JosephIShapiroMD

PubMed

• An ode to valproic acid: A letter to the editor.
  Shapiro-Krew, A., Shapiro, J., Viguera, A.> ;Pharmacological Research. 2024 Jan 1
• Adipocyte Na, K-ATPase Signaling Attenuates Experimental Uremic Cardiomyopathy.
  Komal Sodhi, Xiaoliang Wang, Muhammad A Chaudhary, Hari Vishal Lakhani, Mishghan Zehra, Athar Nawab, Cameron L Cottrill, Fang Bai, Jiang Liu, Juan R Sanabria, Zijian X...> ;Cellular and Molecular Biology. 2023 May 31
• Inhibition of Na/K-ATPase signaling Attenuates Steatohepatitis and Atherosclerosis in Mice Fed a Western Diet.
  Komal Sodhi, Krithika Srikanthan, Perrine Goguet-Rubio, Alexandra Nichols, Athar Nawab, Preeya Shah, Muhammad Chaudhry, Mehiar El-Hamdani, Zijian Xie, Joseph Shapiro> ;Cellular and Molecular Biology. 2023 Feb 28
• 1 citations
  Hypertonic Saline Infusion for Hyponatremia: Limitations of the Adrogué-Madias and Other Formulas.
  Brent Wagner, Deepak Malhotra, Darren Schmidt, Dominic S Raj, Zeid J Khitan, Joseph I Shapiro, Antonios H Tzamaloukas> ;Kidney360. 2023 Apr 1
• Retraction Note: The Na/K-ATPase oxidant amplification loop regulates aging.
  Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L Klug, Jiang Liu, Xiaoliang Wang, Krithika Srikanthan, Perrine Goguet-Rubio, Athar Nawab, Rebecca Pratt, Megan...> ;Scientific Reports. 2022 Jun 1
• Retraction Note: pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet.
  Komal Sodhi, Krithika Srikanthan, Perrine Goguet-Rubio, Alexandra Nichols, Amrita Mallick, Athar Nawab, Rebecca Martin, Preeya T Shah, Muhammad Chaudhry, Saroj Sigdel,...> ;Scientific Reports. 2022 May 30
• 3 citations
  Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration.
  Komal Sodhi, Rebecca Pratt, Xiaoliang Wang, Hari Vishal Lakhani, Sneha S. Pillai, Mishghan Zehra, Jiayan Wang, Lawrence M. Grover, Brandon J. Henderson, James Denvir, ...> ;Iscience. 2021 Oct 12
• 10 citations
  Acute and Chronic Hyponatremia
  Murad Kheetan, Iheanyichukwu Ogu, Joseph I. Shapiro, Zeid J. Khitan> ;Frontiers in Medicine. 2021 Aug 3
• 6 citations
  The Na/K-ATPase Signaling and SGLT2 Inhibitor-Mediated Cardiorenal Protection: A Crossed Road?
  Jiang Liu, Jiang Tian, Komal Sodhi, Joseph I. Shapiro> ;The Journal of Membrane Biology. 2021 Jul 23
• 11 citations
  The Na/K-ATPase α1/Src interaction regulates metabolic reserve and Western diet intolerance
  Laura C Kutz, Xiaoyu Cui, Jeffrey X. Xie, Shreya Tapan Mukherji, Kayleigh C Terrell, Minqi Huang, Xiaoliang Wang, Jiayan Wang, Adam J Martin, Marco T Pessoa, Liquan Ca...> ;Acta Physiologica. 2021 Mar 22
• 4 citations
  Biased Effect of Cardiotonic Steroids on Na/K-ATPase-Mediated Signal Transduction.
  Yunhui Xu, Pauline V Marck, Minqi Huang, Jeffrey X. Xie, Tong Wang, Joseph I. Shapiro, Liquan Cai, Feng Feng, Zijian Xie> ;Molecular Pharmacology. 2021 Jan 25
• 4 citations
  The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease.
  Kyle Maxwell, Justin Chuang, Muhammad A. Chaudhry, Ying Nie, Fang Bai, Komal Sodhi, Jiang Liu, Joseph I. Shapiro> ;American Journal of Physiology. Renal Physiology. 2021 Feb 1
• 7 citations
  A strategic expression method of miR-29b and its anti-fibrotic effect based on RNA-sequencing analysis.
