MarkEllsworthKleinmanMD

PubMed

• 12 citations
  Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration
  Gopalan Gnanaguru, Alexandre Wagschal, Justin Oh, kahira Saez-Torres, Tong Li, Ryan E. Temel, Mark E. Kleinman, Anders M. Näär, Patricia A. D'Amore> ;Molecular Therapy. 2021 Jul 7
• 18 citations
  Loss of CLN3, the gene mutated in juvenile neuronal ceroid lipofuscinosis, leads to metabolic impairment and autophagy induction in retinal pigment epithelium.
  Yu Zhong, Kabhilan Mohan, Jinpeng Liu, Ahmad Al-Attar, Penghui Lin, Robert M. Flight, Qiushi Sun, Marc O. Warmoes, Rahul Deshpande, Huijuan Liu, Kyung Jung, Mihail I. ...> ;Biochimica Et Biophysica Acta. Molecular Basis of Disease. 2020 Oct 1
• 3 citations
  Imaging Data on Characterization of Retinal Autofluorescent Lesions in a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3 Disease)
  Qing Jun Wang, Kyung Jung, Kabhilan Mohan, Mark E. Kleinman> ;Data in Brief. 2020 Jul 25
• 24 citations
  Vision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease)
  Madhu M. Ouseph, Mark E. Kleinman, Qing Jun Wang> ;Annals of the New York Academy of Sciences. 2016 Jan 8
• 5 citations
  Complement Activation and Inhibition in Retinal Diseases.
  Mark E. Kleinman, Jayakrishna Ambati> ;Developments in Ophthalmology. 2016 Jan 1
• 9 citations
  Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration.
  Andre Berner, Mark E. Kleinman> ;Advances in Experimental Medicine and Biology. 2016 Jan 1
• 68 citations
  Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome
  Bradley D. Gelfand, Charles B. Wright, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Shengjian Li, Benjamin J. Fowler, Ana Bastos-Carvalho, Nagaraj Kerur, Annette Uitten...> ;Cell Reports. 2015 Jun 23
• 11 citations
  The Immune System and AMD.
  Paul A. Frederick, Mark E. Kleinman> ;Current Ophthalmology Reports. 2014 Jan 30
• 3 citations
  Clocking in on Diabetic Retinopathy
  Mark E. Kleinman, Jayakrishna Ambati> ;Diabetes. 2013 Jan 1
• 84 citations
  ERK1/2 activation is a therapeutic target in age-related macular degeneration
  Sami Dridi, Yoshio Hirano, Valeria Tarallo, Younghee Kim, Benjamin J. Fowler, Balamurali K. Ambati, Sasha Bogdanovich, Vince A. Chiodo, William W. Hauswirth, Jennifer ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 Aug 21
• 454 citations
  DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
  Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand, Sami Dridi, Nagaraj Kerur, Younghee Kim, Won Gil Cho, Hiroki Kaneko, Benjamin J. Fowler, Sasha Bogdanovich, Romulo ...> ;Cell. 2012 May 11
• 74 citations
  Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3
  Mark E. Kleinman, Hiroki Kaneko, Won Gil Cho, Sami Dridi, Benjamin J. Fowler, Alexander D Blandford, Romulo Albuquerque, Yoshio Hirano, Hiroko Terasaki, Mineo Kondo, T...> ;Molecular Therapy. 2012 Jan 1
• 3 citations
  A window to innate neuroimmunity: Toll-like receptor-mediated cell responses in the retina.
