ManishR.PatelMD

specializes in Hematology currently practices at Florida Cancer Specialists and is affiliated with Tampa General Hospital

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Office
Florida Cancer Specialists (SAC)
600 North Cattlemen Road, Suite 200
Sarasota, FL 34232
Phone+1 941-377-9993

Fax+1 941-343-0026
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Summary

Dr. Manish Patel, MD is an oncologist in Sarasota, Florida. He is currently licensed to practice medicine in Florida. He is affiliated with HCA Florida Sarasota Doctors Hospital, Sarasota Memorial Hospital - Sarasota, and Lee Memorial Hospital.

Education & Training

University of South Florida MorsaniFellowship, Hematology and Medical Oncology, 2008 - 2011
Vanderbilt University Medical CenterResidency, Internal Medicine, 2005 - 2008
University of Miami Leonard M. Miller School of MedicineClass of 2005

Certifications & Licensure

FL State Medical License 2009 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification OncoEMR, Altos Solutions, Inc., 2012-2014

Clinical Trials

Safety Study of X-82 in Patients With Advanced Solid Tumors Start of enrollment: 2011 Feb 01
Completed
Phase 1
A Rollover Study for Patients Who Participated in Other Romidepsin Protocols Start of enrollment: 2011 May 01
Completed
Phase 2
Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma Start of enrollment: 2011 Oct 01
Completed
Phase 1, Phase 2
Study to Assess the Safety, Tolerability and Pharmacokinetics of Fimepinostat (CUDC-907) in Patients With Lymphoma Start of enrollment: 2012 Dec 01
Completed
Phase 1
Phase I Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of BVD-523 in Patients With Advanced Malignancies Start of enrollment: 2013 Mar 01
Completed
Phase 1, Phase 2
Study to Evaluate the Safety and Tolerability of Andecaliximab as Monotherapy and in Combination With Chemotherapy in Participants With Advanced Solid Tumors Start of enrollment: 2013 Mar 29
Completed
Phase 1
Phase I Dose Escalation Study of VS-4718 in Subjects With Metastatic Non-Hematologic Malignancies Start of enrollment: 2013 Jun 01
Terminated
Phase 1
Rovalpituzumab Tesirine (SC16LD6.5) in Recurrent Small Cell Lung Cancer Start of enrollment: 2013 Jul 01
Completed
Phase 1, Phase 2
Phase 1/2a Dose Escalation Study in Participants With CLL, SLL, or NHL Start of enrollment: 2013 Aug 30
Completed
Phase 1, Phase 2
Study of the Glutaminase Inhibitor CB-839 in Solid Tumors Start of enrollment: 2014 Feb 01
Completed
Phase 1
Study of Intravenous RXDX-107 in Patients With Solid Tumors Start of enrollment: 2015 Sep 01
Terminated
Phase 1
A Phase 1/2 Study of MEDI4276 in Adults Subjects With Select HER2-expressing Advanced Solid Tumors. Start of enrollment: 2015 Sep 23
Completed
Phase 1
Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer Start of enrollment: 2016 Jun 29
Completed
Phase 1
A Phase 1-2 Dose-Escalation and Cohort-Expansion Study of Oral Tomivosertib (eFT-508) in Subjects With Hematological Malignancies Start of enrollment: 2017 Feb 08
Terminated
Phase 1, Phase 2
Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Clinical Activity of Defactinib in Combination With Avelumab in Epithelial Ovarian Cancer Start of enrollment: 2016 Oct 01
Terminated
Phase 1
This Study Aims to Find the Best Dose of BI 907828 (Brigimadlin) in Patients With Different Types of Advanced Cancer (Solid Tumors) Start of enrollment: 2018 May 21
Recruiting
Phase 1
A Study of Rivoceranib and Trifluridine/Tipiracil for Metastatic Colorectal Cancer (mCRC) Start of enrollment: 2019 Nov 18
Completed
Phase 1, Phase 2
A Study of BDTX-189, an Orally Available Allosteric ErbB Inhibitor, in Patients With Advanced Solid Tumors. Start of enrollment: 2019 Dec 19
Terminated
Phase 1, Phase 2
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Publications & Presentations