  Xiaoming Fan, Yingnyu Gao, Xiaolu Zhang, Haroon Y. Lughmani, David J. Kennedy, Steven T. Haller, Sandrine V. Pierre, Joseph I. Shapiro, Jiang Tian> ;Plos One. 2020 Dec 17
• 5 citations
  Stress Signal Regulation by Na/K-ATPase As a New Approach to Promote Physiological Revascularization in a Mouse Model of Ischemic Retinopathy
  Jiayan Wang, Xiaoliang Wang, Yingnyu Gao, Zhucheng Lin, Jing Chen, James W Gigantelli, Joseph I. Shapiro, Zijian Xie, Sandrine V. Pierre> ;Investigative Ophthalmology & Visual Science. 2020 Dec 1
• 25 citations
  The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma.
  Pradeep K Rajan, Utibe-Abasi Udoh, Juan D Sanabria, Moumita Banerjee, Gary Smith, Mathew Schade, Jacqueline A Sanabria, Komal Sodhi, Sandrine V. Pierre, Zijian Xie, Jo...> ;International Journal of Molecular Sciences. 2020 Nov 24
• 5 citations
  The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure.
  Zi Jian Xie, Joel Novograd, Yaakov Itzkowitz, Ariel Sher, Yosef D. Buchen, Komal Sodhi, Nader G. Abraham, Joseph I. Shapiro> ;Antioxidants. 2020 Nov 14
• 1 citations
  Author Correction: The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities.
  Rebecca Pratt, Cameron Brickman, Athar Nawab, Cameron L. Cottrill, Brian Snoad, Hari Vishal Lakhani, Austin S. Jelcick, Brandon J. Henderson, Niharika Bhardwaj, Juan S...> ;Scientific Reports. 2020 Nov 5
• 2 citations
  Can charcoal improve outcomes in COVID-19 infections?
  Zeid J. Khitan, Imran Khawaja, Maurice A. Mufson, Juan Sanabria, Nader G. Abraham, Stephen J. Peterson, Uma Sundaram, Joseph I. Shapiro> ;Medical Hypotheses. 2020 Nov 1
• Response to: Visaria et al. Everything in moderation: Understanding the interplay between salt and sugar intake.
  Zeid J. Khitan, Antonios H. Tzamaloukas, Joseph I. Shapiro, Todd Gress> ;Journal of Clinical Hypertension. 2020 Oct 30
• 7 citations
  Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop.
  Komal Sodhi, James Denvir, Jiang Liu, Juan Sanabria, Yiliang Chen, Roy L. Silverstein, Zijian Xie, Nader G. Abraham, Joseph I. Shapiro> ;International Journal of Molecular Sciences. 2020 Aug 18
• 29 citations
  Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities.
  Steven Tun, Cameron L. Cottrill, Hari Vishal Lakhani, Sneha S. Pillai, Anum Dilip, Hibba Chaudhry, Joseph I. Shapiro, Komal Sodhi> ;Frontiers in Pharmacology. 2020 Aug 13
• 9 citations
  Relationship between dietary sodium and sugar intake: A cross-sectional study of the National Health and Nutrition Examination Survey 2001-2016.
  Todd Gress, Kanaan Mansoor, Yaser Rayyan, Rodhan Khthir, Reema F. Tayyem, Antonios H. Tzamaloukas, Nader G. Abraham, Joseph I. Shapiro, Zeid J. Khitan> ;Journal of Clinical Hypertension. 2020 Sep 1
• 34 citations
  Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm
  Eddie W. Fakhouri, Stephen J. Peterson, Janish Kothari, Ragin Alex, Joseph I. Shapiro, Nader G. Abraham> ;Antioxidants. 2020 Jul 18
• Effects of Short-Term Proteinuria on the Incidence of Stroke in Patients With Different Glucose Tolerance Status.
  Ahlim Alsanani, Joseph I. Shapiro> ;Journal of the American Heart Association. 2020 Jul 7
• 13 citations
  Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic Cardiomyopathy.
  Komal Sodhi, Xiaoliang Wang, Muhammad A. Chaudhry, Hari Vishal Lakhani, Mishghan Zehra, Rebecca Pratt, Athar Nawab, Cameron L. Cottrill, Brian Snoad, Fang Bai, James D...> ;Journal of the American Society of Nephrology. 2020 Jun 25
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Journal Articles

• Brain pH responses to sodium bicarbonate and Carbicarb during systemic acidosis.  
  Shapiro, J.I., M. Whalen, R. Kucera, N. Kindig, G. Filley, and L. Chan, Am. J. Physiol. 256:H1316-H1321
• Brain pH effects of NaHCO3 and Carbicarb in lactic acidosis.  
