Karen(Oerter)KleinMD

Board-certified Pediatric Endocrinologist at Rady Children's Hospital-San Diego and Clinical Professor of Pediatrics at UC San Diego School of Medicine

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Office
3030 Childrens Way
San Diego, CA 92123
Phone+1 858-966-4032

Fax+1 858-966-6227
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Education & Training

National Institutes of Health Clinical Center/Eunice Kennedy Shriver NICHDFellowship, Pediatric Endocrinology, 1988 - 1990
Penn State Milton S Hershey Medical CenterResidency, Pediatrics, 1985 - 1988
Pennsylvania State University College of MedicineClass of 1985

Certifications & Licensure

CA State Medical License 1993 - 2024
DE State Medical License 1994 - 2003
NJ State Medical License 1999 - 2001
PA State Medical License 1986 - 2000
MD State Medical License 1988 - 1999
American Board of Pediatrics Pediatric Endocrinology

Clinical Trials

Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty Start of enrollment: 2015 Aug 31
Completed
Phase 3

Publications & Presentations

PubMed

Timing of onset of menses after GnRH agonist treatment for central precocious puberty.
Marcela Vargas Trujillo, Sanja Dragnic, Stephen Van Komen, Moming Li, Karen O Klein, Peter A Lee> ;Journal of Pediatric Endocrinology & Metabolism. 2024 Apr 15
Using change in predicted adult height during GnRH agonist treatment for individualized treatment decisions in girls with central precocious puberty.
Marcela Vargas Trujillo, Peter A Lee, Kent Reifschneider, Philippe F Backeljauw, Sanja Dragnic, Stephen Van Komen, Jun Yu, Karen O Klein> ;Journal of Pediatric Endocrinology & Metabolism. 2023 Mar 28
2 citations
No pubertal growth spurt, rapid bone maturation, and menarche post GnRHa treatment in girls with precocious puberty.
Audrey Briscoe, Katherine Chen, Karen O Klein> ;Journal of Pediatric Endocrinology & Metabolism. 2022 Nov 25
6 citations
Importance of individualizing treatment decisions in girls with central precocious puberty when initiating treatment after age 7 years or continuing beyond a chronolog...
Marcela Vargas Trujillo, Sanja Dragnic, Petra Aldridge, Karen O Klein> ;Journal of Pediatric Endocrinology & Metabolism. 2021 Apr 14
16 citations
Phase 3 Trial of a Small-volume Subcutaneous 6-Month Duration Leuprolide Acetate Treatment for Central Precocious Puberty
Karen O Klein, Analia Freire, Mirta Gryngarten, Gad B. Kletter, Matthew Benson, Bradley S. Miller, Tala Dajani, Erica A. Eugster, Nelly Mauras> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Oct 1
4 citations
Treatment patterns, health resource utilization and costs among central precocious puberty patients treated with leuprolide or histrelin: an examination of the commerc...
Karen O Klein, Ahmed M. Soliman, Machaon Bonafede, James K. Nelson, ElizaBeth Grubb> ;Journal of Medical Economics. 2020 Apr 1
5 citations
A survey of care pathway and health-related quality of life impact for children with central precocious puberty.
Karen O Klein, Ahmed M. Soliman, ElizaBeth Grubb, Paul Nisbet> ;Current Medical Research and Opinion. 2020 Mar 1
122 citations
Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium
Kanthi Bangalore Krishna, John S. Fuqua, Alan D. Rogol, Karen O Klein, Jadranka Popovic, Christopher P. Houk, Evangelia Charmandari, Peter A. Lee> ;Hormone Research in Paediatrics. 2019 Oct 1
3 citations
Health Care Utilization and Economic Burden in Patients with Central Precocious Puberty: An Assessment of the Commercially Insured and Medicaid Populations.
Karen O Klein, Ahmed M. Soliman, Machaon Bonafede, James K. Nelson, ElizaBeth Grubb> ;Journal of Managed Care & Specialty Pharmacy. 2019 Jun 22
11 citations
Review of Hormone Replacement Therapy in Girls and Adolescents with Hypogonadism.
Karen O Klein, Susan A. Phillips> ;Journal of Pediatric and Adolescent Gynecology. 2019 May 3
7 citations
Sex hormone replacement therapy for individuals with Turner syndrome.
Philippe Backeljauw, Karen O Klein> ;American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 2019 Mar 1
9 citations
Hyperinsulinemic hypoglycemia in seven patients with de novo NSD1 mutations
