JohnDouglasMcCarterMD

PubMed

• 16 citations
  Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-...
  Felix Gonzalez-Lopez de Turiso, Xiaolin Hao, Youngsook Shin, Minna Bui, Iain D. G. Campuzano, Mario G. Cardozo, Michelle C. Dunn, Jason Duquette, Benjamin Fisher, Robe...> ;Journal of Medicinal Chemistry. 2016 Jul 25
• 35 citations
  High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors A Complete Workflow
  Iain D. G. Campuzano, Tisha San Miguel, Todd Rowe, Daniel Onea, Victor J. Cee, Tara Arvedson, John D. McCarter> ;Journal of Biomolecular Screening. 2016 Feb 1
• 24 citations
  Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
  Youngsook Shin, Julia Suchomel, Mario G. Cardozo, Jason Duquette, Xiao He, Kirk Henne, Yi-Ling Hu, Ron C. Kelly, John McCarter, Lawrence R. McGee, Julio C. Medina, Dan...> ;Journal of Medicinal Chemistry. 2016 Jan 14
• Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution.
  Cee, V. J.,Volak, L. P.,Chen, Y.,Bartberger, M. D.,Tegley, C.,Arvedson, T.,McCarter, J.,Tasker, A. S.,Fotsch, C.> ;J. Med. Chem.. 2015 Nov 19
• 15 citations
  The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.
  Markian Stec, Kristin L. Andrews, Yunxin Bo, Sean Caenepeel, Hongyu Liao, John D. McCarter, Erin L. Mullady, Tisha San Miguel, Raju Subramanian, Nuria A. Tamayo, Dougl...> ;Bioorganic & Medicinal Chemistry Letters. 2015 Oct 1
• 15 citations
  Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
  Minna Bui, Xiaolin Hao, Youngsook Shin, Mario G. Cardozo, Xiao He, Kirk Henne, Julia Suchomel, John D. McCarter, Lawrence R. McGee, Tisha San Miguel, Julio C. Medina, ...> ;Bioorganic & Medicinal Chemistry Letters. 2015 Mar 1
• 69 citations
  Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and...
  Timothy D. Cushing, Xiaolin Hao, Youngsook Shin, Kristin L. Andrews, Matthew Frank Brown, Mario G. Cardozo, Yi Chen, Jason Duquette, Ben Fisher, Felix Gonzalez-Lopez d...> ;Journal of Medicinal Chemistry. 2015 Jan 8
• 3 citations
  Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
  Brian A. Lanman, Anthony B. Reed, Victor J. Cee, Fang-Tsao Hong, Liping H. Pettus, Ryan Wurz, Kristin L. Andrews, Jian Jiang, John D. McCarter, Erin L. Mullady, Tisha ...> ;Bioorganic & Medicinal Chemistry Letters. 2014 Dec 15
• 10 citations
  Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
  Jian J. Chen, Wenyuan Qian, Kaustav Biswas, Chester Chenguang Yuan, Albert Amegadzie, Qingyian Liu, Thomas Nixey, Joe Zhu, Mqhele Ncube, Robert M. Rzasa, Frank Chavez,...> ;Bioorganic & Medicinal Chemistry Letters. 2013 Dec 1
• 2 citations
  Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay.
