MarkKellerMDFACC, FASE

Cardiology • Lone Tree, CO

Echocardiography

Cardiologist at University of Colorado Health

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Office
Lone Tree Health Center
9548 Park Meadows Drive
Lone Tree, CO 80124
Phone+1 720-848-2200
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Summary

I work as a clinical cardiologist for the University of Colorado at Lone Tree Health Center and Anschutz Medical Center. I am board certified in Internal Medicine, Cardiovascular Disease, and Echocardiography. I worked in the academic setting for 8 years doing research in echocardiography and vascular pathophysiology, and then I went into private practice in the Denver metro area for fifteen years. In 2012, I went back to academics, and accepted a job at the University of Colorado as a clinical cardiologist.

Education & Training

University of Virginia Medical CenterFellowship, Cardiovascular Disease, 1986 - 1989
University of ChicagoResidency, Internal Medicine, 1983 - 1986
University of ChicagoInternship, Internal Medicine, 1983 - 1984
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1983
The University of ColoradoB.A., Biology, 1979
The University of ColoradoBA, Biology, 1979

Certifications & Licensure

CO State Medical License 1992 - 2025
IL State Medical License 1983 - 1987
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Burroughs-Wellcome Young Investigator Award 1988
Young Investigator Award Burroughs-Wellcome, 1988
National Research Service Award National Institute of Health, 1987
Chancellor's Recognition Award The University of Colorado, 1979
Claribel Kendell Award The University of Colorado, 1978
Phi Beta Kappa The University of Colorado, 1978
Regents' Scholar The University of Colorado, 1975
Fellow (FACC) American College of Cardiology
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Publications & Presentations

PubMed

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
Trampush, J. W.,Yang, M. L.,Yu, J.,Knowles, E.,Davies, G.,Liewald, D. C.,Starr, J. M.,Djurovic, S.,Melle, I.,Sundet, K.,Christoforou, A.,Reinvang, I.,DeRosse, P.,Lunde...> ;Mol. Psychiatry. 2017 Jan 18
Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.
Liu, M.,Malone, S. M.,Vaidyanathan, U.,Keller, M. C.,Abecasis, G.,McGue, M.,Iacono, W. G.,Vrieze, S. I.> ;Psychol Med. 2016 Dec 21
Meta-analysis of genome-wide association studies of anxiety disorders.
Otowa, T.,Hek, K.,Lee, M.,Byrne, E. M.,Mirza, S. S.,Nivard, M. G.,Bigdeli, T.,Aggen, S. H.,Adkins, D.,Wolen, A.,Fanous, A.,Keller, M. C.,Castelao, E.,Kutalik, Z.,der A...> ;Mol. Psychiatry. 2016 Jan 13
Genome-wide autozygosity is associated with lower general cognitive ability.
Howrigan, D. P.,Simonson, M. A.,Davies, G.,Harris, S. E.,Tenesa, A.,Starr, J. M.,Liewald, D. C.,Deary, I. J.,McRae, A.,Wright, M. J.,Montgomery, G. W.,Hansell, N.,Mart...> ;Mol. Psychiatry. 2015 Sep 24
1 citations
Physiological assessment of coronary artery disease and myocardial viability in ischemic syndromes using adenosine echocardiography.
R. Alex Case, B S Robert Buckmire, David P. McLaughlin, Mark Keller> ;Echocardiography. 1994 Mar 1
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Journal Articles