  Mark E. Kleinman, Jayakrishna Ambati> ;Advances in Experimental Medicine and Biology. 2012 Jan 1
• 456 citations
  DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
  Hiroki Kaneko, Sami Dridi, Valeria Tarallo, Bradley D. Gelfand, Benjamin J. Fowler, Won Gil Cho, Mark E. Kleinman, Steven L. Ponicsan, William W. Hauswirth, Vince A. C...> ;Nature. 2011 Mar 17
• 21 citations
  The Multifactorial Nature of Retinal Vascular Disease
  Mark E. Kleinman, Judit Z. Baffi, Jayakrishna Ambati> ;Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde. 2010 Aug 18
• 4 citations
  Triamcinolone Crystal Size
  Mark E. Kleinman, Scott J. Westhouse, Jayakrishna Ambati, P. Andrew Pearson, Lawrence Halperin> ;Ophthalmology. 2010 Aug 1
• 278 citations
  Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth
  Romulo Albuquerque, Takahiko Hayashi, Won Gil Cho, Mark E. Kleinman, Sami Dridi, Atsunobu Takeda, Judit Z. Baffi, Kiyoshi Yamada, Hiroki Kaneko, Martha G. Green, Josep...> ;Nature Medicine. 2009 Sep 1
• 179 citations
  CCR3 is a target for age-related macular degeneration diagnosis and therapy
  Atsunobu Takeda, Judit Z. Baffi, Mark E. Kleinman, Won Gil Cho, Miho Nozaki, Kiyoshi Yamada, Hiroki Kaneko, Romulo Albuquerque, Sami Dridi, Kuniharu Saito, B.J. Raisle...> ;Nature. 2009 Jul 9
• 115 citations
  Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth
  Won Gil Cho, Romulo Albuquerque, Mark E. Kleinman, Valeria Tarallo, Adelaide Greco, Miho Nozaki, Martha G. Green, Judit Z. Baffi, Balamurali K. Ambati, Massimo De Falc...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Apr 28
• 167 citations
  Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration
  Zhenglin Yang, Charity A. Stratton, Peter J. Francis, Mark E. Kleinman, Perciliz L. Tan, Daniel Gibbs, Zongzhong Tong, Haoyu Chen, Ryan Constantine, Xian Yang, Yuhong ...> ;The New England Journal of Medicine. 2008 Oct 2
• 9 citations
  Fifty years later: the disk goes to the prom
  Mark E. Kleinman, Jayakrishna Ambati> ;The Journal of Clinical Investigation. 2008 Aug 1
• 687 citations
  Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
  Mark E. Kleinman, Kiyoshi Yamada, Atsunobu Takeda, Vasu Chandrasekaran, Miho Nozaki, Judit Z. Baffi, Romulo Albuquerque, S. Yamasaki, M. Itaya, Yuzhen Pan, Binoy Appuk...> ;Nature. 2008 Apr 3
• 13 citations
  Cycloheximide and disulfoton are positive in the photoclastogencity assay but do not absorb UV irradiation: another example of pseudophotoclastogenicity?
  Anthony M. Lynch, Sharon Robinson, Phil Wilcox, Mark D. Smith, Mark E. Kleinman, Kaina Jiang, Robert W. Rees> ;Mutagenesis. 2008 Mar 1
• 153 citations
  Hypoxia-Induced Mediators of Stem/Progenitor Cell Trafficking Are Increased in Children With Hemangioma
  Mark E. Kleinman, Matthew R. Greives, Samara S. Churgin, Keith M. Blechman, Eric I. Chang, Daniel J. Ceradini, Oren M. Tepper, Geoffrey C. Gurtner> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2007 Dec 1
• 10 citations
  A geometrically sound technique of vermilion repair in unilateral cleft lip.
