ManishKumarAghiMDPhD

PubMed

• Lymphatic endothelial-like cells in the glioblastoma tumor niche drive metabolic alterations that promote stem cell proliferation and survival.
  Reilly L Kidwell, Manish K Aghi> ;Neuro-Oncology. 2024 Feb 28
• Cancer-associated fibroblast-secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas.
  Shashwat Tripathi, Hinda Najem, Corey Dussold, Sebastian Pacheco, Jason Miska, Kathleen McCortney, Alicia Steffens, Jordain Walshon, Daniel Winkowski, Michael Cloney, ...> ;The Journal of Clinical Investigation. 2024 Feb 15
• Survival outcomes and prognostic factors of infratentorial glioblastoma in the elderly.
  Lopez-Rivera, V., Esquenazi, Y., Chandra, A., Ryba, B., Chandran, A., Brandel, M., Dono, A., Sheinberg, D., Aghi, M.> ;Clinical Neurology and Neurosurgery. 2024 Jan 1
• Glioma Cells Secrete Collagen VI to Facilitate Invasion.
  Cha, J., Ding, E., Carvalho, E., Fowler, A., Kumar, S., Aghi, M.> ;Biorxiv. 2023 Dec 12
• 1 citations
  "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
  Hadad, S., Gupta, R., Oberheim Bush, N., Taylor, J., Villanueva-Meyer, J., Young, J., Wu, J., Ravindranathan, A., Zhang, Y., Warrier, G., McCoy, L., Shai, A., Pekmezci...> ;Acta Neuropathologica. 2023 Dec 11
• An engineered glioblastoma model yields novel macrophage-secreted drivers of invasion.
  Erin A Akins, Dana Wilkins, Sanjay Kumar, Aghi, M.> ;Biorxiv. 2023 Nov 19
• 1 citations
  Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations.
  Garcia, J., Akins, E., Jain, S., Wolf, K., Zhang, J., Choudhary, N., Lad, M., Shukla, P., Rios, J., Seo, K., Gill, S., Carson, W., Carette, L., Zheng, A., Raleigh, D.,...> ;The Journal of Clinical Investigation. 2023 Nov 16
• Correlation of Brain Metastasis Genomic Alterations with Preoperative Imaging Features.
  Amalie S V Uggerly, Daniel D Cummins, Minh P Nguyen, Manish K Aghi, Ramin A Morshed, Saggi, S., Saggi, S., Saggi, S., Satvir Saggi> ;World Neurosurgery. 2024 Jan 1
• Intraventricular meningioma resection and visual outcomes.
  John P Andrews, Daniel D Cummins, Ramin A Morshed, Benyam Kinde, Manish K Aghi, Michael W McDermott, Mitchel S Berger, Philip V Theodosopoulos> ;Journal of Neurosurgery. 2024 Apr 1
• 3 citations
  Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification.
  Ken K Y Ho, Ursula B Kaiser, Phillippe Chanson, Monica Gadelha, John Wass, Lynnette Nieman, Andrew Little, Manish K Aghi, Lori Raetzman, Kalmon Post, Gerald Raverot, A...> ;Nature Reviews. Endocrinology. 2023 Nov 1
• Socioeconomic differences between medically and surgically treated prolactinomas: a retrospective review of 598 patients.
  Robert C Osorio, Alexander F Haddad, Danielle M Hart, Nathaniel Goldrich, Aarav Badani, Aymen S Kabir, Ryan Juncker, Jun Y Oh, Luis Carrete, Zain Peeran, Eric J Chalif...> ;Journal of Neurosurgery. 2024 Mar 1
• Analysis of upfront resection or stereotactic radiosurgery for local control of solid and cystic cerebellar hemangioblastomas.
  Luis R Carrete, Ramin A Morshed, Jacob S Young, Lauro N Avalos, Penny K Sneed, Manish K Aghi, Michael W McDermott, Philip V Theodosopoulos> ;Journal of Neurosurgery. 2024 Feb 1
• Association of CDKN2A alterations with increased postoperative seizure risk after resection of brain metastases.
