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Office
55 Fruit St, Yawkey 7.824
Boston, MA 02114Phone+1 617-724-3868Fax+1 617-724-3895- Is this information wrong?
Summary
- Dr. Kenneth Tanabe is a Professor of Surgery at Harvard Medical School and Chief of the Division of Surgical Oncology at Massachusetts General Hospital. He is the Deputy Clinical Director of the Massachusetts General Hospital Cancer Center and Director of the MGH Liver Surgery Program. Dr. Tanabe is a member of several of the top national and international organizations for surgery and for oncology. He serves on editorial boards of several top medical journals. His clinical practices focuses on surgical management of patients with liver tumors and patients with melanoma.
Dr. Tanabe directs a research laboratory focused on 1) hepatocellular carcinoma prevention; and 2) experimental gene therapy for liver tumors. His laboratory has been funded by the National Institutes of Health continuously since 1993.
Research in the area of hepatocellular carcinoma focuses on signal transduction pathways involved during malignant transformation of hepatocytes, and molecular mechanisms of cirrhosis progression. Agents that prevent progression of cirrhosis or prevent development of hepatocellular carcinoma in cirrhotic livers are examined in preclinical models before development of clinical trials. The effects on liver are monitored via a gene signature, in collaboration with Yujin Hoshida and Todd Golub at the Broad Institute.
Research in experimental gene therapy for liver tumors focuses on development of replication-conditional viruses that destroy tumors by virtue of replication in the tumor cells, a process that simultaneously produces daughter progeny virion that can infect adjacent tumor cells. Significant progress has been made in alteration of the viral genome to restrict viral replication in normal cells. One virus is now in clinical trial for patients with primary or secondary liver tumors.
Education & Training
- University of Texas M D Anderson Cancer CenterFellowship, Complex General Surgical Oncology, 1990 - 1993
- New York Presbyterian Hospital (Cornell Campus)Residency, Surgery, 1985 - 1990
- University of California San Diego School of MedicineClass of 1985
Certifications & Licensure
- MA State Medical License 1993 - 2026
- ME State Medical License 2020 - 2025
- NH State Medical License 2021 - 2025
- RI State Medical License 2021 - 2024
- TX State Medical License 1990 - 1993
- American Board of Surgery Surgery
- Society of Surgical OncologyFellowship in Surgical Oncology
Awards, Honors, & Recognition
- America's Top Doctors Castle Connolly, 2003-2014
- Boston Magazine Castle Connolly, 2009-2013
- America's Top Doctors for Cancer Castle Connolly, 2005-2013
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Clinical Trials
- rRp450-Phase I Trial in Liver Metastases and Primary Liver Tumors Start of enrollment: 2010 Oct 01
- Erlotinib Hydrochloride in Preventing Liver Cancer in Patients With Cirrhosis of the Liver Start of enrollment: 2014 Nov 24
Publications & Presentations
PubMed
- Portal Vein or Superior Mesenteric Vein Thrombosis with Dose-Escalated Radiation for Borderline or Locally Advanced Pancreatic Cancer.Alicia C Smart, Andrzej Niemierko, Jennifer Y Wo, Cristina R Ferrone, Kenneth K Tanabe, Keith D Lillemoe, Jeffrey W Clark, Lawrence S Blaszkowsky, Jill N Allen, Colin ...> ;Journal of Gastrointestinal Surgery. 2023 Nov 1
- 5 citationsPositron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) Versus the Standard of Care Imaging in the Diagnosis of Peritoneal Carcinomatosis.Felipe S Furtado, Mark Z Wu, Shadi A Esfahani, Cristina R Ferrone, Lawrence S Blaszkowsky, Jeffrey W Clark, David P Ryan, Lipika Goyal, Joseph W Franses, Jennifer Y Wo...> ;Annals of Surgery. 2023 Apr 1
- Correction to: Oncolytic HSV1 targets different growth phases of breast cancer leptomeningeal metastases.Darshini Kuruppu, Deepak Bhere, Christian T Farrar, Khalid Shah, Anna-Liisa Brownell, Umar Mahmood, Kenneth K Tanabe> ;Cancer Gene Therapy. 2023 Jun 1
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Journal Articles
- Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of CirrhosisKenneth K Tanabe, Ricard Masia, Derek J Erstad, Michael Lanuti, Journal of gastrointestinal surgery
- Facility Type Is Associated with Margin Status and Overall Survival in Patients with Intrahepatic Cholangiocarcinoma Who Undergo ResectionCristina R Ferrone, Kenneth K Tanabe, Motaz Qadan, Journal of The American College of Surgeons
- Single-Institution Experience of Hepatic Resection in the Elderly at a Tertiary Referral CenterJessica L Mueller, Cristina R Ferrone, Parsia A Vagefi, Kenneth K Tanabe, Motaz Qadan, Journal of The American College of Surgeons
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Other
- Cutaneous melanoma: Management of in transit metastasesTanabe KK, Tyler D
http://www.uptodate.com/contents/cutaneous-melanoma-management-of-in-transit-metastases
UpToDate, Wolters Kluwer Health - 2012-04-09 - Cutaneous melanoma: Management of local recurrenceTanabe KK, Tyler D
http://www.uptodate.com/contents/cutaneous-melanoma-management-of-local-recurrence
UpToDate, Wolters Kluwer Health - 2012-05-29
Authored Content
- Single-Institution Experience of Hepatic Resection in the Elderly at a Tertiary Referral CenterOctober 2018
- Facility Type Is Associated with Margin Status and Overall Survival in Patients with Intrahepatic Cholangiocarcinoma Who Undergo ResectionOctober 2018
Press Mentions
- Healing HarmoniesFebruary 10th, 2016
- Boston German Consul General Hosts Massachusetts General Hospital Music in Medicine ProgramFebruary 10th, 2016
Grant Support
- Training Program In Cancer BiologyNational Cancer Institute2007–2011
- Targeting Diffuse Liver Metastases With Herpes VirusNational Cancer Institute2006–2010
- Phase I Clinical Trial Of Viral Oncolysis Of Liver Tumo*National Cancer Institute2006–2007
- Targetting Diffuse Liver Metastases With Herpes VirusNational Cancer Institute2000–2002
- CD44 Alternative Splicing In Colorectal CarcinomasNational Cancer Institute1994–1998
Professional Memberships
- Member
Hospital Affiliations
- Massachusetts General HospitalBoston, Massachusetts
- Lowell General HospitalLowell, Massachusetts
- Newton-Wellesley HospitalNewton Lower Falls, Massachusetts
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