Matthew John Weiss MD

General Surgery•New Hyde Park, NY

Hepatobiliary Surgery, Pancreas, Surgical Oncology (Other than Breast)

Deputy Physician-in-Chief & Surgical Director of Northwell Health Cancer Institute

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1111 Marcus AveNew Hyde Park, NY 11042
Phone+1 516-321-2239

Summary

Dr. Matthew Weiss is a general surgeon in New Hyde Park, NY and is affiliated with the Northwell Health System. He received his medical degree from Sidney Kimmel Medical College and has been in practice 14 years. He was previously the chief of hepatopancreatobiliary surgery at Johns Hopkins. He specializes in hepatobiliary surgery, pancreas, and surgical oncology (other than breast) and is experienced in trauma and surgical critical care, surgical oncology (non-breast), colorectal surgery, general / gastrointestinal surgery, and hepatopancreatobiliary surgery.

Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Complex General Surgical Oncology, 2010 - 2012
Johns Hopkins UniversityResidency, Surgery, 2003 - 2010
Massachusetts General HospitalPost-Doctoral Fellowship, 2005 - 2007
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 2003

Certifications & Licensure

NY State Medical License 2010 - 2026
FL State Medical License 2018 - 2020
MD State Medical License 2012 - 2019
MA State Medical License 2005 - 2007
American Board of Surgery Surgery

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013-2014
Fellow (FACS) American College of Surgeons

Clinical Trials

Palliative Stereotactic Radiation for Pancreatic or Periampullary Adenocarcinoma Start of enrollment: 2013 Jan 01
COMPLETED
PHASE2

Publications & Presentations

PubMed

Time-varying hazards of recurrence patterns among patients with colorectal liver metastases undergoing liver resection and the role of the modified tumor burden score.
Odysseas P Chatzipanagiotou, Jun Kawashima, Andrea Baldo, Andrea Ruzzenente, George A Poultsides
European Journal of Surgical Oncology. 2025-12-01
Satellite lesions versus intrahepatic metastasis in multifocal intrahepatic cholangiocarcinoma: Prognostic impact and genomic profiling.
Tao Wei, Zhi-Jie Ma, Shouliang Guo, Matthew Weiss, Irinel Popescu
Hepatology. 2025-10-30
Characteristics of "Very Early" Intrahepatic Cholangiocarcinoma Undergoing Liver Resection and Its Relationship With Carbohydrate Antigen 19-9.
Yutaka Endo, Jun Kawashima, Selamawit Woldesenbet, Miho Akabane, Andrea Ruzzente
Journal of Surgical Oncology. 2025-10-01

Journal Articles

Pancreatic Cancer Arising in the Remnant Pancreas Is Not Always a Relapse of the Preceding Primary
John L Cameron, Christopher L Wolfgang, Jin He, Matthew J Weiss, Ralph H Hruban, Michael Goggins, Nature
Single‐Cell Sequencing Defines Genetic Heterogeneity in Pancreatic Cancer Precursor Lesions
Kevin Waters, Jin He, Christopher L Wolfgang, Ralph H Hruban, Michael G Goggins, Matthew J Weiss, Justin Poling, The Journal of Pathology
Outcome of Patients with Borderline Resectable Pancreatic Cancer in the Contemporary Era of Neoadjuvant Chemotherapy
Alex B Blair, Joseph Herman, Martin Makary, John L Cameron, Amol Narang, Daniel Laheru, Christopher Wolfgang, Matthew J Weiss, Ammar A Javed, Jin He, Journal of gastrointestinal surgery
Blood Type as a Predictor of High-Grade Dysplasia and Associated Malignancy in Patients with Intraductal Papillary Mucinous Neoplasms
Martin A Makary, Michael Goggins, James Griffin, Katherine E Poruk, Jin He, Matthew J Weiss, John L Cameron, Christopher L Wolfgang, Journal of gastrointestinal surgery
Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I Do It
Matthew Weiss, Herbert J Zeh, Journal of gastrointestinal surgery
The Impact of Extent of Liver Resection Among Patients with Neuroendocrine Liver Metastasis: An International Multi-Institutional Study
Bradley N Reames, Todd W Bauer, Michele M Gage, Shishir Maithel, Ryan C Fields, Matthew J Weiss, Timothy M Pawlik, Jin He, Journal of gastrointestinal surgery
Implications of the Pattern of Disease Recurrence on Survival Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma
Jin He, Ammar A Javed, John L Cameron, Alex B Blair, Elliot K Fishman, Matthew J Weiss, Ralph H Hruban, Christopher L Wolfgang, Annals of Surgical Oncology
Pancreaticoduodenectomy with en Bloc Vein Resection for Locally Advanced Pancreatic Cancer: A Case Series Without Venous Reconstruction
Bradley N Reames, Matthew J Weiss, Christopher L Wolfgang, Jin He, Elliot K Fishman, Michele M Gage, Annals of Palliative Medicine
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Lectures

BRAF V600E Mutation as a Negative Prognostic Determinant in Resected Colorectal Liver Metastases—Reply
ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/24/2020

Press Mentions

Northwell Health Performs First New Liver Tumor Treatment on Long IslandJuly 25th, 2025
Northwell Cancer Institute Only Center on Long Island to Develop Program to Treat Liver Tumors With Noninvasive Targeted Ultrasound BeamsNovember 20th, 2024
Targeting Cancer’s Achilles HeelSeptember 9th, 2022
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