MarkEvanLindsayMDPhD

PubMed

• Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease.
  Raghavan, A., Pirruccello, J., Ellinor, P., Lindsay, M.> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2024 Feb 1
• Treatment of calcific arterial disease via enhancement of autophagy using GSK343.
  Christian L Lino Cardenas, Wanlin Jiang, Lova P Kajuluri, Kuldeep Singh, Katrina Ostrom, Rebecca Li, Francois Cherbonneau, Sophie Boerboom, Claire Birchenough, Kangsan...> ;Iscience. 2023 Nov 17
• Transcriptional profile of the rat cardiovascular system at single cell resolution.
  Alessandro Arduini, Stephen J Fleming, Ling Xiao, Amelia W Hall, Amer-Denis Akkad, Mark Chaffin, Kayla J Bendinelli, Nathan R Tucker, Irinna Papangeli, Helene Mantineo...> ;Biorxiv. 2023 Nov 16
• AORTA Gene: Polygenic prediction improves detection of thoracic aortic aneurysm.
  James P Pirruccello, Shaan Khurshid, Honghuang Lin, Weng Lu-Chen, Siavash Zamirpour, Shinwan Kany, Avanthi Raghavan, Satoshi Koyama, Ramachandran S Vasan, Emelia J Ben...> ;Medrxiv. 2023 Aug 25
• 3 citations
  The Genetic Determinants of Aortic Distention.
  James P Pirruccello, Joel T Rämö, Seung Hoan Choi, Mark D Chaffin, Shinwan Kany, Mahan Nekoui, Elizabeth L Chou, Sean J Jurgens, Samuel F Friedman, Dejan Juric, James ...> ;Journal of the American College of Cardiology. 2023 Apr 11
• 1 citations
  A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome.
  Christian Lacks Lino Cardenas, Lauren C Briere, David A Sweetser, Mark E Lindsay, Patricia L Musolino> ;The Journal of Clinical Investigation. 2023 Mar 1
• 10 citations
  Genetics and mechanisms of thoracic aortic disease.
  Elizabeth Chou, James P Pirruccello, Patrick T Ellinor, Mark E Lindsay> ;Nature Reviews. Cardiology. 2023 Mar 1
• 5 citations
  Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals.
  James P Pirruccello, Honghuang Lin, Shaan Khurshid, Mahan Nekoui, Lu-Chen Weng, Ramachandran S Vasan, Eric M Isselbacher, Emelia J Benjamin, Steven A Lubitz, Mark E Li...> ;JAMA. 2022 Nov 15
• 8 citations
  Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta.
  Elizabeth L Chou, Mark Chaffin, Bridget Simonson, James P Pirruccello, Amer-Denis Akkad, Mahan Nekoui, Christian Lacks Lino Cardenas, Kenneth C Bedi Jr, Craig Nash, De...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2022 Nov 1
• An additional patient with SMAD4-Juvenile Polyposis-Hereditary hemorrhagic telangiectasia and connective tissue abnormalities: SMAD4 loss-of-function and gain-of-funct...
  Gregory M Gheewalla, Jay Luther, Saumya Das, Jeffrey B Kreher, Eleanor R Scimone, Ashley W Wong, Mark E Lindsay, Angela E Lin> ;American Journal of Medical Genetics. Part A. 2022 Oct 1
• 1 citations
  Review of the Pathologic Characteristics in Myhre Syndrome: Gain-of-Function Pathogenic Variants incause a Multisystem Fibroproliferative Response.
  Lois J Starr, Mark E Lindsay, Deborah Perry, Gregory Gheewalla, Paul A VanderLaan, Adnan Majid, Charlie Strange, George-Claudiu Costea, Adrian Lungu, Angela E Lin> ;Pediatric and Developmental Pathology. 2022 Sep 17
• 10 citations
  Spatially Distinct Genetic Determinants of Aortic Dimensions Influence Risks of Aneurysm and Stenosis.
  Mahan Nekoui, James P Pirruccello, Paolo Di Achille, Seung Hoan Choi, Samuel N Friedman, Victor Nauffal, Kenney Ng, Puneet Batra, Jennifer E Ho, Anthony A Philippakis,...> ;Journal of the American College of Cardiology. 2022 Aug 2
• 31 citations
  Genetic analysis of right heart structure and function in 40,000 people.
  James P Pirruccello, Paolo Di Achille, Victor Nauffal, Mahan Nekoui, Samuel F Friedman, Marcus D R Klarqvist, Mark D Chaffin, Lu-Chen Weng, Jonathan W Cunningham, Shaa...> ;Nature Genetics. 2022 Jun 1
• 7 citations
