JohnCharlesMorrisMD

Professor of Medicine, Co-Director, Comprehensive Lung Cancer Center, Associate Director, UCCI Translational Research and Director, Experimental Therapeutics

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Office
234 Goodman Street
Hematology/Oncology
Cincinnati, OH 45219
Phone+1 513-475-8500

Fax+1 513-584-4281
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Education & Training

NIH Clinical Center1995 - 1999
Icahn School of Medicine at Mount SinaiFellowship, Hematology and Medical Oncology, 1986 - 1988
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalChief Residency, Internal Medicine, 1985 - 1986
Icahn School of Medicine at Mount Sinai/Mount Sinai HospitalResidency, Internal Medicine, 1982 - 1985
SUNY Upstate Medical UniversityClass of 1982

Certifications & Licensure

NY State Medical License 1983 - 2024
OH State Medical License 2010 - 2022
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012

Clinical Trials

Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Start of enrollment: 2008 Aug 08
Active, not recruiting
Phase 3
Corticolimbic Degeneration and Treatment of Dementia Start of enrollment: 2004 Nov 01
Completed
Phase 4
S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery Start of enrollment: 2011 Apr 01
Active, not recruiting
Phase 3
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
Active, not recruiting
Phase 3
S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer Start of enrollment: 2012 Feb 01
Completed
Phase 2
S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer Start of enrollment: 2013 Sep 12
Active, not recruiting
Phase 3
Safety, Efficacy and Pharmacokinetic Study of PRLX 93936 in Patients With Multiple Myeloma Start of enrollment: 2012 Mar 01
Unknown status
Phase 1, Phase 2
Immunotherapy Study in Progressive or Relapsed Non-Small Cell Lung Cancer Start of enrollment: 2013 Feb 01
Terminated
Phase 2, Phase 3
Chemotherapy Plus Cetuximab in Combination With VTX-2337 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Start of enrollment: 2013 Oct 14
Completed
Phase 2
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer Start of enrollment: 2013 Oct 22
Active, not recruiting
Phase 1, Phase 2
Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches Start of enrollment: 2014 Nov 01
Completed
Phase 2
Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Sep 01
Completed
Phase 2, Phase 3
Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers Start of enrollment: 2015 Dec 29
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

