MarkSGeorgeMD

Distinguished Professor of Psychiatry, Radiology and Neuroscience Layton McCurdy Endowed Chair Director, Brain Stimulation Laboratory at MUSC

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Office
67 President St
Charleston, SC 29425
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Education & Training

National Institutes of Health Clinical CenterResidency, Psychiatry, 1991 - 1993
Medical University of South CarolinaResidency, Psychiatry, 1985 - 1990
Medical University of South CarolinaClass of 1985

Certifications & Licensure

SC State Medical License 1986 - 2025
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Psychiatry

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Magnetic Brain Stimulation for the Treatment of Adult Depression Start of enrollment: 2005 Feb 01
Completed
Phase 2, Phase 3
Treatment-Resistant Depression Registry Start of enrollment: 2006 Jan 01
Completed
Transcranial Magnetic Stimulation (TMS) for Suicidal Ideation Start of enrollment: 2010 Oct 01
Unknown status
Phase 3
The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues Start of enrollment: 2010 Mar 01
Terminated
Safety and Efficacy Study of Deep Transcranial Magnetic Stimulation in Bipolar Depression Start of enrollment: 2012 May 01
Unknown status
Not Applicable
rTMS for Depressed Teens: A Sham-Controlled Trial, Part 1 Start of enrollment: 2013 Apr 01
Terminated
Not Applicable
rTMS for Depressed Teens: A Sham-Controlled Trial, Part 2 Start of enrollment: 2013 Mar 01
Terminated
Not Applicable
Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation. Start of enrollment: 2014 Aug 20
Completed
Phase 3
A Safety & Efficacy Study With Deep Transcranial Magnetic Stimulation for the Treatment of Post-Traumatic Stress Disorder (PTSD) Start of enrollment: 2016 Nov 17
Terminated
Not Applicable
Focal Electrically-Administered Seizure Therapy (FEAST) Studies at Two Enrolling Sites to Further Test and Refine the Treatment Start of enrollment: 2015 Aug 01
Completed
Phase 2, Phase 3
Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents Start of enrollment: 2015 Oct 01
Unknown status
Not Applicable
taVNS Paired With Bottle Feeding in Infants Failing Oral Feeds Start of enrollment: 2017 Oct 01
Completed
Early Phase 1
Individualizing tDCS Dose Start of enrollment: 2024 May 31
Recruiting
Not Applicable
Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD) Start of enrollment: 2021 Jul 26
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

