Lee Ratner MD

PubMed

• Viral oncogenes drive biphenotypic lymphoproliferative malignancy in transgenic mice.
  Daniel A Rauch, John Harding, Ancy Joseph, Lee Ratner
  Scientific Reports. 2025-10-17
• 2 citations
  Neoadjuvant BMS-813160, Nivolumab, Gemcitabine, and Nab-Paclitaxel for Patients with Pancreatic Cancer.
  Patrick M Grierson, Crystal Wolf, Rama Suresh, Andrea Wang-Gillam, Benjamin R Tan
  Clinical Cancer Research. 2025-09-02
• Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis.
  Ancy Joseph, Xiaogang Cheng, John Harding, Jacob Al-Saleem, Patrick Green
  Plos Pathogens. 2025-06-01

Journal Articles

• V1 and V2 Domains of HIV Envelope Contribute to CCR5 Antagonist Resistance  
  Lee Ratner, MD, mBio
• Outcome of patients with relapsed/refractory AIDS-related lymphoma diagnosed 1999-2008 in the AIDS Malignancy Consortium  
  Bayraktar UD, Peetrich A, Gupta N, Lensing S, Moore P, Reid EG, Aboulafia DM, Ratner L, Mitsuyasu R, Stier E, Henry DH, Barr P, Noy A, Leukemia & Lymphoma, 1/1/2013
• Cytolytic nanoparticles attenuate HIV-1 infectivity  
  Hood JL, Jallouk AP, Campbell N, Ratner L, Wickline SA, Antiviral Therapy, 1/1/2013
• Treatment factors affecting outcomes in HIV associated non-Hodgkin’s lymphomas: a pooled analysis of 1546 patients  
  Barta SK, Xue X, Wang D, Tamari R, Lee JY, Mounier N, Kaplan LD, Ribera J-M, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Wilson W, Wyen C, Oriol A, Navarro J-T, D..., Blood, 1/1/2013
• IFN-alpha restricts HTLV-1 and HTLV-2 infection through PKR activation  
  Cachat A, Chevalier S, Alais S, Ko NL, Ratner L, Journo C, Dutarre H, Mahieux R, J Virology, 1/1/2013
• The SMAC mimetic RMT52652HCL induces apoptosis in EBV AND HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C a...  
  Ramachandiran S, Cain J, Liao A, He Y, Guo, X, Boise L, Fu H, Ratner L, Khoury HJ, and Bernal-Mizrachi L, Leukemia Research, 1/1/2012
• Vpx is critical for SIVmne infection of pigtail macaques  
  Belshan M, Kimata J, Brown C, Cheng X, McCulley A, Larsen A, Thippeshappa R, Hodara V, Giavedoni L, Hirsch V, Ratner L, Retrovirology, 1/1/2012
• HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection  
  McCulley A, Ratner L, Virology, 1/1/2012
• Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis  
  Zane L, Yasunaga J, Mitagami Y, Matsuoka M, Yedavalli V, Tan S-W, Ratner L, Liu X, and Jeang KT, Retrovirology, 1/1/2012
• Liposomal doxorubicin, rituximab, cyclophosphamide, vincristine, and prednisone (DR-COP) in AIDS-related lymphoma: AIDS Malignancy Consortium Study 047  
  Levine AM, Noy A, Lee J, Cesarman E, Ramos JC, Henry D, Sparano J, Reid E, Mitsuyasu R, Dezube B, Ratner L, Tulpule A, Journal of Clinical Oncology, 1/1/2012
• The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30II mRNA  
  Choudhary G, Ratner L, Virology, 1/1/2011
• Adjustable post-formulation drug loading of nanostructures for metered control of NF-kB signaling  
  Pan H, Ivashyna O, Sinha B, Lanza GM, Ratner L, Schlesinger PH, Wickline SA, Biomaterials, 1/1/2011
• Integrase inhibitors effective againt human T-cell leukemia virus type 1  
  Seegulam, ME, Ratner L, Antimicrobial Agents and Chemotherapy, 1/1/2011
• Targeting HTLV-1 activation of NFkB in mouse models and ATLL patients  
  Rauch DA, Ratner L, Viruses, 1/1/2011
• Molecular determinants of human T-lymphotropic virus type 1 transmission and spread  
  Lairmore MD, Anupam R, Bowden N, Haines R, Haynes RA, Ratner L, Green PL, Viruses, 1/1/2011
• HIV-1 determinants of thrombocytopenia at the stage of CD34+ progenitor cell differentiation in vivo lie in the viral envelop gp120 V3 loop region  
  Zhang M, Evans S, Yuan J, Ratner L, and Koka PS, Virology, 1/1/2010
• Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step  
  Harmon B, Campbell N, Ratner L, PLoS Pathogens, 1/1/2010
• Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective without excessive toxicity in HIV-associated, B-cell non-Hodgkin's lymphoma  
  Sparano JA, Lee J, Kaplan LD, Levine A, Harrington W, Ambinder R, Wachsman W, Aboulafia D, Noy A, Henry D, Von Roenn J, Dezube B, Remick S, Shah M, Leichman L, Ratner ..., Blood, 1/1/2010
• The Arf tumor suppressor regulates bone remodeling and osteosarcoma development  
  Rauch DA, Hurchla MA, Harding JC, Deng H, Shea L, Eagleton MC, Niewiesk S, Lairmore M, Piwnica-Worms D, Rosol T, Weber JD, Ratner L, Weilbaecher K, PLOS One, 1/1/2010
• Bioluminescence imaging of myeloperoxidase activity in vivo  
  Gross S, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D, Nature Medicine, 1/1/2009
• Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors  
  Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L, Blood, 1/1/2009
• Mutation of critical serine residues in HIV-1 matrix result in an envelope incorporation defect which can be rescued by truncation of the gp41 cytoplasmic tail  
  Bhatia A, Kaushik R, Pontow S, Vander Heyden N, Ratner L, Virology, 1/1/2009
• Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma  
  Ratner L, Harrington W, Feng X, Grant C, Jacobson S, Noy A, Sparano J, Lee J, Ambinder R, Campbell N, Lairmore M, for the AIDS Malignancy Consortium, PLOS One, 1/1/2009
• A novel role for IL2R-Jak signaling in retrovirus virion maturation and infectivity  
  Taylor JM, Brown M, Nejmeddine M, Kim KJ, Ratner L, Lairmore M, Bangham C, Nicot C, J Virology, 1/1/2009
• T-cell activation promotes tumorigenesis in inflammation associated cancer  
  Rauch D, Gross S, Harding J, Bokhari S, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L, Retrovirology, 1/1/2009
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Abstracts/Posters

• A Randomized Trial of EPOCH-Based Chemotherapy with Vorinostat for Highly Aggressive HIV-Associated Lymphomas: Updated Results Evaluating Impact of Diagnosis-to-Treatm...
  Lee Ratner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Safety and Efficacy of Brentuximab Vedotin in Combination with AVD in Stage II-IV HIV-Associated Classical Hodgkin Lymphoma: Results of the Phase 2 Study, AMC 085
  Lee Ratner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Response-Adapted Therapy with Infusional EPOCH Chemotherapy Plus Rituximab in HIV-Associated, B-Cell Non-Hodgkin's Lymphoma
  Lee Ratner, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019