MelanieGCreeMDPhD

PubMed

• Estimating insulin sensitivity and β-cell function from the oral glucose tolerance test: validation of a new insulin sensitivity and secretion (ISS) model.
  Green, M. C., Joon Ha, Stephanie T Chung, Max Springer, Joon Young Kim, Phil Chen, Aaryan Chhabra, Melanie G Cree, Cecilia Diniz Behn, Anne E Sumner, Silva A Arslanian...> ;American Journal of Physiology. Endocrinology and Metabolism. 2024 Apr 1
• Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity.
  Talyia M Fordham, Nazeen S Morelli, Yesenia Garcia-Reyes, Meredith A Ware, Haseeb Rahat, Divya Sundararajan, Kelly N Z Fuller, Cameron Severn, Laura Pyle, Craig R Mall...> ;Obesity. 2024 Apr 1
• Distinct Reproductive Phenotypes Segregate With Differences in Body Weight in Adolescent Polycystic Ovary Syndrome.
  Chen-Patterson, A., Khan, T., Bernier, A., Burgert, T., Davis, V., Geller, D., Paprocki, E., Shah, R., Witchel, S., Pereira-Eshraghi, C., Sopher, A., Cree, M., Torchen...> ;Journal of the Endocrine Society. 2024 Jan 5
• 3 citations
  Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver.
  Eunsook S Jin, Craig R Malloy, Gaurav Sharma, Erin Finn, Kelly N Z Fuller, Yesenia Garcia Reyes, Mark A Lovell, Sarkis C Derderian, Jonathan A Schoen, Thomas H Inge, G...> ;Redox Biology. 2023 Jul 1
• 1 citations
  In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome
  Stephanie Cung, Laura Pyle, Kristin Nadeau, Dana Dabelea, Melanie Cree-Green, Shanlee M Davis> ;Journal of Investigative Medicine. 2021 Sep 7
• 13 citations
  Differential loss of β-cell function in youth vs. adults following treatment withdrawal in the Restoring Insulin Secretion (RISE) study.
  Kristina M. Utzschneider, Mark Tripputi, Alexandra Kozedub, Elena Barengolts, Sonia Caprio, Melanie Cree-Green, Sharon L. Edelstein, Laure El Ghormli, Tamara S. Hannon...> ;Diabetes Research and Clinical Practice. 2021 Jul 15
• 5 citations
  Weight Management in Adolescents with Polycystic Ovary Syndrome.
  Jaime M. Moore, Stephanie W Waldrop, Melanie Cree-Green> ;Current Obesity Reports. 2021 May 27
• 1 citations
  Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β-Cell Function.
  Anny H. Xiang, Mayra P. Martinez, Enrique Trigo, Kristina M. Utzschneider, Melanie Cree-Green, Silva A. Arslanian, David A. Ehrmann, Sonia Caprio, Passant Mohamed, Dar...> ;Obesity. 2021 May 26
• 18 citations
  Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity
  Julia Hudnut-Beumler, Jill L. Kaar, Anya Taylor, Megan M. Kelsey, Kristen J. Nadeau, Philip Zeitler, Janet K. Snell-Bergeon, Laura Pyle, Melanie Cree-Green> ;Pediatric Diabetes. 2021 Apr 27
• 11 citations
  Care for Adolescents With Polycystic Ovary Syndrome: Development and Prescribing Patterns of a Multidisciplinary Clinic.
  C. Torres-Zegarra, D. Sundararajan, J. Benson, H. Seagle, M. Witten, N. Walders-Abramson, Stacey L. Simon, Patricia Huguelet, Natalie J. Nokoff, Melanie Cree-Green> ;Journal of Pediatric and Adolescent Gynecology. 2021 Mar 29
• 3 citations
  Precision and accuracy of hyperglycemic clamps in a multicenter study.
  Kieren J. Mather, Ashley H. Tjaden, Kristen J. Nadeau, Thomas A. Buchanan, Steven E. Kahn, Silva A. Arslanian, Sonia Caprio, Karen M. Atkinson, Melanie Cree-Green, Kri...> ;American Journal of Physiology. Endocrinology and Metabolism. 2021 Apr 1
• 72 citations
  Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota
  Beza Jobira, Daniel N. Frank, Laura Pyle, Lori J. Silveira, Megan M. Kelsey, Yesenia Garcia-Reyes, Charles E. Robertson, Diana Ir, Kristen J. Nadeau, Melanie Cree-Green> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1
• 19 citations
  Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity
  Stacey L. Simon, Haseeb Rahat, Anne-Marie Carreau, Yesenia Garcia-Reyes, Ann C. Halbower, Laura Pyle, Kristen J. Nadeau, Melanie Cree-Green> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Apr 1
• Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report.