  Location of Aortic Enlargement and Risk of Type A Dissection at Smaller Diameters.
  Asvin M Ganapathi, David N Ranney, Mark D Peterson, Mark E Lindsay, Himanshu J Patel, Reed E Pyeritz, Santi Trimarchi, Stuart Hutchison, Kevin M Harris, Kevin L Greaso...> ;Journal of the American College of Cardiology. 2022 May 17
• 2 citations
  Expanded cardiovascular phenotype of Myhre syndrome includes tetralogy of Fallot suggesting a role for SMAD4 in human neural crest defects.
  Gerarda Cappuccio, Nicola Brunetti-Pierri, Paul Clift, Christopher Learn, John C Dykes, Catherine L Mercer, Bert Callewaert, Ilse Meerschaut, Alessandro Mauro Spinelli...> ;American Journal of Medical Genetics. Part A. 2022 May 1
• 15 citations
  Fibrillar Collagen Variants in Spontaneous Coronary Artery Dissection.
  Seyedeh Maryam Zekavat, Elizabeth L Chou, Melica Zekavat, Akhil Pampana, Kaavya Paruchuri, Christian Lacks Lino Cardenas, Satoshi Koyama, Yousef Ghazzawi, Erina Kii, M...> ;JAMA Cardiology. 2022 Apr 1
• 5 citations
  Vascular smooth muscle cell phenotype switching in carotid atherosclerosis.
  Elizabeth L Chou, Christian L Lino Cardenas, Mark Chaffin, Alessandro D Arduini, Dejan Juric, James R Stone, Glenn M LaMuraglia, Matthew J Eagleton, Mark F Conrad, Eri...> ;JVS-Vascular Science. 2022 Jan 1
• 67 citations
  Deep learning enables genetic analysis of the human thoracic aorta.
  James P. Pirruccello, Mark Chaffin, Elizabeth L. Chou, Stephen J. Fleming, Honghuang Lin, Mahan Nekoui, Shaan Khurshid, Samuel Friedman, Alexander G. Bick, Alessandro ...> ;Nature Genetics. 2021 Nov 26
• 12 citations
  Structural and Functional Analysis of Female Sex Hormones against SARS-CoV-2 Cell Entry.
  Jorge Alberto Aguilar-Pineda, Mazen Albaghdadi, Wanlin Jiang, Karin J. Vera-López, Rita Nieto-Montesinos, Karla Lucia F Alvarez, Gonzalo Davila Del-Carpio, Badhin Góme...> ;International Journal of Molecular Sciences. 2021 Oct 26
• Case 30-2021: A 47-Year-Old Man with Recurrent Unilateral Head and Neck Pain.
  Mark E. Lindsay, David M. Dudzinski, Byung C. Yoon, Michael R. Jaff, Joseph V. Thakuria> ;The New England Journal of Medicine. 2021 Sep 30
• 16 citations
  Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease.
  Jorge Alberto Aguilar-Pineda, Karin J. Vera-López, Pallavi Shrivastava, Miguel A. Chávez-Fumagalli, Rita Nieto-Montesinos, Karla L. Alvarez-Fernandez, Luis D. Goyzueta...> ;Iscience. 2021 Aug 19
• 7 citations
  Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction.
  Rajeev Malhotra, Christopher J. Nicholson, Dongyu Wang, Vijeta Bhambhani, Samantha M. Paniagua, Charles Slocum, Haakon H. Sigurslid, Christian L. Lino Cardenas, Rebecc...> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Jun 18
• 8 citations
  Role of Clinical Genetic Testing in the Management of Aortopathies.
  Stephanie L. Harris, Mark E. Lindsay> ;Current Cardiology Reports. 2021 Jan 21
• 1 citations
  Structural and functional analysis of female sex hormones against SARS-Cov2 cell entry.
  Jorge Alberto Aguilar-Pineda, Mazen Albaghdadi, Wanlin Jiang, Karin J Vera Lopez, Gonzalo Davila Del-Carpio, Badhin Gomez Valdez, Mark E. Lindsay, Rajeev Malhotra, Chr...> ;Biorxiv. 2020 Jul 29
• 17 citations
  Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits
  Mohammed M. Chowdhury, Kanwarpal Singh, Mazen Albaghdadi, Haitham Khraishah, Adam Mauskapf, Chase W. Kessinger, Eric A. Osborn, Stephan Kellnberger, Zhonglie Piao, Chr...> ;JACC. Basic to Translational Science. 2020 Jun 10
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Journal Articles

• Original Investigation Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection  
  Gregor U Andelfinger, Alan F Scott, Harry C Dietz, Mark E Lindsay, Dianna M Milewicz, ScienceDirect