JulioCBarredoMD

Pediatric Hematology & Oncology • Miami, FL

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Office
UM/Dept of Hem/Onc P O Box 016960 (D-820)
Ste 121
Miami, FL 33101
Phone+1 305-585-5635

Fax+1 305-325-8387
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Education & Training

Children's Hospital Los AngelesFellowship, Pediatric Hematology/Oncology, 1987 - 1991
SUNY Downstate Health Sciences UniversityResidency, Pediatrics, 1984 - 1987
National University of San MarcosClass of 1981

Certifications & Licensure

SC State Medical License 1991 - 2025
FL State Medical License 2006 - 2025
CA State Medical License 1989 - 2024
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Top Doctors:South Florida Castle Connolly, 2012
Super Doctor SuperDoctors.com
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Clinical Trials

Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia Start of enrollment: 1996 Jan 01
Completed
Phase 2
Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia Start of enrollment: 2000 Aug 01
Completed
Phase 3
Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Start of enrollment: 2004 Mar 25
Recruiting
Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes Start of enrollment: 2004 Nov 01
Completed
Not Applicable
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma Start of enrollment: 2008 Feb 04
Active, not recruiting
Phase 3
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
Completed
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) Start of enrollment: 2011 Jul 18
Completed
Phase 1
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Metformin in Children With Relapsed or Refractory Solid Tumors Start of enrollment: 2012 Sep 24
Completed
Phase 1
Dendritic Cell Vaccine for Children and Adults With Sarcoma Start of enrollment: 2014 Jan 06
Active, not recruiting
Phase 1
Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma Start of enrollment: 2013 Aug 21
Completed
Phase 1
Dendritic Cell Vaccine Therapy With In Situ Maturation in Pediatric Brain Tumors Start of enrollment: 2013 Sep 03
Terminated
Phase 1
Umbilical Cord Blood (UCB) Transplantation in Pediatric Patients With High Risk Leukemia and Myelodysplasia Start of enrollment: 2008 Aug 01
Completed
Not Applicable
Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma Start of enrollment: 2014 Aug 01
Completed
Phase 2
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Start of enrollment: 2014 Jul 11
Active, not recruiting
Phase 2, Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL Start of enrollment: 2019 Mar 25
Completed
Phase 1
Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia Start of enrollment: 2019 Oct 25
Active, not recruiting
Phase 2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