  Sonalee Jaya Ravi, Melanie Cree-Green> ;Journal of Investigative Medicine High Impact Case Reports. 2019 Jan 1
• 58 citations
  Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.
  Melanie Cree-Green, Bryan C. Bergman, Eda Cengiz, Larry A. Fox, Tamara S. Hannon, Kellee M. Miller, Brandon M. Nathan, Laura Pyle, Darcy E. Kahn, Michael Tansey, Eilee...> ;The Journal of Clinical Endocrinology and Metabolism. 2019 Aug 1
• 46 citations
  Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome
  Stacey L. Simon, Laura McWhirter, Cecilia Diniz Behn, Kate M Bubar, Jill L. Kaar, Laura Pyle, Haseeb Rahat, Yesenia Garcia-Reyes, Anne-Marie Carreau, Kenneth P. Wright...> ;The Journal of Clinical Endocrinology and Metabolism. 2019 Aug 1
• 81 citations
  Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.
  Petter Bjornstad, Michal Schäfer, Uyen Truong, Melanie Cree-Green, Laura Pyle, Amy Baumgartner, Yesenia Garcia Reyes, Aristides K. Maniatis, Sunil Nayak, R. Paul Wadwa...> ;Circulation. 2018 Dec 18
• 8 citations
  Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes.
  Rebecca L. Scalzo, Irene E. Schauer, Deirdre Rafferty, Leslie A. Knaub, Nina Kvaratskhelia, Taro Kaelix Johnson, Gregory B. Pott, Layla A Abushamat, Mary O. Whipple, A...> ;The Journal of Physiology. 2021 Mar 5
• Fasting plasma metabolomic profiles are altered by three days of standardized diet and restricted physical activity.
  Laura Pyle, Anne-Marie Carreau, Haseeb Rahat, Yesenia Garcia-Reyes, Bryan C. Bergman, Kristen J. Nadeau, Melanie Cree-Green> ;Metabolism Open. 2021 Feb 6
• Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study.
  Mokhlesi B, Tjaden AH, Temple KA, Edelstein SL, Sam S, Nadeau KJ, Hannon TS, Manchanda S, Mather KJ, Kahn SE, Ehrmann DA, Van Cauter E, RISE Consortium> ;Diabetes care. 2021-02-05
• 9 citations
  Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome.
  Stanley Andrisse, Yesenia Garcia-Reyes, Laura Pyle, Megan M. Kelsey, Kristen J. Nadeau, Melanie Cree-Green> ;Journal of the Endocrine Society. 2021 Feb 2
• 12 citations
  Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome.
  Beza Jobira, Daniel N. Frank, Lori J. Silveira, Laura Pyle, Megan M. Kelsey, Yesenia Garcia-Reyes, Charles E. Robertson, Diana Ir, Kristen J. Nadeau, Melanie Cree-Green> ;Plos One. 2021 Jan 19
• 8 citations
  Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration.
  Kai Bartlette, Anne-Marie Carreau, Danielle Xie, Yesenia Garcia-Reyes, Haseeb Rahat, Laura Pyle, Kristen J. Nadeau, Melanie Cree-Green, Cecilia Diniz Behn> ;Metabolism Open. 2021 Jan 7
• 8 citations
  Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes.
