JosephAnthonyGarciaJr.MD

Cardiology • Bronx, NY

Adult Congenital Heart Disease

Associate Professor, Internal Medicine, University of Texas Southwestern Medical Center, Southwestern Medical School

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Office
James J. Peters VAMC
130 Kingsbridge Road
Bronx, NY 10468
Phone+1 718-584-9000
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Education & Training

University of Texas Southwestern Medical CenterFellowship, Cardiovascular Disease, 1995 - 1996
University of Texas Southwestern Medical CenterResidency, Internal Medicine, 1993 - 1995
David Geffen School of Medicine at UCLAClass of 1993

Certifications & Licensure

TX State Medical License 1996 - 2025
WI State Medical License 1994 - 1997

Publications & Presentations

PubMed

1 citations
Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements.
Jason S. Nagati, Philippe H. Kobeissy, Minh Q. Nguyen, Min Xu, Trent Garcia, Sarah A. Comerford, Robert E. Hammer, Joseph A. Garcia> ;The Journal of Biological Chemistry. 2021 Sep 1
5 citations
Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia.
Benjamin Wang, Ying-Jie Peng, Xiaoyu Su, Chongxu Zhang, Jason S Nagati, Joseph A Garcia, Nanduri R. Prabhakar> ;Journal of Applied Physiology. 2021 Feb 4
6 citations
A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling.
Jason S. Nagati, Min Xu, Trent Garcia, Sarah A. Comerford, Robert E. Hammer, Joseph A. Garcia> ;Plos One. 2019 Nov 14
24 citations
Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells
Rui Chen, Min Xu, Jason S. Nagati, Joseph A. Garcia> ;Plos One. 2017 Dec 27
192 citations
Impaired cued and contextual memory in NPAS2-deficient mice
Joseph A. Garcia, Di Zhang, Sandi Jo Estill, C. H. Michnoff, Jared Rutter, Martin Reick, Kristin D. Scott, Ramon Diaz-Arrastia, Steven L. McKnight> ;Science. 2000 Jun 23
3 citations
Corrigendum: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Wataru Kimura, Feng Xiao, Diana C. Canseco, Shalini Muralidhar, Suwannee Thet, Helen M. Zhang, Yezan Abderrahman, Rui Chen, Joseph A. Garcia, John M. Shelton, James A....> ;Nature. 2016 Apr 14
234 citations
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart
Wataru Kimura, Feng Xiao, Diana C. Canseco, Shalini Muralidhar, Suwannee Thet, Helen M. Zhang, Yezan Abderrahman, Rui Chen, Joseph A. Garcia, John M. Shelton, James A....> ;Nature. 2015 Jul 9
48 citations
The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.
Rui Chen, Min Xu, Jason S. Nagati, Richard T. Hogg, Alok Das, Robert D. Gerard, Joseph A. Garcia> ;Plos One. 2015 Feb 17
55 citations
An acetate switch regulates stress erythropoiesis.
Min Xu, Jason S. Nagati, Jian Xie, Jiwen Li, Holly Walters, Young Ah Moon, Robert D. Gerard, Chou Long Huang, Sarah A. Comerford, Robert E. Hammer, Jay D. Horton, Rui ...> ;Nature Medicine. 2014 Sep 1
66 citations
Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis
Guoxiang Yuan, Ying-Jie Peng, Vaddi Damodara Reddy, Vladislav V. Makarenko, Jayasri Nanduri, Shakil A. Khan, Joseph A. Garcia, Ganesh K. Kumar, Gregg L. Semenza, Nandu...> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 May 7
215 citations
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Thomas H. Scheuermann, Qiming Li, He-Wen Ma, Jason Key, Lei Zhang, Rui-rui Chen, Joseph A. Garcia, Jacinth Naidoo, Jamie Longgood, Doug E. Frantz, Uttam K. Tambar, Kev...> ;Nature Chemical Biology. 2013 Apr 1
