J. CarterRalpheMD

Pediatric Cardiology • Madison, WI

Pediatric Cardiac Genetics

Associate Professor, Chief, Pediatric Cardiology

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Office
600 Highland Ave
H6/516G CSC
Madison, WI 53792
Phone+1 608-263-6420

Fax+1 608-263-0440
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Education & Training

University of Iowa Hospitals and ClinicsFellowship, Pediatric Cardiology, 2000 - 2003
University of Iowa Hospitals and ClinicsResidency, Pediatrics, 1997 - 2000
State University of New York Downstate Medical Center College of MedicineClass of 1997

Certifications & Licensure

IL State Medical License 2013 - 2026
MI State Medical License 2010 - 2026
WI State Medical License 2007 - 2025
IA State Medical License 1997 - 2016
PA State Medical License 2004 - 2008
American Board of Pediatrics Pediatric Cardiology

Publications & Presentations

PubMed

1 citations
Correction to: Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proo...
Ryan Pewowaruk, John Ralphe, Luke Lamers, Alejandro Roldán-Alzate> ;Cardiovascular Engineering and Technology. 2022 Feb 1
1 citations
Non-invasive MRI Derived Hemodynamic Simulation to Predict Successful vs. Unsuccessful Catheter Interventions for Branch Pulmonary Artery Stenosis: Proof-of-Concept an...
Ryan Pewowaruk, John Ralphe, Luke Lamers, Alejandro Roldán-Alzate> ;Cardiovascular Engineering and Technology. 2021 Oct 1
3 citations
Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model
Ryan Pewowaruk, Gregory P. Barton, Cody Johnson, J. Carter Ralphe, Christopher J. François, Luke Lamers, Alejandro Roldán-Alzate> ;Journal of Cardiovascular Magnetic Resonance. 2021 Feb 25
31 citations
Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology.
Willem J. de Lange, Emily T. Farrell, Caroline R Kreitzer, Derek R Jacobs, Di Lang, Alexey V. Glukhov, J. Carter Ralphe> ;American Journal of Physiology. Heart and Circulatory Physiology. 2021 Apr 1
10 citations
Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues.
Jake A. Melby, Willem J. de Lange, Jianhua Zhang, David S. Roberts, Stanford D. Mitchell, Trisha Tucholski, Gina Kim, Andreas Kyrvasilis, Sean J. McIlwain, Timothy J. ...> ;Journal of Proteome Research. 2021 Jan 4
4 citations
Pulmonary artery and lung parenchymal growth following early versus delayed stent interventions in a swine pulmonary artery stenosis model.
Ryan Pewowaruk, Joshua L. Hermsen, Cody Johnson, Alexandra A. Erdmann, Kevin A. Pettit, Scott W Aesif, J. Carter Ralphe, Christopher J. François, Alejandro Roldán-Alza...> ;Catheterization and Cardiovascular Interventions. 2020 Oct 16
51 citations
Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics.
Trisha Tucholski, Wenxuan Cai, Zachery R. Gregorich, Elizabeth F. Bayne, Stanford D. Mitchell, Sean J. McIlwain, Willem J. de Lange, Max Wrobbel, Hannah Karp, Zachary ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Oct 6
1 citations
Technical Performance Score Predicts Perioperative Outcomes in Complex Congenital Heart Surgery Performed in a Small-to-Medium-Volume Program.
Entela B. Lushaj, Heather L. Bartlett, Luke Lamers, Shannon Arndt, Joshua L. Hermsen, J. Carter Ralphe, Petros V. Anagnostopoulos> ;Pediatric Cardiology. 2020 Jan 1
44 citations
An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes
Wenxuan Cai, Jianhua Zhang, Willem J. de Lange, Zachery R. Gregorich, Hannah Karp, Emily T. Farrell, Stanford D. Mitchell, Trisha Tucholski, Ziqing Lin, Mitch Biermann...> ;Circulation Research. 2019 Nov 8
50 citations
Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells
