MarkJosephKellyMD

PubMed

• 7 citations
  Recognition of histone H3 methylation states by the PHD1 domain of histone demethylase KDM5A
  James E. Longbotham, Mark J. S. Kelly, Danica Galonić Fujimori> ;ACS Chemical Biology. 2021 Feb 23
• 39 citations
  Expanding the space of protein geometries by computational design of de novo fold families
  Xingjie Pan, Michael C. Thompson, Yang Zhang, Lin Liu, James S. Fraser, Mark J. S. Kelly, Tanja Kortemme> ;Science. 2020 Aug 28
• 39 citations
  Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.
  Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark J. S. Kelly, Jingyi Chi, Peng Zhang, Lawrence M. Lifshitz, Karl D. Bellve, Leslie A. Rowland, Batuhan...> ;Cell Reports. 2020 Aug 4
• 29 citations
  Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration.
  Adilson L. Guilherme, Batuhan Yenilmez, Alexander H. Bedard, Felipe Henriques, Dianxin Liu, Alexandra Lee, Lauren Goldstein, Mark J. S. Kelly, Sarah M. Nicoloro, Min C...> ;Cell Reports. 2020 May 5
• 68 citations
  Computational design of a modular protein sense-response system
  Anum A. Glasgow, Yao-Ming Huang, Daniel J. Mandell, Michael C. Thompson, Ryan Ritterson, Amanda L. Loshbaugh, Jenna Pellegrino, Cody Krivacic, Roland A. Pache, Kyle A....> ;Science. 2019 Nov 22
• 21 citations
  Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis.
  Shashi Kant, Siobhan M. Craige, Kai Chen, Michaella M. Reif, Heather Learnard, Mark J. S. Kelly, Amada D. Caliz, Khanh-Van Tran, Kasmir Ramo, Owen M. Peters, Marc R. F...> ;Nature Communications. 2019 Sep 17
• 55 citations
  A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.
  John V. Lin King, Joshua J. Emrick, Mark J. S. Kelly, Volker Herzig, Glenn F. King, Katalin F. Medzihradszky, David Julius> ;Cell. 2019 Sep 5
• 13 citations
  HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI.
  Marina Radoul, Chloé Najac, Pavithra Viswanath, Joydeep Mukherjee, Mark J. S. Kelly, Anne Marie Gillespie, Myriam M. Chaumeil, Pia Eriksson, Romelyn Delos Santos, Russ...> ;NMR in Biomedicine. 2019 Feb 1
• 32 citations
  CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure.
  Yuefei Shen, Jessica Cohen, Sarah M. Nicoloro, Mark Kelly, Batuhan Yenilmez, Felipe Henriques, Emmanouela Tsagkaraki, Yvonne J. K. Edwards, Xiaodi Hu, Randall H. Fried...> ;The Journal of Biological Chemistry. 2018 Nov 2
• 28 citations
  Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis
  Adilson L. Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark J. S. Kelly, Donald A. Morgan, Kamal Rahmouni, Michael P. Czech> ;Molecular Metabolism. 2018 Jun 27
• 10 citations
  The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles.
  Y. Rose Citron, Carey J. Fagerstrom, Bettina Keszthelyi, Bo Huang, Nasser M. Rusan, Mark J. S. Kelly, David A. Agard> ;Plos One. 2018 Jan 9
• 292 citations
  IRF3 and type I interferons fuel a fatal response to myocardial infarction.
  Kevin R. King, Aaron D. Aguirre, Yu-Xiang Ye, Yuan Sun, Jason D. Roh, Richard P. Ng, Rainer H. Kohler, Sean P. Arlauckas, Yoshiko Iwamoto, Andrej J. Savol, Ruslan I. S...> ;Nature Medicine. 2017 Nov 6
• 9 citations
  Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.
  Rachel J. Roth Flach, Marina T. DiStefano, Laura V. Danai, Ozlem Senol-Cosar, Joseph C. Yawe, Mark J. S. Kelly, Lorena Garcia Menendez, Michael P. Czech> ;American Journal of Physiology. Endocrinology and Metabolism. 2017 Jun 13
• 46 citations
  A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells
  Jan Stöhr, Haifan Wu, Mimi Nick, Yibing Wu, Manasi P. Bhate, Carlo Condello, Noah R. Johnson, Jeffrey M. Rodgers, Thomas Lemmin, Srabasti Acharya, Julia Becker, Kathle...> ;Nature Chemistry. 2017 Apr 3
• 12 citations
  Protein Kinase Mitogen Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-Induced Hyperinsulinemia