  Daniel D Cummins, Joseph H Garcia, Minh P Nguyen, Satvir Saggi, Jason E Chung, Ezequiel Goldschmidt, Mitchel S Berger, Philip V Theodosopoulos, Edward F Chang, Shawn L...> ;Neurosurgical Focus. 2023 Aug 1
• 1 citations
  Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.
  Harish N Vasudevan, Cyrille Delley, William C Chen, Kanish Mirchia, Sixuan Pan, Poojan Shukla, Alex A Aabedi, Minh P Nguyen, Ramin A Morshed, Jacob S Young, Lauren Bor...> ;JAMA Network Open. 2023 Aug 1
• Genomic alterations associated with rapid progression of brain metastases.
  Amalie S V Uggerly, Daniel D Cummins, Minh P Nguyen, Satvir Saggi, Ezequiel Goldschmidt, Edward F Chang, Michael W McDermott, Mitchel S Berger, Philip V Theodosopoulos...> ;Neurosurgical Focus. 2023 Aug 1
• Introduction. Update on brain metastases.
  Manish K Aghi, Priscilla K Brastianos, Albert H Kim, Steven N Kalkanis, Joerg-Christian Tonn> ;Neurosurgical Focus. 2023 Aug 1
• Genomic alterations associated with postoperative nodular leptomeningeal disease after resection of brain metastases.
  Ramin A Morshed, Daniel D Cummins, Minh P Nguyen, Satvir Saggi, Harish N Vasudevan, Steve E Braunstein, Ezequiel Goldschmidt, Edward F Chang, Michael W McDermott, Mitc...> ;Journal of Neurosurgery. 2024 Feb 1
• High-volume facilities are not always low risk: comparing risk-standardized mortality rates versus facility volume as quality measures in surgical neuro-oncology.
  Eric J Chalif, Jacob S Young, Genaro R Villa, Manish K Aghi, Jacopo Lenzi, Mitchel S Berger> ;Journal of Neurosurgery. 2024 Jan 1
• 1 citations
  Does waiting for surgery matter? How time from diagnostic MRI to resection affects outcomes in newly diagnosed glioblastoma.
  Jacob S Young, Nadeem N Al-Adli, Rachel Muster, Ankush Chandra, Ramin A Morshed, Eric J Chalif, Shawn L Hervey-Jumper, Philip V Theodosopoulos, Michael W McDermott, Mi...> ;Journal of Neurosurgery. 2024 Jan 1
• Gender-Based Disparities in Academic Productivity Arise During Neurosurgery Residency: A Systematic Review.
  Vera Ong, Maya Harary, Mahlet Mekonnen, Leslie Hwang, Shravan Patel, Natalie Mahgerefteh, Diba Nayeri, Anubhav Chandla, Courtney Duong, Isaac Yang, Manish K Aghi, Khas...> ;Neurosurgery. 2023 Nov 1
• In Reply: Neurosurgical Outcomes for Pediatric Central Nervous System Tumors in the United States.
  Eric J Chalif, Ramin A Morshed, Taemin Oh, Cecilia Dalle Ore, Manish K Aghi, Nalin Gupta> ;Neurosurgery. 2023 Jul 1
• 2 citations
  Metabolic Barriers to Glioblastoma Immunotherapy.
  Nikita Choudhary, Robert C Osorio, Jun Y Oh, Manish K Aghi> ;Cancers. 2023 Feb 28
• Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations.
  Joseph H Garcia, Erin A Akins, Saket Jain, Kayla J Wolf, Jason Zhang, Nikita Choudhary, Meeki Lad, Poojan Shukla, Sabraj Gill, Will Carson, Luis Carette, Allison Zheng...> ;Biorxiv. 2023 Feb 24
• 2 citations
  Neurosurgical Outcomes for Pediatric Central Nervous System Tumors in the United States.