The evolution of neuromodulation for chronic stroke: From neuroplasticity mechanisms to brain-computer interfaces.
Triano, M., Brian F Saway, Charles Palmer, Christopher Hughes, Matthew Triano, Rishishankar E Suresh, Jordon Gilmore, Mark George, Steven A Kautz, Nathan C Rowland> ;Neurotherapeutics. 2024 Feb 19
Pairing taVNS and CIMT is feasible and may improve upper extremity function in infants.
McGloon, K., Humanitzki, E., Brennan, J., Summers, P., Brennan, A., Badran, B., Cribb, A., Jenkins, D., Coker-Bolt, P., George, M.> ;Frontiers in Pediatrics. 2024 Jan 1
Improved naming in patients with Broca's aphasia with tDCS.
Rorden, C., Roth, R., Fridriksson, J., Bonilha, L., Sen, S., George, M.> ;Journal of Neurology, Neurosurgery, and Psychiatry. 2024 Feb 14
Biomarkers predict the efficacy of closed-loop rTMS treatment for refractory depression.
Sun, X., Doose, J., Faller, J., McIntosh, J., Saber, G., Huffman, S., Pantazatos, S., Yuan, H., Goldman, R., Brown, T., Sajda, P., George, M.> ;Research Square. 2023 Dec 5
2 citations
EEG synchronized left prefrontal transcranial magnetic stimulation (TMS) for treatment resistant depression is feasible and produces an entrainment dependent clinical ...
Huffman, S., Doose, J., Sun, X., Dancy, M., Faller, J., Li, X., Yuan, H., Goldman, R., Sajda, P., Brown, T., George, M.> ;Brain Stimulation. 2023 Dec 2
Reduced executive and reward connectivity is associated with smoking cessation response to repetitive transcranial magnetic stimulation: A double-blind, randomized, sh...
Xingbao Li, Kevin A Caulfield, Karen J Hartwell, Scott Henderson, Kathleen T Brady, Mark S George> ;Brain Imaging and Behavior. 2024 Feb 1
Transcutaneous Auricular Vagus Nerve Stimulation Attenuates Early Increases in Heart Rate Associated With the Cold Pressor Test.
Christopher W Austelle, Christopher T Sege, Alex T Kahn, Mathew J Gregoski, Danielle L Taylor, Lisa M McTeague, Edward Baron Short, Bashar W Badran, Mark S George> ;Neuromodulation. 2023 Aug 26
1 citations
Transcutaneous auricular vagus nerve stimulation (taVNS) decreases heart rate acutely in neonatal rats.
Melanie W Gail, Catrina Sims-Robinson, Heather Boger, Adviye Ergul, Rupak Mukherjee, Dorothea D Jenkins, Mark S George> ;Brain Stimulation. 2023 Aug 22
1 citations
Adverse Outcome Following Mild Traumatic Brain Injury Is Associated with Microstructure Alterations at the Gray and White Matter Boundary.
Lara Pankatz, Philine Rojczyk, Johanna Seitz-Holland, Sylvain Bouix, Leonard B Jung, Tim L T Wiegand, Elena M Bonke, Nico Sollmann, Elisabeth Kaufmann, Holly Carringto...> ;Journal of Clinical Medicine. 2023 Aug 21
2 citations
Higher Dose Noninvasive Transcutaneous Auricular Vagus Nerve Stimulation Increases Feeding Volumes and White Matter Microstructural Complexity in Open-Label Study of I...
Dorothea D Jenkins, Hunter G Moss, Lauren E Adams, Sally Hunt, Morgan Dancy, Sarah M Huffman, Daniel Cook, Jens H Jensen, Philipp Summers, Sean Thompson, Mark S George...> ;The Journal of Pediatrics. 2023 Nov 1
7 citations
The timing of transcranial magnetic stimulation relative to the phase of prefrontal alpha EEG modulates downstream target engagement.
Spiro P Pantazatos, James R Mclntosh, Golbarg T Saber, Xiaoxiao Sun, Jayce Doose, Josef Faller, Yida Lin, Joshua B Teves, Aidan Blankenship, Sarah Huffman, Robin I Gol...> ;Brain Stimulation. 2023 May 13
4 citations
Time for Brain Medicine.
Joshua C Brown, Helen Dainton-Howard, Jared Woodward, Charles Palmer, Manish Karamchandani, Nolan R Williams, Mark S George> ;The Journal of Neuropsychiatry and Clinical Neurosciences. 2023 Jan 1
Neurosurgery for psychiatric disorders: reviewing the past and charting the future.
Luke Bauerle, Charles Palmer, Claudia A Salazar, Thomas Larrew, Suzanne E Kerns, E Baron Short, Mark S George, Nathan C Rowland> ;Neurosurgical Focus. 2023 Feb 1
7 citations
Pursuing personalized medicine for depression by targeting the lateral or medial prefrontal cortex with Deep TMS.
Abraham Zangen, Samuel Zibman, Aron Tendler, Noam Barnea-Ygael, Uri Alyagon, Daniel M Blumberger, Geoffrey Grammer, Hadar Shalev, Tatiana Gulevski, Tanya Vapnik, Alexa...> ;JCI Insight. 2023 Feb 22
1 citations
Use of non-invasive transcutaneous auricular vagus nerve stimulation: neurodevelopmental and sensory follow-up.
Turki Aljuhani, Patricia Coker-Bolt, Viswanathan Ramakrishnan, Alyssa Brennan, Bashar W Badran, Dorothea Jenkins, Katikaneni, L., George, M.> ;Frontiers in Human Neuroscience. 2023 Jan 1
10 citations
Optimized APPS-tDCS electrode position, size, and distance doubles the on-target stimulation magnitude in 3000 electric field models.
Kevin A Caulfield, Mark S George> ;Scientific Reports. 2022 Nov 22
2 citations
White Matter Microstructure Is Associated with Serum Neuroactive Steroids and Psychological Functioning.
Lisa F Umminger, Philine Rojczyk, Johanna Seitz-Holland, Nico Sollmann, Elisabeth Kaufmann, Philipp Kinzel, Fan Zhang, Janna Kochsiek, Mina Langhein, Cara L Kim, Tim L...> ;Journal of Neurotrauma. 2023 Apr 1
6 citations
A replication study of NMDA receptor agonism sufficiency to enhance 10-Hz rTMS-induced motor cortex plasticity.
Jamie Kweon, Megan Vigne, Rich Jones, Mark S George, Linda L Carpenter, Joshua C Brown> ;Brain Stimulation. 2022 Sep 27
2 citations
Transcutaneous auricular vagus nerve stimulation (taVNS) given for poor feeding in at-risk infants also improves their motor abilities.
Turki Aljuhani, Hannah Haskin, Shelby Davis, Amy Reiner, Hunter G Moss, Bashar W Badran, Mark S George, Dorothea Jenkins, Patricia Coker-Bolt> ;Journal of Pediatric Rehabilitation Medicine. 2022 Jan 1
11 citations
Digitalized transcranial electrical stimulation: A consensus statement.
Andre R Brunoni, Hamed Ekhtiari, Andrea Antal, Paradee Auvichayapat, Chris Baeken, Isabela M Benseñor, Marom Bikson, Paulo Boggio, Barbara Borroni, Filippo Brighina, J...> ;Clinical Neurophysiology. 2022 Nov 1
Reply to "Letter to the editor: Safety of "accelerated" rTMS protocols with twice-daily sessions in patients with schizophrenia - A comment on Caulfield et al."
Kevin A Caulfield, Holly H Fleischmann, Mark S George, Lisa M McTeague> ;Journal of Psychiatric Research. 2022 Dec 1
2 citations
Microdermabrasion facilitates direct current stimulation by lowering skin resistance.
P Y Chhatbar, S Liu, V Ramakrishnan, M S George, S A Kautz, W Feng> ;Skin Health and Disease. 2022 Sep 1
22 citations
Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements.
Kevin A Caulfield, Holly H Fleischmann, Claire E Cox, Julia P Wolf, Mark S George, Lisa M McTeague> ;Brain Stimulation. 2022 Aug 27
18 citations
A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms.
Bashar W Badran, Sarah M Huffman, Morgan Dancy, Christopher W Austelle, Marom Bikson, Steven A Kautz, Mark S George> ;Bioelectronic Medicine. 2022 Aug 25
16 citations
A transdiagnostic review of safety, efficacy, and parameter space in accelerated transcranial magnetic stimulation.
Kevin A Caulfield, Holly H Fleischmann, Mark S George, Lisa M McTeague> ;Journal of Psychiatric Research. 2022 Aug 1
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Lectures