  Kucera, R.R., J.I. Shapiro, M.A. Whalen, N.B. Kindig, G.F. Filley, and L. Chan, Crit.Care Med. 17:1320-1323
• Intraocular pressures during high flux hemodialysis.  
  Austin, J., M. Klein, M. Levy, S.R. Contiguglia, J. Mishell, and J.I. Shapiro, Renal Failure. 12:109-112
• Different effects of bicarbonate and Carbicarb in normal volunteers.  
  Shapiro, J.I., A. Mathew, M.A. Whalen, B. Honigman, W.D. Kaehny, T.L. Petty, and L. Chan, J. Crit. Care. 5:1-4
• Regulation of brain organic osmoles during hypernatremia.  
  Lien Y.H., J.I. Shapiro and L. Chan, J. Clin. Invest. 85:1427-1435
• Plasmapheresis by nephrologists: A survey. Dial.  
  Howard, R., L. Chan, K. Tatum and J.I. Shapiro, Transplant. 19:484-485
• Hemodynamic and hepatic pH responses during different forms of ventilation.  
  Whalen, M.A. and J.I. Shapiro, Mag. Reson.Imaging. 9:229-234
• NMR and biochemical findings of synergistic interaction of ischemic injury and cyclosporine nephrotoxicity in the rat.  
  Chan, L., G. Suleymanlar, D.K. Malhotra, Y.H. Lien, and J.I. Shapiro, Transplant. Proc. 23:711-713
• EEG responses to bicarbonate and Carbicarb during lactic acidosis in the rat.  
  Kucera, R., M. Whalen, and J.I. Shapiro, J. Crit. Illness 6:71-74
• Organic brain osmolytes during induction and therapy of hyponatremia.  
  Lien, Y.H., J.I. Shapiro, and L. Chan, J. Clin. Invest. 88:303-309
• Low protein diet ameliorates renal hypermetabolism in the remnant kidney.  
  Jarusirripipat, C., H.Z. Zhou, J.I. Shapiro, L. Chan and R.W. Schrier, Am. J. Kid. Dis. 18:367-374
• Improved experimental cardiac preservation based on metabolic manipulations.  
  Malhotra, D., H.Z. Zhou, J.I. Shapiro and L. Chan, Transplant. 52:1004- 1008
• Intracellular pH changes during estivation in the land snail Oreohelix stigosa.  
  Rees, B.B., D. Malhotra, J.I. Shapiro, and S.C. Hand, J. Exp. Biol. 159:525-530
• Utility of H-1 NMR spectroscopy in the differential diagnosis of anion gap acidosis.  
  Malhotra, D., J.I. Shapiro and L. Chan, J.A.S.N. 2:1046-1050
• Contractile failure during metabolic acidosis: role of impaired energy metabolism.  
  Zhou, H.Z., D. Malhotra and J.I. Shapiro, Am. J. Physiol. 261:H1481-H1486
• Suppression of sodium NMR double-quantum coherence by chemical shift and relaxation reagents.  
  Hutchison, R.B., J.J.A. Huntley, H. Jin and J.I. Shapiro, J. Chem. Physics. 97:8934-8940
• Alteration in sodium binding sites with prolonged ischemia in the isolated perfused heart.  
  Hutchison, R.B., J.J.A. Huntley, H.Z. Zhou, D.J. Ciesla and J.I. Shapiro, Mag. Reson. Med. 29:391-395
• Intracellular pH in lizards after hypercapnia.  
  Snyder,G.K., J.R. Nestler, J.I. Shapiro, and J. Huntley, Am.J.Physiol. 268:R889-R895
• Oxidative phosphorylation and realkalinization of intracellular pH during recovery from anoxia in Artermia franciscana embryos.  
  Kwan, K., J.I. Shapiro B.B. Rees, and S. Hand, Biochimica et Biophysica Acta . 1232: 5-12
• Pathogenesis of cardiac dysfunction during metabolic acidosis: Therapeutic Implications.  
  Shapiro, J.I, Kidney Int.61: S41-47
• Effects of acute and chronic hypokalemia on metabolic and physiological responses to hypoxia.  
  Shapiro, J.I., A. Banerjee, O.K. Reiss and N. Elkins, Am. J. Physiol. 274:H1598-1604
• Effects of pharmacological preconditioning on cardiac energy metabolism and intracellular pH.  
