JohnJO'SheaMD

PubMed

• 7 citations
  MicroRNA-directed pathway discovery elucidates an miR-221/222-mediated regulatory circuit in class switch recombination.
  Eric J. Wigton, Yohei Mikami, Ryan J. McMonigle, Carlos A. Castellanos, Adam K. Wade-Vallance, Simon K. Zhou, Robin Kageyama, Adam J. Litterman, Suparna Roy, Daisuke K...> ;The Journal of Experimental Medicine. 2021 Nov 1
• 11 citations
  PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
  Jennifer L. Cannons, Alejandro V. Villarino, Senta M. Kapnick, Silvia Preite, Han-Yu Shih, Julio Gomez-Rodriguez, Zenia Kaul, Hirofumi Shibata, Julie Reilley, Bonnie H...> ;Cell Reports. 2021 Oct 12
• 8 citations
  Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin.
  Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Akiharu Kubo, K. Isami, Yohei Mikami, Miho Mukai, Takashi Sasaki, Jun Yamagami, Jun Kudoh, Hiromi Ito, Aki Kamata, Yuta...> ;Science Immunology. 2021 Oct 8
• 43 citations
  JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition.
  Yiming Luo, Madison Alexander, Massimo Gadina, John J. O'Shea, Françoise Meylan, Daniella M. Schwartz> ;The Journal of Allergy and Clinical Immunology. 2021 Oct 1
• 5 citations
  Cutting Edge: Steroid Responsiveness in Foxp3+ Regulatory T Cells Determines Steroid Sensitivity during Allergic Airway Inflammation in Mice.
  Quang Tam Nguyen, Dongkyun Kim, Supinya Iamsawat, Hongnga T. Le, Sohee Kim, Kevin T Qiu, Terry D. Hinds, Peter Bazeley, John J. O'Shea, Jaehyuk Choi, Kewal Asosingh, S...> ;Journal of Immunology. 2021 Jul 23
• 34 citations
  A Decade of Jakinibs: what have we learned and what may be the future.
  Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O'Shea> ;Arthritis & Rheumatology. 2021 Jun 27
• 87 citations
  Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus
  Sarfaraz Hasni, Sarthak Gupta, Michael Davis, Elaine Poncio, Yenealem Temesgen-Oyelakin, Philip M. Carlucci, Xinghao Wang, Mohammad Naqi, Martin P. Playford, Rishi R. ...> ;Nature Communications. 2021 Jun 7
• 5 citations
  Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory.
  Tasha A. Morrison, William H. Hudson, Danielle A. Chisolm, Yuka Kanno, Han-Yu Shih, Rafi Ahmed, Jorge Henao-Mejia, Markus Hafner, John J. O'Shea> ;Cold Spring Harbor Perspectives in Biology. 2021 May 17
• 42 citations
  JAK inhibitors: Ten years after.
  Francesca Romana Spinelli, Françoise Meylan, John J. O'Shea, Massimo Gadina> ;European Journal of Immunology. 2021 Apr 30
• Immunology Lessons from the SARS-CoV-2 Pandemic.
  Wayne M. Yokoyama, Kristin A. Hogquist, John J. O'Shea> ;Annual Review of Immunology. 2021 Apr 26
• 8 citations
  Multi-Dimensional Gene Regulation in Innate and Adaptive Lymphocytes: A View From Regulomes.
  Nilisha Fernando, Giuseppe Sciumè, John J. O'Shea, Han-Yu Shih> ;Frontiers in Immunology. 2021 Mar 25
• 28 citations
  MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23
  Yohei Mikami, Rachael L. Philips, Giuseppe Sciumè, Franziska Petermann, Françoise Meylan, Hiroyuki Nagashima, Chen Yao, Fred P. Davis, Stephen R. Brooks, Hong-Wei Sun,...> ;Immunity. 2021 Mar 9
• Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells.
  Chen Yao, Guohua Lou, Hong-Wei Sun, Ziang Zhu, Yi Sun, Zeyu Chen, Daniel Chauss, E. Ashley Moseman, Jun Cheng, Marc A. D’Antonio, Wangke Shi, Junwei Shi, Kohei Kometan...> ;Nature Immunology. 2021 Mar 3
• 11 citations
  Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma.