AMPK Associates with Chromatin and Phosphorylates the TAF-1 Subunit of the Transcription Initiation Complex to Regulate Histone Gene Expression in ALL Cells.
Guangyan Sun, Guy J Leclerc, Sanjay Chahar, Julio C Barredo> ;Molecular Cancer Research. 2023 Dec 1
The Effect of Health Insurance on Pediatric Cancer Survival: An Analysis of Children Evaluated for Radiation Therapy in Diverse Multicenter Health Systems.
Jessica R Fine, Paulo S Pinheiro, Deukwoo Kwon, Isildinha M Reis, Julio C Barredo, Derek M Isrow, Ransdell, J.> ;Journal of Pediatric Hematology/oncology. 2023 Aug 1
Effects of Cancer Treatment on the Education and Cognition of South Florida Pediatric Cancer Survivors.
Jessica R Fine, Tanvi Bafna, Sarah C Griffith, Julio C Barredo, Derek M Isrow, Ransdell, J.> ;Cureus. 2023 Apr 1
8 citations
Late isolated central nervous system relapse in childhood B-cell acute lymphoblastic leukemia treated with intensified systemic therapy and delayed reduced dose crania...
Caroline Hastings, Yichen Chen, Meenakshi Devidas, A. Kim Ritchey, Naomi J. Winick, William L. Carroll, Stephen P. Hunger, Brent L. Wood, Robert B Marcus, Julio C. Bar...> ;Pediatric Blood & Cancer. 2021 Jul 24
1 citations
Protein Kinase D-Dependent Downregulation of Immediate Early Genes through Class IIA Histone Deacetylases in Acute Lymphoblastic Leukemia.
Guangyan Sun, Anna Shvab, Guy J. Leclerc, Bin Li, Felipe Beckedorff, Ramin Shiekhattar, Julio C. Barredo> ;Molecular Cancer Research. 2021 May 12
1 citations
Pediatric HCT in Florida (2014 -2016): A report from the FPBCC
Deepak Chellapandian, Gauri Sunkersett, Benjamin Oshrine, Jorge Galvez Silva, Edward Ziga, Warren Alperstein, Michael Joyce, Howard M. Katzenstein, Kamar Godder, Paul ...> ;Pediatric Transplantation. 2021 Aug 1
17 citations
Acute lymphoblastic leukemia mortality in Hispanic Americans.
Jamie Shoag, Julio C. Barredo, Izidore S. Lossos, Paulo S. Pinheiro> ;Leukemia & Lymphoma. 2020 Jun 22
11 citations
A phase I study of panobinostat in children with relapsed and refractory hematologic malignancies
John Goldberg, Maria Luisa Sulis, Julia Glade Bender, Sima Jeha, Rebecca Gardner, Jessica A. Pollard, Victor M. Aquino, Theodore W. Laetsch, Naomi J. Winick, Cecilia F...> ;Pediatric Hematology and Oncology. 2020 Apr 27
24 citations
A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metform...
Matteo Trucco, Julio C. Barredo, John M. Goldberg, Gilles M. Leclerc, Gregory A. Hale, Jonathan Gill, Bhuvana A. Setty, Tiffany Smith, Richard Lush, Jae K. Lee, Damon ...> ;Pediatric Blood & Cancer. 2018 Sep 1
17 citations
Effect of a formal oncofertility program on fertility preservation rates-first year experience.
Diana M. Lopategui, Emad Ibrahim, Teodoro C. Aballa, Nancy L. Brackett, Raphael Yechieli, Julio C. Barredo, Ranjith Ramasamy> ;Translational Andrology and Urology. 2018 Jul 1
23 citations
Isolated late testicular relapse of B-cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response-based testicular radiation: A Childre...
Julio C. Barredo, Caroline Hastings, Xiamin Lu, F. Meenakshi Devidas, Yichen Chen, Daniel Armstrong, Naomi J. Winick, Brent L. Wood, Rochelle Yanofsky, Mignon L. Loh, ...> ;Pediatric Blood & Cancer. 2018 May 1
8 citations
Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia.
Shuhua Zheng, Gilles M. Leclerc, Bin Li, Ronan T. Swords, Julio C. Barredo> ;Oncotarget. 2018 Jan 1
3 citations
Adenoid cystic carcinoma of the lacrimal gland in a 14-year-old male.
Michelle M. Falcone, Kimberly D. Tran, Mehdi Tavakoli, Daniel Ortiz, Julio C. Barredo, Wendy W. Lee> ;Orbit. 2017 Jul 24
17 citations
The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia
Gilles M. Leclerc, Shuhua Zheng, Guy J. Leclerc, Joanna DeSalvo, Ronan T. Swords, Julio C. Barredo> ;Leukemia Research. 2016 Nov 1
16 citations
Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress.
Huaping Liu, Metin Kurtoglu, Clara Lucía León-Annicchiarico, Cristina Muñoz-Pinedo, Julio C. Barredo, Guy J. Leclerc, Jaime R. Merchan, Xiongfei Liu, Theodore J. Lampidis> ;Oncotarget. 2016 May 10
3 citations
Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma)
German Campuzano-Zuluaga, Daniel Ortiz, Jing Hong Peng, Offiong F Ikpatt, Yao Shan Fan, Julio C. Barredo, Francisco Vega, Jennifer R. Chapman> ;American Journal of Clinical Pathology. 2016 May 1
8 citations
Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.
Guy J. Leclerc, Joanna DeSalvo, Jianfeng Du, Ningguo Gao, Gilles M. Leclerc, Mark A. Lehrman, Theodore J. Lampidis, Julio C. Barredo> ;Leukemia Research. 2015 Aug 20
80 citations
Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts
Gilles M. Leclerc, Guy J. Leclerc, Jeffim N. Kuznetsov, Joanna DeSalvo, Julio C. Barredo> ;Plos One. 2013 Aug 23
55 citations
Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy.
Haibin Xi, Julio C. Barredo, Jaime R. Merchan, Theodore J. Lampidis> ;Biochemical Pharmacology. 2013 May 15
50 citations
Inhibition of Akt Potentiates 2-DG–Induced Apoptosis via Downregulation of UPR in Acute Lymphoblastic Leukemia
Joanna DeSalvo, Jeffim N. Kuznetsov, Jianfeng Du, Gilles M. Leclerc, Guy J. Leclerc, Theodore J. Lampidis, Julio C. Barredo> ;Molecular Cancer Research. 2012 Jul 1
526 citations
Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)
Winfred C. Wang, Russell E. Ware, Scott T. Miller, Rathi V. Iyer, James F. Casella, Caterina P. Minniti, Sohail Rana, Courtney D. Thornburg, Zora R. Rogers, Ram Kalpat...> ;Lancet. 2011 May 14
74 citations
AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia
Jeffim N. Kuznetsov, Guy J. Leclerc, Gilles M. Leclerc, Julio C. Barredo> ;Molecular Cancer Therapeutics. 2011 Mar 1
10 citations
Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia
Guy J. Leclerc, Christopher Sanderson, Stephen P. Hunger, Meenakshi Devidas, Julio C. Barredo> ;Leukemia Research. 2010 Dec 1
69 citations
AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
Gilles M. Leclerc, Guy J. Leclerc, Guilian Fu, Julio C. Barredo> ;Journal of Molecular Signaling. 2010 Sep 23
14 citations
Controversies in the management of central nervous system leukemia.
Julio C. Barredo, A. Kim Ritchey> ;Pediatric Hematology and Oncology. 2010 Jul 29
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Lectures

Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energ...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Press Mentions

Young Cancer Survivors Share Experiences, Support at Sylvester’s AYA SummitOctober 14th, 2022
Tens of Thousands of Young Women Get Breast Cancer Every Year. There Are Fertility OptionsOctober 6th, 2022

Grant Support

Molecular Determinants Of Methotrexate In Acute Lymphoblastic LeukemiaNational Cancer Institute2007–2008
Pediatric Hydroxyurea Phase III Clinical TrialNational Heart, Lung, And Blood Institute2007
Molecular Determinants Of Methotrexate In AllNational Cancer Institute2006
Molecular Determinants Of Methotrexate In AllNational Cancer Institute2004–2006
Pediatric Hydroxyurea Phases III Clinical Trial - Baby HUGNational Center For Research Resources2005
Pediatric Hydroxyurea Phase III Clinical TrialNational Center For Research Resources2004
Pediatric Oncology Group--The Carolinas ConsortiumNational Cancer Institute2001–2002
Clinical Phenotype Targeted Antifolate ChemotherapyNational Cancer Institute1997–2001