Mark Linskey, MD

Mark Linskey, MD

Neurosurgery Orange, CA

Professor of Neurological Surgery, UC Irvine

Office Address

  • Dept of Surgery, UCI MC,
    333 City Blvd West, 8th Floor, Suite #810
    Orange, CA 92868
    Phone: (714) 456-5533
    Fax: (714) 456-8205

Mark Linskey, MD

Neurosurgery Orange, CA

Professor of Neurological Surgery, UC Irvine


  • Clinician Scientist and Educator with focus on Surgical Neuro-Oncology, Skull base microsurgery, Endoscopic minimally invasive surgery, Image-guided surgery, Gamma Knife Stereotactic Radiosurgery, Stereotactic tumor surgery and cranial nerve disorder surgery (TN, HFS, GPN). Experienced in building and leading academic departments and multidisciplinary clinical programs. Experienced in training medical students and residents as well as establishing and leading ACGME-accredited neurosurgery residency training programs. Clinical and basic science laboratory research interests focused on glioma biology with translational emphasis. Experienced national neurosurgery organizer and leader with focus on evidence-based medicine clinical practice guideline development as well as socio-economic, health policy and regulatory issues as they relate to neurosurgery.

Clinical Specialties & Interests

  • Neurosurgery: Brain & Spinal Tumor, Pituitary Surgery, Skull Base, Stereotactic & Functional Neurosurgery
  • Clinical Interests: Brain Neoplasms; Practice Guidelines as Topic; Evidence-Based Medicine; Radiosurgery; Cavernous Sinus; Acoustic Neuroma; Glioma; Trigeminal Neuralgia; Meningioma; Glossopharyngeal Neuralgia; Pituitary Neoplasms; Hemifacial Spasm; Skull Base Tumors; Metastatic Brain Tumor

Education & Training

  • Ludwig Institute for Cancer Research
  • University Health Centers of Pittsburgh
  • Pittsburgh Cancer Institute
  • University Health Centers of Pittsburgh
  • University Health Centers of Pittsburgh
  • Columbia University College of Physicians & SurgeonsColumbia University College of Physicians & Surgeons
  • Dartmouth CollegeDartmouth College
  • University of Edinburgh

Certifications & Licensure

  • AR State Medical LicenseAR State Medical License1998 - 2012
  • CA State Medical LicenseCA State Medical License1992 - 2017
  • PA State Medical LicensePA State Medical LicenseActive through 2012

      Awards, Honors, & Recognition

      • America's Top DoctorsCastle Connolly, 2014, 2013, 2012, 2011, 2010, 2009
      • Top Doctors:LA AreaCastle Connolly, 2013
      • Top Doctors:San Diego AreaCastle Connolly, 2013

      Clinical Trials

      Publications & Presentations


      Journal Articles

      • Failing to detect occult blood.  Hovsepian DM, Linskey ME, Fedorak R, Ann Intern Med 1986; 105:471
      • Surgery for acoustic neurinomas.  Linskey ME, Lunsford LD, J Neurosurg 1991; 75:497
      • Gamma knife treatment and collateral damage.  Linskey ME, Johnstone P, J Neurosurg 2003; 99:938-940

      Books/Book Chapters

      • The Technique and Evaluation of Contemporary Radiosurgery. Chapter: Commentary on Foote RL, Pollock BE, Stafford SL. Radiosurgery of chordomas, glomus tumors, and malignant skull base tumors Page 304 - 308
        Linskey ME
        Editors: Pollock BE.Futura Publishing, Co, Mount Kiscoe, NY
      • Concepts in Neurosurgery. Vol 10. Chapter: Quality and Cost in Neurological Surgery 
        Linskey ME, Rutigliano M
        Editors: Haines SJ, Nelson PB.Lippincott William & Wilkins, Baltimore
      • Stereotactic Radiosurgery Update. Chapter: Stereotactic radiosurgery for acoustic nerve sheath tumors Page 321 - 334
        Linskey ME, Lunsford LD, Flickinger JC
        Editors: Lunsford LD.Elsevier, New York


      • Efficacy and Evolution of the Socioeconomic Fellowship of the Council of State Neurosurgical Societies. Hussain N, Benzil DL, Lobel DA, Linskey ME, Bloomgarden GM, Bingaman, W, Congress of Neurological Surgeons, Washington, DC
      • PAX6 Expression Is Required for Maintaining Stem Cell Features of Neural Stem-like Cells in Astrocytic Gliomas. Zhou YH, Hu Y, Rajneesh K, Linskey ME, Congress of Neurological Surgeons, San Franscisco, CA
      • Modulated imaging: A novel method for quantifying tissue chromophores in the brain. Mathews MS, Abookasis D, Lay C, Hirschberg H, Linskey ME, Frostig RD, et al, American Association of Neurological Surgeons, Washington, DC


      • Clinical trial design. Congress of Neurological Surgeons, San Francisco, CA
      • Trigeminal neuralgia. TNA- The Facial Pain Association National Conference, San Diego, CA
      • Role for guidelines in the treatment of facial pain. New Orleans, LA


      • Practice Guidelines-Why Bother? IOM, MedPAC and Others Call for Evidence-Based Quality Care. Linskey ME, AANS Bulletin, 2005; 14(1): 17
      • Practice guidelines-Why bother? Linskey ME, Neurosurgery News, 2005; 6(3): 12-14
      • Practice guidelines: Current status in neurosurgery. Linskey ME, Neurosurgery News 2005; 6(4): 6-8

      Professional Memberships

      • Congress of Neurological Surgeons - CNSMember
      • American Association of Neurological Surgeons - AANSFellow
      • Society of Neurological SurgeonsMember
      • Society of University NeurosurgeonsMember
      • Joint Tumor Section (AANS/CNS)Member
      • Society of Neuro-OncologyMember
      • North American Skull Base SocietyMember
      • International Stereotactic Radiosurgery SocietyMember
      • Leksell Gamma Knife SocietyMember
      • Society for NeuroscienceMember
      • Council of State Neurosurgical SocietiesMember
      • California Association of Neurological SurgeonsMember
      • Western Neurosurgical SocietyMember

      Insurance Accepted

      • Aetna Choice POS II
      • Aetna HMO
      • BCBS Blue Card PPO
      • BCBS California PPO
      • Blue Shield California PPO
      • CIGNA HMO
      • CIGNA Open Access
      • CIGNA PPO
      • Connecticare FlexPOS
      • First Health PPO
      • GHI PPO
      • Great West PPO
      • Health Net California Large Group PPO
      • HIP of New York - Select PPO
      • Humana ChoiceCare Network PPO
      • Multiplan PHCS PPO
      • Multiplan PPO
      • Oxford Health Freedom
      • Oxford Health Liberty
      • United Healthcare - Direct Choice Plus POS
      • United Healthcare - Direct Options PPO
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