PubMed

Ezabenlimab (BI 754091), an anti-PD-1 antibody, in patients with advanced solid tumours.
Melissa Johnson, Hendrik-Tobias Arkenau, Natalie Cook, Vanessa Samouëlian, Shigehisa Kitano, Christine Duffy, Miaomiao Ge, Mabrouk Elgadi, Lillian L Siu, Manish R Pate...> ;Cancer Immunology, Immunotherapy. 2024 Mar 30
A Relative Bioavailability, Bioequivalence, and Food Effect Study of Niraparib Tablets in Patients with Advanced Solid Tumors.
Gerald Falchook, Amita Patnaik, Debra L Richardson, R Donald Harvey, Manish R Sharma, Navid Hafez, Erika Hamilton, Sarina A Piha-Paul, Minal Barve, Trisha Wise-Draper,...> ;Clinical Therapeutics. 2024 Feb 23
1 citations
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial.
Desai, J., Alonso, G., Kim, S., Cervantes, A., Karasic, T., Medina, L., Shacham-Shmueli, E., Cosman, R., Falcon, A., Gort, E., Guren, T., Massarelli, E., Miller, W., P...> ;Nature Medicine. 2024 Jan 1
7 citations
The PD-1- and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial.
Jason J Luke, Manish R Patel, George R Blumenschein, Erika Hamilton, Bartosz Chmielowski, Susanna V Ulahannan, Roisin M Connolly, Cesar A Santa-Maria, Jie Wang, Shakee...> ;Nature Medicine. 2023 Nov 1
2 citations
Phase 1 study of JNJ-64619178, a protein arginine methyltransferase 5 inhibitor, in patients with lower-risk myelodysplastic syndromes.
Tamanna Haque, Felix López Cadenas, Blanca Xicoy, Ana Alfonso-Pierola, Uwe Platzbecker, Irit Avivi, Andrew M Brunner, Jöerg Chromik, Daniel Morillo, Manish R Patel, Jo...> ;Leukemia Research. 2023 Nov 1
6 citations
Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Advanced Solid Tumors.
Maria Vieito, Victor Moreno, Anna Spreafico, Irene Brana, Judy S Wang, Meir Preis, Tatiana Hernández, Sofia Genta, Aaron R Hansen, Bernard Doger, Vladimir Galvao, Laur...> ;Clinical Cancer Research. 2023 Sep 15
First-in-human Study of AZD5153, A Small-molecule Inhibitor of Bromodomain Protein 4, in Patients with Relapsed/Refractory Malignant Solid Tumors and Lymphoma.
Erika P Hamilton, Judy S Wang, Amit M Oza, Manish R Patel, Susanna V Ulahannan, Todd Bauer, Janet L Karlix, Jorge Zeron-Medina, Giulia Fabbri, Paola Marco-Casanova, Ga...> ;Molecular Cancer Therapeutics. 2023 Oct 2
Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment.
Mark Roschewski, Manish R Patel, Patrick M Reagan, Nakhle S Saba, Graham P Collins, Hendrik-Tobias Arkenau, Sven de Vos, Barrett Nuttall, Melih Acar, Kathleen Burke, R...> ;Clinical Cancer Research. 2023 Sep 1
6 citations
The MDM2-p53 Antagonist Brigimadlin (BI 907828) in Patients with Advanced or Metastatic Solid Tumors: Results of a Phase Ia, First-in-Human, Dose-Escalation Study.
Patricia LoRusso, Noboru Yamamoto, Manish R Patel, Scott A Laurie, Todd M Bauer, Junxian Geng, Teffany Davenport, Michael Teufel, Jian Li, Mehdi Lahmar, Mrinal M Gounder> ;Cancer Discovery. 2023 Aug 4
1 citations
Phase 1/2 Study of the Pan-PIM Kinase Inhibitor INCB053914 Alone or in Combination With Standard-of-Care Agents in Patients With Advanced Hematologic Malignancies.