  Roehring, T., J.I. Shapiro, E.W. Peterson, R. Freis, F. Robertson and A. Banerjee, Am. J. Physiol. 275:H805-813
• Clinical dose response effects of various calcium channel blockers on cyclosporine blood levels in renal transplant recipients.  
  Jacob, L.P., D. Malhotra and J.I. Shapiro, AJKD.33:301-303
• pH gradients along the nephron; a consequence of countercurrent vascular architecture.  
  Burke, T.J., D. Malhotra and J.I. Shapiro, Kidney Int.56:1826-37
• Endothelial apoptosis in systemic capillary leak syndrome.  
  Assaly, R.A., D. Olson, J. Hammersley, J. Liu, J.I. Shapiro, and B. Kahaleh, Chest.120:1301-1308
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Books/Book Chapters

• Serono Symposium on Drugs and the Kidney. 
  Chapter: Pharmacological therapy of acute renal failure 
  Page 121 - 159Shapiro, J.I., D.C.H. Harris, and R.W. SchrierEditors: G. Remmuzzi.Raven Press, New York
• 30th Congress of the Japanese Society of Dialysis Therapeutics. 
  Chapter: Clinical aspects of acute renal failure 
  Page 45 - 60Shapiro, J.I., and R.W. SchrierRaven Press, New York
• Proceedings of the 6th Asian Pacific Colloquium in Nephrology. 
  Chapter: Cellular events in ischemic acute renal failure 
  Page 22 - 38Schrier, R.W., and J.I. ShapiroRaven Press, New York
• In Proceedings of the 6th Asian Pacific Colloquium in Nephrology. 
  Chapter: Drug induced acute renal failure 
  Schrier, R.W., and J.I. ShapiroEditors: New York.Raven Press
• Clinical Internal Medicine. 
  Chapter: Renal and electrolyte disorders 
  Page 125 - 178Shapiro, J.I., and R.W. SchrierEditors: R.W. Schrier.Little Brown, Boston
• Campbell's Textbook of Urology. 
  Chapter: Etiology, pathogenesis and management of renal failure 
  Shapiro, J.I. and R.W. SchrierEditors: P.C. Walsh, A. B. Retik, T.A. Stamey and E. D. Vaughan.W.B. Saunders Company, Philadelphia
• Renal and Electrolyte Disorders. 
  Chapter: Pathogenesis and management of metabolic acidosis and alkalosis 
  Shapiro, J.I. and W.D. KaehnyEditors: R. W. Schrier.Little Brown, BostonEdition 3,
• Critical Care Secrets. 
  Chapter: Renal and electrolyte disturbances 
  Shapiro, J.IEditors: P. Parsons.Mosby Books, Philadelphia
• Campbell's Textbook of Urology. 
  Chapter: Etiology, pathogenesis and management of renal failure 
  Edelstein, C., Shapiro, J.I. and R.W. SchrierEditors: Philadelphia.W.B. Saunders Company
• Renal and Electrolyte Disorders. 
  Chapter: Pathogenesis and management of metabolic acidosis and alkalosis 
  Shapiro, J.I. and W.D. KaehnyEditors: R. W. Schrier.Little Brown, BostonEdition 3,
• Principles and Practice of Hemodialysis. 
  Chapter: Dialysis considerations in the patient with acute renal failure 
  Venkatasen, J., J.I. Shapiro, and R.W. HamiltonEditors: W. Henrich.Mosby, Boston
• Critical Care Secrets. 
  Chapter: Acute renal failure 
  Ravindaran, A., and J.I. ShapiroEditors: P. Parsons.Mosby, Boston
• Renal and Electrolyte Disorders Vth Edition. 
  Chapter: Pathogenesis and management of metabolic acidosis and alkalosis 
  Shapiro, J.I. and W.D. KaehnyEditors: R. W. Schrier.Little Brown, Boston
• Nephrology in 30 days. 
  Chapter: Simple acid-base disorders: Metabolic alkalosis 
  Kaw, D. and J.I. ShapiroEditors: R.F. Reilly and M.A. Perazella.
• Nephrology in 30 days. 
  Chapter: Respiratory and mixed acid-base disorders 
  Yoon, Y. and J.I. ShapiroEditors: R.F. Reilly and M.A. Perazella.Edition 1,
• Role of the Na/K-ATPase in Health and Disease. 
  Chapter: Introduction 
  Page 2020 - 2025Bagrov, A.Y. and J.I. ShapiroEditors: Bagrov, A.Y. and J.I. Shapiro.Frontiers in BioscienceEdition 10,
• Role of the Na/K-ATPase in Health and Disease. 
