JohnGreggHardyMD

PubMed

• Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array.
  Barber IS, Braae A, Clement N, Patel T, Guetta-Baranes T, Brookes K, Medway C, Chappell S, Guerreiro R, Bras J, Hernandez D, Singleton A, Hardy J, Mann DM, Morgan K> ;Neurobiol. Aging. 2017-01-01
• Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease.
  Escott-Price V, Shoai M, Pither R, Williams J, Hardy J> ;Neurobiol. Aging. 2017-01-01
• Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology.
  Ling H, Kovacs GG, Vonsattel JPG, Davey K, Mok KY, Hardy J, Morris HR, Warner TT, Holton JL, Revesz T> ;Brain. 2016-12-01
• 151 citations
  Novel genetic loci underlying human intracranial volume identified through genome-wide association
  Hieab H.H. Adams, Derrek P. Hibar, Vincent Chouraki, Jason L. Stein, Paul A. Nyquist, Miguel E. Rentería, Stella Trompet, Alejandro Arias-Vasquez, Sudha Seshadri, Sylv...> ;Nature Neuroscience. 2016 Dec 1
• Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.
  Lubbe SJ, Escott-Price V, Brice A, Gasser T, Pittman AM, Bras J, Hardy J, Heutink P, Wood NM, Singleton AB, Grosset DG, Carroll CB, Law MH, Demenais F, Iles MM, Bishop...> ;Neurobiol. Aging. 2016-12-01
• Additional Rare Variant Analysis in Parkinson's Disease Cases with and Without Known Pathogenic Mutations: Evidence for Oligogenic Inheritance.
  Lubbe SJ, Escott-Price V, Gibbs JR, Nalls MA, Bras J, Price TR, Nicolas A, Jansen IE, Mok KY, Pittman AM, Tomkins JE, Lewis PA, Noyce AJ, Lesage S, Sharma M, Schiff ER...> ;Hum. Mol. Genet.. 2016-10-18
• mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
  Manzoni C, Mamais A, Roosen DA, Dihanich S, Soutar MPM, Plun-Favreau H, Bandopadhyay R, Hardy J, Tooze SA, Cookson MR, Lewis PA> ;Sci Rep. 2016-10-12
• ABCA7 p.G215S as potential protective factor for Alzheimer's disease.
  Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, Almeida MR, Holste...> ;Neurobiol. Aging. 2016-10-01
• Identification of Modifier Genes in a Mouse Model of Gaucher Disease.
  Klein AD, Ferreira N, Ben-Dor S, Duan J, Hardy J, Cox TM, Merrill AH, Futerman AH> ;Cell Rep. 2016-09-06
• Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.
  van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RAA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar...> ;Nat. Genet.. 2016-09-01
• Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease.
  Mattsson N, Schott JM, Hardy J, Turner MR, Zetterberg H> ;J. Neurol. Neurosurg. Psychiatr.. 2016-09-01
• The amyloid hypothesis of Alzheimer's disease at 25 years.
  Selkoe DJ, Hardy J> ;EMBO Mol Med. 2016-06-01
• Dementia in Down's syndrome.
  Ballard C, Mobley W, Hardy J, Williams G, Corbett A> ;Lancet Neurol. 2016-05-01
• HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.
  Yaldizli Ö, Sethi V, Pardini M, Tur C, Mok KY, Muhlert N, Liu Z, Samson RS, Wheeler-Kingshott CAM, Yousry TA, Houlden H, Hardy J, Miller DH, Chard DT> ;Mult Scler Relat Disord. 2016-05-01
• Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases.
  Hardy J> ;Biochem. Soc. Trans.. 2016-04-15
• De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions.
  Mencacci NE, Kamsteeg E, Nakashima K, R'Bibo L, Lynch DS, Balint B, Willemsen MAAP, Adams ME, Wiethoff S, Suzuki K, Davies CH, Ng J, Meyer E, Veneziano L, Giunti P, Hu...> ;Am. J. Hum. Genet.. 2016-04-07
• Variation in Recent Onset Parkinson's Disease: Implications for Prodromal Detection.
  Swallow DMA, Lawton MA, Grosset KA, Malek N, Smith CR, Bajaj NP, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams N, Wood NW, Grosset DG> ;J Parkinsons Dis. 2016-03-19
• Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.
  Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage C, Sahbatou M,...> ;Am. J. Hum. Genet.. 2016-03-03
• Gene co-expression networks shed light into diseases of brain iron accumulation.
  Bettencourt C, Forabosco P, Wiethoff S, Heidari M, Johnstone DM, Botía JA, Collingwood JF, Hardy J, Milward EA, Ryten M, Houlden H> ;Neurobiol. Dis.. 2016-03-01
• 35 citations
  Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk
  Timothy J. Hohman, Jessica N. Cooke-Bailey, Christiane Reitz, Gyungah Jun, Adam C. Naj, Gary W. Beecham, Zhi Liu, Regina M. Carney, Jeffrey M. Vance, Michael L. Cuccar...> ;Alzheimer's & Dementia. 2016 Mar 1
• Erratum to: Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay.
  Heywood WE, Galimberti D, Bliss E, Sirka E, Paterson RW, Magdalinou NK, Carecchio M, Reid E, Heslegrave A, Fenoglio C, Scarpini E, Schott JM, Fox NC, Hardy J, Bhatia K...> ;Mol Neurodegener. 2016-02-23
• Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients.
  Guven G, Lohmann E, Bras J, Gibbs JR, Gurvit H, Bilgic B, Hanagasi H, Rizzu P, Heutink P, Emre M, Erginel-Unaltuna N, Just W, Hardy J, Singleton A, Guerreiro R> ;PLoS ONE. 2016-01-01
• The importance of understanding individual differences in Down syndrome.
  Karmiloff-Smith A, Al-Janabi T, D'Souza H, Groet J, Massand E, Mok K, Startin C, Fisher E, Hardy J, Nizetic D, Tybulewicz V, Strydom A> ;F1000Res. 2016-01-01
• Analysis of the genetic variability in Parkinson's disease from Southern Spain.
  Bandrés-Ciga S, Mencacci NE, Durán R, Barrero FJ, Escamilla-Sevilla F, Morgan S, Hehir J, Vives F, Hardy J, Pittman AM> ;Neurobiol. Aging. 2016-01-01
• Is the MC1R variant p.R160W associated with Parkinson's?
  Lubbe SJ, Escott-Price V, Brice A, Gasser T, Hardy J, Heutink P, Sharma M, Wood NW, Nalls M, Singleton AB, Williams NM, Morris HR> ;Ann. Neurol.. 2016-01-01
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