Manish R Patel, William Donnellan, Michael Byrne, Adam S Asch, Amer M Zeidan, Maria R Baer, Amir T Fathi, Andrew T Kuykendall, Fred Zheng, Chris Walker, Lulu Cheng, Ci...> ;Clinical Lymphoma, Myeloma & Leukemia. 2023 Sep 1
A phase 1 first-in-human study of GS-0189, an anti-signal regulatory protein alpha (SIRPα) monoclonal antibody, in patients with relapsed/refractory (R/R) non-Hodgkin ...
Mayur Narkhede, Nancy L Bartlett, Sami Ibrahimi, Leslie Popplewell, Anna Seto, Jamie Bates, Yeonju Lee, Vaishnavi Ganti, Ling Han, Tianling Chen, Manish R Patel> ;Ejhaem. 2023 May 1
1 citations
Spleen tyrosine kinase/FMS-like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma: updated data with mivavot...
Leo I Gordon, Reem Karmali, Jason B Kaplan, Rakesh Popat, Howard A Burris 3rd, Silvia Ferrari, Sumit Madan, Manish R Patel, Giuseppe Gritti, Dima El-Sharkawi, F Ian Ch...> ;Oncotarget. 2023 Jan 26
2 citations
Efficacy and safety of rucaparib treatment in patients with BRCA-mutated, relapsed ovarian cancer: final results from Study 10.
Rebecca S Kristeleit, Yvette Drew, Amit M Oza, Susan M Domchek, Susana Banerjee, Rosalind M Glasspool, Judith Balmaña, Lee-May Chen, Manish R Patel, Howard A Burris, T...> ;British Journal of Cancer. 2023 Jan 1
4 citations
Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors.
Aung Naing, Alain P Algazi, Gerald S Falchook, Benjamin C Creelan, John Powderly, Seth Rosen, Minal Barve, Niharika B Mettu, Pierre L Triozzi, John Hamm, Gongfu Zhou, ...> ;Cancer. 2023 Jan 1
MCL-133 Pirtobrutinib, a Highly Selective, Non-Covalent (Reversible) BTK Inhibitor in Previously Treated Mantle Cell Lymphoma: Updated Results From the Phase 1/2 BRUIN...
Jonathon B Cohen, Nirav N Shah, Alvaro J Alencar, James N Gerson, Manish R Patel, Bita Fakhri, Wojciech Jurczak, Xuan Ni Tan, Katharine L Lewis, Timothy Fenske, Cather...> ;Clinical Lymphoma, Myeloma & Leukemia. 2022 Oct 1
15 citations
Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors.
Emerson A Lim, Johanna C Bendell, Gerald S Falchook, Todd M Bauer, Charles G Drake, Jennifer H Choe, Daniel J George, Janet L Karlix, Susanna Ulahannan, Kris F Sachsen...> ;Clinical Cancer Research. 2022 Nov 14
5 citations
Serial monitoring of genomic alterations in circulating tumor cells of ER-positive/HER2-negative advanced breast cancer: feasibility of precision oncology biomarker de...
Andi K Cani, Emily M Dolce, Elizabeth P Darga, Kevin Hu, Chia-Jen Liu, Jackie Pierce, Kieran Bradbury, Elaine Kilgour, Kimberly Aung, Gaia Schiavon, Danielle Carroll, ...> ;Molecular Oncology. 2022 May 1
19 citations
Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial.
Funda Meric-Bernstam, Nizar M Tannir, Othon Iliopoulos, Richard J Lee, Melinda L Telli, Alice C Fan, Angela DeMichele, Naomi B Haas, Manish R Patel, James J Harding, M...> ;Clinical Cancer Research. 2022 Apr 14
7 citations
