LawrenceSteinmanMD

PubMed

• Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis.
  Marius Marc-Daniel Mader, Alan Napole, Danwei Wu, Micaiah Atkins, Alexa Scavetti, Yohei Shibuya, Aulden Foltz, Oliver Hahn, Yongjin Yoo, Ron Danziger, Christina Tan, T...> ;Nature Neuroscience. 2024 Mar 21
• Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
  Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlod...> ;Nature Communications. 2024 Feb 20
• Hunger guides immunity to friend versus foe.
  Or-Geva, N., Steinman, L.> ;Nature Neuroscience. 2024 Mar 1
• A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis.
  Hashemi, E., Narain Srivastava, I., Aguirre, A., Tilahan Yoseph, E., Kaushal, E., Awani, A., Kyu Ryu, J., Akassoglou, K., Talebian, S., Chu, P., Pisani, L., Musolino, ...> ;Biorxiv. 2023 Nov 10
• Elevated α5 integrin expression on myeloid cells in motor areas in amyotrophic lateral sclerosis is a therapeutic target.
  Aude Chiot, Shanu F Roemer, Lisa Ryner, Alina Bogachuk, Katie Emberley, Dillon Brownell, Gisselle A Jimenez, Michael Leviten, Randall Woltjer, Dennis W Dickson, Lawren...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Aug 8
• 1 citations
  T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
  Sharon A Sagan, Zahra Moinfar, Carson E Moseley, Ravi Dandekar, Collin M Spencer, Alan S Verkman, Ole Petter Ottersen, Raymond A Sobel, John Sidney, Alessandro Sette, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Jul 25
• A Phase 1 Study of Oral Vitamin Din Boys and Young Men With X-Linked Adrenoleukodystrophy.
  Keith P Van Haren, Kristen Cunanan, Avni Awani, Meng Gu, Dalia Peña, Lindsay C Chromik, Michal Považan, Nicole C Rossi, Jordan Goodman, Vandana Sundaram, Jennifer Wint...> ;Neurology. Genetics. 2023 Apr 1
• Augmentation of a neuroprotective myeloid state by hematopoietic cell transplantation.
  Marius Marc-Daniel Mader, Alan Napole, Danwei Wu, Yohei Shibuya, Alexa Scavetti, Aulden Foltz, Micaiah Atkins, Oliver Hahn, Yongjin Yoo, Ron Danziger, Christina Tan, T...> ;Biorxiv. 2023 Mar 12
• 1 citations
  An intrinsically disordered protein, osteopontin, driving neuropathology in Alzheimer's dementia.
  Lawrence Steinman> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Feb 7
• 9 citations
  Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger disease.
  Lawrence Steinman, Roberto Patarca, William Haseltine> ;The Journal of Experimental Medicine. 2023 Feb 6
• 3 citations
  Roadmap for understanding mechanisms on how Epstein-Barr virus triggers multiple sclerosis and for translating these discoveries in clinical trials.
  Tobias V Lanz, William H Robinson, Peggy P Ho, Lawrence Steinman> ;Clinical & Translational Immunology. 2023 Jan 1
• Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder: From the National Multiple Sclerosis Society Case Conference Proceedings.
  Carolyn Goldschmidt, Steven L Galetta, Robert P Lisak, Laura J Balcer, Andrew Hellman, Michael K Racke, Amy E Lovett-Racke, Roberto Cruz, Matthew S Parsons, Neda Satta...> ;Neurology(R) Neuroimmunology & Neuroinflammation. 2023 Jan 1
• 1 citations
  Bioavailable central nervous system disease-modifying therapies for multiple sclerosis.
  Hans-Peter Hartung, Bruce A C Cree, Michael Barnett, Sven G Meuth, Amit Bar-Or, Lawrence Steinman> ;Frontiers in Immunology. 2023 Jan 1
• Reply to Fillmore et al.: Additional evidence of non-SARS-CoV-2 coronavirus cross-immunity.
  Matthew D Solomon, Lawrence Steinman, Vincent X Liu> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Nov 16