  Eric J Chalif, Ramin A Morshed, Taemin Oh, Cecilia Dalle Ore, Manish K Aghi, Nalin Gupta> ;Neurosurgery. 2023 Feb 1
• 1 citations
  Facility Volume and Pituitary Surgery.
  Eric J Chalif, Manish K Aghi> ;Otolaryngology--Head and Neck Surgery. 2023 Jun 1
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Journal Articles

• The Genetic Landscape of Gliomas Arising After Therapeutic Radiation  
  Iwei Yeh, Corey Raffel, Mitchel Berger, Joanna J Phillips, James P Grenert, Boris C Bastian, David A Solomon, Nicholas Butowski, Sabine Mueller, Cassie Kline, Manish A..., Acta Neuropathologica
• Functional Brain Mapping: Overview of Techniques and Their Application to Neurosurgery  
  Manish K Aghi, Jonathan Rick, Neurosurgical Review
• Single-Cell Profiling of Human Gliomas Reveals Macrophage Ontogeny as a Basis for Regional Differences in Macrophage Activation in the Tumor Microenvironment  
  Daniel A Lim, S John Liu, Manish Aghi, Hideho Okada, Nduka M Amankulor, Arnold R Kriegstein, BioMed Central
• The prognostic implications of Hyman's subtype for patients with Kadish stage C esthesioneuroblastoma.  
  Kaur G, Kane AJ, Sughrue ME, Madden M, Oh MC, Sun MZ, Safaee M, El-Sayed I, Aghi MK, McDermott MW, Berger MS, Parsa AT., Journal of Clinical Neuroscience, 1/1/2013
• Gliosarcoma arising from an oligodendroglioma (oligosarcoma).  
  Hiniker A, Hagenkord JM, Powers MP, Aghi MK, Prados MD, Perry A., Clinical Neuropathology, 1/1/2013
• Gene expression profile identifies mesenchymal tyrosine kinase c-Met as a targetable mediator of anti-angiogenic therapy resistance.  
  Jahangiri A, Carbonell WS, De Lay M, Hu Y-L, Lu K, Paquette J, Tokuyasu TA, Tsao S, Chaumeil MM, Ronen SM, Bergers G, Aghi MK., Clinical Cancer Research, 1/1/2013
• Endoscopic surgery for tuberculum sellae meningiomas: a systematic review and meta-analysis.  
  Clark AJ, Jahangiri A, Garcia RM, George J, Sughrue ME, McDermott MW, El-Sayed I, Aghi MK, Neurosurgical Review, 1/1/2013
• Targeting Beta1 Integrin Potentiates Bevacizumab Therapy and Inhibits Growth of Bevacizumab-Resistant Glioblastoma Multiforme.  
  Carbonell WS, De Lay M, Jahangiri A, Park C, Aghi MK., Cancer Research, 1/1/2013
• Surgical outcomes in choroid plexus papillomas: an institutional experience.  
  Safaee M, Clark AJ, Bloch O, Oh MC, Singh A, Auguste KI, Gupta N, McDermott MW, Aghi MK, Berger MS, Parsa AT, Journal of Neurooncology, 1/1/2013
• A Comprehensive Long-Term Retrospective Analysis of Silent Corticotrophic Adenomas versus Hormone-Negative Adenomas.  
  Jahangiri A, Wagner JR, Pekmezci M, Hiniker A, Chang EF, Kunwar S, Blevins L, Aghi MK, Neurosurgery, 1/1/2013
• Nuclear localization of the mitochondrial factor HIGD1A during severe stress.  
  Ameri K, Rajah A, Nguyen V, Sanders T, Jahangiri A, De Lay M, Yeghiazarians Y, Jeffrey SS, RInaudo PF, Rowitch DH, Aghi MK, and Maltepe E, PLOS One, 1/1/2013
• Minimally Invasive Approaches to the Anterior Skull Base.  