  Chapter: Role of cardiotonic steroids in uremic cardiomyopathy 
  Page 2036 - 2044Mohmand, B., D. Malhotra and J.I. ShapiroEditors: Bagrov, A.Y. and J.I. Shapiro.Frontiers in Bioscience
• Critical Care Secrets. 
  Chapter: Acute renal failure 
  Kaw, .D. and J.I. ShapiroEditors: P. Parsons.Mosby, BostonEdition 4,
• Renal and Electrolyte Disorders. 
  Chapter: Pathogenesis and management of metabolic acidosis and alkalosis 
  Ratnam, S and J.I. ShapiroEditors: R. W. Schrier.Little Brown, BostonEdition 6,
• Endocytosis, Structural Components, Functions and Pathways. 
  Chapter: The Na/K-ATPase and signaling 
  Liu, J and J.I. ShapiroNova Science Publishers, Inc
• Advances in Renal Physiology. 
  Chapter: Cardiotonic steroids, hypertension and cardiovascular disease 
  Gohara, S, D Malhotra, S Vetteth, and JI Shapiro
• Current Hypertension Reviews. 
  Chapter: Cardiotonic steroids, hypertension and cardiovascular disease 
  Gohara, S, D Malhotra, S Vetteth, and JI Shapiro
• Cardiomyopathies. 
  Chapter: Cardiotonic steroids and cardiac fibrosis 
  Vetteth, S. S. Gohara, and J.I.ShapiroEditors: J. Veselka.Tech, Rojeka, Croatia
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Lectures

• Alkalization therapy of metabolic acidosis. 
  Multiple Location, 1987, 1992, 1993
• Biomedical Applications of NMR Spectroscopy. 
  University of Colorado
• Obstructive Uropathy. 
  Aspen Renal Conference
• Treatment of Metabolic Acidosis. 
  Aspen Renal Conference
• Pathogenesis and treatment of metabolic acidosis. 
  US Army Conference on ICU Care, Ft. Gordon, Ga
• Clinical-pathological case studies of renal transplant patients. 
  Aspen Renal Conference
• New treatments in acute renal failure. 
  Washington, Pennsylvania
• Therapy of anion-gap metabolic acidosis. 
  American Society of Nephrology
• Pathogenesis and treatment of metabolic alkalosis. 
  Fitzimmons Army Medical Center
• Prescription dialysis based on urea kinetics; is this approach rational? 
  Association of Dialysis Nurses and Technicians Annual Meeting
• Alkalization therapy as part of fluid resuscitation. 
  US Navy at Bethesda Naval Hospital
• Acid-base disturbances in liver disease. 
  American Society of Nephrology
• Acid-base disturbances associated with liver disease. 
  Medical College of Ohio, 1997, Aspen Renal Conference, 1997
• Effects of hypokalemia on cardiac energetics and function. 
  Washington University, St. Louis, MO
• Energetic effects of hypokalemia. 
  University of Colorado
• Acid-base disturbances associated with liver transplantation. 
  Breckenridge Controversies in Transplantation Conference
• Effects of hypokalemia on cardiac energetics and growth. 
  Roche Symposium on Hypertension Therapy, Troy, Michigan
• Effects of hypokalemia on cardiac metabolism, function and growth. 
  Medical College of Ohio, 1998, Toledo Hospital,1998
• Urea kinetics: What do they mean? 
  Medical College of Ohio
• Water metabolism in women; what every obstetrician/gynecologist needs to know. 
  St. Vincent’s Hospital
• Effects of sodium pump inhibition on cardiac function and growth. 
  Medical College of Ohio
• Uremic Cardiomyopathy: New look at an old disease. 
  Multiple Location, 2000, 2001, 2002, 2003, 2004
• Diabetic Nephropathy. 
  Medical College of Ohio Symposium on Diabetes
• Body Chemistry, Blood Pressure. 
  Multiple Location, 2001, 2002, 2003, 2004
• Treatment of Type II Diabetes: Focus on Dyslipidemia. 
  Merck "Cyberlecture Series
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Other

• Hypertension and Diabetic Nephropathy. 
  Shapiro, J.I, World Hypertension League Website
  http://www.mco.edu/org/whl/prof.html#art
• Metabolic Acidosis: B.M.J. 
  Kaw, .D. and J.I. Shapiro, Point of Care