  Rajesh S. Powar, Sandeep M. Patil, Mark E. Kleinman> ;Journal of Plastic, Reconstructive & Aesthetic Surgery. 2007 Apr 1
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Journal Articles

• Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration  
  Berner AK, Kleinman ME, Adv Exp Med Biol, 1/1/2016
• Vision Loss in Juvenile Neuronal Ceroid Lipofuscinosis  
  Ouseph M, Kleinman ME, Wang Q, Ann N Y Acad Sci, 1/1/2016
• Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome  
  Gelfand BD, Wright CB, Kim Y, Yasuma T, Yasuma R, Li S, Fowler BJ, Bastos-Carvalho A, Kerur N, Uittenbogaard A, Han YS, Lou D, Kleinman ME, McDonald WH, Nunez G, Georg..., Cell Reports, 1/1/2015
• Complement Activation and Inhibition in Retinal Diseases  
  Kleinman ME, Ambati J, Dev Ophthalmol, 1/1/2015
• The Immune system and AMD  
  Frederick PA and Kleinman ME, Current Reports in Ophthalmology, 1/1/2014
• Small interfering RNAs induce retinal degeneration via TLR3 and IRF3  
  Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJC, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Bogdanovich S, Baffi J..., Molecular Therapy, 1/1/2012
• ERK1/2 activation is a therapeutic target in age-related macular degeneration  
  Dridi, S., Hirano, Y., Tarallo, V., Kim, Y., Fowler, B.J., Ambati, B.K., Bogdanovich, S., Chiodo, V.A., Hauswirth, W.W., Kugel, J.F., Goodrich, J.A., Ponicsan, S.L., H..., Proceedings of the National Academy of Sciences, 1/1/2012
• Alternatively Spliced Vascular Endothelial Growth Factor Receptor-2 is an Essential Endogenous Inhibitor of Lymphatic Vessel Growth  
  Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki..., Nature Medicine, 1/1/2009
• Small Interfering RNA-induced TLR3 Activation Inhibits Blood and Lymphatic Vessel Growth  
  Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S and Ambati J, Proc Natl Acad Sci USA, 1/1/2009
• Sequence- and Target-independent Suppression of Angiogenesis by siRNA  
  Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi J, Albuquerque RJC, Yamasaki S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Kariko K, Shibuya M, ..., Nature, 1/1/2008
• Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration  
  Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J..., New England Journal of Medicine, 1/1/2008
• Hypoxic Mediators of Progenitor Cell Mobilization and Recruitment Are Increased in Children with Hemangioma  
  Kleinman ME, Greives MR, Churgin SS, Blechman KM, Ceradini DJ, Chang E, Blei F, Gurtner GC, Arteriosclerosis, Thrombosis, and Vascular Biology, 1/1/2007
• A Geometrically Sound Technique of Vermilion Repair in Unilateral Cleft Lip  
  Powar RS, Patil S, Kleinman ME, Journal of Plastic, Reconstructive & Aesthetic Surgery, 1/1/2007
• Molecular Genetic Investigation of Maternal-Fetal Microchimerism in Infantile Hemangioma  
  Pittman KM, Losken W, Kleinman ME, Marcus JR, Blei F, Gurtner GC, Marchuk DA, Journal of Investigative Dermatology, 1/1/2006
• Adult Vasculogenesis occurs through the In Situ Recruitment, Proliferation and Tubulization of Circulating Bone Marrow-Derived Cells  
  Tepper OM, Capla JM, Galiano RD, Ceradini DJ, Callaghan MJ, Kleinman ME, Gurtner GC, Blood, 1/1/2005
• Circulating Endothelial Progenitor Cells and Vascular Anomalies  
  Kleinman ME, Blei F, Gurtner GC, Lymphatic Research and Biology, 1/1/2005
• Selective Recruitment of Endothelial Progenitor Cells to Ischemic Tissues with Increased Neovascularization  
  Park S, Tepper OM, Galiano RD, Capla JM, Baharestani S, Kleinman ME, Pelo CR, Levine JP, Gurtner GC, Journal of Plastic and Reconstructive Surgery, 1/1/2004
• Progenitor Cell Trafficking is Regulated by Hypoxic Gradients through HIF-1 Induction of SDF-1  
  Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC, Nature Medicine, 1/1/2004
• Increased Circulating AC133+ CD34+ Endothelial Progenitor Cells in Children with Hemangioma  
  Kleinman ME, Tepper OM, Capla JM, Bhatt KA, Ceradini DJ, Galiano RD, Blei F, Levine JP, Gurtner GC, Lymphatic Research and Biology, 1/1/2003
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Books/Book Chapters

• Retinal Pharmacotherapy 
  Chapter: Complement Inhibition in Retinal Disease. 
  Kleinman ME and Ambati JEditors: Nguyen, Rodrigues, Farah, and Mieler.Edition 2nd,2015
• Genomics and Clinical Medicine 
  Chapter: Age-Related Macular Degeneration. 
  Kleinman ME and Ambati JEditors: Kumar and Eng.Edition 2nd,2014
• The New Visual Neurosciences. 
  Chapter: Molecular Mechanisms of Non-Neovascular AMD. 
  Kleinman ME and Ambati JEditors: Chalupa and Werner.2013
• AMD: State of the Art. 
  Chapter: The Role of the Immune System. 
