KeithW.MillerMD

PubMed

• HASH(0x3d1cd78)
  Jayakar, S. S.,Zhou, X.,Chiara, D. C.,Jarava-Barrera, C.,Savechenkov, P. Y.,Bruzik, K. S.,Tortosa, M.,Miller, K. W.,Cohen, J. B.> ;Mol. Pharmacol.. 2019 Apr 07
• HASH(0x2811128)
  Masiulis, S.,Desai, R.,Uchański, T.,Martin, I. S.,Laverty, D.,Karia, D.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K. W.,Aricescu, A. R.> ;Nature. 2019 Feb 09
• Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.
  Wu, B.,Jayakar, S. S.,Zhou, X.,Titterton, K.,Chiara, D. C.,Szabo, A. L.,Savechenkov, P. Y.,Kent, D. E.,Cohen, J. B.,Forman, S. A.,Miller, K. W.,Bruzik, K. S.> ;Eur J Med Chem. 2018 Dec 14
• Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.
  Woll, K. A.,Zhou, X.,Bhanu, N. V.,Garcia, B. A.,Covarrubias, M.,Miller, K. W.,Eckenhoff, R. G.> ;FASEB J.. 2018 Mar 06
• High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing α4β3δ subunits.
  Zhou, X.,Desai, R.,Zhang, Y.,Stec, W. J.,Miller, K. W.,Jounaidi, Y.> ;PLoS ONE. 2018 Jan 21
• Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
  Desai, R.,Savechenkov, P. Y.,Zolkowska, D.,Ge, R. L.,Rogawski, M. A.,Bruzik, K. S.,Forman, S. A.,Raines, D. E.,Miller, K. W.> ;J. Physiol. (Lond.). 2015 Sep 18
• Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing.
  Zhang, X.,Miller, K. W.> ;Mol. Cell Proteomics. 2014 Dec 05
• Research at the Harvard Anesthesia Departments.
  Forman, S. A.,Miller, K. W.,Talmor, D.,Hickey, P.,Strichartz, G.,Wiener-Kronish, J.> ;Anesthesiology. 2014 Oct 10
• Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors.
  Forman, S. A.,Chiara, D. C.,Miller, K. W.> ;Neuropharmacology. 2014 Oct 16
• Human α1β3γ2L Gamma-Aminobutyric Acid Type A Receptors: High-Level Production and Purification in a Functional State.
  Dostalova, Z.,Zhou, X.,Liu, A.,Zhang, X.,Zhang, Y.,Desai, R.,Forman, S. A.,Miller, K. W.> ;Protein Sci.. 2013 Nov 30
• Structural Models of Ligand-Gated Ion Channels: Sites of Action for Anesthetics and Ethanol.
  Olsen, R. W.,Li, G. D.,Wallner, M.,Trudell, J. R.,Bertaccini, E. J.,Lindahl, E.,Miller, K. W.,Alkana, R. L.,Davies, D. L.> ;Alcohol. Clin. Exp. Res.. 2013 Oct 30
• Carboetomidate: An Analog of Etomidate That Interacts Weakly with 11?-Hydroxylase.
  Shanmugasundararaj, S.,Zhou, X.,Neunzig, J.,Bernhardt, R.,Cotten, J. F.,Ge, R.,Miller, K. W.,Raines, D. E.> ;Anesth. Analg.. 2013 Jun
• The Pyrrole Etomidate Analog Carboetomidate Potently Inhibits Human 5-HT3A Receptor Function: Comparisons with Etomidate and Potential Implications for Emetogenesis.
  Desai, R.,Miller, K. W.,Raines, D. E.> ;Anesth. Analg.. 2013 Mar
• Mapping general anesthetic binding site(s) in human ?1?3 ?-aminobutyric acid type A (GABAA) receptors with [³H]TDBzl-etomidate, a photoreactive etomidate an...
  Chiara, D.C., Dostalova, Z., Jayakar, S.S., Zhou, X., Miller, K.W., Cohen, J.B.> ;Biochemistry. 2012 Jan 31
• The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.
  Shanmugasundararaj, S., Lehle, S., Yamodo, H.I., Husain, S.S., Tseng, C., Nguyen, K., Addona, G.H., Miller, K.W.> ;PLoS One. 2012
• p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol.
  Stewart, D.S., Savechenkov, P.Y., Dostalova, Z., Chiara, D.C., Ge, R., Raines, D.E., Cohen, J.B., Forman, S.A., Bruzik, K.S., Miller, K.W.> ;J Med Chem. 2011 Dec 8
• Two Alcohol Binding Residues Interact across a Domain Interface of the L1 Neural Cell Adhesion Molecule and Regulate Cell Adhesion.
  Dou, X., Menkari, C.E., Shanmugasundararaj, S., Miller, K.W., Charness, M.E.> ;J Biol Chem. 2011 May 6
• Mechanisms of anesthesia: past, present, and a glimpse into the future.
  Miller, K.W., Orser, B.A., Roth, S.H.> ;Can J Anaesth. 2011 Feb
• Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
  Forman, S.A., Miller, K.W.> ;Can J Anaesth. 2011 Feb
• p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
  Husain, S.S., Stewart, D., Desai, R., Hamouda, A.K., Li, S.G., Kelly, E., Dostalova, Z., Zhou, X., Cotten, J.F., Raines, D.E., Olsen, R.W., Cohen, J.B., Forman, S.A., ...> ;J Med Chem. 2010 Sep 9
• High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors.
  Dostalova, Z., Liu, A., Zhou, X., Farmer, S.L., Krenzel, E.S., Arevalo, E., Desai, R., Feinberg-Zadek, P.L., Davies, P.A., Yamodo, I.H., Forman, S.A., Miller, K.W.> ;Protein Sci. 2010 Sep
• Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.
  Cotten, J.F., Forman, S.A., Laha, J.K., Cuny, G.D., Husain, S.S., Miller, K.W., Nguyen, H.H., Kelly, E.W., Stewart, D., Liu, A., Raines, D.E.> ;Anesthesiology. 2010 Mar
• Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization.
  Yamodo, I.H., Chiara, D.C., Cohen, J.B., Miller, K.W.> ;Biochemistry. 2010-01-12
• Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
  Cotten, J.F., Husain, S.S., Forman, S.A., Miller, K.W., Kelly, E.W., Nguyen, H.H., Raines, D.E.> ;Anesthesiology. 2009-08-01
• Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.
  Chiara, D.C., Hong, F.H., Arevalo, E., Husain, S.S., Miller, K.W., Forman, S.A., Cohen, J.B.> ;Mol Pharmacol. 2009-05-01
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