JohnBLiaoMDPhD

Gynecologic Oncology

Associate Professor, Obstetrics & Gynecology, University of Washington School of Medicine, Fred Hutchinson Cancer Center

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Office
1959 NE Pacific St
Seattle, WA 98195
Phone+1 206-598-8300

Fax+1 206-598-6963
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Education & Training

University of Pennsylvania Health SystemFellowship, Gynecologic Oncology, 2007 - 2010
Yale UniversityPhD, Investigative Medicine, 2007
Yale School of MedicinePost-Doctoral Fellowship, Molecular Oncology and Virology, 2002 - 2004
George Washington UniversityResidency, Obstetrics and Gynecology, 1998 - 2002
George Washington University School of Medicine and Health SciencesClass of 1998, MD
Yale UniversityBA, Molecular Biophysics and Biochemistry, 1994

Certifications & Licensure

WA State Medical License 2010 - 2025
CT State Medical License 2002 - 2010
PA State Medical License 2007 - 2010
VA State Medical License 1998 - 2002
American Board of Obstetrics and Gynecology Obstetrics & Gynecology
American Board of Obstetrics and Gynecology Gynecologic Oncology

Clinical Trials

Pembrolizumab and Carboplatin in Treating Patients With Relapsed or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Start of enrollment: 2017 Mar 14
Completed
Phase 1, Phase 2
A Study of DSP-7888 Dosing Emulsion in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Solid Tumors Start of enrollment: 2017 Dec 14
Completed
Phase 1, Phase 2
Study of HPN536 in Patients With Advanced Cancers Associated With Mesothelin Expression Start of enrollment: 2019 Apr 16
Completed
Phase 1, Phase 2
Modified Immune Cells (Autologous CAR T Cells) in Treating Patients With Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer Start of enrollment: 2019 Apr 30
Recruiting
Phase 1
Study With Afuresertib and Paclitaxel in Platinum Resistant Ovarian Start of enrollment: 2020 Jun 09
Active, not recruiting
Phase 2
Pembrolizumab and Carboplatin for the Treatment of Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Start of enrollment: 2021 Mar 18
Recruiting
Phase 2
A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors Start of enrollment: 2020 Aug 18
Active, not recruiting
Phase 2
Oral AMXT 1501 Dicaprate in Combination With IV DFMO Start of enrollment: 2022 Nov 29
Recruiting
Phase 1, Phase 2
Adjuvant Therapeutic Cancer Vaccine (AST-201, pUMVC3-hIGFBP-2) in Patients With Advanced Ovarian Cancer Start of enrollment: 2023 Nov 15
Not yet recruiting
Phase 2
AB-1015, an Integrated Circuit T (ICT) Cell Therapy in Patients With Platinum Resistant Epithelial Ovarian Cancer Start of enrollment: 2022 Nov 29
Recruiting
Phase 1
A Study of NX-1607 in Adults With Advanced Malignancies Start of enrollment: 2021 Sep 29
Recruiting
Phase 1
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Publications & Presentations