The importance of two-dimensional echocardiographic assessment of left ventricular systolic function in patients presenting to the emergency room with cardiac-related ...
Sabia P, Abbott R, Afrookteh A, Keller MW, Touchstone D, Kaul S, Circulation
Arteriolar constriction in skeletal muscle during vascular stunning: role of mast cells.
Keller MW, Arteriolar constriction in skeletal muscle during vascular stunning: role of mast cells., 1/1/1997
Prevention of coronary vascular abnormalities early in reperfusion with TGF-B may not prevent late coronary vascular injury.
Keller MW, Kong Y, Robertson AD, Horwitz LD, J Cardiovasc Pharmacol, 1/1/1997
Arteriolar constriction in skeletal muscle during vascular stunning: role of mast cells
Keller MW, Amer J Physiol, 1/1/1997
Prevention of coronary vascular abnormalities early in reperfusion with TGF-B may not prevent late coronary vascular injury
Keller MW, Kong Y, Robertson AD, Horwitz LD, J Cardiovasc Pharmacol, 1/1/1997
Unsuspected aortic valve vegetation detected during, intraoperative echocardiographic monitoring for CABG: Considerations and intervention.
London MJ, Brown JM, Campbell DN, Keller MW, Cardiothoracic and Vascular Anesthesia, 1/1/1996
Unsuspected aortic valve vegetation detected during intraoperative transesophageal echocardiographic monitoring for coronary artery bypass grafting
London MJ, Brown JM, Campbell DN, Keller MW, Journal of Cardiothoracic and Vascular Anesthesia, 1/1/1996
Value of two-dimensional echocardiography for determining the basis of hemodynamic compromise in critically ill patients: A prospective study.
Kaul S, Stratienko A, Pollock S, Marieb M, Keller M, Sabia P, J Am Soc Echocardiography, 1/1/1994
Time course of endothelial healing following injury due to ischemia and reperfusion.
Horwitz LD, Kaufman D, Keller MW, Kong Y, Circulation, 1/1/1994
Physiologic assessment of coronary artery disease and myocardial viability in ischemic syndromes using adenosine echocardiography
Case RA, Buckmire R, McLaughlin D, Keller MW, Echocardiography, 1/1/1994
Value of twodimensional echocardiography for determining the basis of hemodynamic compromise in critically ill patients: A prospective study
Kaul S, Stratienko A, Pollock S, Marieb M, Keller MW, Sabia P, J Am Soc Echocardiography, 1/1/1994
Time course of endothelial healing following injury due to ischemia and reperfusion
Horwitz LD, Kaufman D, Keller MW, Kong Y, Circulation, 1/1/1994
A micropipette which allows in situ perfusion of arterioles and capillaries.
Damon DN, Keller MW, Gretz JE, Duling BR, Microvasc Research, 1/1/1993
Determination of capillary tube hematocrit during arteriolar microperfusion.
Keller MW, Damon DN, Duling BR., Am J Physiol, 1/1/1993
Physiologic assessment of coronary artery disease and myocardial viability using adenosine echocardiography: Comparison with coronary angiography and thallium scintig...
Case RA, Buckmire R, McLaughlin D, Keller MW., Echocardiography, 1/1/1993
A micropipette which allows in situ perfusion of arterioles and capillaries
Damon DN, Keller MW, Gretz JE, Duling BR, Microvasc Research, 1/1/1993
Determination of capillary tube hematocrit during arteriolar microperfusion
Keller MW, Damon DN, Duling BR, Am J Physiol, 1/1/1993
Microcirculatory dysfunction following hyperkalemic cardioplegia, infusion and blood reperfusion: Effects of adenosine.
Keller MW, Geddes L, Spotnitz WD, Kaul S, Duling BR, Circulation, 1/1/1991
Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial infarction: A prospective study using two-dimensional echocardiography.
Sabia P, Afrookteh A, Touchstone D, Keller MW, Esquivel L, Kaul S, Circulation, 1/1/1991
Microcirculatory dysfunction following hyperkalemic cardioplegia, infusion and blood reperfusion: Effects of adenosine
Keller MW, Geddes L, Spotnitz WD, Kaul S, Duling BR, Circulation, 1/1/1991
Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial infarction: A prospective study using two-dimensional echocardiography
Sabia P, Afrookteh A, Touchstone D, Keller MW, Esquivel L, Kaul S, Circulation, 1/1/1991
Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography.
Keller MW Spotnitz WD, Matthew TL, Glasheen WP, Watson DD, Kaul S., Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography., 1/1/1990
Intraoperative demonstration of coronary collateral flow using, myocardial contrast two-dimensional echocardiography.
Spotnitz WD, Matthew TL, Keller MW, Powers ER, Kaul S., Am J Cardiol, 1/1/1990
Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography
Keller MW, Spotnitz WD, Matthew TL, Glasheen WP, Watson DD, Kaul S, J Am Coll Cardiol, 1/1/1990
Intraoperative demonstration of coronary collateral flow using myocardial contrast two-dimensional echocardiography
Spotnitz WD, Matthew TL, Keller MW, Powers ER, Kaul S, Am J Cardiol, 1/1/1990
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Books/Book Chapters

