulator when expressed in Xenopus oocytes  
  Edwards JC, J. Membrane Biol, 1/1/2006
• Chloride Channel and c-Src Control of Osteoclast HCl Transport and Bone Resorption  
  Edwards JC, Cohen C, Xu CW, and Schlesinger PH, J. Biol. Chem., 1/1/2006
• Vascular Biology in uremia: insights into novel mechanisms of vascular injury  
  Al-Aly Z., and Edwards J, Adv. Chronic Kidney Disease, 1/1/2004
• CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo  
  Berryman M, Bruno J, Price J, and Edwards JC, J. Biol. Chem, 1/1/2004
• AKAP350 at the golgi apparatus II: association of AKAP350 with a novel chloride intracellular channel (CLIC) family member  
  Shanks RA, Larocca MC, Berryman M, Edwards JC, Urushidani T, Navarre J, and Goldenring JR, J. Biol. Chem., 1/1/2002
• Differential Expression of a chloride intracellular channel gene, CLIC4, in TGF-beta 1 mediated conversion of fibroblasts to myofibroblasts  
  Roonov-Jessen L, Villadsen R, Edwards JC, and Petersen OW, Am. J. Pathol, 1/1/2002
• CLIC-1 Directly Inserts From the Aqueous Phase Into Phospholipid Membranes Where it Functions as a Chloride Channel  
  Tulk BM, Kapadia S, and Edwards JC, Am. J. Physiol.: Cell Physiol, 1/1/2002
• The bovine kidney microsomal chloride channel p64 is regulated by p59-fyn, a src family tryosine kinase  
  Edwards JC, and Kapadia S, J. Biol. Chem., 1/1/2000
• CLIC-1 Functions as a Chloride Channel when Expressed and Purified from Bacteria  
  Tulk BM, Schlesinger, PH, and Edwards, JC, J. Biol. Chem., 1/1/2000
• A novel p64-related Cl channel: subcellular distribution and nephron segment-specific expresssion  
  Edwards JC, Am. J. Physiol. (Renal), 1/1/1999
• NCC27, a homolog of intracellular chloride channel p64, is expressed in the brush border of renal proximal tubule  
  Tulk BM, and Edwards JC, Am. J. Physiol. (Renal), 1/1/1998
• Functional expression of p64, an intracellular chloride channel  
  Edwards JC, Tulk BM, and Schlesinger P, J. Mem. Biol., 1/1/1998
• Characterization of the osteoclast ruffled border chloride channel and its role in bone resorption  
  Schlesinger PH, Blair HC, Teitelbaum SL, and Edwards JC, J. Biol. Chem, 1/1/1997
• Subcellular distribution and targeting of the intracellular chloride channel, p64  
  Redhead C, Sullivan SK, Kosecki C, Fugiwara K, and Edwards JC, Mol. Biol. Cell, 1/1/1997
• Cellular distribution and regulation of NHE -1 isoform of the Na-H exchanger in the avian osteoclast  
  Gupta A, Edwards JC and Hruska KA, Bone, 1/1/1996
• Avian cathepsin B cDNA: sequence and demonstration that mRNAs of two sizes produced in cell types producing large quantities of enzyme  
  Dong SS, Stransky GI, Whitaker CH, Jordan SE, Schlesinger PH, Edwards JC and Blair HC, Biochim. Biophy. Acta., 1/1/1995
• The apical Cl/HCO3 exchanges of ß intercalated cells is band 3  
  Van Adelsberg J, Edwards JC, Al-Awqati Q, J. Biol. Chem., 1/1/1993
• Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes  
  Landry D, Sullivan S, Nicolaides M, Redhead C, Edelman A, Field M, Al-Awqati Q, Edwards JC, J. Biol. Chem., 1/1/1993
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Abstracts/Posters

• The chloride channel activity of ApoL1
  Edwards, JC, Am. Soc. Of Nephrol Annual Meeting, 1/1/2014
• Chloride Channels CLIC1 and CLIC4 Function in Proximal Tubule Endocytosis
  Edwards, JC and Cheng, Y-W, Am. Soc. Of Nephrol. Annual Meeting, 1/1/2011
• CLIC1 Potentiates Acute Toxic Injury
  Ulmasov BV, Bruno, J, and Edwards JC, Am. Soc. of Nephrol. Annual Meeting, 1/1/2010
• CLIC4 and Acute Toxic Kidney Injury
  Kahl CR and Edwards JC, Am. Soc. of Nephrol. Annual Meeting, 1/1/2010
• Chloride Channel CLIC4 Functions in Angiogenesis by Supporting Acidification of Vacuoles along the Endothelial Tubulogenesis Pathway.
  Edwards, JC, Bruno, J., J. Am. Soc. Nephrol, 1/1/2008
• CLIC4 Knockout mice show defective endothelial tubulogenesis
  Edwards, JC, Ulmasov, B., and Bruno, J., J. Am. Soc. Nephrol., 1/1/2007
• Generation and phenotypic characterization of CLIC-family chloride channel knockout mice
  Edwards, JC, Bruno, J., and Ulmasov, B., J. Am. Soc. Nephrol., 1/1/2006
• Oxidation Regulates CLIC-1 Chloride Channel Activity and Membrane Association
  Edwards, JC, and Bruno, J, American Society for Cell Biology Annual Meeting, 1/1/2004
• Mapping membrane association domains in the CLIC-1 chloride channel
  Edwards, JC, J. Am. Soc. Nephrol., 1/1/2004
• CLIC-1 chloride channel is expressed in the apical domain of proximal tubule and other absorptive epithelia where it resides in vesicles along the endocytic pathway
  Edwards, JC, J. Am. Soc. Nephrol., 1/1/2003
• Recruitment of CLIC1 Chloride Channel into phospholipid membranesis enhanced by presence of a receptor cytoplasmic domain
  Edwards, JC, and Tulk, BM, J. Am. Soc. Nephrol., 1/1/2002
• Purified Recombinant CLIC-4 functions as a unique chloride selective channel when reconstituted in phsopholipid vesicles
  Edwards, JC, Tulk, BM, and Kapadia, S, J. Am. Soc. Nephrol., 1/1/2001
• CLIC-1 forms choride selective channels when inserted into membranes from the aqueous phase
  Tulk, BM, Kapadia, SA, and Edwards, JC, Biophys, 1/1/2001
• Functional CLIC1 directly inserts into membranes from the aqueous phase
  Edwards, JC, Tulk, BM, and Kapadia, S, J. Am. Soc. Nephrol, 1/1/2000
• The CLIC-1 chloride channel is regulated by CFTR in Xenopus oocytes
  Edwards, JC, Tulk, BM, Nichols, C, Sha, Q, and Schlesinger, P., J. Am. Soc. Nephrol., 1/1/1999
• CFTR Modulates the Activity of CLIC1 in Xenopus oocytes
  Tulk, BM, Sha, Q, Nichols, C., Schlesinger, P., and Edwards, JC, Pediatric Pulmonology, 1/1/1999
• Expression, purification and characterization of NCC27, a novel intracellular chloride channel
  Tulk, BM, Schlesinger, P, and Edwards, JC, Biophys. J., 1/1/1999
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Other

• Analysis of yeast mitochondrial RNA synthesis using a homologous in vitro transcription system (Doctoral Dissertation) 
  Edwards JC, University of Chicago
  1/1/1983