PubMed

5 citations
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer.
Mary L Disis, Sarah F Adams, Jyoti Bajpai, Marcus O Butler, Tyler Curiel, Shelley A Dodt, Laura Doherty, Leisha A Emens, Claire F Friedman, Margaret Gatti-Mays, Meliss...> ;Journal for Immunotherapy of Cancer. 2023 Jun 1
Timing and duration of bevacizumab treatment and survival in patients with recurrent ovarian, fallopian tube, and peritoneal cancer: a multi-institution study.
Talayeh S Ghezelayagh, Emily S Wu, Emma L Barber, Minh D Dao, Emese Zsiros, Renata R Urban, Heidi J Gray, Barbara A Goff, Chirag A Shah, Nikki L Neubauer, James Y Dai,...> ;European Journal of Gynaecological Oncology. 2023 Feb 1
6 citations
Immunization with a Plasmid DNA Vaccine Encoding the N-Terminus of Insulin-like Growth Factor Binding Protein-2 in Advanced Ovarian Cancer Leads to High-level Type I I...
Denise L. Cecil, John B. Liao, Yushe Dang, Andrew L. Coveler, Angela Shaulov Kask, Yi Yang, Jennifer Childs, Doreen Higgins, Mary L. Disis> ;Clinical Cancer Research. 2021 Sep 15
8 citations
Pembrolizumab with low-dose carboplatin for recurrent platinum-resistant ovarian, fallopian tube, and primary peritoneal cancer: survival and immune correlates
John B. Liao, William R. Gwin, Renata R. Urban, Katie M. Hitchcock-Bernhardt, Andrew L. Coveler, Doreen Higgins, Jennifer Childs, Hania Shakalia, Ron E. Swensen, Sasha...> ;Journal for Immunotherapy of Cancer. 2021 Sep 1
17 citations
Elevated tumor mutational burden and prolonged clinical response to anti-PD-L1 antibody in platinum-resistant recurrent ovarian cancer.
Christopher B. Morse, Julia A. Elvin, John B. Liao> ;Gynecologic Oncology Reports. 2017 Jun 27
20 citations
Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer
John B. Liao, Kelsie J Ovenell, Erin E M Curtis, Denise L. Cecil, Marlese Koehnlein, Lauren Rastetter, Ekram Gad, Mary L. Disis> ;Journal for Immunotherapy of Cancer. 2015 May 19
34 citations
Tumor infiltrating lymphocytes and homologous recombination deficiency are independently associated with improved survival in ovarian carcinoma.
Christopher B. Morse, Mirna N. Toukatly, Mark R. Kilgore, Kathy Agnew, Sarah S. Bernards, Barbara M. Norquist, Kathryn P. Pennington, Rochelle L. Garcia, John B. Liao,...> ;Gynecologic Oncology. 2019 May 1
19 citations
Gynecologic cancers and solid organ transplantation.
John B. Liao, Cynthia E. Fisher, Margaret M. Madeleine> ;American Journal of Transplantation. 2019 May 1
8 citations
Novel Therapeutics for Ovarian Cancer: The 11th Biennial Rivkin Center Ovarian Cancer Research Symposium.
Neil Johnson, John B. Liao> ;International Journal of Gynecological Cancer. 2017 Nov 1
29 citations
Combining a symptom index, CA125 and HE4 (triple screen) to detect ovarian cancer in women with a pelvic mass.
Barbara A. Goff, Kathy Agnew, Moni Blazej Neradilek, Heidi J. Gray, John B. Liao, Renata R. Urban> ;Gynecologic Oncology. 2017 Nov 1
84 citations
Surgical and oncologic outcomes after robotic radical hysterectomy as compared to open radical hysterectomy in the treatment of early cervical cancer.
Chirag A. Shah, Tiffany L. Beck, John B. Liao, Nadia V. Giannakopoulos, Dan S. Veljovich, Pam Paley> ;Journal of Gynecologic Oncology. 2017 Jul 3
13 citations
Phase II trial of albumin-bound paclitaxel and granulocyte macrophage colony-stimulating factor as an immune modulator in recurrent platinum resistant ovarian cancer.
John B. Liao, Ron E. Swensen, Kelsie J Ovenell, Katie M. Hitchcock-Bernhardt, Jessica Reichow, Minjun C. Apodaca, Leonard A D'Amico, Jennifer Childs, Doreen Higgins, B...> ;Gynecologic Oncology. 2017 Mar 1
10 citations
Immunotherapy for gynecologic cancers
John B. Liao> ;Gynecologic Oncology. 2016 Jul 1
8 citations
Bevacizumab toxicity in heavily pretreated recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancers
J.Y. Martin, Renata R. Urban, John B. Liao, Barbara A. Goff> ;Journal of Gynecologic Oncology. 2016 May 3
15 citations
Route of hysterectomy and surgical outcomes from a statewide gynecologic oncology population: is there a role for vaginal hysterectomy?
Tiffany L. Beck, Christopher B. Morse, Heidi J. Gray, Barbara A. Goff, Renata R. Urban, John B. Liao> ;American Journal of Obstetrics and Gynecology. 2016 Mar 1
28 citations
Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms: Clinical correlates.
John B. Liao, Yuen Yee Yip, Elizabeth M. Swisher, Kathy Agnew, Karl Erik Hellström, Ingegerd Hellström> ;Gynecologic Oncology. 2015 Jun 1
9 citations
Recurrence patterns after extended treatment with bevacizumab for ovarian, fallopian tube, and primary peritoneal cancers.
Minh D. Dao, Laura M. Alwan, Heidi J. Gray, Hisham K. Tamimi, Barbara A. Goff, John B. Liao> ;Gynecologic Oncology. 2013 Aug 1
17 citations
Therapeutic vaccines for ovarian cancer.
John B. Liao, Mary L. Disis> ;Gynecologic Oncology. 2013 Sep 1
34 citations
Clinical predictors of bevacizumab-associated gastrointestinal perforation
Janos L. Tanyi, Georgia McCann, A.R. Hagemann, George Coukos, Stephen C. Rubin, John B. Liao, Christina S. Chu> ;Gynecologic Oncology. 2011 Mar 1
19 citations
Vaginal intraepithelial neoplasia (VAIN) after radiation therapy for gynecologic malignancies: A clinically recalcitrant entity
John B. Liao, Stephanie Jean, Ivy Wilkinson-Ryan, Ashley E. Ford, Janos L. Tanyi, A.R. Hagemann, Lilie L. Lin, Cindy McGrath, Stephen C. Rubin> ;Gynecologic Oncology. 2011 Jan 1
26 citations
The emergence of immunomodulation: Combinatorial immunochemotherapy opportunities for the next decade
Lana E. Kandalaft, Nathan Singh, John B. Liao, Andrea Facciabene, Jonathan S. Berek, Daniel J. Powell, George Coukos> ;Gynecologic Oncology. 2010 Feb 1
40 citations
Vaginal cuff dehiscence after robotic total laparoscopic hysterectomy.
Barbara L. Robinson, John B. Liao, Sarah Adams, Thomas C. Randall> ;Obstetrics and Gynecology. 2009 Aug 1
24 citations
Single-Dose, Therapeutic Vaccination of Mice with Vesicular Stomatitis Virus Expressing Human Papillomavirus Type 16 E7 Protein
John B. Liao, Jean Publicover, John K. Rose, Daniel DiMaio> ;Clinical and Vaccine Immunology. 2008 May 1
52 citations
Viruses and human cancer.
John B. Liao> ;The Yale Journal of Biology and Medicine. 2006 Dec 1
42 citations
Human papillomaviruses and cervical cancer.
Daniel DiMaio, John B. Liao> ;Advances in Virus Research. 2006 Jan 1
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Lectures

Pembrolizumab with low dose carboplatin for recurrent platinum resistant ovarian, fallopian tube, and primary peritoneal cancer-interim results.
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

SCCA’s Immunotherapy Leaders Featured at the American Society of Clinical Oncology (ASCO) Annual MeetingMay 31st, 2018
Weekly Quick Hits (BioHealth Capital Region) – Week of June 5, 2023June 10th, 2023