KathleenMRuppelMD

PubMed

• 11 citations
  Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function.
  Makenna M Morck, Debanjan Bhowmik, Divya Pathak, Aminah Dawood, James Spudich, Kathleen M Ruppel> ;Elife. 2022 Jun 29
• 77 citations
  Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
  Sara Ranjbarvaziri, Kristina B. Kooiker, Mathew Ellenberger, Giovanni Fajardo, Mingming Zhao, Alison Schroer Vander Roest, Rahel A. Woldeyes, Tiffany T. Koyano, Robyn ...> ;Circulation. 2021 Nov 23
• 41 citations
  Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.
  Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck, Kristina B. Kooiker, Gwanghyun Jung, Dan Song, Aminah Dawood, Arnav Jhingran, Gaspard Pardon, Sara Ranjbarvazi...> ;Proceedings of the National Academy of Sciences of the United States of America. 2021 Jun 15
• 15 citations
  Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy.
  Carmen Suay-Corredera, Maria Rosaria Pricolo, Diana Velázquez-Carreras, Divya Pathak, Neha Nandwani, Carolina Pimenta-Lopes, David Sánchez-Ortiz, Iñigo Urrutia-Irazaba...> ;ACS Nano. 2021 Jun 1
• 15 citations
  Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness
  Máté Gyimesi, Ádám I. Horváth, Demeter Túrós, Sharad Kumar Suthar, Máté Pénzes, Csilla Kurdi, Louise Canon, Carlos Kikuti, Kathleen M. Ruppel, Darshan V. Trivedi, Jame...> ;Cell. 2020 Oct 15
• 32 citations
  The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches
  Darshan V. Trivedi, Suman Nag, Annamma Spudich, Kathleen M. Ruppel, James A. Spudich> ;Annual Review of Biochemistry. 2020 Jun 22
• 49 citations
  The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
  Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck, Arjun S. Adhikari, Shaik Naseer Pasha, Kathleen M. Ruppel, James A. Spudich> ;Science Advances. 2020 Apr 1
• 19 citations
  Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties.
  Carlos Vera, Chloe A. Johnson, Jonathan Walklate, Arjun S. Adhikari, Marina Svicevic, Srboljub M. Mijailovich, Ariana C. Combs, Stephen J. Langer, Kathleen M. Ruppel, ...> ;The Journal of Biological Chemistry. 2019 Nov 15
• 44 citations
  β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.
  Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar, Dan Song, Kristina B. Kooiker, Daniel Bernstein, James A. Spudich, Kathleen M. Ruppel> ;Nature Communications. 2019 Jun 18
• 207 citations
  Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
  Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar, Marcus Henze, Weikang Ma, Henry Gong, Christopher S. Rogers, Joshua M. Gorham, Fiona L. Wong, Makenna M. Mor...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 Aug 28
• 43 citations
  Dilated cardiomyopathy myosin mutants have reduced force-generating capacity
  Zoltan Ujfalusi, Carlos Vera, Srbolujub M. Mijailovich, Marina Svicevic, Elizabeth Choe Yu, Masataka Kawana, Kathleen M. Ruppel, James A. Spudich, Michael A. Geeves, L...> ;The Journal of Biological Chemistry. 2018 Jun 8
• 44 citations
  Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level.
  Chao Liu, Masataka Kawana, Dan Song, Kathleen M. Ruppel, James A. Spudich> ;Nature Structural & Molecular Biology. 2018 Jun 1
• 96 citations
  Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
  Darshan V. Trivedi, Arjun S. Adhikari, Saswata S. Sarkar, Kathleen M. Ruppel, James A. Spudich> ;Biophysical Reviews. 2018 Feb 1
• 134 citations
  The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
  Suman Nag, Darshan V. Trivedi, Saswata S. Sarkar, Arjun S. Adhikari, Margaret S. Sunitha, Shirley Sutton, Kathleen M. Ruppel, James A. Spudich> ;Nature Structural & Molecular Biology. 2017 May 8
• 45 citations
  Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.
  Masataka Kawana, Saswata S. Sarkar, Shirley Sutton, Kathleen M. Ruppel, James A. Spudich> ;Science Advances. 2017 Feb 1
• 57 citations
  Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
  Arjun S. Adhikari, Kristina B. Kooiker, Saswata S. Sarkar, Chao Liu, Daniel Bernstein, James A. Spudich, Kathleen M. Ruppel> ;Cell Reports. 2016 Dec 13
• 82 citations
  Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation.
  Julian R. Homburger, Eric M. Green, Colleen Caleshu, Margaret S. Sunitha, Rebecca E. Taylor, Kathleen M. Ruppel, Raghu Metpally, Steven D. Colan, Michelle Michels, Sha...> ;Proceedings of the National Academy of Sciences of the United States of America. 2016 Jun 14
• 51 citations
  Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
  James A. Spudich, Tural Aksel, Sadie Bartholomew, Suman Nag, Masataka Kawana, Elizabeth Choe Yu, Saswata S. Sarkar, Jongmin Sung, Ruth F. Sommese, Shirley Sutton, Caro...> ;The Journal of Experimental Biology. 2016 Jan 1
• 4 citations
  Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human card...
  Stephen Pan, Ruth F. Sommese, Karim Sallam, Suman Nag, Shirley Sutton, Susan M. Miller, James A. Spudich, Kathleen M. Ruppel, Euan A. Ashley> ;BMC Medical Genetics. 2015 Oct 26
• 78 citations
  Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function
  Suman Nag, Ruth F. Sommese, Zoltan Ujfalusi, Ariana C. Combs, Stephen J. Langer, Shirley Sutton, Leslie A. Leinwand, Michael A. Geeves, Kathleen M. Ruppel, James A. Sp...> ;Science Advances. 2015 Oct 1
• 50 citations
  Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules
  Jongmin Sung, Suman Nag, Kim I. Mortensen, Christian L. Vestergaard, Shirley Sutton, Kathleen M. Ruppel, Henrik Flyvbjerg, James A. Spudich> ;Nature Communications. 2015 Aug 4
• 74 citations
  Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.
  Tural Aksel, Elizabeth Choe Yu, Shirley Sutton, Kathleen M. Ruppel, James A. Spudich> ;Cell Reports. 2015 May 12
• 45 citations
  Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac my...
  Ruth F. Sommese, Suman Nag, Shirley Sutton, Susan M. Miller, James A. Spudich, Kathleen M. Ruppel> ;Plos One. 2013 Dec 18
• 133 citations
  Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function
  Ruth F. Sommese, Jongmin Sung, Suman Nag, Shirley Sutton, John C. Deacon, Elizabeth Choe, Leslie A. Leinwand, Kathleen M. Ruppel, James A. Spudich> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Jul 30
• Essential role for Galpha13 in endothelial cells during embryonic development.
  Ruppel, K. M.,Willison, D.,Kataoka, H.,Wang, A.,Zheng, Y. W.,Cornelissen, I.,Yin, L.,Xu, S. M.,Coughlin, S. R.> ;Proc Natl Acad Sci U S A. 2005 Jun 7
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Journal Articles

• Deciphering the Super Relaxed State of Human Β-cardiac Myosin and the Mode of Action of Mavacamten from Myosin Molecules to Muscle Fibers  
  Kathleen M Ruppel, Eric M Green, Proceedings of the National Academy of Sciences