  Ivan M, Jahangiri A, El-Sayed IH, Aghi MK., Neurosurgery Clinics of North America, 1/1/2013
• Skull base chordomas.  
  Jahangiri A, Jian B, Miller L, El-Sayed IH, Aghi MK., Neurosurgery Clinics of North America, 1/1/2013
• Hypoxia-induced autophagy promotes tumor cell survival and adaptation to anti-angiogenic treatment in glioblastoma.  
  Hu Y-L, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK., Cancer Research, 1/1/2012
• Application of novel response/progression measures for surgically delivered therapies for gliomas.  
  Aghi MK, Vogelbaum MA, Jost S, Heimberger AB, Sampson JH, Wen PY, Macdonald DR, Van den Bent MJ, Chang SM, Neurosurgery, 1/1/2012
• Tumor cell autophagy as an adaptive response mediating resistance to treatments like anti-angiogenic therapy.  
  Hu YL, Jahangiri A, DeLay M, Aghi MK, Cancer Research, 1/1/2012
• Microarray analysis verifies two distinct phenotypes of glioblastomas resistant to anti-angiogenic therapy.  
  De Lay M, Jahangiri A, Carbonell WS, Hu Y-L, Tsao S, Tom MW, Paquette J, Tokuyasu TA, Aghi MK., Clinical Cancer Research, 1/1/2012
• Hypoxia-induced tumor cell autophagy mediates resistance to anti-angiogenic therapy.  
  Hu YL, Jahangiri A, De Lay M, Aghi MK., Autophagy, 1/1/2012
• VEGF inhibits tumor cell invasion through a novel c-Met/VEGFR2 complex.  
  Lu KV, Chang JP, Pandika MM, Aghi MK, Meyronet D, Isachenko N, Fouse SD, Phillips JJ, Cheresh DA, Bergers G, Cancer Cell, 1/1/2012
• Impact of extent of resection for recurrent glioblastoma on overall survival.  
  Bloch O, Han SJ, Cha S, Sun MZ, Aghi MK, McDermott MW, Berger MS, Parsa AT, Journal of Neurosurgery, 1/1/2012
• Identification of pY654-b-catenin as a critical co-factor in hypoxia-inducible factor-1asignaling and tumor response to hypoxia.  
  Wei Y, Sennino B, Ulsamer A, Xi Y, Kwan I, Brumwell A, Tan K, Aghi MK, McDonald D, Chapman HA, Oncogene, 1/1/2012
• Oncolytic herpes simplex virus engineering and preparation.  
  Agarwalla PK, Aghi MK., Methods in Molecular Biology, 1/1/2012
• Pseudoprogression and treatment effect.  
  Jahangiri A, Aghi MK., Neurosurgery Clinics of North America, 1/1/2012
• Medical versus surgical management of prolactinomas.  
  Oh M, Kunwar S, Blevins L, Aghi MK., Neurosurgery Clinics of North America, 1/1/2012
• Hu Y-L, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK.  
  Hu Y-L, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK., Cancer Research, 1/1/2012
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Books/Book Chapters

• Tumors of the Central Nervous System 
  Chapter: Management of atypical meningiomas. 
  Page 127 - 136Agarwalla PK, Aghi MK.Editors: Hayat MA.Springer Publishing Company, New York, NYEdition 1st ,2012
• Schmidek and Sweet’s Operative Neurosurgical Techniques: Indications, Methods, and Results 
  Chapter: Surgical management of cerebellar tumors in adults. 
  Page 169 - 177Ngwenya LB, Baig M, Aghi MK, Chiocca EA.Editors: Quinones-Hinojosa A.WB Saunders, New York, NYEdition 6th ,2012
• The Evidence for Neurosurgery 
  Chapter: Surgical management of pituitary tumors. 