  Kalie L. Tommerdahl, Karl V. Baumgartner, Michal Schäfer, Petter Bjornstad, Isabella Melena, Shannon Hegemann, Amy Baumgartner, Laura Pyle, Melanie Cree-Green, Uyen Tr...> ;Diabetes Care. 2021 Jan 5
• 37 citations
  Lean NAFLD: an underrecognized and challenging disorder in medicine
  Sheila Maier, Amanda Wieland, Melanie Cree-Green, Kristen J. Nadeau, Shelby Sullivan, Miguel A. Lanaspa, Thomas Jensen> ;Reviews in Endocrine & Metabolic Disorders. 2021 Jan 3
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Journal Articles

• Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span  
  Reusch JEB, Kumar TR, Regensteiner JG, Zeitler PS; Conference Participants, Endocrinology, 1/1/2018
• Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome  
  M. Cree-Green; H. Rahat; B.R. Newcomer; B.C. Bergman; M.S. Brown; G.V. Coe; L. Newnes; Y. Garcia-Reyes; S. Bacon; J.E. Thurston; L. Pyle; A. Scherzinger; K. J. Nadeau, J Endocr Soc, 1/1/2017
• Increased Hepatic Steatosis in Obese Adolescents with Hyperandrogenism Relates to Peripheral Insulin Resistance and Markers of De Novo Lipogenesis  
  M. Cree-Green, B. Bergman, G.L. Coe, L. Newnes, A. Sherzinger, L. Pyle, K.J. Nadeau, Obesity, 1/1/2016
• Maternal pre-pregnancy BMI predicts neonatal hepatic fat  
  . Brumbaugh, P. Tearse, M. Cree-Green, L. Fenton, M. Brown, A. Scherzinger, R. Reynolds, M. Alston, C. Hoffman, Z. Pan, J.E. Friedman, L.A. Barbour., J Pediatr, 1/1/2013
• Invited review: Autoimmunity and insulin resistance in T1D  
  N. Nokoff, M. Rewers, M. Cree-Green, Discov Med, 1/1/2012
• Human mitochondrial oxidative capacity is acutely impaired following burn trauma  
  M.G. Cree, R. Y. Fram, T. Qian, A.Aarsland, D.N.Herndon, R.R. Wolfe, Am J Surg, 1/1/2008
• Insulin sensitivity is related to fat oxidation and protein kinase C, but not intracellular diacylglycerol in children with burn injury  
  M.G. Cree, J. Zwetsloot, D.N. Herndon, R.Y. Fram, B.R. Newcomer, G.L. Dohm, D. Sun, A. Aarsland, R.R. Wolfe, J Burn Care and Research, 1/1/2008
• Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate  
  M.G. Cree, T. Qian, D.N. Herndon, B. Morio, R. Fram, J.J. Zwetsloot, A. P. Sanford, A. Aarsland, R. R. Wolfe, Ann Surg, 1/1/2007
• Calculation of the acetate correction factor for fatty acid oxidation measurements in severely burned children  
  R.Y. Fram, M.G. Cree, D.N. Herndon, D. Chinkes, R.R. Wolfe, AJP Endo & Metab, 1/1/2007
• Glucose and fat metabolism following severe burn injury Invited review  
  M.G. Cree, A. Aarsland, D.N. Herndon, R.R. Wolfe, Crit Care Med, 1/1/2007
• Milk ingestion stimulates net muscle protein synthesis following resistance exercise  
  T.A. Elliot, M.G. Cree, A.P. Sanford, R.R. Wolfe, K.D. Tipton, Med & Sci Sports & Exercise, 1/1/2006
• Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones  
  L.J. Lu, M. Cree, S. Josyula, M. Nagamani, J.J. Grady, K.E. Anderson, Cancer Res, 1/1/2000
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Books/Book Chapters

• Pediatric Endocrinology and Inborn Errors of Metabolism 
  Chapter: Vaginal Bleeding and Menstrual Disorders 
  B.I. Frohnert, M. Cree-Green, C.A. TerrellEdition 2nd,2017
• Aging Men's Health 
  Chapter: Effect of Androgens on Muscle, Bone, and Hair in Men 
  Page 83 - 93M. Sheffield-Moore, D. Paddon-Jones, M.G. Cree, D.W. Lackan, and R.J. UrbanEditors: Tan RS.Thieme Medical Publishers, New York, NY2005

Abstracts/Posters

• Comparing methods for estimating the rate of appearance of exogenous glucose in an oral glucose tolerance test
  Kai, M. Cree-Green, B.C. Bergman, K.J. Nadeau, C. Diniz Behn, SIAM, 1/1/2018
• Modeling tissue-specific insulin resistance in obese adolescent girls during an oral glucose tolerance test
  C. Diniz Behn , B.C. Bergman, K.J. Nadeau, M. Cree-Green, SIAM, 1/1/2018
• Metformin Improves Insulin Sensitivity and Vascular Health in Youth with Type 1 Diabetes (T1D): The Effects of MEtformin on CardiovasculaR function in AdoLescents with...
