MarkHGreeneMD

Oncology • Rockville, MD

NIH Emeritus Investigator

Join to view full profile

Dr. Greene is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Greene's full profile

Already have an account?

Office
9609 Medical Center Dr
Clinical Genetics Branch, NCI, Rm 6E-543
Rockville, MD 20850
Phone+1 301-385-1190
Is this information wrong?

Education & Training

Massachusetts General HospitalResidency, Internal Medicine, 1970 - 1972
Tufts University School of MedicineClass of 1970
National Institutes of Health Clinical CenterFellowship, Medical Oncology

Certifications & Licensure

CA State Medical License 1974 - Present
AZ State Medical License 1985 - Present
MD State Medical License 1978 - 2024
MN State Medical License 1991 - 1999
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Clinical Trials

Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer Start of enrollment: 2002 Jul 01
Completed
Removal of the Ovaries/Fallopian Tubes and CA-125 Screening to Reduce the Risk of Ovarian Cancer in Women at Increased Genetic Risk Start of enrollment: 2003 Jul 09
Completed
Genetics of Familial Testicular Cancer Start of enrollment: 2004 Jan 02
Completed
A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women Start of enrollment: 2011 Jun 21
Completed
Join now to see all

Publications & Presentations

PubMed

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk.
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda...> ;Medrxiv. 2024 Mar 4
11 citations
Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights.
Stella Koutros, Lambertus A Kiemeney, Parichoy Pal Choudhury, Roger L Milne, Evangelina Lopez de Maturana, Yuanqing Ye, Vijai Joseph, Oscar Florez-Vargas, Lars Dyrskjø...> ;European Urology. 2023 Jul 1
2 citations
Germline Exome Sequencing for Men with Testicular Germ Cell Tumor Reveals Coding Defects in Chromosomal Segregation and Protein-targeting Genes.
Louise C Pyle, Jung Kim, Jonathan Bradfield, Scott M Damrauer, Kurt D'Andrea, Lawrence H Einhorn, Rama Godse, Hakon Hakonarson, Peter A Kanetsky, Rachel L Kember, Lind...> ;European Urology. 2024 Apr 1
Cancer in myotonic dystrophy: A new discovery in an old disease.
Shahinaz M Gadalla, Mark H Greene> ;Muscle & Nerve. 2023 Aug 1
1 citations
Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers.
Dhawan, M. S., Hakkaart, C., Pearson, J., Marquart, L., Dennis, J., Wiggins, G., Barnes, D., Robinson, B., Mace, P., Aittomäki, K., Andrulis, I., Arun, B., Azzollini, ...> ;Communications Biology. 2022 Oct 6
1 citations
Effect of risk-reducing salpingo-oophorectomy on sex steroid hormone serum levels among postmenopausal women: an NRG Oncology/Gynecologic Oncology Group study.
Phuong L Mai, Austin Miller, Amanda Black, Roni T Falk, John F Boggess, Katherine Tucker, Ashley R Stuckey, Gustavo C Rodriguez, Cheung Wong, Thomas T Amatruda, Kelly ...> ;American Journal of Obstetrics and Gynecology. 2022 Jul 1
4 citations
Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk.
Chiara Grasso, Maja Popovic, Elena Isaevska, Fulvio Lazzarato, Valentina Fiano, Daniela Zugna, John Pluta, Benita Weathers, Kurt D'Andrea, Kristian Almstrup, Lynn Anso...> ;Cancer Epidemiology, Biomarkers & Prevention. 2022 Sep 2
58 citations
Cancer Risks Associated WithandPathogenic Variants.
Shuai Li, Valentina Silvestri, Goska Leslie, Timothy R Rebbeck, Susan L Neuhausen, John L Hopper, Henriette Roed Nielsen, Andrew Lee, Xin Yang, Lesley McGuffog, Michae...> ;Journal of Clinical Oncology. 2022 May 10
Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk.
Eileen O Dareng, Jonathan P Tyrer, Daniel R Barnes, Michelle R Jones, Xin Yang, Katja K H Aben, Muriel A Adank, Simona Agata, Irene L Andrulis, Hoda Anton-Culver, Nata...> ;European Journal of Human Genetics. 2022 May 1
4 citations
Embodied risk for families with Li-Fraumeni syndrome: Like electricity through my body.
Allison Werner-Lin, Rowan Forbes Shepherd, Jennifer L Young, Catherine Wilsnack, Shana L Merrill, Mark H Greene, Payal P Khincha> ;Social Science & Medicine. 2022 May 1
16 citations
Polygenic risk modeling for prediction of epithelial ovarian cancer risk.