Kai Chun Yang, Astrid Breitbart, Willem J. de Lange, Peter Hofsteen, Akiko Futakuchi-Tsuchida, Joy Xu, Cody Schopf, Maria V. Razumova, Alex Jiao, Robert J. Boucek, Lil...> ;JACC. Basic to Translational Science. 2018 Dec 31
3 citations
Novel Lipid Thresholds for Screening Predict the Need for Pharmacotherapy.
Amy Zawacki, Ann Dodge, Jens C. Eickhoff, Wendy Sun, Erin Marriott, J. Carter Ralphe, Amy L. Peterson> ;The Journal of Pediatrics. 2018 Nov 1
19 citations
In Pediatric Familial Hypercholesterolemia, Lipoprotein(a) Is More Predictive than LDL-C for Early Onset of Cardiovascular Disease in Family Members
Amy Zawacki, Ann Dodge, Kaitlin M. Woo, J. Carter Ralphe, Amy L. Peterson> ;Journal of Clinical Lipidology. 2018 Nov 1
18 citations
Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling
Emily F. Farrell, Annie E. Armstrong, Adrian C. Grimes, Francisco J. Naya, Willem J. de Lange, J. Carter Ralphe> ;Frontiers in Physiology. 2018 Oct 25
16 citations
The HCM-linked W792R mutation in cardiac myosin binding protein-C reduces C6 FnIII domain stability
Dan Smelter, Willem J. de Lange, Wenxuan Cai, J. Carter Ralphe> ;American Journal of Physiology. Heart and Circulatory Physiology. 2018 Feb 16
10 citations
Linking metabolic and contractile dysfunction in aged cardiac myocytes.
Gregory P. Barton, Willem J. de Lange, John C. Ralphe, Judd M. Aiken, Gary M. Diffee> ;Physiological Reports. 2017 Nov 1
15 citations
Increased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy
Emily T. Farrell, Adrian C. Grimes, Willem J. de Lange, Annie E. Armstrong, J. Carter Ralphe> ;Frontiers in Physiology. 2017 Jun 14
10 citations
Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes
Alison J. Kriegel, Melanie Gartz, Muhammad Afzal, Willem J. de Lange, J. Carter Ralphe, Jennifer L. Strande> ;Journal of Cardiovascular Translational Research. 2017 Jun 1
6 citations
Diastolic Hypotension, Troponin Elevation, and Electrocardiographic Changes Associated With the Management of Moderate to Severe Asthma in Children.
Daniel B. Fagbuyi, Shekhar T. Venkataraman, J. Carter Ralphe, Noel S. Zuckerbraun, Raymond D. Pitetti, Yan Lin, Kwonho Jeong, Richard A. Saladino, Mioara D. Manole> ;Academic Emergency Medicine. 2016 Jul 1
91 citations
Cardiac MyBP-C Regulates the Rate and Force of Contraction in Mammalian Myocardium
Richard L. Moss, Daniel P. Fitzsimons, J. Carter Ralphe> ;Circulation Research. 2015 Jan 2
59 citations
Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.
Kunil K. Raval, Ran Tao, Brent E. White, Willem J. de Lange, Chad H. Koonce, Junying Yu, Priya S. Kishnani, James A. Thomson, Deane F. Mosher, John C. Ralphe, Timothy ...> ;The Journal of Biological Chemistry. 2015 Jan 30
53 citations
Neonatal mouse-derived engineered cardiac tissue: a novel model system for studying genetic heart disease.
W. J. de Lange, Laura F. Hegge, Adrian C. Grimes, Carl W. Tong, Taylor M. Brost, Richard L. Moss, John C. Ralphe> ;Circulation Research. 2011 Jun 24
24 citations
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.
Willem J. de Lange, Adrian C. Grimes, Laura F. Hegge, Alexander M. Spring, Taylor M. Brost, J. Carter Ralphe> ;The Journal of General Physiology. 2013 Sep 1
10 citations
Just sinus bradycardia or something more serious
Kelly R. Egan, J. Carter Ralphe, Larry Weinhaus, Kathleen R. Maginot> ;Case Reports in Pediatrics. 2013 Feb 11
19 citations
3D engineered cardiac tissue models of human heart disease: learning more from our mice.
J. Carter Ralphe, Willem J. de Lange> ;Trends in Cardiovascular Medicine. 2013 Feb 1
26 citations
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.
Willem J. de Lange, Adrian C. Grimes, Laura F. Hegge, J. Carter Ralphe> ;The Journal of General Physiology. 2013 Jan 1
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