  K.J. Nadeau, P. Bjornstad, M. Schäfer, M. Cree-Green, A. Baumgartner, Y. Garcia-Reyes, L.Pyle, A. Maniatis, S.Nayak, R. P. Wadwa, L. Browne, U. Truong, J.E.B. Reusch, ADA, 1/1/2018
• Late reactive hypoglycemia as a sign of early glycemic dysfunction in obese adolescent girls
  A.-M. Carreau, H. Rahat, Y. Garcia-Reyes, L. Pyle, K.J. Nadeau*, M.Cree-Green*, ADA, 1/1/2018
• School Year Circadian Misalignment is Associated with Insulin Resistance in Obese Girls
  S.L. Simon, C. Diniz Behn, Jill L. Kaar, PhD, Laura Pyle, PhD, H. Rahat, Y. Garcia-Reyes, MS, K.P. Wright JR., A.C. Halbower, MD, K.J. Nadeau* & M. Cree-Green*, Sleep, 1/1/2018
• Estimated Glomerular Filtration Rate Correlates with Ascending Aortic Wall Shear Stress in Adolescents with Type 1 Diabetes
  P.Bjornstad, D.M. Maahs, D. Z. Cherney, M. Cree-Green, A. West, L. Pyle, K.J. Nadeau, PAS, 1/1/2018
• Standardizing Depression Screening in Adolescents with Type 2 Diabetes within a Multi-Disciplinary Clinic
  TA Ellis, M Cree-Green, C. Retamal-Munoz, MM Kelsey, KJ Nadeau, J. of Investigative Medicine, 1/1/2018
• Hepatic stiffness Relates to Markers of Hepatocellular Stress and Post-Prandial Metabolism in Obese Adolescent girls
  M Cree-Green, A.M Carreau, T Jensen, Y Garcia-Reyes, H Rahat, D Befory, BR Newcomer, MS Brown, KJ Nadeau, J. of Investigative Medicine, 1/1/2018
• The Branched chain Amino Acid Valine is Higher and Relates to Insulin Sensitivity in Polycystic Ovarian Syndrome
  H. Rahat; Y. Garcia-Reyes; L. Pyle; K.J. Nadeau; M. Cree-Green, J. of Investigative Medicine, 1/1/2018
• Youth with Type 2 Diabetes Have Hepatic and Peripheral IR
  Stuppy JJ, Cree-Green M, Bergman B, Coe G, Baumgartner A, Bacon S, Sherzinger A, Pyle L, Nadeau KJ, J. of Investigative Medicine, 1/1/2018
• Associations between Liver Stiffness by Magnetic Resonance Elastography (MRE), Liver Phospholipids Metabolites and Post-OGTT Metabolism in Obese Adolescent girls with ...
  A-M Carreau, T Jensen, Y Garcia-Reyes, H Rahat, D Befroy, BR Newcomer, MS Brown, KJ Nadeau, M Cree-Green, Keystone Symposia on Obesity and NAFLD, 1/1/2018
• Obese Adolescents with Polycystic Ovary Syndrome have Decreased Diversity and Relative Abundance in the Gastrointestinal Microbiota
  B. Jobira, D. Frank, M. Kelsey, D. Ir, C.E. Robertson, Y. Garcia-Reyes, H. Rahat, KJ. Nadeau, M. Cree-Green, AE-PCOS, 1/1/2017
• Extreme hyperandrogenism worsens metabolic but not physical outcomes in obese adolescents with polycystic ovarian syndrome
  M. Cree-Green, M. Torres, A. Scherzinger, L. Pyle, MM. Kelsey, K. J. Nadeau, PES annual meeting, 1/1/2017
• Is it extreme polycystic ovarian syndrome or a tumor?
  Ravi S, Cree-Green M, PES annual meeting, 1/1/2017
• Youth with type 2 diabetes have hepatic, adipose and peripheral insulin resistance
  Pyle L, Stuppy JJ, Cree-Green M, Bergman B, Coe G, Baumgartner A, Bacon S, Sherzinger A, Nadeau KJ, ISPAD, 1/1/2017
• Predicting Insulin Resistance in Adolescent Girls with PCOS
  M. Cree-Green, N.M. Cai, J.E. Thurston, G. V. Coe, L. Newnes, A.D. Baumgartner, L. Pyle, K. J. Nadeau, Endocrine Society Annual Meeting, 1/1/2017
• Markers of Cardiometabolic Health in Female-to-Male Transgender Youth on Testosterone Vs Females with Polycystic Ovarian Syndrome
  Nokoff NJ, M. Cree-Green, Scarbro S, Coe G, K. J. Nadeau, Kelsey MM, Endocrine Society Annual Meeting, 1/1/2017
• Youth with Type 1 Diabetes Have Hepatic and Peripheral Insulin Resistance
  Stuppy JJ, Cree-Green M, Bergman B, Coe G, Baumgartner A, Bacon S, Sherzinger A, Pyle L, Nadeau KJ, J. of Investigative Medicine, 1/1/2017