2 citations
A Phase I Study of the Non-Receptor Kinase Inhibitor Bosutinib in Combination with Pemetrexed in Patients with Selected Metastatic Solid Tumors.
Nagla Abdel Karim, Asad Ullah, Hongkun Wang, Mahran Shoukier, Steven Pulliam, Ahmed Khaled, Nikhil Patel, John C Morris> ;Current Oncology. 2022 Dec 3
Does Molecular Profiling of-Mutant Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Help in Treatment Strategy Planning?
Nagla Abdel Karim, Asad Ullah, Peterson Pathrose, Hassana Fathallah, Ashley Perry, John C Morris, Jiang Wang, Sandra L Starnes> ;Current Oncology. 2022 Jul 7
7 citations
Regional age-related atrophy after screening for preclinical alzheimer disease.
Lauren N. Koenig, Pamela LaMontagne, Matthew F. Glasser, Randall J. Bateman, David M. Holtzman, Igor Yakushev, Jasmeer P. Chhatwal, Gregory S. Day, Clifford R. Jack, C...> ;Neurobiology of Aging. 2022 Jan 1
29 citations
A deep learning framework identifies dimensional representations of Alzheimer's Disease from brain structure.
Zhijian Yang, Ilya M. Nasrallah, Haochang Shou, Junhao Wen, Jimit Doshi, Mohamad Habes, Guray Erus, Ahmed Abdulkadir, Susan M. Resnick, Marilyn S. Albert, Paul Maruff,...> ;Nature Communications. 2021 Dec 3
3 citations
Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease
Virginia Buckles, Chengjie Xiong, Randall J. Bateman, Jason Hassenstab, Ricardo F. Allegri, Sarah B. Berman, Jasmeer P. Chhatwal, Adrian Danek, Anne M. Fagan, Bernardi...> ;Alzheimer's & Dementia. 2021 Dec 2
8 citations
Incidence of Clinically Relevant Thyroid Cancers Remains Stable for Almost a Century: A Population-Based Study
Natalia Genere, Omar M. El Kawkgi, Rachel Giblon, Salvatore Vaccarella, John C. Morris, Ian D. Hay, Juan P. Brito> ;Mayo Clinic Proceedings. 2021 Nov 1
4 citations
Validation of AD8-Philippines (AD8-P): A Brief Informant-Based Questionnaire for Dementia Screening in the Philippines.
Jacqueline Dominguez, Ma. Fe De Guzman, Ma. Lourdes C. Joson, Krizelle Cleo Fowler, Boots P. Natividad, Precy S Cruz, Jose Leo Vista Jiloca, Primitivo B Mactal, Jayvee...> ;International Journal of Alzheimer's Disease. 2021 Oct 31
2 citations
Outcomes and Patterns of Recurrence for Anaplastic Thyroid Cancer Treated With Comprehensive Chemoradiotherapy.
R.W. Gao, Robert L. Foote, Yolanda I. Garces, Daniel J. Ma, Michelle A. Neben-Wittich, David M. Routman, Samir H. Patel, Stephen J. Ko, Lisa A. McGee, Keith C. Bible, ...> ;Practical Radiation Oncology. 2021 Oct 26
47 citations
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer’s disease
Brendan P. Lucey, Julie K. Wisch, Anna H. Boerwinkle, Eric C. Landsness, Cristina D. Toedebusch, Jennifer S. McLeland, Omar Butt, Jason Hassenstab, John C. Morris, Bea...> ;Brain. 2021 Oct 22
32 citations
Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal ...
Alexa Pichet Binette, Etienne Vachon-Presseau, John C. Morris, Randall J. Bateman, Tammie L.S. Benzinger, D. Louis Collins, Judes Poirier, John C.S. Breitner, Sylvia V...> ;Biological Psychiatry. 2021 Apr 15
52 citations
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease.
Michael Ewers, Ying Luan, Lukas Frontzkowski, Julia Neitzel, Anna Rubinski, Martin Dichgans, Jason Hassenstab, Brian A. Gordon, Jasmeer P. Chhatwal, Johannes Levin, Pe...> ;Brain. 2021 Mar 16
10 citations
Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation.
Pratishtha Chatterjee, Michelle Tegg, Steve Pedrini, Anne M. Fagan, Chengjie Xiong, Abhay K. Singh, Kevin Taddei, Samantha L. Gardener, Colin L. Masters, Peter R. Scho...> ;International Journal of Molecular Sciences. 2021 Mar 13
8 citations
Spatially constrained kinetic modeling with dual reference tissues improves 18F-flortaucipir PET in studies of Alzheimer disease
Yun Zhou, Shaney Flores, Syahir Mansor, Russ C. Hornbeck, Zhude Tu, Joel S. Perlmutter, Beau M. Ances, John C. Morris, Robert J. Gropler, Tammie L.S. Benzinger> ;European Journal of Nuclear Medicine and Molecular Imaging. 2021 Feb 18
150 citations
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
Ruth Chia, Marya S. Sabir, Sara Bandres-Ciga, Sara Saez-Atienzar, Regina H. Reynolds, Emil K. Gustavsson, Ronald L. Walton, Samreen Ahmed, Coralie Viollet, Jinhui Ding...> ;Nature Genetics. 2021 Feb 15
7 citations
Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25.
Omar Butt, Justin M. Long, Rachel L. Henson, Elizabeth M. Herries, Courtney L. Sutphen, Anne M. Fagan, Carlos Cruchaga, Jack H. Ladenson, David M. Holtzman, John C. Mo...> ;Neurobiology of Aging. 2021 Feb 11
3 citations
The ideological divide in confidence in science and participation in medical research.
Matthew Gabel, Jonathan Gooblar, Catherine M. Roe, John C. Morris> ;Scientific Reports. 2021 Feb 4
19 citations
Possible Consequences of the Approval of a Disease-Modifying Therapy for Alzheimer Disease.
Erik S. Musiek, John C. Morris> ;JAMA Neurology. 2021 Feb 1
37 citations
Socioeconomic Status Mediates Racial Differences Seen Using the AT(N) Framework.
Karin L. Meeker, Julie K. Wisch, Darrell Hudson, Dean W. Coble, Chengjie Xiong, Ganesh M. Babulal, Brian A. Gordon, Suzanne E. Schindler, Carlos Cruchaga, Shaney Flore...> ;Annals of Neurology. 2021 Feb 1
7 citations
Cerebrospinal fluid Aβ42 moderates the relationship between brain functional network dynamics and cognitive intraindividual variability
Karin L. Meeker, Beau M. Ances, Brian A. Gordon, Cort W. Rudolph, Patrick Luckett, David A. Balota, John C. Morris, Anne M. Fagan, Tammie L.S. Benzinger, Jill D. Waring> ;Neurobiology of Aging. 2021 Feb 1
50 citations
The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monté-Rubio, Mercè Boada, Agustín Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Düzel, Octavio Rodríguez Gómez, Tammi...> ;Molecular Psychiatry. 2021 Feb 1
11 citations
Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease.
Nelly Joseph-Mathurin, Guoqiao Wang, Kejal Kantarci, Clifford R. Jack, Eric McDade, Jason Hassenstab, Tyler Blazey, Brian A. Gordon, Yi Su, Gengsheng Chen, Parinaz Mas...> ;Neurology. 2021 Jan 25
15 citations
Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults.
Daniel S. Albrecht, Abhay P. Sagare, Maricarmen Pachicano, Melanie D. Sweeney, Arthur W. Toga, Berislav V. Zlokovic, Helena C. Chui, Elizabeth Joe, Lon S. Schneider, J...> ;Brain, Behavior, and Immunity. 2021 Jan 22
12 citations
Modeling autosomal dominant Alzheimer's disease with machine learning
Patrick Luckett, Austin A. McCullough, Brian A. Gordon, Jeremy F. Strain, Shaney Flores, Aylin Dincer, John E. McCarthy, Todd A. Kuffner, Ari Stern, Karin L. Meeker, S...> ;Alzheimer's & Dementia. 2021 Jan 21
14 citations
Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease
Robert X. Smith, Jeremy F. Strain, Aaron Tanenbaum, Anne M. Fagan, Jason Hassenstab, Eric McDade, Suzanne E. Schindler, Brian A. Gordon, Chengjie Xiong, Jasmeer P. Chh...> ;Brain Connectivity. 2021 Apr 13
10 citations
Lack of association between acute stroke, post-stroke dementia, race, and β-amyloid status.
Lauren N. Koenig, Lena McCue, Elizabeth A. Grant, Parinaz Massoumzadeh, Catherine M. Roe, Chengjie Xiong, Krista L. Moulder, Liang Wang, Allyson R. Zazulia, Peggy Kell...> ;Neuroimage. Clinical. 2021 Jan 5
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Press Mentions

A Progress Report: Expanding Palliative Care with Project ECHOFebruary 19th, 2019
More Non-Smokers Being Diagnosed with Lung CancerNovember 9th, 2018
Recent Studies Unveil Clues to Using Immunotherapy as Cancer TreatmentJuly 3rd, 2018
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