  Rachel J. Roth Flach, Laura V. Danai, Marina T. DiStefano, Mark J. S. Kelly, Lorena Garcia Menendez, Agata Jurczyk, Rohit Sharma, Dae Young Jung, Jong Hun Kim, Jason K...> ;The Journal of Biological Chemistry. 2016 Jul 29
• 25 citations
  Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
  Celeste Alverez, Stacie L. Bulfer, Ramappa Chakrasali, Michael S. Chimenti, Raymond J. Deshaies, Neal Jeffrey Green, Mark J. S. Kelly, Matthew G. LaPorte, Taber S. Lew...> ;ACS Medicinal Chemistry Letters. 2016 Feb 11
• 21 citations
  Allosteric N-WASP activation by an inter-SH3 domain linker in Nck
  Julia Okrut, Sumit Prakash, Qiong Wu, Mark J. S. Kelly, Jack Taunton> ;Proceedings of the National Academy of Sciences of the United States of America. 2015 Nov 24
• 9 citations
  A Fragment-Based Ligand Screen Against Part of a Large Protein Machine The ND1 Domains of the AAA+ ATPase p97/VCP
  Michael S. Chimenti, Stacie L. Bulfer, R. Jeffrey Neitz, Adam R. Renslo, Matthew P. Jacobson, Thomas L. James, Michelle R. Arkin, Mark J. S. Kelly> ;Journal of Biomolecular Screening. 2015 Feb 17
• 80 citations
  Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
  Idelisse Ortiz Torres, Kristopher M. Kuchenbecker, Chimno I. Nnadi, Robert J. Fletterick, Mark J. S. Kelly, Danica Galonić Fujimori> ;Nature Communications. 2015 Feb 17
• 10 citations
  Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions.
  Samuel J. Pfaff, Michael S. Chimenti, Mark J. S. Kelly, Michelle R. Arkin> ;Methods in Molecular Biology. 2015 Jan 1
• 37 citations
  Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone.
  Timothy O. Street, Xiaohui Zeng, Riccardo Pellarin, Massimiliano Bonomi, Andrej Sali, Mark J. S. Kelly, Feixia Chu, David A. Agard> ;Journal of Molecular Biology. 2014 Jun 12
• 12 citations
  13C NMR Metabolomic Evaluation of Immediate and Delayed Mild Hypothermia in Cerebrocortical Slices After Oxygen-Glucose Deprivation
  Jia Liu, Mark R. Segal, Mark J. S. Kelly, Jeffrey G. Pelton, Myungwon Kim, Thomas L. James, Lawrence Litt> ;Anesthesiology. 2013 Nov 1
• 25 citations
  1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries
  Jia Liu, R Ann Sheldon, Mark R. Segal, Mark J. S. Kelly, Jeffrey G. Pelton, Donna M. Ferriero, Thomas L. James, Lawrence Litt> ;Pediatric Research. 2013 May 24
• 15 citations
  Design of a Phosphorylatable PDZ Domain with Peptide-Specific Affinity Changes
  Colin A. Smith, Catherine A. Shi, Matthew K. Chroust, Thomas E. Bliska, Mark J. S. Kelly, Matthew P. Jacobson, Tanja Kortemme> ;Structure. 2013 Jan 8
• 37 citations
  Metabolomics of Oxidative Stress in Recent Studies of Endogenous and Exogenously Administered Intermediate Metabolites
  Jia Liu, Lawrence Litt, Mark R. Segal, Mark J. S. Kelly, Jeffrey G. Pelton, Myungwon Kim> ;International Journal of Molecular Sciences. 2011 Sep 28
• Join now to see all

Lectures

• "Current Management of Renal Angiomyolipoma" 
  Santa Monica, CA - 1/12/2015
• Update of NCCN Management of Pathological T2 Bladder Cancer. 
  Santa Monica, CA - 1/12/2015
• The Evaluation and Management of Urinary Retention in the Acute Care Setting. 
  Santa Monica, CA - 1/11/2015
• Active Surveillance for Men with Low-Risk Adenocarcinoma of the Prostate. "Who Is a Candidate for Surveillance, Who Is Not?" 
  1/11/2014
• Reconciling the R.E.N.A.L. Nephrometry Tool and the updated NCCN Management Guidelines for Kidney Cancer. "Upholding Oncological Principles and Avoiding Chronic Kidney... 
  1/11/2014
• Squamous Cell Carcinoma of the Penis. Natural History, Epidemiology, Diagnosis, Staging and Management. 
  1/10/2014
• The use of multiparimetric MRI Imaging in the Management of Clinically Localized Prostate Cancer. 
  1/8/2014
• Join now to see all