18 citations
Endothelial progenitor cell response to antiproliferative drug exposure
Subhash Banerjee, Hao Xu, Eric Fuh, Kytai T. Nguyen, Joseph A. Garcia, Emmanouil S. Brilakis, Deepak L. Bhatt> ;Atherosclerosis. 2012 Nov 1
65 citations
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Rui Chen, Min Xu, Richard T. Hogg, Jiwen Li, Bertis B. Little, Robert D. Gerard, Joseph A. Garcia> ;The Journal of Biological Chemistry. 2012 Aug 31
37 citations
The Hypoxic Epicardial and Subepicardial Microenvironment
Fatih Kocabas, Ahmed I. Mahmoud, Drazen Sosic, Enzo R. Porrello, Rui Chen, Joseph A. Garcia, Ralph J. DeBerardinis, Hesham A. Sadek> ;Journal of Cardiovascular Translational Research. 2012 May 8
117 citations
Hypoxia increases Sirtuin 1 expression in a hypoxia inducible factor-dependent manner
Rui Chen, Elhadji M. Dioum, Richard T. Hogg, Robert D. Gerard, Joseph A. Garcia> ;The Journal of Biological Chemistry. 2011 Apr 22
92 citations
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
Ying-Jie Peng, Jayasri Nanduri, Shakil A. Khan, Guoxiang Yuan, Ning Wang, Brian J. Kinsman, Damodara Reddy Vaddi, Ganesh K. Kumar, Joseph A. Garcia, Gregg L. Semenza, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2011 Feb 15
25 citations
EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis
Michaela Gruber, Lijoy K. Mathew, Anja Runge, Joseph A. Garcia, M. Celeste Simon> ;Biology of Reproduction. 2010 Jun 1
11 citations
Adenoviral targeting of gene expression to tumors
Richard T. Hogg, Joseph A. Garcia, Robert D. Gerard> ;Cancer Gene Therapy. 2010 Feb 5
28 citations
Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity.
Matthew S. Alexander, Xiaozhong Shi, Kevin A. Voelker, Robert W. Grange, Joseph A. Garcia, Robert E. Hammer, Daniel J. Garry> ;Developmental Biology. 2010 Jan 15
6 citations
Aiming Straight for the Heart: Prolyl Hydroxylases Set the BAR
Joseph A. Garcia> ;Science Signaling. 2009 Nov 10
378 citations
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
Elhadji M. Dioum, Rui Chen, Matthew S. Alexander, Quiyang Zhang, Richard T. Hogg, Robert D. Gerard, Joseph A. Garcia> ;Science. 2009 Jun 5
106 citations
Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy.
Jolene Bohensky, Shawn P. Terkhorn, Theresa A. Freeman, Christopher S. Adams, Joseph A. Garcia, Irving M. Shapiro, Vickram Srinivas> ;Arthritis and Rheumatism. 2009 May 1
142 citations
Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities
Jayasri Nanduri, Ning Wang, Guoxiang Yuan, Shakil A. Khan, Dangjai Souvannakitti, Ying-Jie Peng, Ganesh K. Kumar, Joseph A. Garcia, Nanduri R. Prabhakar> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Jan 27
37 citations
Transcriptional Regulation During Development of the Ductus Arteriosus
Kathryn N. Ivey, David L Sutcliffe, James A. Richardson, Ronald I. Clyman, Joseph A. Garcia, Deepak Srivastava> ;Circulation Research. 2008 Aug 15
32 citations
HIF-2α-Haploinsufficient Mice Have Blunted Retinal Neovascularization Due to Impaired Expression of a Proangiogenic Gene Battery
Elhadji M. Dioum, Stephen L. Clarke, Kan Ding, Joyce J. Repa, Joseph A. Garcia> ;Investigative Ophthalmology & Visual Science. 2008 Jun 1
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Hospital Affiliations

James J. Peters Veterans Affairs Medical CenterBronx, New York