Mark Linskey, MD

Mark Linskey, MD

Neurosurgery Orange, CA

Professor of Neurological Surgery, UC Irvine

Office Address

Office Map
  • Dept of Surgery, UCI MC,
    333 City Blvd West, 8th Floor, Suite #810
    Orange, CA 92868
    Phone: (714) 456-5533
    Fax: (714) 456-8205


  • Clinician Scientist and Educator with focus on Surgical Neuro-Oncology, Skull base microsurgery, Endoscopic minimally invasive surgery, Image-guided surgery, Gamma Knife Stereotactic Radiosurgery, Stereotactic tumor surgery and cranial nerve disorder surgery (TN, HFS, GPN). Experienced in building and leading academic departments and multidisciplinary clinical programs. Experienced in training medical students and residents as well as establishing and leading ACGME-accredited neurosurgery residency training programs. Clinical and basic science laboratory research interests focused on glioma biology with translational emphasis. Experienced national neurosurgery organizer and leader with focus on evidence-based medicine clinical practice guideline development as well as socio-economic, health policy and regulatory issues as they relate to neurosurgery.

Dr. Linskey's Clinical Specialties & Interests

  • Neurosurgery: Brain & Spinal Tumor, Skull Base, Pituitary Surgery, Stereotactic & Functional
  • Clinical Interests: Brain Neoplasms; Practice Guidelines as Topic; Evidence-Based Medicine; Radiosurgery; Cavernous Sinus; Acoustic Neuroma; Glioma; Trigeminal Neuralgia; Meningioma; Glossopharyngeal Neuralgia; Pituitary Neoplasms; Hemifacial Spasm; Skull Base Tumors; Metastatic Brain Tumor

Dr. Linskey's Faculty Appointments & Work History

  • Staff NeurosurgeonHoag/UCI Gamma Knife Center
    Newport Beach, CA
  • Staff NeurosurgeonHoag Memorial Hospital Presbyterian
    Newport Beach, CA
  • Staff NeurosurgeonSaint Joseph Hospital
    Orange, CA
  • Staff NeurosurgeonChildren’s Hospital of Orange County
    Orange, CA
  • Staff NeurosurgeonUniversity of California, Irvine, Medical Center
    Orange, CA
    Chief of Neurosurgery Service (2004-2009); Associate Professor of Neurological Surgery (2004-2012); Professor of Neurological Surgery (2012-present); Professor of Otolaryngology- Head & Neck Surgery (2012-present);
  • Naval Reserve, Active Staff Appointment, NeurosurgeryCentralized Credentials Review and Privileging Dept Naval Healthcare Support Office
    Jacksonville, FL
  • Co-DirectorArkansas Cancer Research Center
    Little Rock, AR
    Director, Brain Tumor (1998-2004)
  • Staff NeurosurgeonUniversity Hospital of Arkansas
    Little Rock, AR
    Associate Professor of Neurological Surgery (1998-2004); Co-Director, Gamma Knife Stereotactic (1998-2004)
  • Acting Head, Pediatric NeurosurgeryArkansas Children's Hospital & University of Arkansas for Medical Sciences
    Little Rock, AR
    Assistant Chief (1999-2002)
  • Staff NeurosurgeonMcClellan Veteran’s Administration Hospital
    Little Rock, AR
  • Staff NeurosurgeonChildren’s Hospital of Arkansas
    Little Rock, AR
  • Staff NeurosurgeonScripps Memorial Hospital
    La Jolla, CA
  • Staff NeurosurgeonSan Diego Gamma Knife Center
    La Jolla
  • Staff NeurosurgeonNaval Medical Center
    San Diego, CA
    Staff Neurosurgeon (1994-1996); Head Department of Neurosurgery (1995); Head Division of Neurosurgery (1996-1998); Interim Program Director Neurological Surgery (1997)

Dr. Linskey's Education & Medical Training

  • Ludwig Institute for Cancer ResearchLudwig Institute for Cancer ResearchFellowship, Neuro-Oncology Research Fellowship
  • University Health Centers of PittsburghUniversity Health Centers of PittsburghChief Residency, Neurosurgery
  • Pittsburgh Cancer InstitutePittsburgh Cancer InstitutePost Doctoral Fellowship, Research
  • University Health Centers of PittsburghUniversity Health Centers of PittsburghResidency, Neurosurgery
  • University Health Centers of PittsburghUniversity Health Centers of PittsburghInternship, General Surgery
  • Columbia Univ Coll of Phys & SurgColumbia University College of Physicians and SurgeonsMedical School
  • Dartmouth CollegeDartmouth CollegeOther Training, BA, Philosophy, Summa Cum Laude
  • University of EdinburghUniversity of EdinburghOther Training, N/A, Philosophy