Eileen O Dareng, Jonathan P Tyrer, Daniel R Barnes, Michelle R Jones, Xin Yang, Katja K H Aben, Muriel A Adank, Simona Agata, Irene L Andrulis, Hoda Anton-Culver, Nata...> ;European Journal of Human Genetics. 2022 Mar 1
10 citations
Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants
Hongyan Li, Christoph Engel, Miguel de la Hoya, Paolo Peterlongo, Drakoulis Yannoukakos, Luca Livraghi, Paolo Radice, Mads Thomassen, Thomas Hansen, Anne-Marie Gerdes,...> ;Genetics in Medicine. 2021 Nov 30
3 citations
Family Identity and Roles in the Context of Li-Fraumeni Syndrome: "No One's Like Us Mutants".
Catherine Wilsnack, Jennifer L. Young, Shana L. Merrill, Victoria Groner, Jennifer T. Loud, Renee C. Bremer, Mark H. Greene, Payal P. Khincha, Allison Werner-Lin> ;Health & Social Work. 2021 Nov 16
11 citations
Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores.
Daniel R. Barnes, Valentina Silvestri, Goska Leslie, Lesley McGuffog, Joe Dennis, Xin Yang, Julian Adlard, Bjarni A. Agnarsson, Munaza Ahmed, Kristiina Aittomäki, Iren...> ;Journal of the National Cancer Institute. 2021 Jul 28
23 citations
Identification of 22 susceptibility loci associated with testicular germ cell tumors.
John Pluta, Louise C. Pyle, Kevin T. Nead, Rona Wilf, Mingyao Li, Nandita Mitra, Benita Weathers, Kurt D'Andrea, Kristian Almstrup, Lynn Anson-Cartwright, Javier Benit...> ;Nature Communications. 2021 Jul 23
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A. O'Mara, Joe Dennis, Jonathan Tyrer, Daniel R. Barnes, Lesley McGuffog, Goska Leslie, Manjeet K. Bolla, Muri...> ;Nature Communications. 2021 May 14
1 citations
Histological Features of Sporadic and Familial Testicular Germ Cell Tumors Compared and Analysis of Age-Related Changes of Histology.
Andreas Stang, Mary L. McMaster, Isabell A. Sesterhenn, Elizabeth A. Rapley, Robert Huddart, Ketil Heimdal, Katherine A. McGlynn, J. W. Oosterhuis, Mark H. Greene> ;Cancers. 2021 Apr 1
2 citations
Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk
Derek Brown, Qing Lan, Nathaniel Rothman, John Pluta, Kristian Almstrup, Marlene Danner Dalgaard, Mark H. Greene, Tom Grotmol, Chey Loveday, Stephen M. Schwartz, Clare...> ;Cancer Epidemiology, Biomarkers & Prevention. 2021 Mar 18
4 citations
Identification of Genetic Risk Factors for Familial Urinary Bladder Cancer: An Exome Sequencing Study.
Pemov, A., Wegman-Ostrosky, T., Kim, J., Koutros, S., Douthitt, B., Jones, K., Zhu, B., Baris, D., Schwenn, M., Johnson, A., Karagas, M., Carter, B., McCullough, M., L...> ;JCO Precision Oncology. 2021 Jan 1
6 citations
Family Health Leaders: Lessons on Living with Li-Fraumeni Syndrome across Generations.
Ashley Pantaleao, Jennifer L. Young, Norman B. Epstein, Mae Carlson, Renee C. Bremer, Payal P. Khincha, June A. Peters, Mark H. Greene, Kevin Roy, Maria Isabel Achatz,...> ;Family Process. 2020 Dec 1
Lack of Pathogenic Germline DICER1 Variants in Males with Testicular Germ-Cell Tumors
Lauren M Vasta, Mary L McMaster, Laura A. Harney, Alexander Ling, Jung Kim, Anne K. Harris, Ann G Carr, Scott M. Damrauer, Daniel J. Rader, Rachel L. Kember, Peter A. ...> ;Cancer Genetics. 2020 Oct 1
10 citations
Diabetes, metformin and cancer risk in myotonic dystrophy type I.
Rotana Alsaggaf, Ruth M. Pfeiffer, Youjin Wang, Diane Marie M. St. George, Min Zhan, Kathryn R. Wagner, Sania Amr, Mark H. Greene, Shahinaz M. Gadalla> ;International Journal of Cancer. 2020 Aug 1
43 citations
Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 ...
Valentina Silvestri, Goska Leslie, Daniel R. Barnes, Bjarni A. Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L. Andrulis, Rosa B. Barkardottir, Alicia Barroso, ...> ;JAMA Oncology. 2020 Aug 1
69 citations
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants.
Daniel R. Barnes, Matti A. Rookus, Lesley McGuffog, Goska Leslie, T.M. Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomäki, Nadine Andr...> ;Genetics in Medicine. 2020 Jul 15
58 citations
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Yan Zhang, Amber N. Hurson, Haoyu Zhang, Parichoy Pal Choudhury, Douglas F. Easton, Roger L. Milne, Jacques Simard, Per Hall, Kyriaki Michailidou, Joe Dennis, Marjanka...> ;Nature Communications. 2020 Jul 3
Join now to see all