• 4 citations
  Peripheral T-Cells, B-Cells, and Monocytes from Multiple Sclerosis Patients Supplemented with High-Dose Vitamin D Show Distinct Changes in Gene Expression Profiles.
  Dohyup Kim, Emily E Witt, Simone Schubert, Elias Sotirchos, Pavan Bhargava, Ellen M Mowry, Karen Sachs, Biter Bilen, Lawrence Steinman, Avni Awani, Zihuai He, Peter A ...> ;Nutrients. 2022 Nov 9
• 12 citations
  NADmetabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity.
  Tom Meyer, Dor Shimon, Sawsan Youssef, Gal Yankovitz, Adi Tessler, Tom Chernobylsky, Anat Gaoni-Yogev, Rita Perelroizen, Noga Budick-Harmelin, Lawrence Steinman, Lior ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Aug 30
• Michael Sela: Scientist, statesman, sage (1924-2022).
  Lawrence Steinman> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Aug 23
• 2 citations
  Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis.
  Bao Ying Chen, Jessica R Salas, Alyssa O Trias, Arely Perez Rodriguez, Jonathan E Tsang, Miriam Guemes, Thuc M Le, Zoran Galic, H Michael Shepard, Lawrence Steinman, D...> ;Immunology. 2023 Jan 1
• 9 citations
  Risk of severe COVID-19 infection among adults with prior exposure to children.
  Matthew D Solomon, Gabriel J Escobar, Yun Lu, David Schlessinger, Jonathan B Steinman, Lawrence Steinman, Catherine Lee, Vincent X Liu> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Aug 16
• 12 citations
  Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Up to 5 years of follow-up in the DAYBREAK open-label extension trial.
  Bruce Ac Cree, Krzysztof W Selmaj, Lawrence Steinman, Giancarlo Comi, Amit Bar-Or, Douglas L Arnold, Hans-Peter Hartung, Xavier Montalbán, Eva K Havrdová, James K Shef...> ;Multiple Sclerosis. 2022 Oct 1
• Mobilization of innate and adaptive antitumor immune responses by the RNP-targeting antibody ATRC-101.
  Alexander Scholz, Jeff DeFalco, Yvonne Leung, Iraz T Aydin, Cathrin J Czupalla, Wei Cao, Daniel Santos, Nikhil Vad, Shaun M Lippow, Gilson Baia, Michael Harbell, Judev...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 May 10
• 72 citations
  COVID-19 therapeutics: Challenges and directions for the future.
  Philip C Robinson, David F L Liew, Helen L Tanner, John R Grainger, Raymond A Dwek, Ronald B Reisler, Lawrence Steinman, Marc Feldmann, Ling-Pei Ho, Tracy Hussell, Pau...> ;Proceedings of the National Academy of Sciences of the United States of America. 2022 Apr 12
• 292 citations
  Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.
  Tobias V Lanz, R Camille Brewer, Peggy P Ho, Jae-Seung Moon, Kevin M Jude, Daniel Fernandez, Ricardo A Fernandes, Alejandro M Gomez, Gabriel-Stefan Nadj, Christopher M...> ;Nature. 2022 Mar 1
• 45 citations
  Epstein-Barr virus and multiple sclerosis.
  William H Robinson, Lawrence Steinman> ;Science. 2022 Jan 21
• 11 citations
  Plasma neurofilament light chain concentrations as a biomarker of clinical and radiologic outcomes in relapsing multiple sclerosis: Post hoc analysis of Phase 3 ozanim...
  Sarah Harris, Giancarlo Comi, Bruce A.C. Cree, Douglas L. Arnold, Lawrence Steinman, James K Sheffield, Harry Southworth, Ludwig Kappos, Jeffrey A. Cohen, ozanimod stu...> ;European Journal of Neurology. 2021 Jul 22
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Journal Articles

• Engineered DNA Plasmid Reduces Immunity to Dystrophin While Improving Muscle Force in a Model of Gene Therapy of Duchenne Dystrophy  
  Lawrence Steinman, William H Robinson, Proceedings of the National Academy of Sciences