  Ada Chen, Xiaoning Zhao, Laina Mercer, Cheng Su, Leeanne Zalameda, Yichin Liu, Amanda Lembke, Heather Eastwood, Son Dang, Thim Oung, Xiaoyang Xia, Stephen W. Young, Sh...> ;Combinatorial Chemistry & High Throughput Screening. 2013 Aug 31
• 15 citations
  Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
  Ryan Wurz, Longbin Liu, Kevin Yang, Nobuko Nishimura, Yunxin Bo, Liping H. Pettus, Sean Caenepeel, Daniel J. Freeman, John D. McCarter, Erin L. Mullady, Tisha San Migu...> ;Bioorganic & Medicinal Chemistry Letters. 2012 Sep 1
• 33 citations
  Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
  Mark H. Norman, Kristin L. Andrews, Yunxin Y. Bo, Shon Booker, Sean Caenepeel, Victor J. Cee, Noel D'angelo, Daniel J. Freeman, Bradley J. Herberich, Fang-Tsao Hong, C...> ;Journal of Medicinal Chemistry. 2012 Aug 30
• 29 citations
  Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Journal of Medicinal Chemistry. 2012 May 23
• 86 citations
  Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
  David Park Meininger, Leeanne Zalameda, Yichin Liu, Lara P. Stepan, Luis Borges, John D. McCarter, Claire L. Sutherland> ;Biochimica Et Biophysica Acta. 2011 Dec 1
• 15 citations
  Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides
  Seung Seo Lee, Ian R. Greig, David J. Vocadlo, John D. McCarter, Brian O. Patrick, Stephen G. Withers> ;Journal of the American Chemical Society. 2011 Sep 19
• 91 citations
  STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells
  Carol Babij, Yihong Zhang, Robert J.M. Kurzeja, Anke Munzli, Amro Shehabeldin, Manory Fernando, Kim Quon, Paul D. Kassner, Astrid Ruefli-Brasse, Vivienne J. Watson, Fl...> ;Cancer Research. 2011 Sep 1
• 31 citations
  Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles t...
  Markian Stec, Kristin L. Andrews, Shon Booker, Sean Caenepeel, Daniel J. Freeman, Jian Jiang, Hongyu Liao, John McCarter, Erin L. Mullady, Tisha San Miguel, Raju Subra...> ;Journal of Medicinal Chemistry. 2011 Jun 29
• 43 citations
  Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and qui...
  Nobuko Nishimura, Aaron C. Siegmund, Longbin Liu, Kevin Yang, Marian C. Bryan, Kristin L. Andrews, Yunxin Bo, Shon Booker, Sean Caenepeel, Daniel J. Freeman, Hongyu Li...> ;Journal of Medicinal Chemistry. 2011 Jun 20
• 73 citations
  Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors
  Noel D'angelo, Tae-Seong Kim, Kristin L. Andrews, Shon Booker, Sean Caenepeel, Kui Chen, Derin C. D'amico, Daniel J. Freeman, Jian Jiang, Longbin Liu, John D. McCarter...> ;Journal of Medicinal Chemistry. 2011 Feb 18
• 1 citations
  Editorial [Hot topic: Label-free detection technologies (Guest editor: John D. McCarter)].
  John D. McCarter> ;Combinatorial Chemistry & High Throughput Screening. 2009 Aug 31
• 25 citations
  Inhibitors of the Lipid Phosphatase SHIP2 Discovered by High Throughput Affinity Selection-Mass Spectrometry Screening of Combinatorial Libraries
  D. Allen Annis, Cliff C. Cheng, Cheng-Chi Chuang, John D. McCarter, Huw M. Nash, Naim Nazef, Todd Rowe, Robert J.M. Kurzeja, Gerald W. Shipps> ;Combinatorial Chemistry & High Throughput Screening. 2009 Aug 31
• 42 citations
  High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay.
  Yichin Liu, Raphaele Gerber, John Wu, Trace Tsuruda, John D. McCarter> ;Analytical Biochemistry. 2008 Jul 1
• 18 citations
  Synthesis and Testing of 2-Deoxy-2,2-Dihaloglycosides as Mechanism-Based Inhibitors of α-Glycosidases
  Ran Zhang, John D. McCarter, Curtis Braun, Wai Yeung, Gary D. Brayer, Stephen G. Withers> ;The Journal of Organic Chemistry. 2008 Mar 18
• 14 citations
  Discovery of Acetyl-Coenzyme A Carboxylase 2 Inhibitors: Comparison of a Fluorescence Intensity-Based Phosphate Assay and a Fluorescence Polarization-Based ADP Assay f...
  Yichin Liu, Leeanne Zalameda, Ki Won Kim, Minghan Wang, John D. McCarter> ;Assay and Drug Development Technologies. 2007 May 3
• 27 citations
  Keto-1,3,4-oxadiazoles as cathepsin K inhibitors.
  James T. Palmer, Hirschbein Bernard L, Harry Cheung, John McCarter, James W. Janc, Z. Walter Yu, Gregg Wesolowski> ;Bioorganic & Medicinal Chemistry Letters. 2006 Jun 1
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