Katheryn Grand, Christina X Gonzalez-Gandolfi, Amanda M. Ackermann, Deema Aljeaid, Emma Bedoukian, Lynne M. Bird, Diva D. De León, Jullianne Diaz, Robert J. Hopkin, Se...> ;American Journal of Medical Genetics. Part A. 2019 Apr 1
8 citations
Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate.
Karen O Klein, Sanja Dragnic, Ahmed M. Soliman, Peter Bacher> ;Journal of Pediatric Endocrinology & Metabolism. 2018 Jun 27
22 citations
Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty.
Valerie Williams, Ahmed M. Soliman, Amy Barrett, Karen O Klein> ;Journal of Pediatric Endocrinology & Metabolism. 2018 May 24
4 citations
Gonadotropin-Releasing Hormone (GnRHa) Therapy for Central Precocious Puberty (CPP): Review of Nuances in Assessment of Height, Hormonal Suppression, Psychosocial Issu...
Karen O Klein, Peter A. Lee> ;Pediatric Endocrinology Reviews. 2018 Apr 1
66 citations
Estrogen Replacement in Turner Syndrome: Literature Review and Practical Considerations.
Karen O Klein, Robert L. Rosenfield, Richard J. Santen, Aneta Gawlik, Philippe Backeljauw, Claus Højbjerg Gravholt, Theo C J Sas, Nelly Mauras> ;The Journal of Clinical Endocrinology and Metabolism. 2018 May 1
552 citations
Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting
Claus Højbjerg Gravholt, Niels Holmark Andersen, Gerard S. Conway, Olaf M. Dekkers, Mitchell E. Geffner, Karen O Klein, Angela E. Lin, Nelly Mauras, Charmian A. Quigle...> ;European Journal of Endocrinology. 2017 Sep 1
23 citations
Efficacy and safety of triptorelin 6-month formulation in patients with central precocious puberty
Karen O Klein, Joshua Yang, Javier Aisenberg, Nancy Wright, Paul B. Kaplowitz, Najiba Lahlou, Jeannete Linares, Eija Lundstrom, Daniela Purcea, Fernando Cassorla> ;Journal of Pediatric Endocrinology & Metabolism. 2016 Nov 1
27 citations
Bone maturation along the spectrum from normal weight to obesity: a complex interplay of sex, growth factors and weight gain.
Karen O Klein, Ron S. Newfield, Sandra G Hassink> ;Journal of Pediatric Endocrinology & Metabolism. 2016 Mar 1
13 citations
Ultrasensitive estrogen levels at 7 years of age predict earlier thelarche: evidence from girls of the growth and obesity Chilean cohort.
Ana Pereira, Camila Corvalán, Ricardo Uauy, Karen O Klein, Verónica Mericq> ;European Journal of Endocrinology. 2015 Dec 1
2 citations
Is there a role for estrogen activity assays? Recombinant cell bioassay for estrogen: Development and applications.
Karen O Klein> ;Steroids. 2015 Jul 1
14 citations
Randomized clinical trial evaluating metformin versus oral contraceptive pills in the treatment of adolescents with polycystic ovarian syndrome.
Hiba Al-Zubeidi, Karen O Klein> ;Journal of Pediatric Endocrinology & Metabolism. 2015 Jul 1
27 citations
A Pediatrician’s Guide to Central Precocious Puberty
Gad B. Kletter, Karen O Klein, Yolanda Y. Wong> ;Clinical Pediatrics. 2015 May 1
22 citations
36-Month Treatment Experience of Two Doses of Leuprolide Acetate 3-Month Depot for Children With Central Precocious Puberty
Peter A. Lee, Karen O Klein, Nelly Mauras, Tali Lev-Vaisler, Peter Bacher> ;The Journal of Clinical Endocrinology and Metabolism. 2014 Jun 13
67 citations
Metabolic Effects of Oral Versus Transdermal 17β-Estradiol (E2): A Randomized Clinical Trial in Girls With Turner Syndrome
L. Torres-Santiago, Verónica Mericq, Martha Taboada, Nancy Unanue, Karen O Klein, Ravinder J. Singh, Jobayer Hossain, Richard J. Santen, Judith L. Ross, Nelly Mauras> ;The Journal of Clinical Endocrinology and Metabolism. 2013 May 15
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Lectures

Managing the Patient with Precocious Puberty: A case based discussion
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/19/2018
Consensus for Estrogen Replacement in Turner Syndrome
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/18/2018

Press Mentions

Arbor Pharmaceuticals, LLC and Debiopharm International SA Announce Commercial Availability of Triptodur(TM), Triptorelin 6-Month Formulation, FoMay 1st, 2018
FDA: Triptorelin Slows Central Precocious PubertyJuly 10th, 2017
FDA Approves Triptodur for Treatment of Early PubertyJune 30th, 2017