Dr. Linskey's Certifications & Licensure

  • AR State Medical LicenseAR State Medical License1998 - 2012
  • CA State Medical LicenseCA State Medical License1992 - 2015
  • PA State Medical LicensePA State Medical LicenseActive through 2012
  • American Board of Neurological SurgeryAmerican Board of Neurological SurgeryNeurological Surgery, 1996

Dr. Linskey's Awards, Honors, & Recognition

  • UC Irvine, SOMThomas Cesario Clinician of the Year NomineeUC Irvine, SOM, 2012
  • UC Irvine, SOM3rd Stanley van den Noort and Elliot Frohman Mentoring, NomineeUC Irvine, SOM, 2012
  • Congress of Neurological SurgeonsDistinguished Service AwardCongress of Neurological Surgeons, 2011
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Dr. Linskey's Publications & Presentations

PubMed | Citations by Web of Science®

Journal Articles

  • Failing to detect occult blood.Hovsepian DM, Linskey ME, Fedorak R, Ann Intern Med 1986; 105:471
  • Surgery for acoustic neurinomas.Linskey ME, Lunsford LD, J Neurosurg 1991; 75:497
  • Gamma knife treatment and collateral damage.Linskey ME, Johnstone P, J Neurosurg 2003; 99:938-940
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Books/Book Chapters

  • The Technique and Evaluation of Contemporary Radiosurgery.Chapter: Commentary on Foote RL, Pollock BE, Stafford SL. Radiosurgery of chordomas, glomus tumors, and malignant skull base tumorsPage 304 - 308
    Linskey ME
    Editors: Pollock BE.Futura Publishing, Co, Mount Kiscoe, NY
  • Concepts in Neurosurgery. Vol 10.Chapter: Quality and Cost in Neurological Surgery
    Linskey ME, Rutigliano M
    Editors: Haines SJ, Nelson PB.Lippincott William & Wilkins, Baltimore
  • Stereotactic Radiosurgery Update.Chapter: Stereotactic radiosurgery for acoustic nerve sheath tumorsPage 321 - 334
    Linskey ME, Lunsford LD, Flickinger JC
    Editors: Lunsford LD.Elsevier, New York
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  • Efficacy and Evolution of the Socioeconomic Fellowship of the Council of State Neurosurgical Societies.Hussain N, Benzil DL, Lobel DA, Linskey ME, Bloomgarden GM, Bingaman, W, Congress of Neurological Surgeons, Washington, DC
  • PAX6 Expression Is Required for Maintaining Stem Cell Features of Neural Stem-like Cells in Astrocytic Gliomas.Zhou YH, Hu Y, Rajneesh K, Linskey ME, Congress of Neurological Surgeons, San Franscisco, CA
  • Modulated imaging: A novel method for quantifying tissue chromophores in the brain.Mathews MS, Abookasis D, Lay C, Hirschberg H, Linskey ME, Frostig RD, et al, American Association of Neurological Surgeons, Washington, DC
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  • Clinical trial design.Congress of Neurological Surgeons, San Francisco, CA
  • Trigeminal neuralgia.TNA- The Facial Pain Association National Conference, San Diego, CA
  • Role for guidelines in the treatment of facial pain.New Orleans, LA
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  • Practice Guidelines-Why Bother? IOM, MedPAC and Others Call for Evidence-Based Quality Care.Linskey ME, AANS Bulletin, 2005; 14(1): 17
  • Practice guidelines-Why bother?Linskey ME, Neurosurgery News, 2005; 6(3): 12-14
  • Practice guidelines: Current status in neurosurgery.Linskey ME, Neurosurgery News 2005; 6(4): 6-8
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Dr. Linskey's Professional Memberships

  • MemberCongress of Neurological Surgeons - CNSMember
  • FellowAmerican Association of Neurological Surgeons - AANSFellow
  • MemberSociety of Neurological SurgeonsMember
  • MemberSociety of University NeurosurgeonsMember
  • MemberJoint Tumor Section (AANS/CNS)Member
  • MemberSociety of Neuro-OncologyMember
  • MemberNorth American Skull Base SocietyMember
  • MemberInternational Stereotactic Radiosurgery SocietyMember
  • MemberLeksell Gamma Knife SocietyMember
  • MemberSociety for NeuroscienceMember
  • MemberCouncil of State Neurosurgical SocietiesMember
  • MemberCalifornia Association of Neurological SurgeonsMember
  • MemberWestern Neurosurgical SocietyMember

Insurance Accepted

  • Aetna Choice POS II
  • Aetna HMO
  • BCBS Blue Card PPO
  • BCBS California PPO
  • Blue Shield California PPO
  • CIGNA Open Access
  • Connecticare FlexPOS
  • First Health PPO
  • Great West PPO
  • Health Net California Large Group PPO
  • HIP of New York - Select PPO
  • Humana ChoiceCare Network PPO
  • Multiplan PHCS PPO
  • Multiplan PPO
  • Oxford Health Freedom
  • Oxford Health Liberty
  • United Healthcare - Direct Choice Plus POS
  • United Healthcare - Direct Options PPO

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