  Page 211 - 226Oh M, Aghi MK.Editors: Benzel EC, Batjer HH, Steinmetz MP, Krishnaney A, Ghogawala Z.TFM Publishing LTD, United KingdomEdition 1st ,2012
• Advances in the Pathogenesis and Treatment of Glioblastoma Multiforme 
  Chapter: Genes, viruses, toxins, vaccines as therapeutic modalities. 
  Page 42 - 53Shahar T, Aghi MK, Ram ZEditors: Prados MD.Future Medicine Publishers, London, EnglandEdition 1st ,2012
• Pituitary Disorders: Diagnosis and Management 
  Oh M, Aghi MK.Editors: Laws ER, Ezzat S, Asa SL, Rio LM, Michel L.Wiley-Blackwell Publishers, Oxford, EnglandEdition 1st ,2012
• Youmans Neurological Surgery 
  Chapter: Interstitial and Intracavitary Irradiation of Brain Tumors. 
  Page 2609 - 2615Aghi M, Sneed PK, McDermott MW, Berger MS.Editors: Winn RH.Elsevier, St. Louis, MOEdition 6th ,2011
• Schmidek and Sweet’s Operative Neurosurgical Techniques: Indications, Methods, and Results 
  Chapter: Surgical Management of Intracerebral Hemorrhage. 
  Page 1061 - 1074Aghi M, Ogilvy CS, Carter BEditors: Roberts DW, Schmidek HH.WB Saunders, New York, NYEdition 5th ,2006
• Controversies in Neuro-Oncology (Avastin and Malignant Gliomas). 
  Chapter: Neurosurgical Implications of Bevacizumab Therapy of Malignant Gliomas. 
  Page 100 - 106Aghi M, Sneed PK, McDermott MW, Berger MS.Editors: Chen TC, Chamberlain M.Bentham Science Publishers Ltd, Oak Park, IL2006
• Minimally Invasive Neurosurgery 
  Chapter: Gene-based and viral-based therapies. 
  Page 267 - 294Aghi M, Chiocca EA.Editors: Black PM, Proctor MR.Humana Press Inc., Totowa, NJ2005
• Glioblastoma Multiforme, 
  Chapter: Viral therapy for glioblastoma. 
  Page 167 - 179Chiocca EA, Aghi M, Fulci G.Editors: Markert J, DeVita VT, Rosenberg SA, Hellman S.Jones and Bartlett Publishers, Boston, MA2004
• Cancer of the Nervous System 
  Chapter: Gene Therapy 
  Page 225 - 242Aghi M, Chiocca EA.Editors: Black PM, Loeffler JS.Lippincott Williams and Wilkins, Philadelphia, PAEdition 2nd ,2004
• Methods in Molecular Medicine, Gene Therapy of Cancer: Methods and Protocols 
  Chapter: HSV-1 vectors for gene therapy of experimental CNS tumors. 
  Page 287 - 312Herrlinger U, Jacobs A, Aghi M, Schuback DE, Breakefield XO.Editors: Walther W, Stein U.Humana Press Inc., Totowa, NJ2000
• Genetic Manipulation of the Nervous System 
  Chapter: Gene delivery to the nervous system using retroviral vectors. 