  Raud Razzaghi, Shreya Agarwal, Nikita Kotlov, Olga Plotnikova, Krystle Nomie, Da-Wei Huang, George E. Wright, Grace Smith, Moyi Li, Katsuyoshi Takata, Maryam Yamadi, C...> ;The Journal of Experimental Medicine. 2021 Mar 1
• 58 citations
  BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells.
  Chen Yao, Guohua Lou, Hong-Wei Sun, Ziang Zhu, Yi Sun, Zeyu Chen, Daniel Chauss, E. Ashley Moseman, Jun Cheng, Marc A. D’Antonio, Wangke Shi, Junwei Shi, Kohei Kometan...> ;Nature Immunology. 2021 Feb 11
• 23 citations
  Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells.
  Gabriela M. Wiedemann, Simon Grassmann, Colleen M. Lau, Moritz Rapp, Alejandro V. Villarino, Christin Friedrich, Georg Gasteiger, John J. O'Shea, Joseph C. Sun> ;Cell Reports. 2020 Dec 15
• 35 citations
  Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells.
  Giuseppe Sciumè, Yohei Mikami, Dragana Jankovic, Hiroyuki Nagashima, Alejandro V. Villarino, Tasha A. Morrison, Chen Yao, Sadie Signorella, Hong-Wei Sun, Stephen R. Br...> ;Immunity. 2020 Oct 13
• 48 citations
  SnapShot: Jak-STAT Signaling II.
  Alejandro V. Villarino, Massimo Gadina, John J. O'Shea, Yuka Kanno> ;Cell. 2020 Jun 25
• 38 citations
  Translating JAKs to Jakinibs.
  Massimo Gadina, Danielle A. Chisolm, Rachael L. Philips, Iain B. McInness, Paul S. Changelian, John J. O'Shea> ;Journal of Immunology. 2020 Apr 15
• 30 citations
  Environmental arginine controls multinuclear giant cell metabolism and formation
  Julia S. Brunner, Loan Vulliard, Melanie Hofmann, Markus Kieler, Alexander Lercher, Andrea Vogel, Marion Russier, Johanna B. Brüggenthies, Martina Kerndl, Victoria Saf...> ;Nature Communications. 2020 Jan 22
• 6 citations
  JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis.
  Laura Vian, Mimi T. Le, Nathalia Gazaniga, Jacqueline Kieltyka, Christine Liu, Giuseppe Pietropaolo, Stefania Dell'Orso, Stephen R. Brooks, Yasuko Furumoto, Craig J. T...> ;Frontiers in Immunology. 2019 Dec 19
• 161 citations
  Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation
  Hiroyuki Nagashima, Tanel Mahlakõiv, Han-Yu Shih, Fred P. Davis, Françoise Meylan, Yuefeng Huang, Oliver J. Harrison, Chen Yao, Yohei Mikami, Joseph F. Urban, Kathleen...> ;Immunity. 2019 Oct 15
• Henry Metzger, M.D. (1932-2018), The American Association of Immunologists President, 1991-1992.
  DL Kastner, John J. O'Shea> ;Journal of Immunology. 2019 Oct 1
• 40 citations
  The Magnitude of IFN-γ Responses Is Fine-Tuned by DNA Architecture and the Non-coding Transcript of Ifng-as1
  Franziska Petermann, Aleksandra Pekowska, Catrina A. Johnson, Dragana Jankovic, Han-Yu Shih, Kan Jiang, William H. Hudson, Stephen R. Brooks, Hong-Wei Sun, Alejandro V...> ;Molecular Cell. 2019 Sep 19
• 73 citations
  Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells.
  Amber M. Papillion, Michael D. Powell, Danielle A. Chisolm, Holly Bachus, Michael J. Fuller, Amy S. Weinmann, Alejandro V. Villarino, John J. O'Shea, Beatriz León, Ken...> ;Science Immunology. 2019 Sep 13
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