  Kleinman ME and Ambati JEditors: Kaiser.2012
• Retinal Pharmacotherapy. 
  Chapter: Complement Inhibition in Retinal Disease. 
  Kleinman ME and Ambati JEditors: Nguyen, Rodrigues, Farah, and Mieler.2010
• Encyclopedia of the Eye and Vision. 
  Chapter: Retinal Response to Injury. 
  Kleinman ME and Ambati JEditors: Besharse, Dana, and Darlene Dartt.2010
• Ocular Angiogenesis. 
  Chapter: Choroidal Neovascularization: Pathophysiology. 
  Kleinman ME and Ambati JEditors: Das.2010
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Abstracts/Posters

• Epigenetic regulation of autophagy by histone deacetylases in retinal pigment epithelium.
  Dubey S, Lou D, Jung K, Roney J, Brown J, Mohan K, Kleinman ME, Annual ARVO Meeting, Baltimore, MD, 1/1/2017
• Neutralization of IFNAR1 prevents histone deacetylase inhibitor induced retinal pigment epithelium cell death.
  Jung K, Mohan K, Prajapati SC, Dubey S, Lou D, Roney J, Brown J, Kleinman ME, Annual ARVO Meeting, Baltimore, MD, 1/1/2017
• Safety and efficiency of CRISPR-Cas9 gene editing in the retinal pigment epithelium.
  Kleinman ME, Dubey S, Jung K, Roney J, Lou D, Brown J, Mohan K, Annual ARVO Meeting, Baltimore, MD, 1/1/2017
• The Future of Ophthalmic Imaging.
  Kleinman ME, Cincinnati Ophthalmology Society, Spring, 1/1/2017
• An update on translational research and clinical trials for age-related macular degeneration.
  Kleinman ME, Kentucky Academy of Eye Physicians and Surgeons Meeting, Spring, 1/1/2017
• Epigenetic Regulation of Type I IFN Response in Age-Related Macular Degeneration.
  Sung K, Lou D, Mohan K, Dubey S, Prajapati SC, Roney J, Abney JL, Liu J, Kleinman ME, Keystone Interferon Meeting, Banff, Alberta, Canada, 1/1/2017
• Next Generation Sequencing of Transcribed Alu in Dry Age-Related Macular Degeneration.
  Lowery JT, Liu C, Fowler BJ, Lou D, Mohan K, Prajapati SC, Berner AK, Roney J, Abney JL, Gelfand BD, Liu J, Ambati J, Kleinman ME, American Society of Human Genetics Meeting, Vancouver, British Columbia, Canada, 1/1/2016
• HDAC1/2 are critical for RPE homeostasis and health.
  Kleinman ME, Jung K, Roney J, Prajapati SC, Lou D, Dubey S, Brown JL, Mohan K, Annual ARVO Meeting, Seattle, WA, 1/1/2016
• Mohan K, Zhong Y, Liu J, Al-Attar A, Liu H, Jung K, Dow M, Liu J, Fan T, Wang Q, Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2016
• The role of IP-10 in RPE degeneration during AMD progression.
  Roney J, Mohan K, Jung K, Lou D, Prajapati SC, Brown JL, Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2016
• Next-generation sequencing of Alu expression in dry age-related macular degeneration.
  Kleinman ME, Lowery JT, Liu C, Fowler BJ, Lou D, Mohan K, Prajapati SC, Hirano Y, Berner AK, Roney J, Brown JL, Gelfand BD, Keddache M, Hernandez AG, Liu J, Ambati J, ASCI Young Physician Scientist Award Session, Chicago, IL, 1/1/2016
• AMD-like phenotype in a novel mouse model of RPE targeted histone deacetylase deficiency.
  Dubey S, Jung K, Mohan K, Prajapati SC, Roney J, Berner AK, Kleinman ME, RD Meeting, Kyoto, Japan, 1/1/2016
• Next Generation Sequencing of Mobile Genetic Elements in Dry Age-Related Macular Degeneration.
  Kleinman ME, Lowery JT, Liu C, Fowler BJ, Lou D, Prajapati SC, Gelfand BD, Keddache M, Liu J, Ambati J, Annual ARVO Meeting, Denver, CO, 1/1/2015
• An Acyloxy-Conjugated Caspase Probe for in Vivo Retinal Bio-imaging.