American Psychiatric Association Publishing
American College of Physicians, Hilton Head Island, South Carolina - 10/11/2012
26th Annual Update: Disaster, Trauma & Recovery
Medical University of South Carolina Office of CME, Charleston, North Carolina - 5/30/2013

Press Mentions

Stimulating Hope: Personalizing Treatment Options for DepressionMay 10th, 2023
Depression Ruined Her Life for Years. Kansas City Doctor’s ‘Helmet’ Changed EverythingMarch 16th, 2023
MDMA Therapy for Chronic PTSD: Neuroimaging with Veterans & First Responders Provides Further EvidenceJanuary 23rd, 2023
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Grant Support

The Impact Of Real-Time FMRI Feedback On Response To Nicotine CuesNational Institute On Drug Abuse2010–2011
Optimization Of TMS For Depression - Coordinating CenterNational Center For Research Resources2009–2010
The Impact Of Real-Time FMRI Feedback On Response To Nicotine CuesNational Institute On Drug Abuse2008–2009
Optimization Of TMS For Depression - Coordinating CenterNational Institute Of Mental Health2004–2009
Optimization Of TMS For DepressionNational Institute Of Mental Health2004–2009
MRI Study On Cerebral Activation During Specific Hand- And Finger-TasksNational Center For Research Resources2006–2008
Pilot Study Assessing The Effects Of Dar-0100 On Brain Activity In SchizophreniaNational Center For Research Resources2005
Efficacy/Safety Of Single Dose Of Ampakine (R) CX516National Center For Research Resources2004
Creating A Man-Portable Transcranial Magnetic Stimulation SystemNational Center For Research Resources2004
Mood Effects Of Deep Brain Stimulation In ParkinsonsNational Institute Of Neurological Disorders And Stroke2000–2002