Anti-CD79B Antibody-Drug Conjugate DCDS0780A in Patients with B-Cell Non-Hodgkin Lymphoma: Phase 1 Dose-Escalation Study.
Alex F Herrera, Manish R Patel, John M Burke, Ranjana Advani, Bruce D Cheson, Jeff P Sharman, Elicia Penuel, Andrew G Polson, Chen Di Liao, Chunze Li, Eva Schuth, Anja...> ;Clinical Cancer Research. 2022 Apr 1
9 citations
IOLite: phase 1b trial of doublet/triplet combinations of dostarlimab with niraparib, carboplatin-paclitaxel, with or without bevacizumab in patients with advanced can...
Timothy A Yap, Alberto Bessudo, Erika Hamilton, Jasgit Sachdev, Manish R Patel, Jordi Rodon, Lena Evilevitch, Meghan Duncan, Wei Guo, Sujatha Kumar, Sharon Lu, Bruce J...> ;Journal for Immunotherapy of Cancer. 2022 Mar 1
13 citations
Avelumab for platinum-ineligible/refractory recurrent and/or metastatic squamous cell carcinoma of the head and neck: phase Ib results from the JAVELIN Solid Tumor trial.
Joël Guigay, Keun Wook Lee, Manish R. Patel, Amaury Daste, Deborah J. Wong, Sanjay Goel, Michael S. Gordon, Martin Gutierrez, Ani Sarkis Balmanoukian, Christophe Le To...> ;Journal for Immunotherapy of Cancer. 2021 Oct 1
45 citations
Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-Type TP53.
Mansoor N. Saleh, Manish R. Patel, Todd M. Bauer, Sanjay Goel, Gerald Steven Falchook, Geoffrey I. Shapiro, Ki Y. Chung, Jeffrey R. Infante, Robert M. Conry, Guilherme...> ;Clinical Cancer Research. 2021 Oct 1
10 citations
A Phase 1b Trial of Prexasertib in Combination with Standard-of-Care Agents in Advanced or Metastatic Cancer
Kathleen N. Moore, David S. Hong, Manish R. Patel, Shubham Pant, Susanna Varkey Ulahannan, Suzanne F. Jones, Funda Meric-Bernstam, Judy S. Wang, Raid Aljumaily, Erika ...> ;Targeted Oncology. 2021 Sep 1
31 citations
First-in-Human, Phase 1 Dose-Escalation Study of Biparatopic Anti-HER2 Antibody-Drug Conjugate MEDI4276 in Patients with HER2-positive Advanced Breast or Gastric Cancer.
Mark D. Pegram, Erika Hamilton, Antoinette R. Tan, Anna Maria Storniolo, Kemal Balic, Anton I. Rosenbaum, Meina Liang, Peng He, Shannon Marshall, Anita Scheuber, Mayuk...> ;Molecular Cancer Therapeutics. 2021 May 27
90 citations
First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced...
Gerald Steven Falchook, Jeffrey R. Infante, Hendrik-Tobias Arkenau, Manish R. Patel, Emma Dean, Erkut Borazanci, Andrew Brenner, Natalie Cook, Juanita Lopez, Shubham P...> ;Eclinicalmedicine. 2021 Mar 30
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Press Mentions

Florida Cancer Specialists & Research Institute Presents Clinical Research Results at 2022 ASCO® Annual MeetingJune 3rd, 2022
Sarah Cannon to Present Latest Cancer Research Insights at 2021 ASCO® Annual MeetingJune 4th, 2021
Sarah Cannon to Present Latest Cancer Research Insights at ASCO®20 Virtual MeetingMay 28th, 2020

Hospital Affiliations

HCA Florida Sarasota Doctors HospitalSarasota, Florida
Sarasota Memorial Hospital - SarasotaSarasota, Florida
Lee Memorial HospitalFort Myers, Florida