  Mohan K, Sanman L, Jung K, Roney J, Lou D, Brown JL, Bogyo M, Kleinman ME, Annual ARVO Meeting, Denver, CO, 1/1/2015
• Histone deacetylase expression and acetylation in the aging retinal pigment epithelium.
  Prajapati SC, Berner AK, Mohan K, Jung K, Roney J, Lou D, Brown JL, Kleinman ME, Annual ARVO Meeting, Denver, CO, 1/1/2015
• In vivo imaging of retinal pigment epithelium cell death using novel fluorescent probes targeting caspases.
  Mohan K and Kleinman ME, AUPO/RPB Resident and Fellows Research Forum, Tucson, AZ, 1/1/2015
• RPE Cytotoxicity and Caspase Activation after Treatment with Valproic Acid.
  Berner AK, Mohan KB, Lou D, Brown JL, West J, Kono R, Sugino, IK, Zarbin MA, Ambati J, Kleinman ME, Annual ARVO Meeting, Orlando, FL, 1/1/2014
• Histone Deacetylase Expression and Inhibition in Age Related Macular Degeneration.
  Kleinman ME, Berner AK, Mohan KB, Lou D, Brown JL, West J, Kono R, Sugino IK, Zarbin MA, Ambati J, Annual ARVO Meeting, Orlando, FL, 1/1/2014
• In Vivo Molecular Imaging of Cell Death in Age-Related Macular Degeneration.
  Kleinman ME, Mohan KB, Jackson CH, D Lou and Ambati J, Keystone Cell Death Symposium, Santa Fe, NM, 1/1/2014
• Therapeutic approaches to histone reprogramming in age-related macular degeneration.
  Berner AK, Mohan KB, Lou D, Brown JL, West J, Kono R, Sugino IK, Zarbin MA, Kleinman ME, RD Meeting, Pacific Grove, CA, 1/1/2014
• In vivo imaging of retinal pigment epithelium cell death using a novel fluorescent probe targeting caspases.
  Mohan KB, Hirano Y, Berner AK, Lou D, Jackson CH, Brown JL, Johnson GL, Ambati J, Kleinman ME, RD Meeting, Pacific Grove, CA, 1/1/2014
• In vivo imaging of retinal pigment epithelium cell death in age-related macular degeneration.
  Kleinman ME, Mohan KB, Hirano Y, Berner AK, Lou D, Jackson CH, Brown JL, Johnson GL, Ambati J, World Molecular Imaging Society Congress, Seoul, Korea, 1/1/2014
• Co-Localization of an In Vivo Retinal Pigment Epithelial Cell Death Imaging Probe in a Mouse Model of Acute Double-Stranded RNA Toxicity.
  Jackson CJ, Mohan KB, Hirano Y, Berner AK, Lou D, Brown JL, Ambati J, Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2013
• Emerging Strategies for In Vivo Cellular and Molecular Imaging of Retinal Disease
  Kleinman ME, Annual ARVO Meeting, Seattle, WA, 1/1/2013
• Epigenetic Regulation of Eotaxin Expression in Human Retinal Pigment Epithelium.
  Kleinman ME, Berner AK, Lou D, Mohan KB, Jackson CH, Abney JL, Ambati J, Annual ARVO Meeting, Seattle, WA, 1/1/2013
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Lectures

• Current Therapies for AMD. 
  Baltimore, MD, 2013; Denver, CO, 2014 - 1/1/2014
• Update on AMD Research. 
  1/1/2013
• Employing Ocular Electrophysiology in Your Practice. 
  1/1/2013
• Biomarker Imaging in Age Related Macular Degeneration. 
  1/1/2013
• Biomarker Discovery and Translation in Neovascular Age-Related Macular Degeneration. 
  Abu Dhabi, United Arab Emirates - 1/1/2012
• Small interfering RNAs induce retinal toxicity via TLR3 activation. 
  Hyderabad, India - 1/1/2011
• The Future of Stem Cell Therapies in Vascular Diseases. 
  JNMC Medical College, Belgaum, Karnataka, India - 1/1/2005
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