• The effect of Obesity on Insulin resistance and Cardiovascular Risk in Type 1 Diabetes
  Strickland K, Cree-Green M, Bjornstad P, Truong U, Pyle L, Baumgartner A, Coe G, Thurston J, Reusch JE, Nadeau KJ, J. of Investigative Medicine, 1/1/2017
• Insulin Resistance, Relative Postprandial Hyperinsulinemia and Mitochondrial Dysfunction in Normal Weight Girls with PCOS
  Rahat H, Bergman B, Brown M, Singel D, Newcomer B, Coe G, Newnes L, Scherzinger A, Nadeau KJ, Cree-Green M, J. of Investigative Medicine, 1/1/2017
• Altered Flow Hemodynamic Metrics in Descending Aorta Correlate With N-terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) in Youth With Type 1 Diabetes
  M. Schafer, P. Bjornstad, M. McClatchey, K.S. Hunter, M. Cree-Green, A. Baumgartner, A.J Barker, U. Truong, K.J. Nadeau, Circulation, 1/1/2016
• Cardiopulmonary dysfunction and adiponectin in adolescents with type 2 diabetes
  Journal of the American Heart Association, 1/1/2016
• Effect of Metformin on Insulin Sensitivity in Overweight Adolescents with Type 1 Diabetes (T1D)
  K.J. Nadeau, K.M. Miller, M. Cree-Green, E. Tsalikian, M. Tansey, J. Coffey, E. Cengiz, W. Tamborlane, T. Hannon, L. Fox, B. Nathan, R. Beck, I. Libman, MD, PhD8 f..., ADA Annual Meeting, 1/1/2016
• Sex Differences in Insulin Sensitivity in Youth without Diabetes exist, but have no Relationship with Muscle Mitochondrial Function
  M. Cree-Green, L. Pyle, M.S. Brown, B.R. Newcomer, B. Ringham, K.J. Nadeau, D. Dabelea, ADA Annual Meeting, 1/1/2016
• Non-Alcoholic Fatty Liver Disease in Obese Adolescent Girls is Associated With Insulin Resistance and Predictors of Cardiometabolic Disease
  R.L. Sewell, L. Pyle, A. Scherzinger, M. Cree-Green, K. Nadeau, J. of Investigative Medicine, 1/1/2016
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Lectures

• Chemistry in Human Research 
  Bryn Mawr College, Bryn Mawr, PA - 1/1/2017
• Assessment of metabolic disease in youth 
  Bethesda, MD - 1/1/2017
• T in PCOS 
  Washington, DC - 1/1/2017
• Predicting IR in PCOS 
  Orlando, FL - 1/1/2017
• Methods of assessing insulin action in humans 
  Aurora, CO - 1/1/2017
• Interactions between sleep and metabolic disease 
  Wright Sleep Lab, Boulder, CO - 1/1/2017
• IR and NALFD in Girls with PCOS 
  Keystone, CO - 1/1/2017
• Interpreting metabolomic data in biomedical research 
  Aurora, CO - 1/1/2017
• Diagnosing and treating PCOS in adolescence 
  1/1/2017
• Metabolic disease in PCOS 
  Vanderbilt University, TN - 1/1/2016
• IR in adolescence 
  Boston, MA - 1/1/2016
• Hepatic Steatosis in PCOS 
  Carmel, CA - 1/1/2016
• Silent metabolic disease in PCOS 
  Colorado Springs, CO - 1/1/2016
• Use of isotopomer analysis to study hepatic metabolis 
  Aurora, CO - 1/1/2016
• Understanding Hepatic Steatosis in PCOS 
  Aurora, CO - 1/1/2016
• Abnormalities in PCOS 
  Aurora, CO - 1/1/2016
• Mitochondrial function in T2D 
  San Diego, CA - 1/1/2015
• Altered Mitochondrial function in T2D youth 
  Aurora, CO - 1/1/2015
• Glucose Ra Response to Insulin 
  Cleveland, OH - 1/1/2014
• Fatty Liver in PCOS 
  Chicago, IL - 1/1/2014
• Subclinical insulin resistance in PCOS 
  Vancouver, Canada - 1/1/2014
• Mitochondrial Function in DM 
  Aurora, CO - 1/1/2014
• Fatty liver disease in PCOS 
  Aurora, CO - 1/1/2014
• Endocrine SE of ACTH therapy 
  Aurora, CO - 1/1/2014
• Assessment of insulin clamps 
  Aurora, CO - 1/1/2014
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Other

• PhD Thesis Defense 
  M.G. Cree
  UTMB Graduate School, Galveston, TX - 1/1/2005
• Biology Thesis Defense 
  M.G. Cree
  Bryn Mawr College, Bryn Mawr, PA - 1/1/1999