Cardiology Secrets: Questions You Will Be Asked on Rounds, in the Clinic, and on Oral Exams
Chapter: Mitral Valve Prolapse and Mitral Regurgitation
Page 192 - 195Keller MWEditors: Adiar 0 and Havranek E.Hanley and Belfus, Philadelphia1994
Cardiology Secrets: Questions You Will Be Asked on Rounds, in the Clinic, and on Oral Exams
Chapter: Aortic Dissection and Diseases of the Aorta
Page 106 - 109Keller MWEditors: Adiar 0 and Havranek E.Hanley and Belfus, Philadelphia1994
Cardiology Secrets: Questions You Will Be Asked on Rounds, in the Clinic, and on Oral Exams.
Chapter: Mitral Valve Prolapse and Mitral Regurgitation.
Page 192 - 195Keller MWEditors: Adiar O and Havranek E.Hanley and Belfus, Philadelphia1994
Cardiology Secrets: Questions You Will Be Asked on Rounds, in the Clinic, and on Oral Exams.
Chapter: Aortic Dissection and Diseases of the Aorta.
Page 106 - 109Keller MWEditors: Adiar O and Havranek E.Hanley and Belfus, Philadelphia1994
Echocardiography in Coronary Artery Disease
Chapter: New Developments in Contrast echocardiography
Page 443 - 466Keller MW and Feinstein SBEditors: Kerber RE.Futura Publishing Company, Mount Kisco1987
Echocardiography in Coronary Artery Disease
Chapter: New Developments in Contrast echocardiography.
Page 443 - 466Keller MW and Feinstein SBEditors: Kerber RE.Futura Publishing Company, Mount Kisco1987
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Abstracts/Posters