  Page 149 - 180Sena-Esteves M, Aghi M, Pechan P, Kaye E, Breakefield XO.Editors: Lachman D.Academic Press1995
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Lectures

• Panelist for the "Pituitary Tumors" breakfast seminar 
  American Association of Neurological Surgeons - 1/1/2014
• Pituitary Disorders: Advances in Diagnosis and Management 
  University of California, San Francisco, San Francisco, California - 9/27/2013
• Pituitary Disorders: Advances in Diagnosis and Management 
  University of California, San Francisco, San Francisco, California - 9/27/2013
• Asked to present data from my clinical trial using convection enhanced delivery of replicating retrovirus (Invited Talk) 
  Third Annual Targeted Drug Delivery Conference - 1/1/2013
• Senior author on one of 20 abstracts selected for oral presentation from nearly 200 submitted abstracts (Invited Talk) 
  AANS/CNS Tumor Section Satellite Symposium - 1/1/2013
• Senior author on one of 13 abstracts selected for oral presentation from over 200 submitted abstracts (Invited Talk) 
  Congress of Neurological Surgeons (CNS) Annual Meeting - 1/1/2013
• Senior author on abstract selected for oral presentation from over 250 submitted abstracts (Invited Talk) 
  World Federation for Neuro-Oncology / Society for Neuro-Oncology Annual Meeting - 1/1/2013
• Course on Endoscopic Endonasal Surgery of the Cranial Base and Pituitary Fossa, Guest Faculty 
  Pittsburgh, PA - 1/1/2013
• Speaker for the Education Day on "From Drug Discovery to the Clinic" 
  Society for Neuro-Oncology and World Federation for Neuro-Oncology Annual Meeting - 1/1/2013
• Panelist for the "Pituitary Tumors" luncheon seminar 
  Congress of Neurological Surgeons - 1/1/2013
• Pituitary Disorders: Advances in Diagnosis and Management 
  University of California, San Francisco, San Francisco, California - 10/27/2012
• Invited Talk 
  World Congress for Endoscopic Surgery of the Brain, Skull Base, and Spine; Vienna, Austria - 1/1/2012
• Senior author on one of 20 oral presentations selected from over 200 submitted abstracts (Invited talk) 
  American Association of Neurologic Surgeons Annual Meeting - 1/1/2012
• Discussed clinical trial results (Invited Talk) 
  Second International Meeting of the Society for CNS Interstitial Delivery of Therapeutics - 1/1/2012
• Webinar Presenter - for patient and provider education 
  Pituitary Network Association (PNA) - 1/1/2012
• Lecturer for the "Update on Brain Tumors for the General Neurosurgeon" Course 
  Congress of Neurological Surgeons - 1/1/2012
• "Antero-Lateral Skull Base Approaches," Co-Director 
  Stryker National Skull Base Surgery Lecture and Anatomy Lab-Based Course - 1/1/2012
• "Pituitary Disorders: Advances in Diagnosis and Management" (Co-director) 
  CME Course - 1/1/2012
• Speaker for the Education Day on Tumor Biomarkers 
  Society for Neuro-Oncology - 1/1/2012
• Skull Base Course (Guest Faculty) 
  University of Washington, Seattle, WA - 1/1/2012
• One of 4 oral plenary sessions in main auditorium in front of over 300 scientists and oncologists (Plenary session) 
  13th International Symposium on Anti-Angiogenic Therapy - 1/1/2011
• Grand Rounds 
  The Queen's Medical Center; Honolulu, HI - 1/1/2011
• Senior author on one of 20 oral presentations selected from over 200 submitted abstracts (Invited Talk) 
  Congress of Neurologic Surgeons, Annual Meeting - 1/1/2011
• "Novel Therapies in the Management of Malignant Brain Tumors: Avastin and Surgery" (Faculty) 
  Congress of Neurologic Surgeons (CNS) University of Neurosurgery Tumor Webinar - 1/1/2011
• Speaker for the Education Day on Clinical Trial Design 
  Society for Neuro-Oncology - 1/1/2011
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Other

• UCSF doctors use viruses to attack brain tumors. 
  ABC Bay Area News
  ABC Bay Area News: UCSF Neurosurgeon Manish Aghi becomes the first in the country to deliver a thera - 7/1/2012
• Neurosurgical Implications of Bevacizumab Therapy of Malignant Gliomas. 
  Aghi M, Sneed PK, McDermott MW, Berger MS.
  http://www.benthamdirect.org/pages/b_bookarticle.php
  2/1/2011
• The healing power of pets. 
  ABC Bay Area News
  ABC Bay Area News: UCSF Neurosurgeon Manish Aghi removes pituitary tumor from visually impaired pati - 4/1/2009