Effects of transforming growth factor beta on coronary endothelial permeability and function follow ischemia and reperfusion in the myocardium.
Keller MW, Kong Y, Horwitz LD, Circulation, 1/1/1993
Microvascular changes after cardioplegia solution infusion and blood reperfusion: Effects of adenosine on reperfusion injury.
Keller MW, Duling BR, J Molecular Cellular Cardiol, 1/1/1991
Microvascular changes after cardioplegia solution infusion and blood reperfusion: Effects of adenosine on reperfusion injury.
Keller MW, Duling BR, Annals of Biomedical Engineering, 1/1/1991
Adenosine echocardiography for risk stratification in unstable angina of post-thrombolysis: Comparison with thallium.
Case AR, McLaughlin DP, Keller MW, Circulation, 1/1/1991
An in vitro model for the assessment of mitral valve area using contrast echocardiography.
Keller MW, J Am Coll Cardiol, 1/1/1990
How valuable is the Swan-Ganz catheter in critically ill patients?
Stratienko AA, Keller MW, Sabia PJ, Pollock SG, Marieb MD, Kaul S, J Am Coll Cardiol, 1/1/1990
Myocardial contrast echocardiography cannot be used to assess endocardial/epicardial blood flow ratio.
Kaul S, Keller MW, Glasheen WP, Touchstone DA, Spotnitz WD, Gutgesell HP, J Am Coll Cardiol, 1/1/1989
Two-dimensional echocardiography can reduce hospital admissions for acute myocardial infarction by more than one-third: Results of a prospective study performed in the...
Sabia P, Afrookteh A, Touchstone DA, Keller MW, Kaul S, J Am Coll Cardiol, 1/1/1989
Influence of the method of injection of contrast into the cross-clamped aortic root on parameters of regional blood flow during intraoperative myocardial contrast echo...
Keller MW, Spotnitz WD, Matthew T, Glasheen WP, Kaul S, Clin Res, 1/1/1989
Demonstration of collateral flow using myocardial contrast echocardiography in patients undergoing coronary artery bypass surgery.
Matthew TL, Spotnitz W, Keller MW, Kaul S, Circulation, 1/1/1989
Perfusion with cardioplegia solutions changes microbubble rheology: Implications for intracoronary myocardial contrast echocardiography.
Keller MW, Kaul S, Spotnitz SD, Duling BR, Circulation, 1/1/1989
Prognostic power of the 2-D echocardiogram in the emergency room.
Sabia P, Afrookteh A, Touchstone DA, Keller MW, Kaul S, Circulation, 1/1/1989
2-D echo versus Swan- Ganz catheter in critically ill patients: a prospective study.
Stratienko A, Keller MW, Sabia P, Pollock S, Marieb M, Kaul S, Circulation, 1/1/1989
The behavior of sonicated albumin microbubbles in the microcirculation: A basis for their use as myocardial echo contrast agents.
Keller MW, Segal SS, Kaul S, Duling BR, Clin Res, 1/1/1988
The behavior of sonicated albumin microbubbles in the microcirculation: A basis for their use as myocardial echo contrast agents.
Keller MW, Segal SS, Kaul S, Duling BR, J Am Coll Cardiol, 1/1/1988
Pathologic effects of sonicated albumin microbubbles on the myocardium, brain, and kidneys: How much is safe?
Keller MW, Glasheen WP, Teja K, Kaul S, J Am Coll Cardiol, 1/1/1988
Success of internal mammary bypass grafting can be assessed in intraoperatively using myocardial contrast echocardiography.
Spotnitz WD, Keller MW, Nolan SP, Kaul S, J Am Coll Cardiol, 1/1/1988
Quantitative intraoperative myocardial contrast echocardiography: Implications for preventing perioperative infarction.
Keller MW, Sponitz WD, Matthew TL, Glasheen WP, Watson DD, Kaul S, Circulation, 1/1/1988
Superiority of 2D echo for the detection of acute myocardial infarction in the emergency room: A prospective study.
Sabia P, Afrookteh A, Touchstone DA, Keller MW, Esquivel L, Kaul S, Circulation, 1/1/1988
Assessment of coronary blood flow reserve using myocardial contrast echocardiography.
Keller MW, Smucker M, Burwell L, Glasheen WP, Watson DD, Kaul S, Circulation, 1/1/1987
Myocardial contrast echocardiography without hyperemic response or hemodynamic effects.
Keller MW, Glasheen WP, Gear A, Kaul S, Circulation, 1/1/1987
Quatitation of transpulmonary contrast echocardiography.
Keller MW Feinstein SB, Watson DD, Clinical Research, 1/1/1987
Successful transpulmonary contrast echocardiography in monkeys.
Feinstein SB, Keller MW, Dick CD, J Am Coll Cardiol, 1/1/1987
Automated production and analysis of surfactant stabilized echo contrast agents for use in clinical imaging.
Keller MW, Feinstein SB, Clin Res, 1/1/1985
Automated evaluation of contrast agents�In Situ assessment of bubble formation, diameter and decay.
Keller MW, Feinstein SB, Powsner S, Groves M, Ultrasonor Bulletin. Abstracts of the 6th Symposium on Echocardiography, 1/1/1985
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Lectures

Cardiac Source of Embolus.
University of Colorado - 1/1/2015
Sudden cardiac death in sports.
University of Colorado - 1/1/2015
Will I have a heart attack?
Lone Tree Health Center - 1/1/2015
ECG tutorial for Medical Assistants.
Lone Tree Health Center - 1/1/2015
Aortic emergencies.
University of Colorado - 1/1/2014
Update on lipids, blood pressure.
Lone Tree Health Center - 1/1/2014
Atrial fibrillation.
Lone Tree Health Center - 1/1/2014
Update on Lipid Guidelines.
1/1/2013
Survival of the Fittest.
Medical Center of Aurora - 1/1/2010
Diabetes and the Heart.
Medical Center of Aurora - 1/1/2005
Echo in Atrial Fibrillation.
Medical Center of Aurora - 1/1/2003
Contrast Echocardiography.
Kaiser Permanente, Denver, CO - 1/1/1998
Annual Fall Meeting of the Biomedical Engineering Society (Invited Faculty)
University of Virginia, Charlottesville, VA - 1/1/1991
8th Symposium on Echocardiography (Invited Faculty)
Erasmus University, Rotterdam, The Netherlands - 1/1/1989
Contrast Agent Development.
Thorax Center, The Netherlands - 1/1/1989
Advances in Echocardiography (Invited Faculty)
University of Chicago, Chicago, IL - 1/1/1988
Myocardial Contrast Echocardiography.
University of Washington - 1/1/1988
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